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基于深度学习模型的非小细胞肺癌新辅助免疫联合化疗疗效预测
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作者 谭婧 赵宏 +4 位作者 杨墨轩 熊佳航 赵丹 周立娟 车南颖 《中国肿瘤临床》 CAS CSCD 北大核心 2024年第11期561-566,共6页
目的:基于深度学习算法,使用临床数据构建人工智能(artificial intelligence,AI)模型,评估其预测非小细胞肺癌(nonsmall cell lung cancer,NSCLC)新辅助免疫联合化疗疗效的可行性。方法:收集2020年1月至2024年1月于首都医科大学附属北... 目的:基于深度学习算法,使用临床数据构建人工智能(artificial intelligence,AI)模型,评估其预测非小细胞肺癌(nonsmall cell lung cancer,NSCLC)新辅助免疫联合化疗疗效的可行性。方法:收集2020年1月至2024年1月于首都医科大学附属北京胸科医院确诊且接受新辅助免疫联合化疗的132例NSCLC患者的临床病理数据。对影响新辅助免疫联合化疗疗效的主要因素进行统计学分析。根据统计学分析结果以及查阅相关文献对变量进行筛选,构建变量数据集。基于多层感知机(multi-layer perceptron,MLP)算法采用5折交叉验证建立深度学习模型,应用接收者操作特征(receiver operating characteristic,ROC)曲线评估模型性能。结果:132例患者中单因素分析显示获得主要病理缓解(major pathological response,MPR)组与未获得MPR组的患者在性别(P=0.020)、吸烟史(P=0.004)、癌胚抗原(carcinoembryonic antigen,CEA)(P=0.038)及程序性死亡配体-1(programmed death-ligand 1,PD-L1)是否≥1%(P=0.038)方面差异具有统计学意义;获得完全病理缓解(complete pathological response,pCR)组与未获pCR组患者在肿瘤大小是否≤3 cm(P=0.007)和CEA水平方面(P=0.010)差异具有统计学意义。经5折交叉验证后,MPR预测模型在验证集和测试集的平均受试者工作特征曲线下面积(area under the curve,AUC)值分别为0.72及0.71。结论:该深度学习模型能够有效预测NSCLC患者新辅助免疫联合化疗疗效。 展开更多
关键词 肺癌 新辅助治疗 深度学习
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Pluggable multitask diffractive neural networks based on cascaded metasurfaces 被引量:4
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作者 Cong He dan zhao +8 位作者 Fei Fan Hongqiang Zhou Xin Li Yao Li Junjie Li Fei Dong Yin-Xiao Miao Yongtian Wang Lingling Huang 《Opto-Electronic Advances》 SCIE EI CAS CSCD 2024年第2期23-31,共9页
Optical neural networks have significant advantages in terms of power consumption,parallelism,and high computing speed,which has intrigued extensive attention in both academic and engineering communities.It has been c... Optical neural networks have significant advantages in terms of power consumption,parallelism,and high computing speed,which has intrigued extensive attention in both academic and engineering communities.It has been considered as one of the powerful tools in promoting the fields of imaging processing and object recognition.However,the existing optical system architecture cannot be reconstructed to the realization of multi-functional artificial intelligence systems simultaneously.To push the development of this issue,we propose the pluggable diffractive neural networks(P-DNN),a general paradigm resorting to the cascaded metasurfaces,which can be applied to recognize various tasks by switching internal plug-ins.As the proof-of-principle,the recognition functions of six types of handwritten digits and six types of fashions are numerical simulated and experimental demonstrated at near-infrared regimes.Encouragingly,the proposed paradigm not only improves the flexibility of the optical neural networks but paves the new route for achieving high-speed,low-power and versatile artificial intelligence systems. 展开更多
关键词 optical neural networks diffractive deep neural networks cascaded metasurfaces
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Challenges and Opportunities in Preserving Key Structural Features of 3D-Printed Metal/Covalent Organic Framework 被引量:1
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作者 Ximeng Liu dan zhao John Wang 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第8期362-381,共20页
Metal-organic framework(MOF)and covalent organic framework(COF)are a huge group of advanced porous materials exhibiting attractive and tunable microstructural features,such as large surface area,tunable pore size,and ... Metal-organic framework(MOF)and covalent organic framework(COF)are a huge group of advanced porous materials exhibiting attractive and tunable microstructural features,such as large surface area,tunable pore size,and functional surfaces,which have significant values in various application areas.The emerging 3D printing technology further provides MOF and COFs(M/COFs)with higher designability of their macrostructure and demonstrates large achievements in their performance by shaping them into advanced 3D monoliths.However,the currently available 3D printing M/COFs strategy faces a major challenge of severe destruction of M/COFs’microstructural features,both during and after 3D printing.It is envisioned that preserving the microstructure of M/COFs in the 3D-printed monolith will bring a great improvement to the related applications.In this overview,the 3D-printed M/COFs are categorized into M/COF-mixed monoliths and M/COF-covered monoliths.Their differences in the properties,applications,and current research states are discussed.The up-to-date advancements in paste/scaffold composition and printing/covering methods to preserve the superior M/COF microstructure during 3D printing are further discussed for the two types of 3D-printed M/COF.Throughout the analysis of the current states of 3D-printed M/COFs,the expected future research direction to achieve a highly preserved microstructure in the 3D monolith is proposed. 展开更多
关键词 Metal-organic frameworks Covalent organic frameworks 3D printing Microstructure MONOLITH
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An adaptive finite-difference method for seismic traveltime modeling based on 3D eikonal equation
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作者 Bao-Ping Qiao Qing-Qing Li +2 位作者 Wei-Guang He dan zhao Qu-Bo Wu 《Petroleum Science》 SCIE EI CAS CSCD 2024年第1期195-205,共11页
3D eikonal equation is a partial differential equation for the calculation of first-arrival traveltimes and has been widely applied in many scopes such as ray tracing,source localization,reflection migration,seismic m... 3D eikonal equation is a partial differential equation for the calculation of first-arrival traveltimes and has been widely applied in many scopes such as ray tracing,source localization,reflection migration,seismic monitoring and tomographic imaging.In recent years,many advanced methods have been developed to solve the 3D eikonal equation in heterogeneous media.However,there are still challenges for the stable and accurate calculation of first-arrival traveltimes in 3D strongly inhomogeneous media.In this paper,we propose an adaptive finite-difference(AFD)method to numerically solve the 3D eikonal equation.The novel method makes full use of the advantages of different local operators characterizing different seismic wave types to calculate factors and traveltimes,and then the most accurate factor and traveltime are adaptively selected for the convergent updating based on the Fermat principle.Combined with global fast sweeping describing seismic waves propagating along eight directions in 3D media,our novel method can achieve the robust calculation of first-arrival traveltimes with high precision at grid points either near source point or far away from source point even in a velocity model with large and sharp contrasts.Several numerical examples show the good performance of the AFD method,which will be beneficial to many scientific applications. 展开更多
关键词 3D eikonal equation Accurate traveltimes Global fast sweeping 3D inhomogeneous media Adaptive finite-difference method
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Porous framework materials for energy&environment relevant applications:A systematic review
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作者 Yutao Liu Liyu Chen +16 位作者 Lifeng Yang Tianhao Lan Hui Wang Chenghong Hu Xue Han Qixing Liu Jianfa Chen Zeming Feng Xili Cui Qianrong Fang Hailong Wang Libo Li Yingwei Li Huabin Xing Sihai Yang dan zhao Jinping Li 《Green Energy & Environment》 SCIE EI CAS CSCD 2024年第2期217-310,共94页
Carbon peaking and carbon neutralization trigger a technical revolution in energy&environment related fields.Development of new technologies for green energy production and storage,industrial energy saving and eff... Carbon peaking and carbon neutralization trigger a technical revolution in energy&environment related fields.Development of new technologies for green energy production and storage,industrial energy saving and efficiency reinforcement,carbon capture,and pollutant gas treatment is in highly imperious demand.The emerging porous framework materials such as metal–organic frameworks(MOFs),covalent organic frameworks(COFs)and hydrogen-bonded organic frameworks(HOFs),owing to the permanent porosity,tremendous specific surface area,designable structure and customizable functionality,have shown great potential in major energy-consuming industrial processes,including sustainable energy gas catalytic conversion,energy-efficient industrial gas separation and storage.Herein,this manuscript presents a systematic review of porous framework materials for global and comprehensive energy&environment related applications,from a macroscopic and application perspective. 展开更多
关键词 Porous framework materials CATALYSIS SEPARATION Gas storage Carbon neutrality
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Research on the flow stability and noise reduction characteristics of quasi-periodic elastic support skin
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作者 Lu Chen Shao-gang Liu +5 位作者 dan zhao Li-qiang Dong Kai Li Shuai Tang Jin Cui Hong Guo 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第3期222-236,共15页
To enhance flow stability and reduce hydrodynamic noise caused by fluctuating pressure,a quasiperiodic elastic support skin composed of flexible walls and elastic support elements is proposed for fluid noise reduction... To enhance flow stability and reduce hydrodynamic noise caused by fluctuating pressure,a quasiperiodic elastic support skin composed of flexible walls and elastic support elements is proposed for fluid noise reduction.The arrangement of the elastic support element is determined by the equivalent periodic distance and quasi-periodic coefficient.In this paper,a dynamic model of skin in a fluid environment is established.The influence of equivalent periodic distance and quasi-periodic coefficient on flow stability is investigated.The results suggest that arranging the elastic support elements in accordance with the quasi-periodic law can effectively enhance flow stability.Meanwhile,the hydrodynamic noise calculation results demonstrate that the skin exhibits excellent noise reduction performance,with reductions of 10 dB in the streamwise direction,11 dB in the spanwise direction,and 10 dB in the normal direction.The results also demonstrate that the stability analysis method can serve as a diagnostic tool for flow fields and guide the design of noise reduction structures. 展开更多
关键词 Flow stability Quasi-period Flexible wall Elastic support element Hydrodynamic noise
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KSKV:Key-Strategy for Key-Value Data Collection with Local Differential Privacy
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作者 dan zhao Yang You +2 位作者 Chuanwen Luo Ting Chen Yang Liu 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第6期3063-3083,共21页
In recent years,the research field of data collection under local differential privacy(LDP)has expanded its focus fromelementary data types to includemore complex structural data,such as set-value and graph data.Howev... In recent years,the research field of data collection under local differential privacy(LDP)has expanded its focus fromelementary data types to includemore complex structural data,such as set-value and graph data.However,our comprehensive review of existing literature reveals that there needs to be more studies that engage with key-value data collection.Such studies would simultaneously collect the frequencies of keys and the mean of values associated with each key.Additionally,the allocation of the privacy budget between the frequencies of keys and the means of values for each key does not yield an optimal utility tradeoff.Recognizing the importance of obtaining accurate key frequencies and mean estimations for key-value data collection,this paper presents a novel framework:the Key-Strategy Framework forKey-ValueDataCollection under LDP.Initially,theKey-StrategyUnary Encoding(KS-UE)strategy is proposed within non-interactive frameworks for the purpose of privacy budget allocation to achieve precise key frequencies;subsequently,the Key-Strategy Generalized Randomized Response(KS-GRR)strategy is introduced for interactive frameworks to enhance the efficiency of collecting frequent keys through group-anditeration methods.Both strategies are adapted for scenarios in which users possess either a single or multiple key-value pairs.Theoretically,we demonstrate that the variance of KS-UE is lower than that of existing methods.These claims are substantiated through extensive experimental evaluation on real-world datasets,confirming the effectiveness and efficiency of the KS-UE and KS-GRR strategies. 展开更多
关键词 KEY-VALUE local differential privacy frequency estimation mean estimation data perturbation
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Impact of web-based positive psychological intervention on emotions,psychological capital,and quality of life in gastric cancer patients on chemotherapy
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作者 Yu-Yu Xin dan zhao 《World Journal of Clinical Cases》 SCIE 2024年第26期5877-5884,共8页
BACKGROUND Gastric cancer is a malignant digestive tract tumor that originates from the epithelium of the gastric mucosa and occurs in the gastric antrum,particularly in the lower curvature of the stomach.AIM To evalu... BACKGROUND Gastric cancer is a malignant digestive tract tumor that originates from the epithelium of the gastric mucosa and occurs in the gastric antrum,particularly in the lower curvature of the stomach.AIM To evaluate the impact of a positive web-based psychological intervention on emotions,psychological capital,and quality of survival in gastric cancer patients on chemotherapy.METHODS From January 2020 to October 2023,121 cases of gastric cancer patients on chemotherapy admitted to our hospital were collected and divided into a control group(n=60)and an observation group(n=61)according to the admission order.They were given either conventional nursing care alone and conventional nursing care combined with web-based positive psychological interventions,respectively.The two groups were compared in terms of negative emotions,psychological capital,degree of cancer-caused fatigue,and quality of survival.RESULTS After intervention,the number of patients in the observation group who had negative feelings toward chemotherapy treatment was significantly lower than that of the control group(P<0.05);the Positive Psychological Capital Questionnaire score was considerably higher than that of the control group(P<0.05);the degree of cancer-caused fatigue was significantly lower than that of the control group(P<0.05);and the Quality of Life Scale for Cancer Patients(QLQ-30)score was significantly higher than that of the control group(P<0.05).CONCLUSION Implementing a web-based positive psychological intervention for gastric cancer chemotherapy patients can effectively improve negative emotions,enhance psychological capital,and improve the quality of survival. 展开更多
关键词 Internet Positive psychology Gastric cancer chemotherapy Negative emotions Psychological capital Quality of survival
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OsGA3ox通过合成不同活性GA调控水稻育性及株高 被引量:3
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作者 郝小花 胡爽 +6 位作者 赵丹 田连福 谢子靖 吴莎 胡文俐 雷晗 李东屏 《遗传》 CAS CSCD 北大核心 2023年第9期845-855,共11页
赤霉素(gibberellin,GA)是一种重要的激素,参与调控植物多种生长发育过程。GA生物合成通路已基本阐明,其中赤霉素3β羟化酶(gibberellin 3β-hydroxylase,GA3ox)是多种活性GA合成的关键酶。水稻中有2个GA3ox基因(OsGA3ox1和OsGA3ox2),... 赤霉素(gibberellin,GA)是一种重要的激素,参与调控植物多种生长发育过程。GA生物合成通路已基本阐明,其中赤霉素3β羟化酶(gibberellin 3β-hydroxylase,GA3ox)是多种活性GA合成的关键酶。水稻中有2个GA3ox基因(OsGA3ox1和OsGA3ox2),其生理功能虽有初步研究,但它们在合成活性GA调控水稻发育过程中是如何分工协作尚不清楚。本研究通过CRISPR/Cas9技术获得基因编辑突变体ga3ox1和ga3ox2,发现ga3ox1花粉育性显著下降,而ga3ox2株高显著变矮,表明OsGA3ox1是花粉正常发育必需的,而OsGA3ox2是茎叶伸长必需的。组织表达分析表明,OsGA3ox1主要在未开的花中表达,OsGA3ox2主要在未伸长的叶中表达。进一步对野生型(WT)和两个ga3ox突变体未开的花、未伸长的叶及根中的GA进行检测分析,发现OsGA3ox1在花中催化GA9形成GA7与花粉育性密切相关;OsGA3ox2在未伸长的叶中催化GA20形成GA1调控株高;OsGA3ox1在根中催化GA19形成GA20,调控GA3的生成。总之,OsGA3ox1和OsGA3ox2响应发育信号,在不同组织分工协作合成内源GA,调控水稻生长和发育。本研究为阐明OsGA3ox1和OsGA3ox2在GA生物合成中的作用以及深入理解OsGA3ox的功能提供参考。 展开更多
关键词 水稻 赤霉素 赤霉素3β羟化酶基因 功能分析
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Double-target neural circuit-magnetic stimulation improves motor function in spinal cord injury by attenuating astrocyte activation 被引量:6
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作者 dan zhao Ye Zhang +5 位作者 Ya Zheng Xu-Tong Li Cheng-Cheng Sun Qi Yang Qing Xie Dong-Sheng Xu 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第5期1062-1066,共5页
Multi-target neural circuit-magnetic stimulation has been clinically shown to improve rehabilitation of lower limb motor function after spinal cord injury. However, the precise underlying mechanism remains unclear. In... Multi-target neural circuit-magnetic stimulation has been clinically shown to improve rehabilitation of lower limb motor function after spinal cord injury. However, the precise underlying mechanism remains unclear. In this study, we performed double-target neural circuit-magnetic stimulation on the left motor cortex and bilateral L5 nerve root for 3 successive weeks in a rat model of incomplete spinal cord injury caused by compression at T10. Results showed that in the injured spinal cord, the expression of the astrocyte marker glial fibrillary acidic protein and inflammatory factors interleukin 1β, interleukin-6, and tumor necrosis factor-α had decreased, whereas that of neuronal survival marker microtubule-associated protein 2 and synaptic plasticity markers postsynaptic densification protein 95 and synaptophysin protein had increased. Additionally, neural signaling of the descending corticospinal tract was markedly improved and rat locomotor function recovered significantly. These findings suggest that double-target neural circuit-magnetic stimulation improves rat motor function by attenuating astrocyte activation, thus providing a theoretical basis for application of double-target neural circuit-magnetic stimulation in the clinical treatment of spinal cord injury. 展开更多
关键词 ASTROCYTE inflammatory response microtubule-associated protein 2 motor function motor-evoked potential neural circuit-magnetic stimulation neural repair neuromodulation technique spinal cord injury synaptic plasticity
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Mongolia Contributed More than 42%of the Dust Concentrations in Northern China in March and April 2023 被引量:6
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作者 Siyu CHEN dan zhao +8 位作者 Jianping HUANG Jiaqi HE Yu CHEN Junyan CHEN Hongru BI Gaotong LOU Shikang DU Yue ZHANG Fan YANG 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2023年第9期1549-1557,共9页
Dust storms are one of the most frequent meteorological disasters in China,endangering agricultural production,transportation,air quality,and the safety of people’s lives and property.Against the backdrop of climate ... Dust storms are one of the most frequent meteorological disasters in China,endangering agricultural production,transportation,air quality,and the safety of people’s lives and property.Against the backdrop of climate change,Mongolia’s contribution to China’s dust cannot be ignored in recent years.In this study,we used the Weather Research and Forecasting model coupled with Chemistry(WRF-Chem),along with dynamic dust sources and the HYSPLIT model,to analyze the contributions of different dust sources to dust concentrations in northern China in March and April 2023.The results show that the frequency of dust storms in 2023 was the highest observed in the past decade.Mongolia and the Taklimakan Desert were identified as two main dust sources contributing to northern China.Specifically,Mongolia contributed more than 42%of dust,while the Taklimakan Desert accounted for 26%.A cold high-pressure center,a cold front,and a Mongolian cyclone resulted in the transport of dust aerosols from Mongolia and the Taklimakan Desert to northern China,where they affected most parts of the region.Moreover,two machine learning methods[the XGBoost algorithm and the Synthetic Minority Oversampling Technique(SMOTE)]were used to forecast the dust storms in March 2023,based on ground observations and WRF-Chem simulations over East Asia.XGBoost-SMOTE performed well in predicting hourly PM10 concentrations in China in March 2023,with a mean absolute error of 33.8μg m−3 and RMSE of 54.2μg m−3. 展开更多
关键词 dust aerosol Mongolian dust transboundary contribution WRF-Chem HYSPLIT model
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多孔碳材料制备及其电容性能——绿色化学综合创新实验设计 被引量:3
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作者 高亚辉 李娟 +4 位作者 尹国杰 张拦 赵丹 常美佳 张少文 《大学化学》 CAS 2023年第8期108-117,共10页
基于高质量应用型人才的培养目标,设计了“多孔碳材料制备及其电容性能”综合性实验项目,提升学生实践和创新能力培养。在学生掌握基础理论和多孔碳材料制备原理的基础上,设计了方案制定、材料制备及表征、性能测定、数据处理及论文撰... 基于高质量应用型人才的培养目标,设计了“多孔碳材料制备及其电容性能”综合性实验项目,提升学生实践和创新能力培养。在学生掌握基础理论和多孔碳材料制备原理的基础上,设计了方案制定、材料制备及表征、性能测定、数据处理及论文撰写等多个环节。经过训练,使学生熟悉科学研究思路,掌握管式炉操作、扫描电子显微镜、X射线粉末衍射和拉曼光谱表征样品的制备,N_(2)吸附-脱附和电容性能测试过程测试方法及数据处理方法等的实验操作和技能。最终达到强化学生科研兴趣、可持续发展意识和创新精神培养目标。 展开更多
关键词 综合性实验 绿色化学 生物质 多孔碳 比电容
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用于气体分离的含多孔材料的混合基质膜--从金属有机框架到离散分子笼 被引量:1
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作者 Ziqi Yang Zhongjie Wu +3 位作者 Shing Bo Peh Yunpan Ying Hao Yang dan zhao 《Engineering》 SCIE EI CAS CSCD 2023年第4期40-55,M0003,共17页
混合基质膜(MMMs)将多孔材料与聚合物基质相结合,因其互补特性和协同激活已经在气体分离领域引起了相当大的研究兴趣。多孔材料的可塑性和多样性赋予MMMs可延伸的功能和出色的分离性能。为了发挥MMMs的全部潜力,研究人员关注多孔填料与... 混合基质膜(MMMs)将多孔材料与聚合物基质相结合,因其互补特性和协同激活已经在气体分离领域引起了相当大的研究兴趣。多孔材料的可塑性和多样性赋予MMMs可延伸的功能和出色的分离性能。为了发挥MMMs的全部潜力,研究人员关注多孔填料与聚合物基质的合理匹配,以实现这些材料之间界面的增强相容性。在本文中,我们重点介绍采用不同策略将金属-有机框架(MOFs)和金属-有机笼(MOCs)与聚合物基质相结合制备MMMs的最新进展。文中进一步讨论未来MMMs发展所面临的机遇和挑战,并旨在通过合理的材料设计和选择推动MMMs的制备。 展开更多
关键词 Gas separation Metal-organic frameworks Metal-organic cages Mixed-matrix membranes Interfacial compatibility
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新时代社区教育共同体构建的理论基础与路径选择 被引量:3
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作者 赵丹 《西北成人教育学院学报》 2023年第5期11-17,共7页
社区教育是基层社会治理的重要环节,在新时代构建以“人人有责、人人尽责、人人享有”为基本内核的社区教育共同体,是实现基层社会治理善治的题中之义。在社会治理共同体视域下探讨“新时代社区教育”的构建,是一种趋于融合型社区教育... 社区教育是基层社会治理的重要环节,在新时代构建以“人人有责、人人尽责、人人享有”为基本内核的社区教育共同体,是实现基层社会治理善治的题中之义。在社会治理共同体视域下探讨“新时代社区教育”的构建,是一种趋于融合型社区教育发展的思路,有着严密的理论逻辑和清晰的现实逻辑。基于此,文章从社会系统、学习者、学习资源、教学互动等四个维度,分析了构建新时代社区教育共同体的实践路径,以为基层社会治理善治贡献新时代社区教育力量提供借鉴。 展开更多
关键词 新时代 社区教育共同体 理论基础 实践路径
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Vibration and Sound Radiation of Cylindrical Shell Covered with a Skin Made of Micro Floating Raft Arrays Excited by Turbulence 被引量:1
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作者 dan zhao Qiong Wu +5 位作者 Minyao Gan Ke Li Wenhong Ma Qun Wu Liqiang Dong Shaogang Liu 《Computer Modeling in Engineering & Sciences》 SCIE EI 2023年第3期2041-2055,共15页
To reduce the vibration and sound radiation of underwater cylindrical shells,a skin composed of micro floating raft arrays and a compliant wall is proposed in this paper.A vibroacoustic coupling model of a finite cyli... To reduce the vibration and sound radiation of underwater cylindrical shells,a skin composed of micro floating raft arrays and a compliant wall is proposed in this paper.A vibroacoustic coupling model of a finite cylindrical shell covered with this skin for the case of turbulence excitation is established based on the shell theories of Donnell.The model is solved with the modal superposition method to investigate the effects of the structural parameters of micro floating raft elements on the performance of reducing vibration and sound radiation of the cylindrical shell of this skin.The results indicate that increasing the stiffness ratio,damping ratio,mass ratio,or decreasing the interval betweenmicro floating raft elements can improve the vibration and sound radiation reduction performance of this skin over the frequency range 0∼2000 Hz.Moreover,the mean quadratic velocity level and sound radiation power level of the finite cylindrical shell with this skin can be reduced by 12.00 dB and 9.65 dB respectively compared to the finite cylindrical shell with homogeneous viscoelastic coating in the frequency range from0∼2000Hz,implying a favorable performance of this skin for reducing the vibration and sound radiation of cylindrical shells. 展开更多
关键词 Finite cylindrical shell vibration and sound radiation noise reduction turbulent pulsating pressure micro floating raft
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Risk factors and prediction model for inpatient surgical site infection after elective abdominal surgery 被引量:1
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作者 Jin Zhang Fei Xue +8 位作者 Si-Da Liu Dong Liu Yun-Hua Wu dan zhao Zhou-Ming Liu Wen-Xing Ma Ruo-Lin Han Liang Shan Xiang-Long Duan 《World Journal of Gastrointestinal Surgery》 SCIE 2023年第3期387-397,共11页
BACKGROUND Surgical site infections(SSIs) are the commonest healthcare-associated infection. In addition to increasing mortality, it also lengthens the hospital stay and raises healthcare expenses. SSIs are challengin... BACKGROUND Surgical site infections(SSIs) are the commonest healthcare-associated infection. In addition to increasing mortality, it also lengthens the hospital stay and raises healthcare expenses. SSIs are challenging to predict, with most models having poor predictability. Therefore, we developed a prediction model for SSI after elective abdominal surgery by identifying risk factors.AIM To analyse the data on inpatients undergoing elective abdominal surgery to identify risk factors and develop predictive models that will help clinicians assess patients preoperatively.METHODS We retrospectively analysed the inpatient records of Shaanxi Provincial People’s Hospital from January 1, 2018 to January 1, 2021. We included the demographic data of the patients and their haematological test results in our analysis. The attending physicians provided the Nutritional Risk Screening 2002(NRS 2002)scores. The surgeons and anaesthesiologists manually calculated the National Nosocomial Infections Surveillance(NNIS) scores. Inpatient SSI risk factors were evaluated using univariate analysis and multivariate logistic regression. Nomograms were used in the predictive models. The receiver operating characteristic and area under the curve values were used to measure the specificity and accuracy of the model.RESULTS A total of 3018 patients met the inclusion criteria. The surgical sites included the uterus(42.2%), the liver(27.6%), the gastrointestinal tract(19.1%), the appendix(5.9%), the kidney(3.7%), and the groin area(1.4%). SSI occurred in 5% of the patients(n = 150). The risk factors associated with SSI were as follows: Age;gender;marital status;place of residence;history of diabetes;surgical season;surgical site;NRS 2002 score;preoperative white blood cell, procalcitonin(PCT), albumin, and low-density lipoprotein cholesterol(LDL) levels;preoperative antibiotic use;anaesthesia method;incision grade;NNIS score;intraoperative blood loss;intraoperative drainage tube placement;surgical operation items. Multivariate logistic regression revealed the following independent risk factors: A history of diabetes [odds ratio(OR) = 5.698, 95% confidence interval(CI): 3.305-9.825, P = 0.001], antibiotic use(OR = 14.977, 95%CI: 2.865-78.299, P = 0.001), an NRS 2002 score of ≥ 3(OR = 2.426, 95%CI: 1.199-4.909, P = 0.014), general anaesthesia(OR = 3.334, 95%CI: 1.134-9.806, P = 0.029), an NNIS score of ≥ 2(OR = 2.362, 95%CI: 1.019-5.476, P = 0.045), PCT ≥ 0.05 μg/L(OR = 1.687, 95%CI: 1.056-2.695, P = 0.029), LDL < 3.37 mmol/L(OR = 1.719, 95%CI: 1.039-2.842, P = 0.035), intraoperative blood loss ≥ 200 mL(OR = 29.026, 95%CI: 13.751-61.266, P < 0.001), surgical season(P < 0.05), surgical site(P < 0.05), and incision grade I or Ⅲ(P < 0.05). The overall area under the receiver operating characteristic curve of the predictive model was 0.926, which is significantly higher than the NNIS score(0.662).CONCLUSION The patient’s condition and haematological test indicators form the bases of our prediction model. It is a novel, efficient, and highly accurate predictive model for preventing postoperative SSI, thereby improving the prognosis in patients undergoing abdominal surgery. 展开更多
关键词 Surgical site infections Risk factors Abdominal surgery Prediction model
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Effect of cognitive behavior therapy training and psychological nursing on the midwifery process in the delivery room 被引量:1
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作者 Qin Shi Jie Wang +1 位作者 dan zhao Ling-Yan Gu 《World Journal of Psychiatry》 SCIE 2023年第12期1053-1060,共8页
BACKGROUND The severe physical and psychological impact of pain on the physical and mental health of women during labor leads to increased risks and complications during childbirth,presenting a major public health con... BACKGROUND The severe physical and psychological impact of pain on the physical and mental health of women during labor leads to increased risks and complications during childbirth,presenting a major public health concern.Some studies have shown that cognitive behavioral therapy(CBT)has a positive effect on maternal psychology during delivery,reducing stress and shortening labor time.Thus,CBT training for mothers and delivery room staff may be beneficial in minimizing complications and adverse effects during natural birth.AIM To investigate the clinical effects of CBT training and psychological care during delivery,and their therapeutic effects on women in labor.METHODS This study used a retrospective analysis and included 140 mothers admitted to the maternity ward between January 2021 and January 2023.The study subjects were randomized into two groups:control(n=70)and observation(n=70).Routine care,CBT training,and psychological care were provided to mothers in both groups.Psychological status scores,delivery time,and satisfaction with care pre-and post-delivery were compared,and the incidence of complications after receiving care was analyzed between the two groups.RESULTS Although the psychological state of both groups improved significantly in the late stages of labor,the psychological state scores of the mothers in the observation group were significantly lower than those of the mothers in the control group(P<0.05).The duration of labor and incidence of complications in the observation group were significantly lower than those in the control group(P<0.05).The mothers in the observation group were significantly more satisfied with nursing care during the course of labor than those in the control group(P<0.05).CONCLUSION CBT training and psychological care for mothers in the midwifery process can effectively improve anxiety and depression,shorten labor duration,reduce postnatal complications,and improve nursing satisfaction and nurse-patient relationships.Its clinical application is effective and has popularization value,providing a new way to protect maternal mental health. 展开更多
关键词 Cognitive behavior therapy Cognitive behavior therapy training Psychological care CHILDBIRTH Mental health
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新辅助免疫治疗联合化疗在可手术的非小细胞肺癌的初步疗效评估 被引量:14
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作者 周世杰 郝学峰 +11 位作者 于大平 刘树库 曹小庆 苏崇玉 宋小运 肖宁 李云松 杨威 赵丹 王敬慧 刘志东 许绍发 《中国肺癌杂志》 CAS CSCD 北大核心 2021年第6期420-425,共6页
背景与目的初步研究证实新辅助免疫联合化疗对可手术非小细胞肺癌近期疗效显著,但国内相关临床试验较少。本研究回顾性分析应用新辅助免疫治疗联合化疗的可手术Ⅰb期-Ⅲb期非小细胞肺癌的临床病理资料,初步评估新辅助免疫治疗联合化疗... 背景与目的初步研究证实新辅助免疫联合化疗对可手术非小细胞肺癌近期疗效显著,但国内相关临床试验较少。本研究回顾性分析应用新辅助免疫治疗联合化疗的可手术Ⅰb期-Ⅲb期非小细胞肺癌的临床病理资料,初步评估新辅助免疫治疗联合化疗的疗效及安全性。方法回顾性分析2019年11月-2020年12月期间于首都医科大学附属北京胸科医院胸外科治疗的临床分期Ⅰb期-Ⅲb期的非小细胞肺癌患者20例,术前应用免疫联合化疗新辅助治疗,根据影像学和病理学方法分别评估疗效。结果全组患者新辅助治疗后影像学评估疗效,客观有效率(objective responserate,ORR)为85.0%(完全缓解4例,部分缓解13例),疾病稳定1例(5.0%),疾病进展2例(10.0%)。其中17例后续接受手术治疗,16例达到R0(no residual tumor)切除,1例R1(microscopic residual tumor)切除。术后病理评估:主要病理缓解率(major pathologic response,MPR)为47.1%(8/17),其中完全病理缓解率(complete pathologic response,CPR)为29.4%(5/17)。主要不良反应:免疫相关性肺炎(Ⅳ级)1例,Ⅲ级及以上血液学毒性9例(45.0%)。结论新辅助免疫联合化疗对于可手术的非小细胞肺癌近期疗效显著,具有一定的安全性及有效性。但新辅助免疫联合化疗的远期疗效、最佳周期数以及理想预测免疫治疗效果的标记物仍有待研究。 展开更多
关键词 肺肿瘤 免疫治疗 新辅助治疗 手术
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经自然腔道取标本完全腹腔镜下结直肠癌根治术的研究 被引量:30
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作者 赵丹 陈杰 +2 位作者 丁成明 贾泽明 彭健 《中国内镜杂志》 北大核心 2017年第12期36-40,共5页
目的通过观察经自然腔道(NOSE)取标本完全腹腔镜下结直肠癌根治术术中和术后生活质量情况,探讨该技术的可行性及临床疗效。方法纳入2015年4月-2017年6月符合NOSE法条件的40例结直肠癌患者,随机分为对照组(传统腹腔镜)和NOSE组,每组20例... 目的通过观察经自然腔道(NOSE)取标本完全腹腔镜下结直肠癌根治术术中和术后生活质量情况,探讨该技术的可行性及临床疗效。方法纳入2015年4月-2017年6月符合NOSE法条件的40例结直肠癌患者,随机分为对照组(传统腹腔镜)和NOSE组,每组20例。观察分析两组患者的术中情况和术后生活质量。结果所有患者均按照预期目标完成手术,无中转其他手术方式者。两组患者均无术后并发症发生。两组患者的手术时间和术中出血量差异有统计学意义(P<0.05),住院时间差异无统计学意义(P>0.05),NOSE组术后生活质量评分(SF-36量表)在躯体功能、疼痛、角色、认知情况及整体健康状况5个维度上优于对照组,差异有统计学意义(P<0.05)。结论 NOSE法完全腹腔镜下结直肠癌根治术具有整体健康状况好、日常工作和生活受限少、躯体功能和角色功能恢复快等优点,因而对符合条件的患者可推广应用。 展开更多
关键词 NOSE法 免腹部切口 完全腹腔镜技术 结直肠癌
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405例肺癌合并肺结核患者临床特征及驱动基因检测分析 被引量:10
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作者 胡瑛 杨新杰 +3 位作者 聂理会 赵丹 安军 李宝兰 《中国肺癌杂志》 CAS CSCD 北大核心 2020年第5期337-342,共6页
背景与目的随着肺癌研究进展,靶向治疗、免疫检查点抑制剂等新的治疗方法已经开始应用于肺癌患者,因此需要进一步了解合并肺结核的肺癌患者的临床及实验室特点,从而为此类患者的临床治疗提供新的思路。本研究目的是分析肺癌合并肺结核... 背景与目的随着肺癌研究进展,靶向治疗、免疫检查点抑制剂等新的治疗方法已经开始应用于肺癌患者,因此需要进一步了解合并肺结核的肺癌患者的临床及实验室特点,从而为此类患者的临床治疗提供新的思路。本研究目的是分析肺癌合并肺结核患者的临床特征、驱动基因检测结果及其之间关系。方法回顾性分析我院2014年1月-2019年12月收治的405例肺癌合并肺结核患者,应用统计学方法分析其临床特征与驱动基因状态之间的关系。结果405例肺癌合并肺结核患者中男性占77.3%,有吸烟史患者占85.3%,病理类型以肺腺癌为主,当胸部影像学有空洞改变时以鳞癌为主要类型。214例患者进行驱动基因检测,表皮生长因子受体(epidermal growth factor receptor,EGFR)基因突变率为35.9%,其中41.8%为外显子19缺失突变,50.9%为外显子21 L858R突变。当胸部影像有空洞改变时,EGFR突变率显著降低(16.1%)。间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)融合基因检测阳性率为2.5%,原癌基因1酪氨酸激酶(c-ros oncogene 1 receptorkinase,ROS1)突变率为1.9%,肉瘤病毒致癌基因同源物B1(V-raf murine sarcoma viral oncogene homolog B1,BRAF)基因突变率为1.1%,克尔斯滕大鼠肉瘤病毒致癌基因同源物(Kirsten Rat Sarcoma Viral Oncogene Homolog,KRAS)基因突变率为10.1%。女性肺癌合并肺结核患者基因突变率为50.0%,男性为27.9%。结论肺癌合并肺结核患者以有吸烟史的男性患者为主,病理类型以腺癌为主。基因突变阳性率与单纯肺癌无明显差异,但是当胸部影像有空洞表现时,基因突变率显著降低。 展开更多
关键词 肺肿瘤 肺结核 驱动基因
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