Objective: To evaluate the treatment outcome of iron isomaltoside compared with an oral iron supplement in the management of iron deficiency anemia (IDA). Methods: The study included patients with IDA who visited the ...Objective: To evaluate the treatment outcome of iron isomaltoside compared with an oral iron supplement in the management of iron deficiency anemia (IDA). Methods: The study included patients with IDA who visited the Outpatient Clinic of the Department of Hematology, the Affiliated Hospital of Qingdao University from October 2021 to August 2022 and met the inclusion and exclusion criteria. According to the actual application of iron supplementation, the patients were divided into two groups: iron isomaltoside treatment group and oral iron treatment group. Baseline measurements were collected before the start of treatment, and measurements were collected subsequently at intervals of 1 week, 1 month, and 3 months. The hematological parameters analyzed included Hemoglobin (Hb), Mean corpuscular hemoglobin (MCH), Mean Hemoglobin content (MCH), Mean corpuscular Hemoglobin concentration (MCHC), and Platelet (Plt). Safety data and adverse event profiles were recorded. Results: Intra-group comparisons: After 1 month of treatment, the Hb significantly improved (P 0.05). Inter-group comparisons: The biochemical parameters were significantly improved (P 0.05) in the iron isomaltoside group compared with those in the oral iron group after 1 month of iron supplementation in patients with mild and moderate anemia. Adverse reactions were tolerable for the patients in both iron isomaltoside group and oral iron group. Only 1 patient in iron isomaltoside group developed anaphylactic shock during medication and recovered after aggressive rescue. Conclusions: Iron isomaltoside which increases Hb more rapidly compared with the oral iron supplementation has few adverse reactions and good acceptance.展开更多
Background:Dihydroartemisinin(DHA)is reported to be a potential anticancer agent,and the mechanisms underlying the effects of DHA on diffuse large B cell lymphoma however are still obscure.This study aimed to assess t...Background:Dihydroartemisinin(DHA)is reported to be a potential anticancer agent,and the mechanisms underlying the effects of DHA on diffuse large B cell lymphoma however are still obscure.This study aimed to assess the antitumor effect of DHA on diffuse large B cell lymphoma cells and to determine the potential underlying mechanisms of DHA-induced cell apoptosis.Methods:Here,the Cell Counting Kit 8 assay was conducted to study cell proliferation.We performed Annexin V-FITC/propidium iodide staining,real-time polymerase chain reaction,and western blot analysis to analyze cell apoptosis and potential molecular mechanisms.Results:The results showed that DHA substantially suppressed cell proliferation and induced cell apoptosis in vitro in a time-and concentration-dependent fashion.Moreover,STAT3 activity could be inhibited after stimulation with DHA.Conclusion:These results imply that the underlying anti-tumoral effect of DHA may increase apoptosis in diffuse large B cell lymphoma cells via the STAT3 signaling pathway.In addition,DHA might be an effective drug for diffuse large B cell lymphoma therapy.展开更多
Intracavity tunneling induced transparency in asymmetric double-quantum wells embedded in a microcavity in the ultrastrong-coupling regime is investigated by the input-output theory developed by Ciuti and Carusotto. I...Intracavity tunneling induced transparency in asymmetric double-quantum wells embedded in a microcavity in the ultrastrong-coupling regime is investigated by the input-output theory developed by Ciuti and Carusotto. In this system a narrow spectra can be realized under anti-resonant terms of the external dissipation. Fano-interference asymmetric line profile is found in the absorption spectra.展开更多
The image filtering technology is widely used in many fields, such as environmental monitoring and assessment, space remote sensing, recognition and tracking of infrared target. In this paper, aiming at the problem of...The image filtering technology is widely used in many fields, such as environmental monitoring and assessment, space remote sensing, recognition and tracking of infrared target. In this paper, aiming at the problem of poor generalization capability and over-fitting with artificial neutral network for infrared image filtering, a new filtering method is presented. The structure elements are used to set up the training samples. And then, based on support vector machine theory, it builds the learning ma-chine with proper model and trains the samples. The result can be used to suppress the background SNR of following image. The experimental result with infrared image shows that the method can obtain higher SNR than conventional neutral network and fixed Top-Hat operator method, especially in low SNR.展开更多
文摘Objective: To evaluate the treatment outcome of iron isomaltoside compared with an oral iron supplement in the management of iron deficiency anemia (IDA). Methods: The study included patients with IDA who visited the Outpatient Clinic of the Department of Hematology, the Affiliated Hospital of Qingdao University from October 2021 to August 2022 and met the inclusion and exclusion criteria. According to the actual application of iron supplementation, the patients were divided into two groups: iron isomaltoside treatment group and oral iron treatment group. Baseline measurements were collected before the start of treatment, and measurements were collected subsequently at intervals of 1 week, 1 month, and 3 months. The hematological parameters analyzed included Hemoglobin (Hb), Mean corpuscular hemoglobin (MCH), Mean Hemoglobin content (MCH), Mean corpuscular Hemoglobin concentration (MCHC), and Platelet (Plt). Safety data and adverse event profiles were recorded. Results: Intra-group comparisons: After 1 month of treatment, the Hb significantly improved (P 0.05). Inter-group comparisons: The biochemical parameters were significantly improved (P 0.05) in the iron isomaltoside group compared with those in the oral iron group after 1 month of iron supplementation in patients with mild and moderate anemia. Adverse reactions were tolerable for the patients in both iron isomaltoside group and oral iron group. Only 1 patient in iron isomaltoside group developed anaphylactic shock during medication and recovered after aggressive rescue. Conclusions: Iron isomaltoside which increases Hb more rapidly compared with the oral iron supplementation has few adverse reactions and good acceptance.
基金supported by the Shandong Provincial Natural Science Foundation of China(ZR2019MH096).
文摘Background:Dihydroartemisinin(DHA)is reported to be a potential anticancer agent,and the mechanisms underlying the effects of DHA on diffuse large B cell lymphoma however are still obscure.This study aimed to assess the antitumor effect of DHA on diffuse large B cell lymphoma cells and to determine the potential underlying mechanisms of DHA-induced cell apoptosis.Methods:Here,the Cell Counting Kit 8 assay was conducted to study cell proliferation.We performed Annexin V-FITC/propidium iodide staining,real-time polymerase chain reaction,and western blot analysis to analyze cell apoptosis and potential molecular mechanisms.Results:The results showed that DHA substantially suppressed cell proliferation and induced cell apoptosis in vitro in a time-and concentration-dependent fashion.Moreover,STAT3 activity could be inhibited after stimulation with DHA.Conclusion:These results imply that the underlying anti-tumoral effect of DHA may increase apoptosis in diffuse large B cell lymphoma cells via the STAT3 signaling pathway.In addition,DHA might be an effective drug for diffuse large B cell lymphoma therapy.
文摘Intracavity tunneling induced transparency in asymmetric double-quantum wells embedded in a microcavity in the ultrastrong-coupling regime is investigated by the input-output theory developed by Ciuti and Carusotto. In this system a narrow spectra can be realized under anti-resonant terms of the external dissipation. Fano-interference asymmetric line profile is found in the absorption spectra.
基金This research is partly supported by the innovative research fund of aerospace, research fund for the program of new century excellent talents in Heilongjiang provincial university No. 1155-ncet-008 and the National Natural Science Foundation of China under grant No. 60903083, 61502123.
文摘The image filtering technology is widely used in many fields, such as environmental monitoring and assessment, space remote sensing, recognition and tracking of infrared target. In this paper, aiming at the problem of poor generalization capability and over-fitting with artificial neutral network for infrared image filtering, a new filtering method is presented. The structure elements are used to set up the training samples. And then, based on support vector machine theory, it builds the learning ma-chine with proper model and trains the samples. The result can be used to suppress the background SNR of following image. The experimental result with infrared image shows that the method can obtain higher SNR than conventional neutral network and fixed Top-Hat operator method, especially in low SNR.
