To improve the corneal permeability and water-solubility of disulfiram(DSF), which is an ocular drug for cataract, P188 was selected as a matrix to prepare solid dispersion of DSF(DSF SD) by hot melt method. The DSF S...To improve the corneal permeability and water-solubility of disulfiram(DSF), which is an ocular drug for cataract, P188 was selected as a matrix to prepare solid dispersion of DSF(DSF SD) by hot melt method. The DSF SD was characterized by DSC, XRD, and IR, and the results suggested that DSF was amorphous in DSF SD. The DSF SD was added to borate buffer solution(BBS) contained 20% poloxamer P407 and 1.2% poloxamer P188 to form in-situ gel. In vitro and in vivo experiments revealed that DSF SD combined with in-situ gel(DSF SD/in-situ gel) increased the residence time and the amount of DSF penetrated through the corneal. The pharmacodynamics studies exhibited DSF SD/in-situ gel delayed the development of selenium-induced cataract at some content. These results investigated that DSF SD/in-situ gel as a drug delivery system can improve DSF ocular permeability.展开更多
Taking the waterhead area of the middle line project for diverting water from the south to the north,Hanjiang watershed in Shiquan, as an example,ecological remediation of the small watershed was studied from aspects ...Taking the waterhead area of the middle line project for diverting water from the south to the north,Hanjiang watershed in Shiquan, as an example,ecological remediation of the small watershed was studied from aspects of necessity,practicability,plans and aims. The ecological restoration for soil and water conservation in Hanjiang River basin can not only control soil erosion and effectively protect water resources to provide clean water for people living in the lower reaches of Hanjiang mainstream,but also increase farmers' income and protect environment, which is both typical and exemplary.展开更多
基金supported by Liaoning Provincial Key Labora-tory of Drug Preparation Design and Evaluation of Liaoning Provincial Education Department(LZ2014045)
文摘To improve the corneal permeability and water-solubility of disulfiram(DSF), which is an ocular drug for cataract, P188 was selected as a matrix to prepare solid dispersion of DSF(DSF SD) by hot melt method. The DSF SD was characterized by DSC, XRD, and IR, and the results suggested that DSF was amorphous in DSF SD. The DSF SD was added to borate buffer solution(BBS) contained 20% poloxamer P407 and 1.2% poloxamer P188 to form in-situ gel. In vitro and in vivo experiments revealed that DSF SD combined with in-situ gel(DSF SD/in-situ gel) increased the residence time and the amount of DSF penetrated through the corneal. The pharmacodynamics studies exhibited DSF SD/in-situ gel delayed the development of selenium-induced cataract at some content. These results investigated that DSF SD/in-situ gel as a drug delivery system can improve DSF ocular permeability.
基金Supported by the Foundation for Scientific Research of Yangling Vocation and Technical College(A2010001)
文摘Taking the waterhead area of the middle line project for diverting water from the south to the north,Hanjiang watershed in Shiquan, as an example,ecological remediation of the small watershed was studied from aspects of necessity,practicability,plans and aims. The ecological restoration for soil and water conservation in Hanjiang River basin can not only control soil erosion and effectively protect water resources to provide clean water for people living in the lower reaches of Hanjiang mainstream,but also increase farmers' income and protect environment, which is both typical and exemplary.
