Under the online teaching model,the evaluation literacy of college English teachers has become one of the critical factors affecting students’learning effects[1].This study uses a self-compiled questionnaire to inves...Under the online teaching model,the evaluation literacy of college English teachers has become one of the critical factors affecting students’learning effects[1].This study uses a self-compiled questionnaire to investigate the current status of evaluation literacy of college English teachers under the online teaching model from four aspects:evaluation awareness,evaluation knowledge,evaluation ability,and evaluation ethics.The results show that college English teachers’overall evaluation literacy level is relatively high,but there are areas for improvement.Based on the survey results,suggestions are put forward to improve teachers’evaluation literacy,such as changing teaching concepts and increasing self-reflection;strengthening training and learning to enhance professional development awareness;conducting cooperative research and emphasizing team strengths.展开更多
Synthetic molecules that can mediate the coupled transport of Cl^(-) with K^(+) and/or Na+across the lipid bilayers have aroused great interest due to their potential as a novel therapeutic strategy by disrupting cell...Synthetic molecules that can mediate the coupled transport of Cl^(-) with K^(+) and/or Na+across the lipid bilayers have aroused great interest due to their potential as a novel therapeutic strategy by disrupting cellular ion homeostasis.Based on the structural advantages of molecular rotaxanes,we herein show that two rotaxane-based transporters[2]R and[3]R induce coupled K^(+)/Cl^(-) channel transport by introducing Cl^(-) recognition sites in the thread and K^(+) binding group in the wheel,respectively.The welldesigned molecular structures allow the insertion of unimolecular rotaxanes into the lipid bilayer,thus achieving effective ion transport by means of thermodynamically controlled movement and driven by the difference in ion concentration inside and outside the vesicles.In addition,the use of a three-component rotaxane can accelerate ion transport through a cooperative shuttlerelay mechanism in which two wheels move along the thread in the lipid membrane,thereby enabling[3]R to have higher ion transport capacity.This work represents a major advance in the use of rotaxane molecules to accomplish more complex and effective tasks.展开更多
The Grand Canyon is a massive rift in the Colorado Plateau. How and when it developed has been debated for nearly 150 years. Most geologists believe the unusual landscape was primarily shaped by water erosion.Here we ...The Grand Canyon is a massive rift in the Colorado Plateau. How and when it developed has been debated for nearly 150 years. Most geologists believe the unusual landscape was primarily shaped by water erosion.Here we propose a stress-rifting model to provide an alternative explanation for the origin of Grand Canyon.This paper adopts a brittle–ductile double layer model to simulate the deformation and rifting of the plateau due to the mantle-melting-induced expansion. Our results show that the uplift induced by thermal expansion and its associated horizontal extension can cause open fractures that extend from the brittle surface to the underlying ductile layer in a top-down way. In addition, we find that episodic uplift can deepen and connect multiple fractures together to form a larger fracture network. Our findings suggest that the formation of the Grand Canyon might have been driven by plateau uplift and its associated rifting under crustal extension, wherein water erosion played only a minor role in shaping the course of the Colorado River. The new paradigm provides simpler explanations to some of the long-standing geological mysteries surrounding the canyon.展开更多
Substrate photopatterning has provided versatile applications in biomedical fields. Herein, an universal and efficient photoligation reaction has been used to prepare a patterned capture substrate for a sandwich SERS ...Substrate photopatterning has provided versatile applications in biomedical fields. Herein, an universal and efficient photoligation reaction has been used to prepare a patterned capture substrate for a sandwich SERS immunoassay. Photoirradiation induces mild and efficient immobilization of antibodies at the desired region of a gold surface, and the antibody-antigen interaction helps the substrate to capture the antigens in solution specifically. After exposing to SERS probes, i.e., the gold nanoparticles labelled with both antibodies and intrinsically strong Raman reporters, multiple quantitative SERS determination of antigens can be achieved with high sensitivity and specificity. The limit of detection can be as low as 10^(-12) mol/L for four kinds of cancer biomarkers, which provides a promising method for the construction of highly sensitive and high-throughput SERS detection chip and the application of in vitro diagnosis.展开更多
文摘Under the online teaching model,the evaluation literacy of college English teachers has become one of the critical factors affecting students’learning effects[1].This study uses a self-compiled questionnaire to investigate the current status of evaluation literacy of college English teachers under the online teaching model from four aspects:evaluation awareness,evaluation knowledge,evaluation ability,and evaluation ethics.The results show that college English teachers’overall evaluation literacy level is relatively high,but there are areas for improvement.Based on the survey results,suggestions are put forward to improve teachers’evaluation literacy,such as changing teaching concepts and increasing self-reflection;strengthening training and learning to enhance professional development awareness;conducting cooperative research and emphasizing team strengths.
基金supported by the National Natural Science Foundation of China(22171085)the Shanghai Science Technology Communication(21ZR1415500)Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism(Shanghai Municipal Education Commission,Grant 2021 Sci&Tech 03-28)。
文摘Synthetic molecules that can mediate the coupled transport of Cl^(-) with K^(+) and/or Na+across the lipid bilayers have aroused great interest due to their potential as a novel therapeutic strategy by disrupting cellular ion homeostasis.Based on the structural advantages of molecular rotaxanes,we herein show that two rotaxane-based transporters[2]R and[3]R induce coupled K^(+)/Cl^(-) channel transport by introducing Cl^(-) recognition sites in the thread and K^(+) binding group in the wheel,respectively.The welldesigned molecular structures allow the insertion of unimolecular rotaxanes into the lipid bilayer,thus achieving effective ion transport by means of thermodynamically controlled movement and driven by the difference in ion concentration inside and outside the vesicles.In addition,the use of a three-component rotaxane can accelerate ion transport through a cooperative shuttlerelay mechanism in which two wheels move along the thread in the lipid membrane,thereby enabling[3]R to have higher ion transport capacity.This work represents a major advance in the use of rotaxane molecules to accomplish more complex and effective tasks.
基金Financial support to the first and second authors was provided by Shaoxing University and Dalian University of TechnologyFinancial support to the third author was provided by the National Natural Science Foundation of China (51579031, 41502321)Taishan Scholor Program and Aoshan Elite Scientist Plan
文摘The Grand Canyon is a massive rift in the Colorado Plateau. How and when it developed has been debated for nearly 150 years. Most geologists believe the unusual landscape was primarily shaped by water erosion.Here we propose a stress-rifting model to provide an alternative explanation for the origin of Grand Canyon.This paper adopts a brittle–ductile double layer model to simulate the deformation and rifting of the plateau due to the mantle-melting-induced expansion. Our results show that the uplift induced by thermal expansion and its associated horizontal extension can cause open fractures that extend from the brittle surface to the underlying ductile layer in a top-down way. In addition, we find that episodic uplift can deepen and connect multiple fractures together to form a larger fracture network. Our findings suggest that the formation of the Grand Canyon might have been driven by plateau uplift and its associated rifting under crustal extension, wherein water erosion played only a minor role in shaping the course of the Colorado River. The new paradigm provides simpler explanations to some of the long-standing geological mysteries surrounding the canyon.
基金supported by Shanghai Science and Technology Commission (No. 21ZR1415500)the National Nature Science Foundation of China (NSFC, Nos. 21907029, 22171085)。
文摘Substrate photopatterning has provided versatile applications in biomedical fields. Herein, an universal and efficient photoligation reaction has been used to prepare a patterned capture substrate for a sandwich SERS immunoassay. Photoirradiation induces mild and efficient immobilization of antibodies at the desired region of a gold surface, and the antibody-antigen interaction helps the substrate to capture the antigens in solution specifically. After exposing to SERS probes, i.e., the gold nanoparticles labelled with both antibodies and intrinsically strong Raman reporters, multiple quantitative SERS determination of antigens can be achieved with high sensitivity and specificity. The limit of detection can be as low as 10^(-12) mol/L for four kinds of cancer biomarkers, which provides a promising method for the construction of highly sensitive and high-throughput SERS detection chip and the application of in vitro diagnosis.
