Achieving highly-efficient and stable perovskite solar cells(PSCs) with a simplified structure remains challenging, despite the tremendous potential for reducing preparation cost and facile processability by removing ...Achieving highly-efficient and stable perovskite solar cells(PSCs) with a simplified structure remains challenging, despite the tremendous potential for reducing preparation cost and facile processability by removing hole transport layer(HTL). In this work, eco-friendly glucose(Gl) as an interface modifier for HTL-free narrow bandgap tin-lead(Sn-Pb) PSCs is proposed. Gl not only enhances the wettability of the indium tin oxide to promote perovskite heterogeneous nucleation on substrate, but also realizes defect passivation by interacting with uncoordinated Pb^(2+) and Sn^(2+) in perovskite films. As a result, the quality of the perovskite films has been significantly improved, accompanied by reduced defects of bottom interface and optimized energy level structure of device, leading to an efficiency increase and a less nonradiative voltage loss of 0.102 V(for a bandgap of ~1.26 eV). Consequently, the optimized PSC delivers an unprecedented efficiency over 21% with high open-circuit voltage and enhanced stability, outperforming the control device. This work demonstrates a cost-effective approach to develop simplified structure high efficiency HTL-free Sn-Pb PSC.展开更多
<strong>Objective:</strong> To evaluate the effect of physical methods on the prevention of venous thrombosis in patients with peripherally inserted central catheter (PICC). <strong>Methods:</stro...<strong>Objective:</strong> To evaluate the effect of physical methods on the prevention of venous thrombosis in patients with peripherally inserted central catheter (PICC). <strong>Methods:</strong> Randomized controlled trials meeting the inclusion and exclusion criteria were retrieved from the following databases: Cochrane library, Pubmed, EMbase, Web of science, Ovid, CBM, CNKI, Wanfang, VIP, then Review Manage (RevMan) 5.3 software was used for data analysis. <strong>Results:</strong> A total of 24 RCTs including 3496 patients were analyzed in the study. The results of meta-analysis showed that various forms of upper limb movements could effectively decrease the incidence of venous thrombosis in the patients with PICC [<em>RR</em> = 0.23, 95% <em>CI</em> (0.16, 0.33), <em>P</em> < 0.01], upper limb movements could effectively improve the mean blood flow velocity of basilic vein [<em>MD</em> = 1.65, 95% <em>CI</em> (1.19, 2.11), <em>P</em> < 0.01]. <strong>Conclusion:</strong> Upper limb movements can effectively decrease the incidence of phlebothrombosis and improve the mean flow velocity of basilic vein in the patients undergoing PICC. Other forms of physical prevention methods need to be further studied due to insufficient sample size.展开更多
Background Broilers have a robust metabolism and high body temperature,which make them less tolerant to hightemperature(HT)environments and more susceptible to challenges from elevated temperatures.Gut microbes,functi...Background Broilers have a robust metabolism and high body temperature,which make them less tolerant to hightemperature(HT)environments and more susceptible to challenges from elevated temperatures.Gut microbes,functioning as symbionts within the host,possess the capacity to significantly regulate the physiological functions and environmental adaptability of the host.This study aims to investigate the effects of gut microbial intervention on the body temperature and thermogenesis of broilers at different ambient temperatures,as well as the underlying mechanism involving the"gut-brain"axis.Methods Broilers were subjected to gut microbiota interference with or without antibiotics(control or ABX)starting at 1 day of age.At 21 day of age,they were divided into 4 groups and exposed to different environments for 7 d:The control and ABX groups at room temperature(RT,24±1℃,60%relative humidity(RH),24 h/d)and the control-HT and ABX-HT groups at high temperature(HT,32±1℃,60%RH,24 h/d).Results The results demonstrated that the antibiotic-induced gut microbiota intervention increased body weight and improved feed conversion in broiler chickens(P<0.05).Under HT conditions,the microbiota intervention reduced the rectal temperature of broiler chickens(P<0.05),inhibited the expression of avUCP and thermogenesisrelated genes in breast muscle and liver(P<0.05),and thus decreased thermogenesis capacity.Furthermore,the gut microbiota intervention blunted the hypothalamic‒pituitary‒adrenal axis and hypothalamic–pituitary–thyroid axis activation induced by HT conditions.By analyzing the cecal microbiota composition of control and ABX chickens maintained under HT conditions,we found that Alistipes was enriched in control chickens.In contrast,antibioticinduced gut microbiota intervention resulted in a decrease in the relative abundance of Alistipes(P<0.05).Moreover,this difference was accompanied by increased hypothalamic 5-hydroxytryptamine(5-HT)content and TPH2 expression(P<0.05).Conclusions These findings underscore the critical role of the gut microbiota in regulating broiler thermogenesis via the gut-brain axis and suggest that the hypothalamic 5-HT pathway may be a potential mechanism by which the gut microbiota affects thermoregulation in broilers.展开更多
[Objectives]To explore the stability of sanguinarine and chelerythrine in Macleaya cordata(Willd.)R.Br.[Methods]The solubility and stability of sanguinarine and chelerythrine in seven solvents were measured by HPLC.Be...[Objectives]To explore the stability of sanguinarine and chelerythrine in Macleaya cordata(Willd.)R.Br.[Methods]The solubility and stability of sanguinarine and chelerythrine in seven solvents were measured by HPLC.Besides,the effects of water quality,light source,oxidant,temperature,and pH on stability were investigated.[Results]The solubility and stability of sanguinarine and chelerythrine in methanol and ethanol are good;the stability of sanguinarine and chelerythrine in distilled water and rainwater is not affected by light and is very stable,but they are unstable in tap water whether they are protected from light or not;oxidants have a great influence on the stability of sanguinarine and chelerythrine;sanguinarine and chelerythrine are stable at room temperature lower than 54℃;sanguinarine is stable in pH 2.5-7.0,while chelerythrine is stable in pH 2.5-8.0.[Conclusions]The good stability of sanguinarine and chelerythrine under specific conditions shows that they have broad development prospects and value.展开更多
[Objectives]To determine the optimal preparation technology of Clerodendrum bungei Steud.extract gel by orthogonal test and gel quality test method in General Rule 0114 of Chinese Pharmacopoeia(Volume IV,2020 Edition)...[Objectives]To determine the optimal preparation technology of Clerodendrum bungei Steud.extract gel by orthogonal test and gel quality test method in General Rule 0114 of Chinese Pharmacopoeia(Volume IV,2020 Edition),and to study its anorectal pharmacodynamics and drug release in vitro.[Methods]Carbomer 940,propylene glycol and absolute ethyl alcohol were selected as the main factors,and the preparation technology of C.bungei Steud.extract gel was optimized by orthogonal test.The mouse model of ulcerative hemorrhoids was established with glacial acetic acid(HAC)and compared with Ma Yinglong musk hemorrhoids ointment.The recovery of trauma was compared between the two groups.At the same time,porcine small intestine was used as semi-permeable membrane to make diffusion cell to simulate anal environment,and the drug release in vitro was studied.[Results]The C.bungei Steud.extract gel was smooth in appearance and good in stability.It could effectively treat anal ulcer in mice and release quickly in vitro.[Conclusions]The formula is reasonable,and the effect of animal experiment is remarkable,which can provide a new treatment plan for ulcerative hemorrhoids.展开更多
Amide proton transfer (APT) magnetic resonance imaging (MRI) is an important molecularimaging technique at the protein level in tissue. Neurodegenerative diseases have a highlikelihood of causing abnormal protein accu...Amide proton transfer (APT) magnetic resonance imaging (MRI) is an important molecularimaging technique at the protein level in tissue. Neurodegenerative diseases have a highlikelihood of causing abnormal protein accumulation in the brain, which can be detectedby APT MRI. This article briefly introduces the principles and image processing technologyof APT MRI, and reviews the current state of research on Alzheimer's disease and Parkinson's disease using this technique. Early applications of this approach in these twoneurodegenerative diseases are encouraging, which also suggests continued technicaldevelopment and larger clinical trials to gauge the value of this technique.展开更多
Dykstra’s alternating projection algorithm was proposed to treat the problem of finding the projection of a given point onto the intersection of some closed convex sets. In this paper, we first apply Dykstra’s alter...Dykstra’s alternating projection algorithm was proposed to treat the problem of finding the projection of a given point onto the intersection of some closed convex sets. In this paper, we first apply Dykstra’s alternating projection algorithm to compute the optimal approximate symmetric positive semidefinite solution of the matrix equations AXB = E, CXD = F. If we choose the initial iterative matrix X<sub>0</sub> = 0, the least Frobenius norm symmetric positive semidefinite solution of these matrix equations is obtained. A numerical example shows that the new algorithm is feasible and effective.展开更多
[Objectives]This study was conducted to analyze and study the growth and development of muscle fibers at different stages,so as to provide a theoretical basis for subsequent research on developmental biology and nutri...[Objectives]This study was conducted to analyze and study the growth and development of muscle fibers at different stages,so as to provide a theoretical basis for subsequent research on developmental biology and nutritional regulation.[Methods]The body weights of black goat lambs in groups at different month age(0-6 months old)were recorded,and the diameter,area and number of muscle fibers were measured by tissue section and hematoxylin-eosin staining.The curves of body weight and muscle fiber growth and development of black goat lambs were drawn.[Results]The black goat lambs maintained a high absolute growth intensity of 2.95-4.35 kg/30 d throughout the rearing cycle,and the body weight continued to increase significantly,while the relative growth coefficient decreased from 93.05%at the age of 30 d to 13.83%at the age of 180 d.The diameter and area of muscle fibers in black goat lambs showed obvious"three-stage"growth and development characteristics,and showed different trends of gender advantages in different stages.[Conclusions]This study will help to further optimize the key supporting technologies for production and promote the diversified and comprehensive development of the mutton sheep industry in Sichuan Province.展开更多
This work is devoted to investigate the elasticity, anisotropy, plastic properties, and thermal conductivity of PdSnYb, PdSn2Yb and Heusler alloy Pd2SnYb via employing the first-principles. The magnetic properties of ...This work is devoted to investigate the elasticity, anisotropy, plastic properties, and thermal conductivity of PdSnYb, PdSn2Yb and Heusler alloy Pd2SnYb via employing the first-principles. The magnetic properties of Pd2SnYb, PdSnYb and PdSn2Yb are obtained by the geometry optimization combining with spin polarization. And the stability of these three kinds of materials is ensured by comparing with the enthalpy of formation and binding energy. The Fermi energy has same trend with stability. The details of bulk and Young’s modulus are demonstrated in 3D plots, embodied the elastic anisotropies of PdSnYb, PdSn2Yb, and Pd2SnYb. The calculations of plastic properties are also anisotropic. And the minimum thermal conductivities are small enough for these three materials to be used as thermal barrier coatings.展开更多
DNAzyme amplifiers have been extensively explored as a useful sensing platform,but single DNAzyme amplifier is limited in biosensing applications by its low sensitivity.Herein,a cascade DNAzyme amplifier was designed ...DNAzyme amplifiers have been extensively explored as a useful sensing platform,but single DNAzyme amplifier is limited in biosensing applications by its low sensitivity.Herein,a cascade DNAzyme amplifier was designed by exploiting concurrent amplification cycle principles of toehold-mediated strand displacement reaction(TSDR)and Zn^(2+)-assisted DNAzyme cycle with lower cost and simpler procedures.Compared with single DNAzyme amplifier,the proposed TSDR-propelled cascade DNAzyme amplifier exhibited higher sensitivity by releasing more DNAzyme through TSDR to cleave substrate strand during the DNAzyme cycle.Base on this,let-7a could be sensitively detected in the range of 5-50 nmol/L with a detection limit of 64 pmol/L.Furthermore,the dual signal amplification strategy of the cascade DNAzyme amplifier exhibited excellent selectivity to distinguish single-base mismatched DNA strands,which has been successfully applied to the determination of let-7a in blood serum,showing high promise in early cancer diagnosis.展开更多
Since its commercialization in 1991,lithium-ion batteries have had wide applications.High energy density and low cost are leading goals for lithium batteries.Compared with the traditional intercalation-type lithium-io...Since its commercialization in 1991,lithium-ion batteries have had wide applications.High energy density and low cost are leading goals for lithium batteries.Compared with the traditional intercalation-type lithium-ion battery,conversion-type lithium metal battery undergoes multi-electron reactions,offering a much higher capacity and 2–5 times higher energy density(Fig.1).Moreover,their cathodes can have sustainable and environmentfriendly transition elements such as Fe and Cu.As the cathodes are normally“Li-free”,they are coupled with“Li-containing”anodes,such as Li metal and Li-alloy.Owning to these advantages,conversion-based lithium metal batteries are regarded as“longterm targets”.展开更多
Dear editor:Congenital adrenocortical hyperplasia(CAH)is an autosomal reces-sive disease resulting from a deficiency in the cortisol synthase gene.This deficiency leads to an imbalance in adrenocortical hormones and e...Dear editor:Congenital adrenocortical hyperplasia(CAH)is an autosomal reces-sive disease resulting from a deficiency in the cortisol synthase gene.This deficiency leads to an imbalance in adrenocortical hormones and excess androgen.21 Hydroxylase deficiency(21-OHD)is the most common form of CAH,accounting for 90%~95%of cases.1 This condition is pri-marily caused by a mutation in the CYP21A2 gene,located on chromo-some 6p21.3.2 Depending on the severity of aldosterone deficiency,CAH can be divided into classical(salt-wasting and simple-virilizing forms)and non-classical(NCCAH)types.Excess androgen,the most common factor in classical CAH and NCCAH,can negatively impact fertility in CAH patients.The spontaneous rate of pregnancy without treatment is typically very low in CAH patients.展开更多
Neolamarckia cadamba is an indigenous,timber-producing tree species in Southern China that plays an important role in the sustainable development of the local forestry industry.However,the geographic genetic variation...Neolamarckia cadamba is an indigenous,timber-producing tree species in Southern China that plays an important role in the sustainable development of the local forestry industry.However,the geographic genetic variation across its natural distribution area in Southern China has yet to be characterized for best utilization.Here,we report the geographic genetic variation in growth and wood properties of N.cadamba from 10 provenances that represent the entire natural distribution of N.cadamba in Southern China.There was significant geographic variation in diameter breast height(DBH),height(H),volume(V),vessel length(VL),vessel diameter(VD),VL/VD,and wood basic density(WBD).The variation in tree volume across provenances was greater than that of other growth traits,indicating that volume has a greater potential for selection in provenance trials.The provenance heritabilities of growth traits and wood properties ranged from 0.59 to 0.67 and from 0.40 to 0.45,respectively.Trend surface analysis revealed that patterns of geographic variation associated with growth traits were weakly negatively correlated with those of wood properties.The pattern of geographic variation in growth traits showed a gradual increase from the periphery to the central region,whereas wood properties showed the opposite pattern,and latitude had the greatest effect on both.Wood property measurements suggested that the YNMS provenance produced superior timber wood,whereas the GXLZ,GXFCG,and GXNN provenances produced the best pulpwood.These provenances could potentially provide more valuable breeding materials for the genetic improvement of N.cadamba.展开更多
基金supported by the National Natural Science Foundation of China (Grant No. 12074321)the Young Science and Technology Talents Development Project of Guizhou Provincial Education Department (Grant No. QJH-KY [2022]012)+2 种基金the Fundamental Research Funds for the Central Universities (Grant No. SWU020019)the Natural Science Foundation of Chongqing (Grant No. cstc2020jcyjmsxmx0648)the Chongqing Graduate Student Research Innovation Project (Grant No. CYB22119)。
文摘Achieving highly-efficient and stable perovskite solar cells(PSCs) with a simplified structure remains challenging, despite the tremendous potential for reducing preparation cost and facile processability by removing hole transport layer(HTL). In this work, eco-friendly glucose(Gl) as an interface modifier for HTL-free narrow bandgap tin-lead(Sn-Pb) PSCs is proposed. Gl not only enhances the wettability of the indium tin oxide to promote perovskite heterogeneous nucleation on substrate, but also realizes defect passivation by interacting with uncoordinated Pb^(2+) and Sn^(2+) in perovskite films. As a result, the quality of the perovskite films has been significantly improved, accompanied by reduced defects of bottom interface and optimized energy level structure of device, leading to an efficiency increase and a less nonradiative voltage loss of 0.102 V(for a bandgap of ~1.26 eV). Consequently, the optimized PSC delivers an unprecedented efficiency over 21% with high open-circuit voltage and enhanced stability, outperforming the control device. This work demonstrates a cost-effective approach to develop simplified structure high efficiency HTL-free Sn-Pb PSC.
文摘<strong>Objective:</strong> To evaluate the effect of physical methods on the prevention of venous thrombosis in patients with peripherally inserted central catheter (PICC). <strong>Methods:</strong> Randomized controlled trials meeting the inclusion and exclusion criteria were retrieved from the following databases: Cochrane library, Pubmed, EMbase, Web of science, Ovid, CBM, CNKI, Wanfang, VIP, then Review Manage (RevMan) 5.3 software was used for data analysis. <strong>Results:</strong> A total of 24 RCTs including 3496 patients were analyzed in the study. The results of meta-analysis showed that various forms of upper limb movements could effectively decrease the incidence of venous thrombosis in the patients with PICC [<em>RR</em> = 0.23, 95% <em>CI</em> (0.16, 0.33), <em>P</em> < 0.01], upper limb movements could effectively improve the mean blood flow velocity of basilic vein [<em>MD</em> = 1.65, 95% <em>CI</em> (1.19, 2.11), <em>P</em> < 0.01]. <strong>Conclusion:</strong> Upper limb movements can effectively decrease the incidence of phlebothrombosis and improve the mean flow velocity of basilic vein in the patients undergoing PICC. Other forms of physical prevention methods need to be further studied due to insufficient sample size.
基金the National Natural Science Foundation of China,grant numbers 32372935,32072781.
文摘Background Broilers have a robust metabolism and high body temperature,which make them less tolerant to hightemperature(HT)environments and more susceptible to challenges from elevated temperatures.Gut microbes,functioning as symbionts within the host,possess the capacity to significantly regulate the physiological functions and environmental adaptability of the host.This study aims to investigate the effects of gut microbial intervention on the body temperature and thermogenesis of broilers at different ambient temperatures,as well as the underlying mechanism involving the"gut-brain"axis.Methods Broilers were subjected to gut microbiota interference with or without antibiotics(control or ABX)starting at 1 day of age.At 21 day of age,they were divided into 4 groups and exposed to different environments for 7 d:The control and ABX groups at room temperature(RT,24±1℃,60%relative humidity(RH),24 h/d)and the control-HT and ABX-HT groups at high temperature(HT,32±1℃,60%RH,24 h/d).Results The results demonstrated that the antibiotic-induced gut microbiota intervention increased body weight and improved feed conversion in broiler chickens(P<0.05).Under HT conditions,the microbiota intervention reduced the rectal temperature of broiler chickens(P<0.05),inhibited the expression of avUCP and thermogenesisrelated genes in breast muscle and liver(P<0.05),and thus decreased thermogenesis capacity.Furthermore,the gut microbiota intervention blunted the hypothalamic‒pituitary‒adrenal axis and hypothalamic–pituitary–thyroid axis activation induced by HT conditions.By analyzing the cecal microbiota composition of control and ABX chickens maintained under HT conditions,we found that Alistipes was enriched in control chickens.In contrast,antibioticinduced gut microbiota intervention resulted in a decrease in the relative abundance of Alistipes(P<0.05).Moreover,this difference was accompanied by increased hypothalamic 5-hydroxytryptamine(5-HT)content and TPH2 expression(P<0.05).Conclusions These findings underscore the critical role of the gut microbiota in regulating broiler thermogenesis via the gut-brain axis and suggest that the hypothalamic 5-HT pathway may be a potential mechanism by which the gut microbiota affects thermoregulation in broilers.
基金Supported by Post-doctoral Foundation Project of Heilongjiang Province(LBHZ16094)Special Research Fund Project for Scientific and Technological Innovation Talents in Harbin City(2017RAQXJ115)Doctoral Starting up Project of Harbin University of Commerce(2019DS114).
文摘[Objectives]To explore the stability of sanguinarine and chelerythrine in Macleaya cordata(Willd.)R.Br.[Methods]The solubility and stability of sanguinarine and chelerythrine in seven solvents were measured by HPLC.Besides,the effects of water quality,light source,oxidant,temperature,and pH on stability were investigated.[Results]The solubility and stability of sanguinarine and chelerythrine in methanol and ethanol are good;the stability of sanguinarine and chelerythrine in distilled water and rainwater is not affected by light and is very stable,but they are unstable in tap water whether they are protected from light or not;oxidants have a great influence on the stability of sanguinarine and chelerythrine;sanguinarine and chelerythrine are stable at room temperature lower than 54℃;sanguinarine is stable in pH 2.5-7.0,while chelerythrine is stable in pH 2.5-8.0.[Conclusions]The good stability of sanguinarine and chelerythrine under specific conditions shows that they have broad development prospects and value.
基金Supported by National Natural Science Foundation of China(31671954)。
文摘[Objectives]To determine the optimal preparation technology of Clerodendrum bungei Steud.extract gel by orthogonal test and gel quality test method in General Rule 0114 of Chinese Pharmacopoeia(Volume IV,2020 Edition),and to study its anorectal pharmacodynamics and drug release in vitro.[Methods]Carbomer 940,propylene glycol and absolute ethyl alcohol were selected as the main factors,and the preparation technology of C.bungei Steud.extract gel was optimized by orthogonal test.The mouse model of ulcerative hemorrhoids was established with glacial acetic acid(HAC)and compared with Ma Yinglong musk hemorrhoids ointment.The recovery of trauma was compared between the two groups.At the same time,porcine small intestine was used as semi-permeable membrane to make diffusion cell to simulate anal environment,and the drug release in vitro was studied.[Results]The C.bungei Steud.extract gel was smooth in appearance and good in stability.It could effectively treat anal ulcer in mice and release quickly in vitro.[Conclusions]The formula is reasonable,and the effect of animal experiment is remarkable,which can provide a new treatment plan for ulcerative hemorrhoids.
文摘Amide proton transfer (APT) magnetic resonance imaging (MRI) is an important molecularimaging technique at the protein level in tissue. Neurodegenerative diseases have a highlikelihood of causing abnormal protein accumulation in the brain, which can be detectedby APT MRI. This article briefly introduces the principles and image processing technologyof APT MRI, and reviews the current state of research on Alzheimer's disease and Parkinson's disease using this technique. Early applications of this approach in these twoneurodegenerative diseases are encouraging, which also suggests continued technicaldevelopment and larger clinical trials to gauge the value of this technique.
文摘Dykstra’s alternating projection algorithm was proposed to treat the problem of finding the projection of a given point onto the intersection of some closed convex sets. In this paper, we first apply Dykstra’s alternating projection algorithm to compute the optimal approximate symmetric positive semidefinite solution of the matrix equations AXB = E, CXD = F. If we choose the initial iterative matrix X<sub>0</sub> = 0, the least Frobenius norm symmetric positive semidefinite solution of these matrix equations is obtained. A numerical example shows that the new algorithm is feasible and effective.
基金Supported by Sichuan Mutton Sheep Innovation Team of National Modern Agricultural Industry Technology System(SCCXTD-2021-14)Sichuan Provincial Livestock and Poultry Breeding Key Project(2021YFYZ0003)Modern Animal Husbandry-Breeding of New Herbivore Breeds.
文摘[Objectives]This study was conducted to analyze and study the growth and development of muscle fibers at different stages,so as to provide a theoretical basis for subsequent research on developmental biology and nutritional regulation.[Methods]The body weights of black goat lambs in groups at different month age(0-6 months old)were recorded,and the diameter,area and number of muscle fibers were measured by tissue section and hematoxylin-eosin staining.The curves of body weight and muscle fiber growth and development of black goat lambs were drawn.[Results]The black goat lambs maintained a high absolute growth intensity of 2.95-4.35 kg/30 d throughout the rearing cycle,and the body weight continued to increase significantly,while the relative growth coefficient decreased from 93.05%at the age of 30 d to 13.83%at the age of 180 d.The diameter and area of muscle fibers in black goat lambs showed obvious"three-stage"growth and development characteristics,and showed different trends of gender advantages in different stages.[Conclusions]This study will help to further optimize the key supporting technologies for production and promote the diversified and comprehensive development of the mutton sheep industry in Sichuan Province.
文摘This work is devoted to investigate the elasticity, anisotropy, plastic properties, and thermal conductivity of PdSnYb, PdSn2Yb and Heusler alloy Pd2SnYb via employing the first-principles. The magnetic properties of Pd2SnYb, PdSnYb and PdSn2Yb are obtained by the geometry optimization combining with spin polarization. And the stability of these three kinds of materials is ensured by comparing with the enthalpy of formation and binding energy. The Fermi energy has same trend with stability. The details of bulk and Young’s modulus are demonstrated in 3D plots, embodied the elastic anisotropies of PdSnYb, PdSn2Yb, and Pd2SnYb. The calculations of plastic properties are also anisotropic. And the minimum thermal conductivities are small enough for these three materials to be used as thermal barrier coatings.
基金financially supported by the National Natural Science Foundation of China(NSFC,Nos.22074124 and 22134005)the fund of Fundamental Research Funds for the Central Universities(No.XDJK2020TY001)+1 种基金Chongqing Talents Program for Outstanding Scientists(No.cstc2021ycjh-bgzxm0178)the Chongqing Graduate Student Scientific Research Innovation Project(No.CYB21119)。
文摘DNAzyme amplifiers have been extensively explored as a useful sensing platform,but single DNAzyme amplifier is limited in biosensing applications by its low sensitivity.Herein,a cascade DNAzyme amplifier was designed by exploiting concurrent amplification cycle principles of toehold-mediated strand displacement reaction(TSDR)and Zn^(2+)-assisted DNAzyme cycle with lower cost and simpler procedures.Compared with single DNAzyme amplifier,the proposed TSDR-propelled cascade DNAzyme amplifier exhibited higher sensitivity by releasing more DNAzyme through TSDR to cleave substrate strand during the DNAzyme cycle.Base on this,let-7a could be sensitively detected in the range of 5-50 nmol/L with a detection limit of 64 pmol/L.Furthermore,the dual signal amplification strategy of the cascade DNAzyme amplifier exhibited excellent selectivity to distinguish single-base mismatched DNA strands,which has been successfully applied to the determination of let-7a in blood serum,showing high promise in early cancer diagnosis.
文摘Since its commercialization in 1991,lithium-ion batteries have had wide applications.High energy density and low cost are leading goals for lithium batteries.Compared with the traditional intercalation-type lithium-ion battery,conversion-type lithium metal battery undergoes multi-electron reactions,offering a much higher capacity and 2–5 times higher energy density(Fig.1).Moreover,their cathodes can have sustainable and environmentfriendly transition elements such as Fe and Cu.As the cathodes are normally“Li-free”,they are coupled with“Li-containing”anodes,such as Li metal and Li-alloy.Owning to these advantages,conversion-based lithium metal batteries are regarded as“longterm targets”.
基金funded by the National Natural Science Foundation of China(No.U1903124)
文摘Dear editor:Congenital adrenocortical hyperplasia(CAH)is an autosomal reces-sive disease resulting from a deficiency in the cortisol synthase gene.This deficiency leads to an imbalance in adrenocortical hormones and excess androgen.21 Hydroxylase deficiency(21-OHD)is the most common form of CAH,accounting for 90%~95%of cases.1 This condition is pri-marily caused by a mutation in the CYP21A2 gene,located on chromo-some 6p21.3.2 Depending on the severity of aldosterone deficiency,CAH can be divided into classical(salt-wasting and simple-virilizing forms)and non-classical(NCCAH)types.Excess androgen,the most common factor in classical CAH and NCCAH,can negatively impact fertility in CAH patients.The spontaneous rate of pregnancy without treatment is typically very low in CAH patients.
基金supported by the Forestry Science and Technology Innovation Project in Guangdong Province(No.2019KJCX001)the National Natural Science Foundation of China(No.31600525)+3 种基金the Science and Technology Program of Guangdong,China(No.2017B020201008)the Extension and Demonstration Project of Forest Science and Technology from China State Financial Budget(No.(2018)GDTK-08)the Science and Technology Program of Guangzhou(No.201904020014)the 2018 Big Pig-producing County Reward Funds(Research and promotion of key technologies for healthy feeding of pigs and resource utilization of manure pollution)。
文摘Neolamarckia cadamba is an indigenous,timber-producing tree species in Southern China that plays an important role in the sustainable development of the local forestry industry.However,the geographic genetic variation across its natural distribution area in Southern China has yet to be characterized for best utilization.Here,we report the geographic genetic variation in growth and wood properties of N.cadamba from 10 provenances that represent the entire natural distribution of N.cadamba in Southern China.There was significant geographic variation in diameter breast height(DBH),height(H),volume(V),vessel length(VL),vessel diameter(VD),VL/VD,and wood basic density(WBD).The variation in tree volume across provenances was greater than that of other growth traits,indicating that volume has a greater potential for selection in provenance trials.The provenance heritabilities of growth traits and wood properties ranged from 0.59 to 0.67 and from 0.40 to 0.45,respectively.Trend surface analysis revealed that patterns of geographic variation associated with growth traits were weakly negatively correlated with those of wood properties.The pattern of geographic variation in growth traits showed a gradual increase from the periphery to the central region,whereas wood properties showed the opposite pattern,and latitude had the greatest effect on both.Wood property measurements suggested that the YNMS provenance produced superior timber wood,whereas the GXLZ,GXFCG,and GXNN provenances produced the best pulpwood.These provenances could potentially provide more valuable breeding materials for the genetic improvement of N.cadamba.
