Objective: To observe the effect of intraplantar injection of monosodium iodoacetate (MIA) on pain perception in rats and to investigate the role of transient receptor potential vanilloid type 1 (TRPV1) in the effect....Objective: To observe the effect of intraplantar injection of monosodium iodoacetate (MIA) on pain perception in rats and to investigate the role of transient receptor potential vanilloid type 1 (TRPV1) in the effect. Methods: Adult male Wistar rats were used in the experiment. 1) MIA was injected subcutaneously into the right hindpaw of rats, the low, medium, and high doses of MIA were 0.11, 0.33, and 1 mg, respectively, then the changes of paw withdrawal thermal latency, paw withdrawal mechanical threshold, and dynamic weight bearing within 4 hours after MIA injection were measured. 2) Capsazepine (TRPV1 antagonist, 30 μg) was injected subcutaneously into the right hindpaw of rats at 2 hours after intraplantar injection of MIA (1 mg), then the changes of paw withdrawal thermal latency, paw withdrawal mechanical threshold, and dynamic weight bearing within 1 hour after capsazepine injection were measured. Results: 1) The paw withdrawal thermal latency, paw withdrawal mechanical threshold, and dynamic weight bearing decreased after intraplantar injection of MIA in rats and the effect lasted for at least 4 hours. 2) The MIA-induced reduction in paw withdrawal thermal latency, paw withdrawal mechanical threshold, and dynamic weight bearing were significantly alleviated after intraplantar injection of capsazepine in rats. Conclusion: Intraplantar injection of MIA can produce thermal pain, mechanical pain, and spontaneous pain for more than 4 hours, which may be due to the TRPV1 activation caused by MIA.展开更多
The electrochemical oxidation of 5-hydroxymethylfurfural(HMF) represents a significant avenue for sustainable chemical synthesis, owing to its potential to generate high-value derivatives from biomass feedstocks. Tran...The electrochemical oxidation of 5-hydroxymethylfurfural(HMF) represents a significant avenue for sustainable chemical synthesis, owing to its potential to generate high-value derivatives from biomass feedstocks. Transition metal catalysts offer a cost-effective alternative to precious metals for catalyzing HMF oxidation, with transition bimetallic catalysts emerging as particularly promising candidates. In this review, we delve into the intricate reaction pathways and electrochemical mechanisms underlying HMF oxidation, emphasizing the pivotal role of transition bimetallic catalysts in enhancing catalytic efficiency. Subsequently, various types of transition bimetallic catalysts are explored, detailing their synthesis methods and structural modulation strategies. By elucidating the mechanisms behind catalyst modification and performance enhancement, this review sets the stage for upcoming advancements in the field, ultimately advancing the electrochemical HMF conversion and facilitating the transition towards sustainable chemical production.展开更多
Genomic selection(GS)has been widely used in livestock,which greatly accelerated the genetic progress of complex traits.The population size was one of the significant factors affecting the prediction accuracy,while it...Genomic selection(GS)has been widely used in livestock,which greatly accelerated the genetic progress of complex traits.The population size was one of the significant factors affecting the prediction accuracy,while it was limited by the purebred population.Compared to directly combining two uncorrelated purebred populations to extend the reference population size,it might be more meaningful to incorporate the correlated crossbreds into reference population for genomic prediction.In this study,we simulated purebred offspring(PAS and PBS)and crossbred offspring(CAB)base on real genotype data of two base purebred populations(PA and PB),to evaluate the performance of genomic selection on purebred while incorporating crossbred information.The results showed that selecting key crossbred individuals via maximizing the expected genetic relationship(REL)was better than the other methods(individuals closet or farthest to the purebred population,CP/FP)in term of the prediction accuracy.Furthermore,the prediction accuracy of reference populations combining PA and CAB was significantly better only based on PA,which was similar to combine PA and PAS.Moreover,the rank correlation between the multiple of the increased relationship(MIR)and reliability improvement was 0.60-0.70.But for individuals with low correlation(Cor(Pi,PA or B),the reliability improvement was significantly lower than other individuals.Our findings suggested that incorporating crossbred into purebred population could improve the performance of genetic prediction compared with using the purebred population only.The genetic relationship between purebred and crossbred population is a key factor determining the increased reliability while incorporating crossbred population in the genomic prediction on pure bred individuals.展开更多
The double ionization process of molecules driven by co-rotating two-color circularly polarized fields is investigated with a three-dimensional classical ensemble model. Numerical results indicate that a considerable ...The double ionization process of molecules driven by co-rotating two-color circularly polarized fields is investigated with a three-dimensional classical ensemble model. Numerical results indicate that a considerable part of the sequential double ionization(DI) events of molecules occur through internal collision double ionization(ICD), and the ICD recollision mechanism is significantly different from that in non-sequential double ionization(NSDI). By analyzing the results of internuclear distances R = 5 a.u. and 2 a.u., these two recollision mechanisms are studied in depth. It is found that the dynamic behaviors of the recollision mechanisms of NSDI and ICD are similar. For NSDI, the motion range of electrons after the ionization is relatively large, and the electrons will return to the core after a period of time. In the ICD process,electrons will rotate around the parent ion before ionization, and the distance of the electron motion is relatively small. After a period of time, the electrons will come back to the core and collide with another electron. Furthermore, the molecular internuclear distance has a significant effect on the electron dynamic behavior of the two ionization mechanisms. This study will help to understand the multi-electron ionization process of complex systems.展开更多
Based on the Regional Specialized Meteorological Center(RSMC)Tokyo-Typhoon Center best-track data and the NCEP-NCAR reanalysis dataset,extratropical transitioning(ET)tropical cyclones(ETCs)over the western North Pacif...Based on the Regional Specialized Meteorological Center(RSMC)Tokyo-Typhoon Center best-track data and the NCEP-NCAR reanalysis dataset,extratropical transitioning(ET)tropical cyclones(ETCs)over the western North Pacific(WNP)during 1951–2021 are classified into six clusters using the fuzzy c-means clustering method(FCM)according to their track patterns.The characteristics of the six hard-clustered ETCs with the highest membership coefficient are shown.Most tropical cyclones(TCs)that were assigned to clusters C2,C5,and C6 made landfall over eastern Asian countries,which severely threatened these regions.Among landfalling TCs,93.2%completed their ET after landfall,whereas 39.8%of ETCs completed their transition within one day.The frequency of ETCs over the WNP has decreased in the past four decades,wherein cluster C5 demonstrated a significant decrease on both interannual and interdecadal timescales with the expansion and intensification of the western Pacific subtropical high(WPSH).This large-scale circulation pattern is favorable for C2 and causes it to become the dominant track pattern,owning to it containing the largest number of intensifying ETCs among the six clusters,a number that has increased insignificantly over the past four decades.The surface roughness variation and three-dimensional background circulation led to C5 containing the maximum number of landfalling TCs and a minimum number of intensifying ETCs.Our results will facilitate a better understanding of the spatiotemporal distributions of ET events and associated environment background fields,which will benefit the effective monitoring of these events over the WNP.展开更多
In the heterogeneous reservoirs,CO_(2) flooding easily leads to CO_(2) gas channeling,which can seriously affect sweeping efficiency and reduce oil recovery.After thoroughly investigating the advantages and shortcomin...In the heterogeneous reservoirs,CO_(2) flooding easily leads to CO_(2) gas channeling,which can seriously affect sweeping efficiency and reduce oil recovery.After thoroughly investigating the advantages and shortcomings of various CO_(2) plugging technologies,this paper focuses on the feasibility of improving conventional water-alternating gas(WAG)through CO_(2)-responsive gel materials.Based on the different chemical reaction mechanisms between the unique chemical structure and CO_(2),changes in the material’s physical and chemical properties can respond to CO_(2).The feasibility of utilizing these property changes for CO_(2)-responsive plugging is explored.Various CO_(2)-responsive gels and gel nanoparticles have been extensively researched in different fields,such as energy,medicine,and biology.This paper surveys the molecular structures,chemical compositions,response mechanisms,and changes of these CO_(2)-responsive gels,aiming to draw insights into the carbon dioxide-enhanced oil recovery(CO_(2)-EOR)field.Finally,the key issues and future development direction of CO_(2)-responsive plugging gels were analyzed.展开更多
BACKGROUND Pancreatic cancer is a highly malignant disease.After decades of treatment progress,the current five-year survival rate for patients is still less than 10%.For later-line treatment,the treatment options are...BACKGROUND Pancreatic cancer is a highly malignant disease.After decades of treatment progress,the current five-year survival rate for patients is still less than 10%.For later-line treatment,the treatment options are even more limited.Anti-angiogenic drugs can improve progression-free survival in patients with advanced pancreatic cancer.Preclinical data show that fruquintinib might improve the prognosis of advanced pancreatic cancer by targeting angiogenesis and lymphopoiesis,improving the abnormal vascular structure,and modulating the tumour immune microenvironment.CASE SUMMARY We present two cases of third-line fruquintinib monotherapy that brought an extraprolonged progress-free survival(PFS)of 10 months.Patient 1 took adjuvant gemcitabine-based and first-line nab-paclitaxel-based chemotherapy and then used local radiotherapy combined with programmed cell death 1 receptor(PD-1).Each line lasted approximately 7 months.Moreover,the patient took third-line fruquintinib,which was followed by stable disease for 10 months,during which no additional adverse effect was observed.The patient later refused to take fruquintinib due to difficulty urinating and lower abdominal pain after the coronavirus disease 2019(COVID-19)infection.The patient died in February 2023.Patient 2 also took two prior lines of chemotherapy and then local radiotherapy combined with S-1.After confirmed disease progression,the patient experienced a continuous partial response after using fruquintinib monotherapy in the third line.After the patient had COVID-19 in December 2022,fruquintinib was discontinued.The patient died in January 2023 due to disease progression.CONCLUSION Both cases achieved a PFS benefit from later-line single-agent fruquintinib therapy.With its better safety profile,fruquintinib may be worth exploring and studying in more depth as a later-line treatment for pancreatic cancer patients.展开更多
The measurement uncertainty analysis is carried out to investigate the measurable dimensions of cylindrical workpieces by the rotary-scan method in this paper.Due to the difficult alignment of the workpiece with a dia...The measurement uncertainty analysis is carried out to investigate the measurable dimensions of cylindrical workpieces by the rotary-scan method in this paper.Due to the difficult alignment of the workpiece with a diameter of less than 3 mm by the rotary scan method,the measurement uncertainty of the cylindrical workpiece with a diameter of 3 mm and length of 50 mm which is measured by a roundness measuring machine,is evaluated according to GUM(Guide to the Expression of Uncertainty in Measurement)as an example.Since the uncertainty caused by the eccentricity of the measured workpiece is different with the dimension changing,the measurement uncertainty of cylindrical workpieces with other dimensions can be evaluated the same as the diameter of 3 mm but with different eccentricity.Measurement uncertainty caused by different eccentricities concerning the dimension of the measured cylindrical workpiece is set to simulate the evaluations.Compared to the target value of the measurement uncertainty of 0.1μm,the measurable dimensions of the cylindrical workpiece can be obtained.Experiments and analysis are presented to quantitatively evaluate the reliability of the rotary-scan method for the roundness measurement of cylindrical workpieces.展开更多
This paper investigates the theoretical relationship between corporate governance,fair value accounting,and debt contracts.It primarily examines the individual impacts of corporate governance and fair value accounting...This paper investigates the theoretical relationship between corporate governance,fair value accounting,and debt contracts.It primarily examines the individual impacts of corporate governance and fair value accounting on debt contracts,while also exploring the influence of corporate governance on fair value accounting.The study emphasizes the importance of considering the interests and legal status of creditors in the context of debt contracts.The findings indicate that strong corporate governance can reduce the likelihood of debt default and that the company’s restructuring costs in the event of a default determine whether improved corporate governance will increase or decrease debt costs.Additionally,the study reveals that the strength of corporate governance affects the value relevance of fair value accounting.However,the impact of fair value accounting on debt contracts is not inherently positive or negative;for instance,companies may use fair value adjustments with manipulative intent to enhance performance.Ultimately,the research highlights that discussions about corporate governance should not prioritize shareholder interests exclusively but also consider the legitimate position of creditors.展开更多
Objectives: To explore the relationship between thrombin-antithrombin complex (TAT), plasmin—α plasmin inhibitor complex (PIC), thrombomodulin (TM), tissue plasminogen activator/plasminogen activator inhibitor-1 com...Objectives: To explore the relationship between thrombin-antithrombin complex (TAT), plasmin—α plasmin inhibitor complex (PIC), thrombomodulin (TM), tissue plasminogen activator/plasminogen activator inhibitor-1 complex (t-PAIC) and Gastric cancer. Methods: The plasma levels of TAT, TM, t-PAIC and PIC in patients with gastric cancer (40 in the initial diagnosis group and 35 in the post-treatment group) and 40 healthy controls were measured by chemiluminescent enzyme immunoassay. Then analyze the differences between these indicators in different stages of gastric cancer patients and healthy controls. Results: 1) The plasma levels of TAT, TM, t-PAIC and PIC in the newly diagnosed gastric cancer group were higher than those in the control group and the post-treatment group (P 0.05). 2) The plasma levels of TAT, TM, t-PAIC and PIC were not significantly different among the effective treatment group, the ineffective treatment group and the healthy control group. Conclusion: The changes of TAT, TM, t-PAIC and PIC levels are closely related to the development of patients with gastric cancer, and their increase may indicate that patients have a high risk of thrombosis.展开更多
Purpose:To have a better understanding of library users' social bookmarking behaviors,we conducted a survey of college students to examine how much attention they have paid to social bookmarking results,their soci...Purpose:To have a better understanding of library users' social bookmarking behaviors,we conducted a survey of college students to examine how much attention they have paid to social bookmarking results,their social bookmarking motivations and behaviors on book sharing sites and in their library's OPAC,and their expectations to their library's social bookmarking service.Design/methodology/approach:A questionnaire survey was conducted to investigate social bookmarking behaviors and motivations of users of Wuhan University Library(WUL) on book sharing sites and in WUL's OPAC.A total of 700 questionnaires were distributed and357 valid questionnaires were retrieved.SPSS was used for data analysis.Findings:The results revealed that there were differences between users' social bookmarking behaviors on book sharing sites and in the Library's OPAC.Users preferred to use tags than add tags on book sharing sites.The main tagging motivation on book sharing sites was for meeting users' specific needs such as collection management and book recommendations.As for the Library,the lack of publicity and promotion of the social bookmarking service led to insufficient use of the Library's service.Due to a lack of knowledge of the social bookmarking service,users did not care about the lectures or publicity campaigns about the Library's social bookmarking service.Research limitations:Because social bookmarking was not common among WUL users,and the questionnaires could be handed out to a limited number of people,it was hard to describe users' social bookmarking behaviors in the Library's OPAC by investigating a sample of 357Library users,and therefore we only investigated users' social bookmarking behaviors on the book sharing sites.Practical implications:The survey results provide insights into library users' social bookmarking behaviors and motivations.The study will help academic libraries improve their social bookmarking service.Originality/value:In spite of growing popularity of social bookmarking sites,little has been known about the social bookmarking behaviors of library users.This study investigated college students' social bookmarking behaviors and motivations,providing suggestions for academic libraries to improve their social bookmarking services.展开更多
Pain interventional therapy,known as the most promising medical technology in the 21st century,refers to clinical treatment technology based on neuroanatomy,neuroimaging,and nerve block technology to treat pain diseas...Pain interventional therapy,known as the most promising medical technology in the 21st century,refers to clinical treatment technology based on neuroanatomy,neuroimaging,and nerve block technology to treat pain diseases.Compared with traditional destructive surgery,interventional pain therapy is considered a better and more economical choice of treatment.In recent years,a variety of minimally invasive pain interventional therapy techniques,such as neuroregulation,spinal cord electrical stimulation,intervertebral disc ablation,and intrasheath drug infusion systems,have provided effective solutions for the treatment of patients with post-herpetic neuralgia,complex regional pain syndrome,cervical/lumbar disc herniation,and refractory cancer pain.展开更多
Quantum key distribution(QKD)is a sophisticated method for securing information by leveraging the principles of quantum mechanics.Its objective is to establish a confidential key between authorized partners who are co...Quantum key distribution(QKD)is a sophisticated method for securing information by leveraging the principles of quantum mechanics.Its objective is to establish a confidential key between authorized partners who are connected via both a quantum channel and a classical authentication channel.This paper presents a comprehensive overview of QKD protocols,chip-based QKD systems,quantum light sources,quantum detectors,fiber-based QKD networks,space-based QKD systems,as well as the applications and prospects of QKD technology.展开更多
Quantum key distribution(QKD)system based on passive silica planar lightwave circuit(PLC)asymmetric Mach–Zehnder interferometers(AMZI)is characterized with thermal stability,low loss and sufficient integration scalab...Quantum key distribution(QKD)system based on passive silica planar lightwave circuit(PLC)asymmetric Mach–Zehnder interferometers(AMZI)is characterized with thermal stability,low loss and sufficient integration scalability.However,waveguide stresses,both intrinsic and temperature-induced stresses,have significant impacts on the stable operation of the system.We have designed silica AMZI chips of 400 ps delay,with bend waveguides length equalized for both long and short arms to balance the stresses thereof.The temperature characteristics of the silica PLC AMZI chip are studied.The interference visibility at the single photon level is kept higher than 95%over a wide temperature range of 12℃.The delay time change is 0.321 ps within a temperature change of 40℃.The spectral shift is 0.0011 nm/0.1℃.Temperature-induced delay time and peak wavelength variations do not affect the interference visibility.The experiment results demonstrate the advantage of being tolerant to chip temperature fluctuations.展开更多
Purpose:To screen potential tumor antigens for melanoma vaccine development and identify different immune subtypes.Methods:Transcriptional data(HTSEQ-FPKM)and clinical information of a 472 Melanoma cohort GDC TCGA Mel...Purpose:To screen potential tumor antigens for melanoma vaccine development and identify different immune subtypes.Methods:Transcriptional data(HTSEQ-FPKM)and clinical information of a 472 Melanoma cohort GDC TCGA Melanoma(SKCM)were downloaded from the UCSC XENA website(http://xena.ucsc.edu/).Subsequently,transcriptome data and clinical information of 210 melanoma cohort GSE65904 were downloaded from Gene Expression Omnibus(GEO),a large global public database.All the transcriptome expression data matrices were log2 transformed for subsequent analysis.GEPIA,TIMER,and IMMPORT databases are also used for analysis.Cell function experiments were performed to validate the role of the IDO1 gene in melanoma cell line A375.Results:Our study provides potential tumor antigens for vaccine development in melanoma patients:GZMB,GBP4,CD79A,APOBEC3F,IDO1,JCHAIN,LAG3,PLA2G2D,XCL2.In addition,we divide melanoma patients into two immune subtypes that have significant differences in tumor immunity and may have different responses to vaccination.In view of the unclear role of IDO1 in melanoma,we selected IDO1 for cell assay validation.Cell function assay showed that IDO1 was significantly overexpressed in the melanoma A375 cell line.After IDO1 knockdown,the activity,invasion,migration and healing ability of A375 cell lines were significantly decreased.Conclusion:Our study could provide a reference for the development of vaccines for melanoma patients.展开更多
Tissue dielectric properties can vary upon the incident of an acoustic wave.The goal of this study is to quantify this change due to the acoustoelectric effect(AE),and to obtain the frequency-dependent dielectric prop...Tissue dielectric properties can vary upon the incident of an acoustic wave.The goal of this study is to quantify this change due to the acoustoelectric effect(AE),and to obtain the frequency-dependent dielectric properties of tissues exposed to low-intensity focused ultrasound(LIFU).The dielectric properties of the blood,brain,chest muscle,heart,kidney,leg muscle,liver,lung,pancreas,and spleen of rats were measured by an open-ended coaxial probe method.The acoustic intensity of LIFU focus was 2.97 MPa(67.6 W/cm^(2)),3.95 MPa(120 W/cm^(2)),and 5.17 MPa(204 W/cm^(2)),respectively,and the measurement frequency band was 0.1–7.08 GHz.The measurement results show that with the LIFU modulation,the conductivity and dielectric constant decreased in the high-frequency band,and on the contrary,they increased in the lowfrequency band,and the larger the acoustic intensity was,the more obvious the phenomenon was.This work contributes to a better understanding of the mechanisms by which ultrasound acts on the dielectric properties of biological tissues.It is expected that the findings from this study will provide a basis that the response of tissue to LIFU modulation can be monitored by noninvasive techniques such as microwave-induced thermoacoustic imaging(MTI)and microwave imaging,present a new idea for improving the endogenous contrast between different biological tissues in MTI and acoustoelectric imaging,and possibly lead to the development of a new imaging method based on the relaxation time of tissue after LIFU modulation.展开更多
Due to the complexity of joint structures and the diversity of disorders in the joints,the diagnosis of joint diseases is challenging.Current clinical diagnostic techniques for evaluating joint diseases,such as arthri...Due to the complexity of joint structures and the diversity of disorders in the joints,the diagnosis of joint diseases is challenging.Current clinical diagnostic techniques for evaluating joint diseases,such as arthritis,have strengths and weaknesses.New imaging techniques need to be developed for the diagnosis or auxiliary diagnosis of arthritis.As an emerging nonintrusive low-cost imaging method,microwave-induced thermoacoustic imaging(TAI)can present tissue morphology while providing the tissue microwave energy absorption density distribution related to dielectric properties.TAI is currently in development to potentially visualize joint anatomic structures and to detect arthritis.Here,we offer a mini review to summarize the status of research on TAI of joints and present an outlook to the future development of TAI in the detection of joint diseases.展开更多
Keloids,which are abnormal manifestations of wound healing,can result in significant functional impairment and aesthetic deformities.The pathogenesis of keloids is multifaceted and complex and influenced by various fa...Keloids,which are abnormal manifestations of wound healing,can result in significant functional impairment and aesthetic deformities.The pathogenesis of keloids is multifaceted and complex and influenced by various factors,such as genetics,the environment,and immune responses.The evolution of keloid treatment has progressed from traditional surgical excision to a contemporary combination of therapies including injection and radiation treatments,among others.This article provides a comprehensive review of keloid pathogenesis and treatment,emphasizing the latest advances in the field.Ultimately,this review underscores the necessity for continued research to enhance our understanding of keloid pathogenesis and to devise more effective treatments for this challenging condition.展开更多
文摘Objective: To observe the effect of intraplantar injection of monosodium iodoacetate (MIA) on pain perception in rats and to investigate the role of transient receptor potential vanilloid type 1 (TRPV1) in the effect. Methods: Adult male Wistar rats were used in the experiment. 1) MIA was injected subcutaneously into the right hindpaw of rats, the low, medium, and high doses of MIA were 0.11, 0.33, and 1 mg, respectively, then the changes of paw withdrawal thermal latency, paw withdrawal mechanical threshold, and dynamic weight bearing within 4 hours after MIA injection were measured. 2) Capsazepine (TRPV1 antagonist, 30 μg) was injected subcutaneously into the right hindpaw of rats at 2 hours after intraplantar injection of MIA (1 mg), then the changes of paw withdrawal thermal latency, paw withdrawal mechanical threshold, and dynamic weight bearing within 1 hour after capsazepine injection were measured. Results: 1) The paw withdrawal thermal latency, paw withdrawal mechanical threshold, and dynamic weight bearing decreased after intraplantar injection of MIA in rats and the effect lasted for at least 4 hours. 2) The MIA-induced reduction in paw withdrawal thermal latency, paw withdrawal mechanical threshold, and dynamic weight bearing were significantly alleviated after intraplantar injection of capsazepine in rats. Conclusion: Intraplantar injection of MIA can produce thermal pain, mechanical pain, and spontaneous pain for more than 4 hours, which may be due to the TRPV1 activation caused by MIA.
基金Hubei Provincial Natural Science Foundation of China (2023AFB0049)Scientific Research Fund Project of Wuhan Institute of Technology (K202232 and K2023028)Graduate Education Innovation Fund of Wuhan Institute of Technology (CX2023091)。
文摘The electrochemical oxidation of 5-hydroxymethylfurfural(HMF) represents a significant avenue for sustainable chemical synthesis, owing to its potential to generate high-value derivatives from biomass feedstocks. Transition metal catalysts offer a cost-effective alternative to precious metals for catalyzing HMF oxidation, with transition bimetallic catalysts emerging as particularly promising candidates. In this review, we delve into the intricate reaction pathways and electrochemical mechanisms underlying HMF oxidation, emphasizing the pivotal role of transition bimetallic catalysts in enhancing catalytic efficiency. Subsequently, various types of transition bimetallic catalysts are explored, detailing their synthesis methods and structural modulation strategies. By elucidating the mechanisms behind catalyst modification and performance enhancement, this review sets the stage for upcoming advancements in the field, ultimately advancing the electrochemical HMF conversion and facilitating the transition towards sustainable chemical production.
基金supported by the earmarked fund for China Agriculture Research System(CARS-35)the National Natural Science Foundation of China(32022078)supported by the National Supercomputer Centre in Guangzhou。
文摘Genomic selection(GS)has been widely used in livestock,which greatly accelerated the genetic progress of complex traits.The population size was one of the significant factors affecting the prediction accuracy,while it was limited by the purebred population.Compared to directly combining two uncorrelated purebred populations to extend the reference population size,it might be more meaningful to incorporate the correlated crossbreds into reference population for genomic prediction.In this study,we simulated purebred offspring(PAS and PBS)and crossbred offspring(CAB)base on real genotype data of two base purebred populations(PA and PB),to evaluate the performance of genomic selection on purebred while incorporating crossbred information.The results showed that selecting key crossbred individuals via maximizing the expected genetic relationship(REL)was better than the other methods(individuals closet or farthest to the purebred population,CP/FP)in term of the prediction accuracy.Furthermore,the prediction accuracy of reference populations combining PA and CAB was significantly better only based on PA,which was similar to combine PA and PAS.Moreover,the rank correlation between the multiple of the increased relationship(MIR)and reliability improvement was 0.60-0.70.But for individuals with low correlation(Cor(Pi,PA or B),the reliability improvement was significantly lower than other individuals.Our findings suggested that incorporating crossbred into purebred population could improve the performance of genetic prediction compared with using the purebred population only.The genetic relationship between purebred and crossbred population is a key factor determining the increased reliability while incorporating crossbred population in the genomic prediction on pure bred individuals.
基金the National Key Research and Development Program of China (Grant No.2019YFA0307700)the National Natural Science Foundation of China (Grant Nos.12074145 and 11975012)+1 种基金Jilin Provincial Research Foundation for Basic Research,China (Grant No.20220101003JC)Jilin Provincial Education Department (Grant No.JJKH20230284KJ)。
文摘The double ionization process of molecules driven by co-rotating two-color circularly polarized fields is investigated with a three-dimensional classical ensemble model. Numerical results indicate that a considerable part of the sequential double ionization(DI) events of molecules occur through internal collision double ionization(ICD), and the ICD recollision mechanism is significantly different from that in non-sequential double ionization(NSDI). By analyzing the results of internuclear distances R = 5 a.u. and 2 a.u., these two recollision mechanisms are studied in depth. It is found that the dynamic behaviors of the recollision mechanisms of NSDI and ICD are similar. For NSDI, the motion range of electrons after the ionization is relatively large, and the electrons will return to the core after a period of time. In the ICD process,electrons will rotate around the parent ion before ionization, and the distance of the electron motion is relatively small. After a period of time, the electrons will come back to the core and collide with another electron. Furthermore, the molecular internuclear distance has a significant effect on the electron dynamic behavior of the two ionization mechanisms. This study will help to understand the multi-electron ionization process of complex systems.
基金supported by the National Natural Science Foundation of China(Grant Nos.42075053 and 41975128)。
文摘Based on the Regional Specialized Meteorological Center(RSMC)Tokyo-Typhoon Center best-track data and the NCEP-NCAR reanalysis dataset,extratropical transitioning(ET)tropical cyclones(ETCs)over the western North Pacific(WNP)during 1951–2021 are classified into six clusters using the fuzzy c-means clustering method(FCM)according to their track patterns.The characteristics of the six hard-clustered ETCs with the highest membership coefficient are shown.Most tropical cyclones(TCs)that were assigned to clusters C2,C5,and C6 made landfall over eastern Asian countries,which severely threatened these regions.Among landfalling TCs,93.2%completed their ET after landfall,whereas 39.8%of ETCs completed their transition within one day.The frequency of ETCs over the WNP has decreased in the past four decades,wherein cluster C5 demonstrated a significant decrease on both interannual and interdecadal timescales with the expansion and intensification of the western Pacific subtropical high(WPSH).This large-scale circulation pattern is favorable for C2 and causes it to become the dominant track pattern,owning to it containing the largest number of intensifying ETCs among the six clusters,a number that has increased insignificantly over the past four decades.The surface roughness variation and three-dimensional background circulation led to C5 containing the maximum number of landfalling TCs and a minimum number of intensifying ETCs.Our results will facilitate a better understanding of the spatiotemporal distributions of ET events and associated environment background fields,which will benefit the effective monitoring of these events over the WNP.
基金Supported by the Open Fund Project of Hubei Key Laboratory of Oil and Gas Drilling and Production Engineering(YQZC202105)Yangtze University Student Innovation Program(Yz2022018).
文摘In the heterogeneous reservoirs,CO_(2) flooding easily leads to CO_(2) gas channeling,which can seriously affect sweeping efficiency and reduce oil recovery.After thoroughly investigating the advantages and shortcomings of various CO_(2) plugging technologies,this paper focuses on the feasibility of improving conventional water-alternating gas(WAG)through CO_(2)-responsive gel materials.Based on the different chemical reaction mechanisms between the unique chemical structure and CO_(2),changes in the material’s physical and chemical properties can respond to CO_(2).The feasibility of utilizing these property changes for CO_(2)-responsive plugging is explored.Various CO_(2)-responsive gels and gel nanoparticles have been extensively researched in different fields,such as energy,medicine,and biology.This paper surveys the molecular structures,chemical compositions,response mechanisms,and changes of these CO_(2)-responsive gels,aiming to draw insights into the carbon dioxide-enhanced oil recovery(CO_(2)-EOR)field.Finally,the key issues and future development direction of CO_(2)-responsive plugging gels were analyzed.
基金Supported by Found by the General Program of Wuxi Health and Health Committee,No.MS201908.
文摘BACKGROUND Pancreatic cancer is a highly malignant disease.After decades of treatment progress,the current five-year survival rate for patients is still less than 10%.For later-line treatment,the treatment options are even more limited.Anti-angiogenic drugs can improve progression-free survival in patients with advanced pancreatic cancer.Preclinical data show that fruquintinib might improve the prognosis of advanced pancreatic cancer by targeting angiogenesis and lymphopoiesis,improving the abnormal vascular structure,and modulating the tumour immune microenvironment.CASE SUMMARY We present two cases of third-line fruquintinib monotherapy that brought an extraprolonged progress-free survival(PFS)of 10 months.Patient 1 took adjuvant gemcitabine-based and first-line nab-paclitaxel-based chemotherapy and then used local radiotherapy combined with programmed cell death 1 receptor(PD-1).Each line lasted approximately 7 months.Moreover,the patient took third-line fruquintinib,which was followed by stable disease for 10 months,during which no additional adverse effect was observed.The patient later refused to take fruquintinib due to difficulty urinating and lower abdominal pain after the coronavirus disease 2019(COVID-19)infection.The patient died in February 2023.Patient 2 also took two prior lines of chemotherapy and then local radiotherapy combined with S-1.After confirmed disease progression,the patient experienced a continuous partial response after using fruquintinib monotherapy in the third line.After the patient had COVID-19 in December 2022,fruquintinib was discontinued.The patient died in January 2023 due to disease progression.CONCLUSION Both cases achieved a PFS benefit from later-line single-agent fruquintinib therapy.With its better safety profile,fruquintinib may be worth exploring and studying in more depth as a later-line treatment for pancreatic cancer patients.
基金supported by the National Defense Basic Scientific Research Program of China(Grant numbers JCKY2019427D002)。
文摘The measurement uncertainty analysis is carried out to investigate the measurable dimensions of cylindrical workpieces by the rotary-scan method in this paper.Due to the difficult alignment of the workpiece with a diameter of less than 3 mm by the rotary scan method,the measurement uncertainty of the cylindrical workpiece with a diameter of 3 mm and length of 50 mm which is measured by a roundness measuring machine,is evaluated according to GUM(Guide to the Expression of Uncertainty in Measurement)as an example.Since the uncertainty caused by the eccentricity of the measured workpiece is different with the dimension changing,the measurement uncertainty of cylindrical workpieces with other dimensions can be evaluated the same as the diameter of 3 mm but with different eccentricity.Measurement uncertainty caused by different eccentricities concerning the dimension of the measured cylindrical workpiece is set to simulate the evaluations.Compared to the target value of the measurement uncertainty of 0.1μm,the measurable dimensions of the cylindrical workpiece can be obtained.Experiments and analysis are presented to quantitatively evaluate the reliability of the rotary-scan method for the roundness measurement of cylindrical workpieces.
文摘This paper investigates the theoretical relationship between corporate governance,fair value accounting,and debt contracts.It primarily examines the individual impacts of corporate governance and fair value accounting on debt contracts,while also exploring the influence of corporate governance on fair value accounting.The study emphasizes the importance of considering the interests and legal status of creditors in the context of debt contracts.The findings indicate that strong corporate governance can reduce the likelihood of debt default and that the company’s restructuring costs in the event of a default determine whether improved corporate governance will increase or decrease debt costs.Additionally,the study reveals that the strength of corporate governance affects the value relevance of fair value accounting.However,the impact of fair value accounting on debt contracts is not inherently positive or negative;for instance,companies may use fair value adjustments with manipulative intent to enhance performance.Ultimately,the research highlights that discussions about corporate governance should not prioritize shareholder interests exclusively but also consider the legitimate position of creditors.
文摘Objectives: To explore the relationship between thrombin-antithrombin complex (TAT), plasmin—α plasmin inhibitor complex (PIC), thrombomodulin (TM), tissue plasminogen activator/plasminogen activator inhibitor-1 complex (t-PAIC) and Gastric cancer. Methods: The plasma levels of TAT, TM, t-PAIC and PIC in patients with gastric cancer (40 in the initial diagnosis group and 35 in the post-treatment group) and 40 healthy controls were measured by chemiluminescent enzyme immunoassay. Then analyze the differences between these indicators in different stages of gastric cancer patients and healthy controls. Results: 1) The plasma levels of TAT, TM, t-PAIC and PIC in the newly diagnosed gastric cancer group were higher than those in the control group and the post-treatment group (P 0.05). 2) The plasma levels of TAT, TM, t-PAIC and PIC were not significantly different among the effective treatment group, the ineffective treatment group and the healthy control group. Conclusion: The changes of TAT, TM, t-PAIC and PIC levels are closely related to the development of patients with gastric cancer, and their increase may indicate that patients have a high risk of thrombosis.
基金supported by the National Youth Top-notch Talent Support Program of China
文摘Purpose:To have a better understanding of library users' social bookmarking behaviors,we conducted a survey of college students to examine how much attention they have paid to social bookmarking results,their social bookmarking motivations and behaviors on book sharing sites and in their library's OPAC,and their expectations to their library's social bookmarking service.Design/methodology/approach:A questionnaire survey was conducted to investigate social bookmarking behaviors and motivations of users of Wuhan University Library(WUL) on book sharing sites and in WUL's OPAC.A total of 700 questionnaires were distributed and357 valid questionnaires were retrieved.SPSS was used for data analysis.Findings:The results revealed that there were differences between users' social bookmarking behaviors on book sharing sites and in the Library's OPAC.Users preferred to use tags than add tags on book sharing sites.The main tagging motivation on book sharing sites was for meeting users' specific needs such as collection management and book recommendations.As for the Library,the lack of publicity and promotion of the social bookmarking service led to insufficient use of the Library's service.Due to a lack of knowledge of the social bookmarking service,users did not care about the lectures or publicity campaigns about the Library's social bookmarking service.Research limitations:Because social bookmarking was not common among WUL users,and the questionnaires could be handed out to a limited number of people,it was hard to describe users' social bookmarking behaviors in the Library's OPAC by investigating a sample of 357Library users,and therefore we only investigated users' social bookmarking behaviors on the book sharing sites.Practical implications:The survey results provide insights into library users' social bookmarking behaviors and motivations.The study will help academic libraries improve their social bookmarking service.Originality/value:In spite of growing popularity of social bookmarking sites,little has been known about the social bookmarking behaviors of library users.This study investigated college students' social bookmarking behaviors and motivations,providing suggestions for academic libraries to improve their social bookmarking services.
基金supported by the Lishui Science and Technology Plan Project(Grant Number:2022SJZC020)the Medical Health Science and Technology Project of the Zhejiang Provincial Health Commission(Grant Number:2020KY1084)
文摘Pain interventional therapy,known as the most promising medical technology in the 21st century,refers to clinical treatment technology based on neuroanatomy,neuroimaging,and nerve block technology to treat pain diseases.Compared with traditional destructive surgery,interventional pain therapy is considered a better and more economical choice of treatment.In recent years,a variety of minimally invasive pain interventional therapy techniques,such as neuroregulation,spinal cord electrical stimulation,intervertebral disc ablation,and intrasheath drug infusion systems,have provided effective solutions for the treatment of patients with post-herpetic neuralgia,complex regional pain syndrome,cervical/lumbar disc herniation,and refractory cancer pain.
基金Project supported by the Innovation Program for Quantum Science and Technology (Grant No.2021ZD0300701)the National Key Research and Development Program of China (Grant No.2018YFA0306403)the Strategic Priority Research Program of Chinese Academy of Sciences (Grant No.XDB43000000)。
文摘Quantum key distribution(QKD)is a sophisticated method for securing information by leveraging the principles of quantum mechanics.Its objective is to establish a confidential key between authorized partners who are connected via both a quantum channel and a classical authentication channel.This paper presents a comprehensive overview of QKD protocols,chip-based QKD systems,quantum light sources,quantum detectors,fiber-based QKD networks,space-based QKD systems,as well as the applications and prospects of QKD technology.
基金Project supported by the National Key R&D Program of China (Grant No.2018YFA0306403)the Strategic Priority Research Program of Chinese Academy of Sciences (Grant No.XDB43000000)+1 种基金Innovation Program for Quantum Science and TechnologyComputer Interconnect Technology Alliance Funding (Grant No.20220103)。
文摘Quantum key distribution(QKD)system based on passive silica planar lightwave circuit(PLC)asymmetric Mach–Zehnder interferometers(AMZI)is characterized with thermal stability,low loss and sufficient integration scalability.However,waveguide stresses,both intrinsic and temperature-induced stresses,have significant impacts on the stable operation of the system.We have designed silica AMZI chips of 400 ps delay,with bend waveguides length equalized for both long and short arms to balance the stresses thereof.The temperature characteristics of the silica PLC AMZI chip are studied.The interference visibility at the single photon level is kept higher than 95%over a wide temperature range of 12℃.The delay time change is 0.321 ps within a temperature change of 40℃.The spectral shift is 0.0011 nm/0.1℃.Temperature-induced delay time and peak wavelength variations do not affect the interference visibility.The experiment results demonstrate the advantage of being tolerant to chip temperature fluctuations.
基金supported by the Top Talent Project of Jiangsu Provincial People’s Hospital(No.YNRCZN0310).
文摘Purpose:To screen potential tumor antigens for melanoma vaccine development and identify different immune subtypes.Methods:Transcriptional data(HTSEQ-FPKM)and clinical information of a 472 Melanoma cohort GDC TCGA Melanoma(SKCM)were downloaded from the UCSC XENA website(http://xena.ucsc.edu/).Subsequently,transcriptome data and clinical information of 210 melanoma cohort GSE65904 were downloaded from Gene Expression Omnibus(GEO),a large global public database.All the transcriptome expression data matrices were log2 transformed for subsequent analysis.GEPIA,TIMER,and IMMPORT databases are also used for analysis.Cell function experiments were performed to validate the role of the IDO1 gene in melanoma cell line A375.Results:Our study provides potential tumor antigens for vaccine development in melanoma patients:GZMB,GBP4,CD79A,APOBEC3F,IDO1,JCHAIN,LAG3,PLA2G2D,XCL2.In addition,we divide melanoma patients into two immune subtypes that have significant differences in tumor immunity and may have different responses to vaccination.In view of the unclear role of IDO1 in melanoma,we selected IDO1 for cell assay validation.Cell function assay showed that IDO1 was significantly overexpressed in the melanoma A375 cell line.After IDO1 knockdown,the activity,invasion,migration and healing ability of A375 cell lines were significantly decreased.Conclusion:Our study could provide a reference for the development of vaccines for melanoma patients.
基金the National Natural Science Foundation of China(Grant Nos.82071940 and 62001075)Chongqing Municipal Education Commission Youth Fund,China(Grant Nos.KJQN20200607 and KJQN20200610).
文摘Tissue dielectric properties can vary upon the incident of an acoustic wave.The goal of this study is to quantify this change due to the acoustoelectric effect(AE),and to obtain the frequency-dependent dielectric properties of tissues exposed to low-intensity focused ultrasound(LIFU).The dielectric properties of the blood,brain,chest muscle,heart,kidney,leg muscle,liver,lung,pancreas,and spleen of rats were measured by an open-ended coaxial probe method.The acoustic intensity of LIFU focus was 2.97 MPa(67.6 W/cm^(2)),3.95 MPa(120 W/cm^(2)),and 5.17 MPa(204 W/cm^(2)),respectively,and the measurement frequency band was 0.1–7.08 GHz.The measurement results show that with the LIFU modulation,the conductivity and dielectric constant decreased in the high-frequency band,and on the contrary,they increased in the lowfrequency band,and the larger the acoustic intensity was,the more obvious the phenomenon was.This work contributes to a better understanding of the mechanisms by which ultrasound acts on the dielectric properties of biological tissues.It is expected that the findings from this study will provide a basis that the response of tissue to LIFU modulation can be monitored by noninvasive techniques such as microwave-induced thermoacoustic imaging(MTI)and microwave imaging,present a new idea for improving the endogenous contrast between different biological tissues in MTI and acoustoelectric imaging,and possibly lead to the development of a new imaging method based on the relaxation time of tissue after LIFU modulation.
基金supported by the National Natural Science Foundation of China under Grant No.62001075the Chinese Postdoctoral Science Foundation under Grant No.2022MD723722+1 种基金the Chongqing Postdoctoral Research Project under Grant No.2021XM2026the Scientific and Technological Research Program of Chongqing Municipal Education Commission under Grant No.KJQN202000610.
文摘Due to the complexity of joint structures and the diversity of disorders in the joints,the diagnosis of joint diseases is challenging.Current clinical diagnostic techniques for evaluating joint diseases,such as arthritis,have strengths and weaknesses.New imaging techniques need to be developed for the diagnosis or auxiliary diagnosis of arthritis.As an emerging nonintrusive low-cost imaging method,microwave-induced thermoacoustic imaging(TAI)can present tissue morphology while providing the tissue microwave energy absorption density distribution related to dielectric properties.TAI is currently in development to potentially visualize joint anatomic structures and to detect arthritis.Here,we offer a mini review to summarize the status of research on TAI of joints and present an outlook to the future development of TAI in the detection of joint diseases.
文摘Keloids,which are abnormal manifestations of wound healing,can result in significant functional impairment and aesthetic deformities.The pathogenesis of keloids is multifaceted and complex and influenced by various factors,such as genetics,the environment,and immune responses.The evolution of keloid treatment has progressed from traditional surgical excision to a contemporary combination of therapies including injection and radiation treatments,among others.This article provides a comprehensive review of keloid pathogenesis and treatment,emphasizing the latest advances in the field.Ultimately,this review underscores the necessity for continued research to enhance our understanding of keloid pathogenesis and to devise more effective treatments for this challenging condition.
