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Outcomes of Coaxial Micro-incision Phacoemulsification in Nanophthalmic Eyes: Report of Retrospective Case Series 被引量:5
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作者 Zi Ye Zhaohui Li +3 位作者 Shouzhi He Bing Chen Xiaojuan Xing chunyan ren 《Eye Science》 CAS 2015年第3期94-100,共7页
Purpose: The surgical risk and complication rate after cataract surgery are extremely high in patients with nanophthalmos.This study is designed to compare the visual and refractive outcomes before and after coaxial m... Purpose: The surgical risk and complication rate after cataract surgery are extremely high in patients with nanophthalmos.This study is designed to compare the visual and refractive outcomes before and after coaxial micro-incision phacoemulsification and evaluate postoperative complications.Methods:.Fifty nine patients(89 eyes) with axial length(AL)< 21 mm diagnosed with nanophthalmos were enrolled in this retrospective study. All patients underwent coaxial micro-incision phacoemulsification and IOL implantation..The main outcome measures included anterior chamber depth(ACD),anterior chamber volume(ACV), anterior chamber angle(A CA), intraocular pressure(IOP) and best corrected visual acuity(BCVA). Wilcoxon signed rank test or Mann-Whitney test,and Chi-square test and logistic regression analysis were performed for statistical tests as appropriate.Results:.The median AL was 19.63 mm...Sixty-six eyes(74.16%) had a history of surgical intervention. Postoperative ACD, ACV and ACA were increased significantly(all P<0.001),whereas postoperative IOP was decreased significantly.(P <0.001) after surgery. Previous surgical intervention was related to a reduction in the postoperative ACD and ACA(P<0.01),and both preoperative and postoperative IOP.(P <0.001).Postoperative BCVA was improved in 94.38% of the cases.Intraoperative complications mainly included iridoschisis(6eyes, 6.74%). Early postoperative complications included temporary corneal edema(TCE)(23 eyes, 25.84%), anterior inflammatory response(AIR)(19 eyes, 21.35%), cystoid macular edema(CME)(14 eyes, 15.73%), and uveal effusion(4 eyes, 4.49%). Late postoperative complications included CME(8 eyes, 8.99%), uveal effusion(8 eyes, 8.99%),malignant glaucoma(2 eyes, 2.25%) and posterior capsular opacification(PCO)(10 eyes, 11.24%). The majority of complications(80%) were successfully resolved by pharmacotherapy or operation. The risk of surgical complications was greater in patients with lower AL,ACD,ACV or ACA andhigher nuclear hardness or mean keratometry(Km).Conclusion: With reasonable preoperative management, prudent selection of the lens,.rigorous surgical technique and unerring cognition of potential complications, coaxial microincision phacoemulsification lens surgery can be performed in patients with nanophthalmos and yield favorable outcomes and a low incidence of complications. 展开更多
关键词 白内障手术 超声乳化 同轴 切口 Logistic回归分析 病例 畸形 小眼
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Nitrogen isotopic fractionation of particulate organic matter production and remineralization in the Prydz Bay and its adjacent areas 被引量:1
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作者 chunyan ren Min Chen +5 位作者 Laodong Guo Jian Zeng renming Jia Xiao Liu Minfang Zheng Yusheng Qiu 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2020年第12期42-53,共12页
During the 29 th Chinese National Antarctic Research Expedition,spatial variations in nitrogen isotopic composition of particulate nitrogen(δ15NPN)and their controlling factors were examined in detail with regard to ... During the 29 th Chinese National Antarctic Research Expedition,spatial variations in nitrogen isotopic composition of particulate nitrogen(δ15NPN)and their controlling factors were examined in detail with regard to nitrate drawdown by phytoplankton and particulate nitrogen(PN)remineralization in the Prydz Bay and its adjacent areas.To better constrain the nitrogen transformations,the physical and chemical parameters,including temperature,salinity,nutrients,PN andδ15NPN in seawater column were measured from surface to bottom.In addition,the nitrogen isotopic fractionation factor of nitrate assimilation by phytoplankton in the mixed layer,and the nitrogen isotopic fractionation factor of PN remineralization below the mixed layer were estimated using Rayleigh model and Steady State model,respectively.Our results showed that suspended particles had its lowestδ15NPN in the surface layer,which was due to the preferential assimilation of 14 N in nitrate by phytoplankton.Theδ15NPN in the mixed layer of the Prydz Bay and its adjacent areas decreased from the inner shelf to the outer basin,ascribing to the effect of isotope fractionation during phytoplankton assimilation.In mixed layer,the spatial distribution ofδ15NPN associated with particulate organic matter(POM)production can be well interpreted according to Rayleigh model and Steady State model.The nitrogen isotope fractionation factor during phytoplankton assimilating nitrate was estimated as 10.0‰by Steady State model,which was more reasonable than that calculated by Rayleigh model.These results validate the previous reports of fractionation factor during nitrate assimilation by phytoplankton.Increasingδ15NPN with depth below the euphotic zone correlated with the decreasing PN contents,and it was attributed to preferential remineralization of 14 N in PN by bacteria.In subsurface and deep layer,theδ15NPN distributions also conformed to Rayleigh model and Steady State model during PN remineralization,with a fractionation factor of about 3.6‰and 3.2‰,respectively.It is the first time to estimate the fractionation factor during POM production and remineralization in the Prydz Bay and its adjacent areas.Such fractionation may provide a useful tool for the follow-up study of the nitrogen dynamics in the Southern Ocean. 展开更多
关键词 PN δ^(15)N^(PN) isotopic fractionation POM production REMINERALIZATION Prydz Bay
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Cr^(3+)和Cd^(2+)对普通小球藻生长及抗氧化酶活性的影响 被引量:4
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作者 葸玉琴 赖金霞 +3 位作者 张明旭 任春燕 孔维宝 贾凌云 《微生物学报》 CAS CSCD 北大核心 2021年第7期2091-2100,共10页
【目的】为探究重金属对淡水绿藻生长的影响。【方法】选取对水质检测具有明显指示作用的普通小球藻(Chlorella vulgaris)为实验材料,CdCl2·2H2O和CrCl3·7H2O提供重金属离子,探究不同浓度Cr^(3+)和Cd^(2+)在单一和复合胁迫下... 【目的】为探究重金属对淡水绿藻生长的影响。【方法】选取对水质检测具有明显指示作用的普通小球藻(Chlorella vulgaris)为实验材料,CdCl2·2H2O和CrCl3·7H2O提供重金属离子,探究不同浓度Cr^(3+)和Cd^(2+)在单一和复合胁迫下对藻细胞浓度、叶绿素a及相关抗氧化酶活性的影响。【结果】随着Cr^(3+)和Cd^(2+)浓度不断增加,藻细胞浓度呈先增长后下降趋势;叶绿素a含量呈现先下降后升高再下降的现象,浓度为1 mg/L的单一和复合胁迫下有最大值,且毒性作用表现为Cr^(3+)<Cd^(2+)<Cr^(3+)+Cd^(2+);与藻细胞膜相关的丙二醛(MDA)和过氧化氢(H2O2)含量随着重金属离子浓度的增大而增长;重金属离子浓度低于10 mg/L时对藻细胞内抗氧化酶系统中的超氧化物歧化酶(SOD)、过氧化氢酶(CAT)和过氧化物酶(POD)表现为促进作用,而大于10 mg/L时具有抑制作用。【结论】结果表明在单一或复合重金属胁迫下,普通小球藻会充分调动与抗逆性相关的酶来维持自身的正常生长。 展开更多
关键词 普通小球藻 Cr^(3+)和 Cd^(2+) 生物量 抗氧化酶活性
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PHISDetector:A Tool to Detect Diverse In Silico Phage–host Interaction Signals for Virome Studies 被引量:1
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作者 Fengxia Zhou Rui Gan +4 位作者 Fan Zhang chunyan ren Ling Yu Yu Si Zhiwei Huang 《Genomics, Proteomics & Bioinformatics》 SCIE CAS CSCD 2022年第3期508-523,共16页
Phage-microbe interactions are appealing systems to study coevolution,and have also been increasingly emphasized due to their roles in human health,disease,and the development of novel therapeutics.Phage-microbe inter... Phage-microbe interactions are appealing systems to study coevolution,and have also been increasingly emphasized due to their roles in human health,disease,and the development of novel therapeutics.Phage-microbe interactions leave diverse signals in bacterial and phage genomic sequences,defined as phage-host interaction signals(PHISs),which include clustered regularly interspaced short palindromic repeats(CRISPR)targeting,prophage,and protein-protein interaction signals.In the present study,we developed a novel tool phage-host interaction signal detector(PHISDetector)to predict phage-host interactions by detecting and integrating diverse in silico PHISs,and scoring the probability of phage-host interactions using machine learning models based on PHIS features.We evaluated the performance of PHISDetector on multiple benchmark datasets and application cases.When tested on a dataset of 758 annotated phage-host pairs,PHISDetector yields the prediction accuracies of 0.51 and 0.73 at the species and genus levels,respectively,outperforming other phage-host prediction tools.When applied to 125,842 metagenomic viral contigs(mVCs)derived from 3042 geographically diverse samples,a detection rate of 54.54% could be achieved.Furthermore,PHISDetector could predict infecting phages for 85.6% of 368 multidrug-resistant(MDR)bacteria and 30% of 454 human gut bacteria obtained from the National Institutes of Health(NIH)Human Microbiome Project(HMP).The PHISDetector can be run either as a web server(http://www.microbiome-bigdata.com/PHISDetector/)for general users to study individual inputs or as a stand-alone version(https://github.com/HITImmunologyLab/PHISDetector)to process massive phage contigs from virome studies. 展开更多
关键词 Phage-host interaction Virome CRISPR PROPHAGE Machine learning
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Voluntary CSR disclosure, institutional environment,and independent audit demand 被引量:2
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作者 Peipei Zheng chunyan ren 《China Journal of Accounting Research》 2019年第4期357-377,共21页
Using a sample of A-share listed companies on the Shanghai and Shenzhen Stock Exchanges,this study examines the impact of voluntary corporate social responsibility(CSR)disclosure on independent audit demand in differe... Using a sample of A-share listed companies on the Shanghai and Shenzhen Stock Exchanges,this study examines the impact of voluntary corporate social responsibility(CSR)disclosure on independent audit demand in different institutional environments.The sample covers the 2008–2016 period and excludes firms that are required to disclose CSR information.The findings show that compared with companies that choose to not disclose such information,companies that voluntarily disclose CSR information prefer to employ‘‘small"accounting firms for auditing services,although the auditing fees are much higher.However,as the institutional environment improves,this preference is weakened.Further analyses show that this preference is stronger in enterprises where CSR disclosure is driven by strong political motivations and managerial self-interest motivations.Legitimate motivations and economic motivations do not significantly impact the preference for‘‘small"audit firms.Furthermore,this preference is more obvious in enterprises with poor operational performance and low information disclosure quality,and it increases as CSR disclosure level decreases.The study enriches our understanding of the economic consequences of voluntary CSR disclosure and the factors that influence independent audit demand.The results also have implications for the construction and regulation of China’s system for supervising CSR information disclosure in the transitional phase. 展开更多
关键词 VOLUNTARY DISCLOSURE of corporate social RESPONSIBILITY information AUDITOR selection AUDITING FEES Institutional environment
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Direct interaction of DNMT inhibitors to PrP^C suppresses pathogenic process of prion
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作者 Dae-Hwan Kim chunyan ren +1 位作者 Chongsuk Ryou Jiaojie Li 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2019年第5期952-959,共8页
The conversion of the normal cellular prion protein(PrP^C) to the misfolded pathogenic scrapie prion protein(Pr PSc) is the biochemical hallmark of prion replication. So far, various chemical compounds that inhibit th... The conversion of the normal cellular prion protein(PrP^C) to the misfolded pathogenic scrapie prion protein(Pr PSc) is the biochemical hallmark of prion replication. So far, various chemical compounds that inhibit this conformational conversion have been identified. Here, we report the novel anti-prion activity of SGI-1027 and its meta/meta analogue(M/M), previously known only as potent inhibitors of DNA methyltransferases(DNMTs). These compounds effectively decreased the level of Pr PSc in cultured cells with permanent prion infection, without affecting PrP^Cat the transcriptional or translational levels. Furthermore, SGI-1027 prevented effective prion infection of the cells. In a Pr P aggregation assay, both SGI-1027 and M/M blocked the formation of misfolded Pr P aggregates, implying that binding of these compounds hinders the Pr P conversion process. A series of binding and docking analyses demonstrated that both SGI-1027 and M/M directly interacted with the C-terminal globular domain of PrP^C, but only SGI-1027 bound to a specific region of PrP^C with high affinity, which correlates with its potent antiprion efficacy. Therefore, we report SGI-1027 and related compounds as a novel class of potential antiprion agents that preferentially function through direct interaction with PrP^C. 展开更多
关键词 PRION DNMT THERAPEUTIC compounds PrP^C EPIGENETIC regulation
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