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Effects of triptolide on hippocampal microglial cells and astrocytes in the APP/PS1 double transgenic mouse model of Alzheimer's disease 被引量:7
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作者 Jian-ming Li Yan Zhang +5 位作者 Liang Tang Yong-heng Chen Qian Gao Mei-hua Bao Ju Xiang de-liang lei 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第9期1492-1498,共7页
The principal pathology of Alzheimer's disease includes neuronal extracellular deposition of amyloid-beta peptides and formation of senile pl aques, which in turn induce neuroinflammation in the brain. Triptolide, a ... The principal pathology of Alzheimer's disease includes neuronal extracellular deposition of amyloid-beta peptides and formation of senile pl aques, which in turn induce neuroinflammation in the brain. Triptolide, a natural extract from the vine-like herb Tripterygium wilfordii Hook F, has potent anti-inflammatory and immunosuppressive efficacy. Therefore, we determined if triptolide can inhibit activation and proliferation of microglial cells and astrocytes in the APP/PS1 double transgenic mouse model of Alzheimer's disease. We used 1 or 5 μg/kg/d triptolide to treat APP/PS1 double transgenic mice (aged 4-4.5 months) for 45 days. Unbiased stereology analysis found that triptolide dose-dependent- ly reduced the total number of microglial cells, and transformed microglial cells into the resting state. Further, triptolide (5 μg/kg/d) also reduced the total number of hippocampal astrocytes. Our in vivo test results indicate that triptolide suppresses activation and proliferation of microglial cells and astrocytes in the hippocampus of APP/PS 1 double transgenic mice with Alzheimer's disease. 展开更多
关键词 nerve regeneration neurodegenerative disease traditional Chinese medicine Tripterygium wilfordii Hook F TRIPTOLIDE Alzheimer'sdisease amyloid plaques amyloid-β amyloid precursor protein inflammation MICROGLIA ASTROCYTES neural regeneration
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