Teratomas are congenital tumors that derive from all 3 germ layers. Most teratomas of the head and neck present in the pediatricage group. We report a case of a 5-month-old infant who presented with a teratoma showing...Teratomas are congenital tumors that derive from all 3 germ layers. Most teratomas of the head and neck present in the pediatricage group. We report a case of a 5-month-old infant who presented with a teratoma showing possible obstruction of the airway. The tumor was successfully resected under general anesthesia. The postoperative course was uneventful, and she was fine at a 3-year follow-up.展开更多
Respiratory syncytial virus(RSV)is the main pathogen that causes hospitalization for acute lower respiratory tract infections(ALRIs)in children.With the reopening of communities and schools,the resurgence of RSV in th...Respiratory syncytial virus(RSV)is the main pathogen that causes hospitalization for acute lower respiratory tract infections(ALRIs)in children.With the reopening of communities and schools,the resurgence of RSV in the COVID-19 post-pandemic era has become a major concern.To understand the circulation patterns and genotype variability of RSV in Tianjin before and during the COVID-19 pandemic,a total of 19,531 nasopharyngeal aspirate samples from hospitalized children in Tianjin from July 2017 to June 2022 were evaluated.Direct immunofluorescence and polymerase chain reaction(PCR)were used for screening RSV-positive samples and subtyping,respectively.Further analysis of mutations in the second hypervariable region(HVR2)of the G gene was performed through Sanger sequencing.Our results showed that 16.46%(3215/19,531)samples were RSV positive and a delayed increase in the RSV infection rates occurred in the winter season from December 2020 to February 2021,with the average RSV-positive rate of 35.77%(519/1451).The ON1,with H258Q and H266L substitutions,and the BA9,with T290I and T312I substitutions,are dominant strains that alternately circulate every 1–2 years in Tianjin,China,from July 2017 to June 2022.In addition,novel substitutions,such as N296Y,K221T,N230K,V251A in the BA9 genotype,and L226I in the ON1 genotype,emerged during the COVID-19 pandemic.Analysis of clinical characteristics indicated no significant differences between RSV-A and RSV-B groups.This study provides a theoretical basis for clinical prevention and treatment.However,further studies are needed to explore the regulatory mechanism of host immune responses to different lineages of ON1 and BA9 in the future.展开更多
Neural tube defects （NTDs） are a group of birth anomalies having a profound physical, emotional, and financial effects on families and communities. Their etiology is complex, involving environmental and genetic fact...Neural tube defects （NTDs） are a group of birth anomalies having a profound physical, emotional, and financial effects on families and communities. Their etiology is complex, involving environmental and genetic factors that interact to modulate the incidence and severity of the developing phenotype. The planar cell polarity （PCP） pathway controls the process of convergent extension （CE） during gastrulation and neural tube closure and has been implicated in the pathogenesis of NTDs in animal models and human cohorts. This review summarizes the cumulative results of recent studies on PCP signaling pathway and human NTDs. These results demonstrate that PCP gene alterations contribute to the etiology of human NTDs.展开更多
To gain a broader appreciation of the clinical presentation,operative treatment,and outcome offibrous dysplasia involving the calvarium in children,we retro-spectively reviewed a series of cases offibrous dysplasia invo...To gain a broader appreciation of the clinical presentation,operative treatment,and outcome offibrous dysplasia involving the calvarium in children,we retro-spectively reviewed a series of cases offibrous dysplasia involving the calvarium(4 males and 2 females)with patients’age ranging from 5 to 12 years old.The clinical manifestation,radiographicfindings,surgical treatment,outcome and follow-up were evaluated on the basis of medical records.Fibrous dysplasia in the series was monostotic,involving frontal bone(2 cases),temporal bone(1 case),parietal bone(2 cases)and occipital bone(1 case).The patients most commonly presented with enlarging mass and cosmetic complaints.The treatment given,depending on clinical presentation,was simple biopsy with conservative follow-up(2 cases)to cranial resection(4 cases).All the cases were histopathologically confirmed asfibrous dysplasia.It was demonstrated thatfibrous dysplasia involving the calvarium is a typically benign but slowly progressive disorder of bone.Modern imaging modalities and histopathologic analysis have made diagnosis relatively straightforward.Surgery should be reserved for patients with functional impairment or cosmetic deformity.Because of the benign nature of the condition,the surgery itself should be contemplated with great caution in children.展开更多
Vein of Galen malformations(VGMs)are rare,consisting approximately 1%of intracranial vascular mal-formations,but nearly one third of pediatric vascular mal-formations,which can cause severe morbidity and mortality in ...Vein of Galen malformations(VGMs)are rare,consisting approximately 1%of intracranial vascular mal-formations,but nearly one third of pediatric vascular mal-formations,which can cause severe morbidity and mortality in infants and older children,but more particu-larly in neonates.We presented 2 patients with VGMs which were confirmed by characteristic clinical symptoms and neuroradiological findings(including CT,MRI and/or angiography).One patient underwent embolization fol-lowed by CT,MRI and conventional angiography.The patient’s neurological and cognitive status was normal at present.The other neonate died of congestive heart failure 36 h after birth.展开更多
The spinal epidural space is an uncommon presenting site in primary non-Hodgkin’s lymphomas,especially for children.A boy suffered spinal cord compression syndrome caused by primary spinal epidural non-Hodgkin’s lym...The spinal epidural space is an uncommon presenting site in primary non-Hodgkin’s lymphomas,especially for children.A boy suffered spinal cord compression syndrome caused by primary spinal epidural non-Hodgkin’s lymphoma.Thoracolumbar magnetic reso-nance imaging(MRI)demonstrated an intraspinal mass.An operation was performed with gross total tumor removal.Histological examination revealed a non-Hodgkin’s B-cell lymphoma.Bone marrow aspiration was negative for lymphoma involvement.No other therapies(chemotherapy and/or radiotherapy)were per-formed according to the parents’opinion.The patient died approximately one year after the operation due to brain metastases.The clinical course and imaging features were discussed with a review of literatures.展开更多
文摘Teratomas are congenital tumors that derive from all 3 germ layers. Most teratomas of the head and neck present in the pediatricage group. We report a case of a 5-month-old infant who presented with a teratoma showing possible obstruction of the airway. The tumor was successfully resected under general anesthesia. The postoperative course was uneventful, and she was fine at a 3-year follow-up.
基金funded by the Tianjin Key Medical Discipline(Specialty)Construction Project(Grant number TJYXZDXK-040A)the Public Health and Technology Project of Tianjin(Grant number TJWJ2021QN050).
文摘Respiratory syncytial virus(RSV)is the main pathogen that causes hospitalization for acute lower respiratory tract infections(ALRIs)in children.With the reopening of communities and schools,the resurgence of RSV in the COVID-19 post-pandemic era has become a major concern.To understand the circulation patterns and genotype variability of RSV in Tianjin before and during the COVID-19 pandemic,a total of 19,531 nasopharyngeal aspirate samples from hospitalized children in Tianjin from July 2017 to June 2022 were evaluated.Direct immunofluorescence and polymerase chain reaction(PCR)were used for screening RSV-positive samples and subtyping,respectively.Further analysis of mutations in the second hypervariable region(HVR2)of the G gene was performed through Sanger sequencing.Our results showed that 16.46%(3215/19,531)samples were RSV positive and a delayed increase in the RSV infection rates occurred in the winter season from December 2020 to February 2021,with the average RSV-positive rate of 35.77%(519/1451).The ON1,with H258Q and H266L substitutions,and the BA9,with T290I and T312I substitutions,are dominant strains that alternately circulate every 1–2 years in Tianjin,China,from July 2017 to June 2022.In addition,novel substitutions,such as N296Y,K221T,N230K,V251A in the BA9 genotype,and L226I in the ON1 genotype,emerged during the COVID-19 pandemic.Analysis of clinical characteristics indicated no significant differences between RSV-A and RSV-B groups.This study provides a theoretical basis for clinical prevention and treatment.However,further studies are needed to explore the regulatory mechanism of host immune responses to different lineages of ON1 and BA9 in the future.
文摘Neural tube defects （NTDs） are a group of birth anomalies having a profound physical, emotional, and financial effects on families and communities. Their etiology is complex, involving environmental and genetic factors that interact to modulate the incidence and severity of the developing phenotype. The planar cell polarity （PCP） pathway controls the process of convergent extension （CE） during gastrulation and neural tube closure and has been implicated in the pathogenesis of NTDs in animal models and human cohorts. This review summarizes the cumulative results of recent studies on PCP signaling pathway and human NTDs. These results demonstrate that PCP gene alterations contribute to the etiology of human NTDs.
文摘To gain a broader appreciation of the clinical presentation,operative treatment,and outcome offibrous dysplasia involving the calvarium in children,we retro-spectively reviewed a series of cases offibrous dysplasia involving the calvarium(4 males and 2 females)with patients’age ranging from 5 to 12 years old.The clinical manifestation,radiographicfindings,surgical treatment,outcome and follow-up were evaluated on the basis of medical records.Fibrous dysplasia in the series was monostotic,involving frontal bone(2 cases),temporal bone(1 case),parietal bone(2 cases)and occipital bone(1 case).The patients most commonly presented with enlarging mass and cosmetic complaints.The treatment given,depending on clinical presentation,was simple biopsy with conservative follow-up(2 cases)to cranial resection(4 cases).All the cases were histopathologically confirmed asfibrous dysplasia.It was demonstrated thatfibrous dysplasia involving the calvarium is a typically benign but slowly progressive disorder of bone.Modern imaging modalities and histopathologic analysis have made diagnosis relatively straightforward.Surgery should be reserved for patients with functional impairment or cosmetic deformity.Because of the benign nature of the condition,the surgery itself should be contemplated with great caution in children.
文摘Vein of Galen malformations(VGMs)are rare,consisting approximately 1%of intracranial vascular mal-formations,but nearly one third of pediatric vascular mal-formations,which can cause severe morbidity and mortality in infants and older children,but more particu-larly in neonates.We presented 2 patients with VGMs which were confirmed by characteristic clinical symptoms and neuroradiological findings(including CT,MRI and/or angiography).One patient underwent embolization fol-lowed by CT,MRI and conventional angiography.The patient’s neurological and cognitive status was normal at present.The other neonate died of congestive heart failure 36 h after birth.
文摘The spinal epidural space is an uncommon presenting site in primary non-Hodgkin’s lymphomas,especially for children.A boy suffered spinal cord compression syndrome caused by primary spinal epidural non-Hodgkin’s lymphoma.Thoracolumbar magnetic reso-nance imaging(MRI)demonstrated an intraspinal mass.An operation was performed with gross total tumor removal.Histological examination revealed a non-Hodgkin’s B-cell lymphoma.Bone marrow aspiration was negative for lymphoma involvement.No other therapies(chemotherapy and/or radiotherapy)were per-formed according to the parents’opinion.The patient died approximately one year after the operation due to brain metastases.The clinical course and imaging features were discussed with a review of literatures.
