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Impact of Fuzheng Huayu tablet on antiviral effect of entecavir in patients with hepatitis B cirrhosis 被引量:12
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作者 dan-ying cheng Zhi-Min Zhao +4 位作者 Gang Wan Huan-Wei Zheng Jia-Quan Huang cheng-Hai Liu Hui-Chun Xing 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2022年第5期479-484,共6页
Background:Fuzheng Huayu tablet is a traditional Chinese medicine(TCM)used for the treatment of liver fibrosis and cirrhosis.However,whether the combination with Fuzheng Huayu tablet could affect the antiviral efflcac... Background:Fuzheng Huayu tablet is a traditional Chinese medicine(TCM)used for the treatment of liver fibrosis and cirrhosis.However,whether the combination with Fuzheng Huayu tablet could affect the antiviral efflcacy of nucleos(t)ide remains a concern.The objective of this trial was to explore the impact of Fuzheng Huayu tablet on antiviral effect of entecavir in patients with hepatitis B cirrhosis.Methods:A prospective,randomized control trial was conducted.Patients with compensated hepatitis B cirrhosis were randomly divided into the treatment group(entecavir capsule plus Fuzheng Huayu tablet)and the control group(entecavir capsule plus simulant of Fuzheng Huayu),and followed up for 48 weeks.The dynamic changes of HBV DNA load,the rate of serological conversion of HBeAg,liver function,renal function and liver stiffness measurement(LSM)were monitored.The general clinical data and adverse events were also recorded.Results:There was no significant difference in the rate of virological response and cumulative virological response between the treatment group and the control group(P>0.05).After 48 weeks of treatment,the HBeAg seroconversion rate,biochemical response rate and LSM value were 21.05%and 4.76%(P=0.164),86.96%and 65.96%(P=0.017),9.5 kpa and 10.6 kpa(P=0.827)in the treatment group and the control group,respectively.No serious adverse events related to the study therapy occurred during the trial.Conclusions:The antiviral entecavir combined with Fuzheng Huayu tablet did not affect the antiviral efflcacy of entecavir,but could improve the rate of biochemical response,and had a tendency to improve the rate of serological conversion of HBeAg and liver fibrosis in patients with hepatitis B cirrhosis.Fuzheng Huayu tablet is clinically safe for patients with hepatitis B cirrhosis. 展开更多
关键词 Fuzheng Huayu ENTECAVIR Antiviral efflcacy Hepatitis B cirrhosis
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Characteristics and clinical outcome of nonsteroidal anti-inflammatory drug-induced acute hepato-nephrotoxicity among Chinese patients 被引量:4
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作者 Ya-Li Cao Zhi-Gang Tian +4 位作者 Fang Wang Wen-Ge Li dan-ying cheng Yan-Fang Yang Hong-Mei Gao 《World Journal of Gastroenterology》 SCIE CAS 2014年第38期13956-13965,共10页
AIM: To determine the clinicopathological characteristics of nonsteroidal anti-inflammatory drug (NSAID)-induced acute hepato-nephrotoxicity among Chinese patients.
关键词 Nonsteroidal anti-inflammatory drug Hepato-nephrotoxicity Acute interstitial nephritis Acute hepatitis CHOLESTASIS
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Association of the macrophage migration inhibitory factor promoter polymorphisms with benign lymphoepithelial lesion of lacrimal gland 被引量:1
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作者 Qin-Jian Li Peng-Xiang Zhao +4 位作者 Xu-Juan Zhang Yang Yi dan-ying cheng Jian-Min Ma Xue-Mei Ma 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2017年第8期1229-1232,共4页
AIM: To identify the association of the macrophage migration inhibitory factor (MIF) gene polymorphism with the susceptibility of benign lymphoepithelial lesions (BLEL) of the lacrimal gland. METHODS: A total o... AIM: To identify the association of the macrophage migration inhibitory factor (MIF) gene polymorphism with the susceptibility of benign lymphoepithelial lesions (BLEL) of the lacrimal gland. METHODS: A total of 40 BLEL of lacrimal gland cases were matched with 40 healthy subjects (HS). Extraction the plasma and whole blood DNA of patients of lacrimal gland BLEL and HS. Elisa and polymerase chain reaction was used to determine in plasma contents of MIF and MIF gene SNP-173G〉C and STR -794 CATT(8) polymorphism, respectively. RESULTS: The MIF levels in plasma were significantly higher in patients with lacrimal gland BI.EL versus HS (P〈0.001). The -173 G〉C MIF polymorphism was significantly associated with lacrimal gland BLEL, with a significantly higher frequency of the C allele in lacrimal gland BLEL patients compared with HS (OR=2.38, 95% C1=1.07-5.31, P=0.032), and the -173 C/x is more frequent in patients than in HS, P=0.037. Besides, we found that the carriage rate of the MIF -173C/x is associated with higher plasma levels of MIF in the BLEI. of lacrimal gland. CONCLUSION: MIF -173G/C variants play an insidious role in susceptibility of BLEL of lacrimal gland. Otherwise,there is no statistically significant correlation exists between MIF-794 CATT () and BLEL of lacrimal gland. 展开更多
关键词 benign lymphoepithelial lesion lacrimal gland macrophage migration inhibitory factor gene polymorphism
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A Drug-induced Hepatitis Patient with a Manifestation of Liver Occupying Lesions on Ultrasound B:Case Report and Literature Review
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作者 dan-ying cheng Xiao-mei Wang +1 位作者 Wei-ni Ou Hui-chun Xing 《国际感染病学(电子版)》 CAS 2013年第2期81-83,共3页
Drug-induced liver injury(DILI)is defined as injury to the liver caused by exposure to a drug or some drugs.The number of cases suffering from DILI has been increased.There are few clinical features specifically assoc... Drug-induced liver injury(DILI)is defined as injury to the liver caused by exposure to a drug or some drugs.The number of cases suffering from DILI has been increased.There are few clinical features specifically associated with DILI.The recognition and diagnosis of DILI is difficult.In this report,we have described a DILI case caused by herbal remedies. 展开更多
关键词 Drug-induced liver injury Diagnosis Liver occupying lesions Ultrasound B
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