Metabolic associated fatty liver disorder(MAFLD)characterizes the contributing etiologies(i.e.,type 2 diabetes mellitus,metabolic syndrome,overweight)of individuals with fatty liver disease that affects 1/3rd of the w...Metabolic associated fatty liver disorder(MAFLD)characterizes the contributing etiologies(i.e.,type 2 diabetes mellitus,metabolic syndrome,overweight)of individuals with fatty liver disease that affects 1/3rd of the world population.In 2020,the coronavirus disease 2019(COVID-19)crisis was unprecedented,and people with different comorbidities became more susceptible to the infection caused by severe acute respiratory syndrome coronavirus 2.MAFLD patients are frequently obese with added metabolic menace like diabetes,hypertension,and dyslipidemia leading to greater jeopardy of COVID-19.MAFLD patients are 4 to 6-fold more prone towards infections.COVID-19 induces liver injury with elevated levels of aspartate aminotransferase and alanine aminotransferase and insignificantly elevated bilirubin.Hence,MAFLD in COVID-19 patients worsens the condition significantly.The evidence highlighting the interaction between MAFLD and altered liver functioning in COVID-19 suggested that COVID-19 patients with pre-existing MAFLD are at greater risk of morbidity or intensive care unit admission.Direct hepatic injury,enhanced levels of inflammatory cytokines,declined hepatic mitochondrial activity,and compromised immunity are considered as some underlying mechanisms.The main focus of this review is to discuss the implications of metabolic dysfunction associated with fatty liver disease in COVID-19 patients.The review systematically analyzes the effect of striking two worldwide pandemics(MAFLD and COVID-19)together in the present era.展开更多
India has proposed the helium-cooled solid breeder blanket concept as a tritium breeding module to be tested in ITER.The module has lithium titanate for tritium breeding and beryllium for neutron multiplication.Beryll...India has proposed the helium-cooled solid breeder blanket concept as a tritium breeding module to be tested in ITER.The module has lithium titanate for tritium breeding and beryllium for neutron multiplication.Beryllium also enhances tritium breeding.A design for the module is prepared for detailed analysis.Neutronic analysis is performed to assess the tritium breeding rate,neutron distribution,and heat distribution in the module.The tritium production distribution in submodules is evaluated to support the tritium transport analysis.The tritium breeding density in the radial direction of the module is also assessed for further optimization of the design.The heat deposition profile of the entire module is generated to support the heat removal circuit design.The estimated neutron spectrum in the radial direction also provides a more in-depth picture of the nuclear interactions inside the material zones.The total tritium produced in the HCSB module is around 13.87 mg per full day of operation of ITER,considering the 400 s ON time and 1400 s dwell time.The estimated nuclear heat load on the entire module is around 474 kW,which will be removed by the high-pressure helium cooling circuit.The heat deposition in the test blanket model(TBM)is huge(around 9 GJ)for an entire day of operation of ITER,which demonstrates the scale of power that can be produced through a fusion reactor blanket.As per the Brayton cycle,it is equivalent to 3.6 GJ of electrical energy.In terms of power production,this would be around 1655 MWh annually.The evaluation is carried out using the MCNP5 Monte Carlo radiation transport code and FEDNL 2.1 nuclear cross section data.The HCSB TBM neutronic performance demonstrates the tritium production capability and high heat deposition.展开更多
The Indian test blanket module（TBM） program in ITER is one of the major steps in the Indian fusion reactor program for carrying out the R＆D activities in the critical areas like design of tritium breeding blankets ...The Indian test blanket module（TBM） program in ITER is one of the major steps in the Indian fusion reactor program for carrying out the R＆D activities in the critical areas like design of tritium breeding blankets relevant to future Indian fusion devices（ITER relevant and DEMO）.The Indian Lead–Lithium Cooled Ceramic Breeder（LLCB） blanket concept is one of the Indian DEMO relevant TBM,to be tested in ITER as a part of the TBM program.Helium-Cooled Ceramic Breeder（HCCB） is an alternative blanket concept that consists of lithium titanate（Li_2TiO_3） as ceramic breeder（CB） material in the form of packed pebble beds and beryllium as the neutron multiplier.Specifically,attentions are given to the optimization of first wall coolant channel design and size of breeder unit module considering coolant pressure and thermal loads for the proposed Indian HCCB blanket based on ITER relevant TBM and loading conditions.These analyses will help proceeding further in designing blankets for loads relevant to the future fusion device.展开更多
This paper reviewed the literature on newer threedimensional imaging techniques and their applications in diagnosis and treatment planning of various dental anomalies. Developmental anomalies can occur during any of t...This paper reviewed the literature on newer threedimensional imaging techniques and their applications in diagnosis and treatment planning of various dental anomalies. Developmental anomalies can occur during any of the developmental stages and are manifested clinically after the tooth is fully formed. These dental anomalies may involve a single tooth, a group of teeth, or the entire dentition. Two-dimensional diagnosticimaging, including periapical, occlusal, panoramic, or cephalometric radiographs are essential in localization and management of morphological and eruptive disorders. However, due to their inherent limitations such as insufficient precision because of unusual projection errors and lack of information about spatial relationships, these methods are considered unreliable. Thus, the use of newer image acquisition techniques that allow comprehensive three dimensional imaging and visualization of dental abnormalities is highly recommended for making a confirmatory diagnosis. The significance of accurate endodontic, surgical and orthodontic treatment planning in dental abnormalities cannot be overstated as it pertains to critical anatomic landmarks such as proximity to adjacent teeth or the mandibular canal. The precise information on spatial relationships provided by multiplanar imaging helps the dental surgeon to establish more accurate diagnosis, management strategies and also increases the patient safety. This review highlights the use of high-end diagnostic imaging modalities in diagnosis of the various morphologic and eruptive dental abnormalities.展开更多
Glass science reveals peculiar properties due to the lack of long range order and presence of heterogeneity in Chalcogenide glasses. In thermal studies, structural relaxation at the glass transition region is governed...Glass science reveals peculiar properties due to the lack of long range order and presence of heterogeneity in Chalcogenide glasses. In thermal studies, structural relaxation at the glass transition region is governed by the activation energy of the cooperative unit (zU). In the cooperative molecular dynamics, we are considering the analysis of three activation energies, namely activation energy per BMS (U), activation energy of the cooperative unit (zU) and the apparent activation energy (z2U). From the energetic dynamics of activation energy analysis across the GexSe1-x glass series, data represent three-phase segregation. From our data, we also observed that the value of UCRR/RTg across the GexSe1-x glass series is nominally changed from 34.343 to 36.19.展开更多
This paper examines the impacts of market-oriented electricity reform on macroeconomic variables. It develops an ad hoc econometric model for this purpose, using a panel data of 19 developed countries plus seven Austr...This paper examines the impacts of market-oriented electricity reform on macroeconomic variables. It develops an ad hoc econometric model for this purpose, using a panel data of 19 developed countries plus seven Australian States for the period of 1970-2008. Significance of the impacts is firstly tested against three distinct institutional features of electricity reform, namely： （1） organizational restructuring （i.e., functional unbundling of traditionally vertically integrated industry）; （2） market restructuring （introduction of mandatory bid-based spot market）; and （3） privatization. The extents of the impacts are, then, quantified in terms of relative contribution of such institutional changes to aggregate output growth in short-run, medium-run and long-run. The results reveal that only functional unbundling has made significant contribution to output growth. The results, further, specify that functional unbundling has made, on average, an additional 0.06% and 2.7% contribution to output growth rate in medium-run and long-run respectively.展开更多
Current evidence of concept analyses recommending nanotechnology for biomedical uses abounds in recent research. The area of biotechnology interfaces with nanostructures, reconfigures their composition, and alters the...Current evidence of concept analyses recommending nanotechnology for biomedical uses abounds in recent research. The area of biotechnology interfaces with nanostructures, reconfigures their composition, and alters their characteristics;which influences the dispersion of the particles, the biotransformation they cause, and their potential toxic effect. It is vital to link the idea of the lifecycle of nanostructures to the biological impacts and use methodologies to identify, estimate, and track the gradual bioprocessing of nanostructures in vivo, from a body-wide level to a nanoscopic size. This is necessary because understanding how nanostructures processing, degradation, persistence, and recycling predict potential exposure risks. The safe implementation of nanotechnology-based products in biomedical applications necessitates an extensive understanding of the recycling and transformations of nanomaterials in a living organism. Long-term fate in the body is crucial, as it governs potential environmental risks to human health. Strategies may be used to manage the long-term outcome of nanostructures in an organism since, in addition to composition, their design also affects how long they last and how easily they degrade. The lifespan of nanoparticles, a flexible and biocompatible category of nanostructures that have made it into clinical trials, is the subject of this article. Strategies may be used to manage the long-term outcome of nanoparticles in an organism since, in addition to composition, their design also affects how long they last and how easily they degrade. This review explained the safety of nanoscale materials, biotransformation, and the multifunctional recycling mechanism of nanostructures.展开更多
This study extends the ambit of the debate on electricity transitionby specifically identifying possible policy entry points through which transformative and enduring changes can be made in the electricity and socio-e...This study extends the ambit of the debate on electricity transitionby specifically identifying possible policy entry points through which transformative and enduring changes can be made in the electricity and socio-economic systems to facilitate the transition process.Guided by the"essence"of the multi-level perspective-a prominent framework for the study of energy transition,four such entry points have been identified:1)destabilising the dominant,fossil fuel-based electricity regime to create room for renewable technologies tobreak through;2)reconfiguring the electricity regime,which encompasses technology,short-term operational practices and long-term planning processes,to improve flexibility for accommodating large outputs from variable renewable sources whilst maintaining supply security;3)addressing the impactofcoal power phase-outon coal mining regions in terms of economic development and jobs;and 4)facilitating a shift in transition governance towards a learning-based,reflexive process.Specific areas for policy interventions within each of these entry points have also been discussed in the paper.展开更多
Regio-and stereoselective 1,3-dipolar cycloadditions of C-(3-indolyl)-N-phenylnitrone(10)were carried out with different mono-substituted,disubstituted and cyclic dipolarophiles under mono-mode microwave irradiation t...Regio-and stereoselective 1,3-dipolar cycloadditions of C-(3-indolyl)-N-phenylnitrone(10)were carried out with different mono-substituted,disubstituted and cyclic dipolarophiles under mono-mode microwave irradiation to obtain substituted 3-(indol-30-yl)-N-phenyl-isoxazolidines(16–22).Reactions of nitrone(10)with allenic esters under similar conditions afforded,via a domino process,bis-indole derivatives(23a–c)along with compounds 24 and 25.Similarly,reactions of C-(3-pyridyl)-N-phenylnitrone(26)with mono-substituted,disubstituted and cyclic dipolarophiles were carried out in refluxing dry toluene to obtain substituted 3-(30-pyridyl)-Nphenylisoxazolidines(27–34).Some of the compounds(16f,18b,23a,23c,27c and 29f)display significant cytotoxicity against a number of human cancer cell lines.展开更多
Metalworking fluids are the portion of a big family of lubricants. Metalworking fluids have been widely used for cutting the metal and the most communal category of theses fluids are water mixing fluids. In this artic...Metalworking fluids are the portion of a big family of lubricants. Metalworking fluids have been widely used for cutting the metal and the most communal category of theses fluids are water mixing fluids. In this article, the methods of lubrication using during various operations of machining is presenting and also represent the various benefits of these functional fluids in machining with respect to surface finish, cutting force, temperature at the zone of cutting. The disadvantages and performance of various methods are discussed in terms of output variables and parameters of machining. From the various literatures, it can be reported that fluids of cutting which are made by the oil of vegetable, could be eco-friendly in machining mode with same in performance achieved after using the metalworking fluid which are based on mineral oil. The various lubrication methods are going to be finished because of less cooling rate.展开更多
文摘Metabolic associated fatty liver disorder(MAFLD)characterizes the contributing etiologies(i.e.,type 2 diabetes mellitus,metabolic syndrome,overweight)of individuals with fatty liver disease that affects 1/3rd of the world population.In 2020,the coronavirus disease 2019(COVID-19)crisis was unprecedented,and people with different comorbidities became more susceptible to the infection caused by severe acute respiratory syndrome coronavirus 2.MAFLD patients are frequently obese with added metabolic menace like diabetes,hypertension,and dyslipidemia leading to greater jeopardy of COVID-19.MAFLD patients are 4 to 6-fold more prone towards infections.COVID-19 induces liver injury with elevated levels of aspartate aminotransferase and alanine aminotransferase and insignificantly elevated bilirubin.Hence,MAFLD in COVID-19 patients worsens the condition significantly.The evidence highlighting the interaction between MAFLD and altered liver functioning in COVID-19 suggested that COVID-19 patients with pre-existing MAFLD are at greater risk of morbidity or intensive care unit admission.Direct hepatic injury,enhanced levels of inflammatory cytokines,declined hepatic mitochondrial activity,and compromised immunity are considered as some underlying mechanisms.The main focus of this review is to discuss the implications of metabolic dysfunction associated with fatty liver disease in COVID-19 patients.The review systematically analyzes the effect of striking two worldwide pandemics(MAFLD and COVID-19)together in the present era.
文摘India has proposed the helium-cooled solid breeder blanket concept as a tritium breeding module to be tested in ITER.The module has lithium titanate for tritium breeding and beryllium for neutron multiplication.Beryllium also enhances tritium breeding.A design for the module is prepared for detailed analysis.Neutronic analysis is performed to assess the tritium breeding rate,neutron distribution,and heat distribution in the module.The tritium production distribution in submodules is evaluated to support the tritium transport analysis.The tritium breeding density in the radial direction of the module is also assessed for further optimization of the design.The heat deposition profile of the entire module is generated to support the heat removal circuit design.The estimated neutron spectrum in the radial direction also provides a more in-depth picture of the nuclear interactions inside the material zones.The total tritium produced in the HCSB module is around 13.87 mg per full day of operation of ITER,considering the 400 s ON time and 1400 s dwell time.The estimated nuclear heat load on the entire module is around 474 kW,which will be removed by the high-pressure helium cooling circuit.The heat deposition in the test blanket model(TBM)is huge(around 9 GJ)for an entire day of operation of ITER,which demonstrates the scale of power that can be produced through a fusion reactor blanket.As per the Brayton cycle,it is equivalent to 3.6 GJ of electrical energy.In terms of power production,this would be around 1655 MWh annually.The evaluation is carried out using the MCNP5 Monte Carlo radiation transport code and FEDNL 2.1 nuclear cross section data.The HCSB TBM neutronic performance demonstrates the tritium production capability and high heat deposition.
文摘The Indian test blanket module（TBM） program in ITER is one of the major steps in the Indian fusion reactor program for carrying out the R＆D activities in the critical areas like design of tritium breeding blankets relevant to future Indian fusion devices（ITER relevant and DEMO）.The Indian Lead–Lithium Cooled Ceramic Breeder（LLCB） blanket concept is one of the Indian DEMO relevant TBM,to be tested in ITER as a part of the TBM program.Helium-Cooled Ceramic Breeder（HCCB） is an alternative blanket concept that consists of lithium titanate（Li_2TiO_3） as ceramic breeder（CB） material in the form of packed pebble beds and beryllium as the neutron multiplier.Specifically,attentions are given to the optimization of first wall coolant channel design and size of breeder unit module considering coolant pressure and thermal loads for the proposed Indian HCCB blanket based on ITER relevant TBM and loading conditions.These analyses will help proceeding further in designing blankets for loads relevant to the future fusion device.
文摘This paper reviewed the literature on newer threedimensional imaging techniques and their applications in diagnosis and treatment planning of various dental anomalies. Developmental anomalies can occur during any of the developmental stages and are manifested clinically after the tooth is fully formed. These dental anomalies may involve a single tooth, a group of teeth, or the entire dentition. Two-dimensional diagnosticimaging, including periapical, occlusal, panoramic, or cephalometric radiographs are essential in localization and management of morphological and eruptive disorders. However, due to their inherent limitations such as insufficient precision because of unusual projection errors and lack of information about spatial relationships, these methods are considered unreliable. Thus, the use of newer image acquisition techniques that allow comprehensive three dimensional imaging and visualization of dental abnormalities is highly recommended for making a confirmatory diagnosis. The significance of accurate endodontic, surgical and orthodontic treatment planning in dental abnormalities cannot be overstated as it pertains to critical anatomic landmarks such as proximity to adjacent teeth or the mandibular canal. The precise information on spatial relationships provided by multiplanar imaging helps the dental surgeon to establish more accurate diagnosis, management strategies and also increases the patient safety. This review highlights the use of high-end diagnostic imaging modalities in diagnosis of the various morphologic and eruptive dental abnormalities.
文摘Glass science reveals peculiar properties due to the lack of long range order and presence of heterogeneity in Chalcogenide glasses. In thermal studies, structural relaxation at the glass transition region is governed by the activation energy of the cooperative unit (zU). In the cooperative molecular dynamics, we are considering the analysis of three activation energies, namely activation energy per BMS (U), activation energy of the cooperative unit (zU) and the apparent activation energy (z2U). From the energetic dynamics of activation energy analysis across the GexSe1-x glass series, data represent three-phase segregation. From our data, we also observed that the value of UCRR/RTg across the GexSe1-x glass series is nominally changed from 34.343 to 36.19.
文摘This paper examines the impacts of market-oriented electricity reform on macroeconomic variables. It develops an ad hoc econometric model for this purpose, using a panel data of 19 developed countries plus seven Australian States for the period of 1970-2008. Significance of the impacts is firstly tested against three distinct institutional features of electricity reform, namely： （1） organizational restructuring （i.e., functional unbundling of traditionally vertically integrated industry）; （2） market restructuring （introduction of mandatory bid-based spot market）; and （3） privatization. The extents of the impacts are, then, quantified in terms of relative contribution of such institutional changes to aggregate output growth in short-run, medium-run and long-run. The results reveal that only functional unbundling has made significant contribution to output growth. The results, further, specify that functional unbundling has made, on average, an additional 0.06% and 2.7% contribution to output growth rate in medium-run and long-run respectively.
文摘Current evidence of concept analyses recommending nanotechnology for biomedical uses abounds in recent research. The area of biotechnology interfaces with nanostructures, reconfigures their composition, and alters their characteristics;which influences the dispersion of the particles, the biotransformation they cause, and their potential toxic effect. It is vital to link the idea of the lifecycle of nanostructures to the biological impacts and use methodologies to identify, estimate, and track the gradual bioprocessing of nanostructures in vivo, from a body-wide level to a nanoscopic size. This is necessary because understanding how nanostructures processing, degradation, persistence, and recycling predict potential exposure risks. The safe implementation of nanotechnology-based products in biomedical applications necessitates an extensive understanding of the recycling and transformations of nanomaterials in a living organism. Long-term fate in the body is crucial, as it governs potential environmental risks to human health. Strategies may be used to manage the long-term outcome of nanostructures in an organism since, in addition to composition, their design also affects how long they last and how easily they degrade. The lifespan of nanoparticles, a flexible and biocompatible category of nanostructures that have made it into clinical trials, is the subject of this article. Strategies may be used to manage the long-term outcome of nanoparticles in an organism since, in addition to composition, their design also affects how long they last and how easily they degrade. This review explained the safety of nanoscale materials, biotransformation, and the multifunctional recycling mechanism of nanostructures.
基金This work was supported by the National Natural Science Foundation of China(Grant No.72174056).
文摘This study extends the ambit of the debate on electricity transitionby specifically identifying possible policy entry points through which transformative and enduring changes can be made in the electricity and socio-economic systems to facilitate the transition process.Guided by the"essence"of the multi-level perspective-a prominent framework for the study of energy transition,four such entry points have been identified:1)destabilising the dominant,fossil fuel-based electricity regime to create room for renewable technologies tobreak through;2)reconfiguring the electricity regime,which encompasses technology,short-term operational practices and long-term planning processes,to improve flexibility for accommodating large outputs from variable renewable sources whilst maintaining supply security;3)addressing the impactofcoal power phase-outon coal mining regions in terms of economic development and jobs;and 4)facilitating a shift in transition governance towards a learning-based,reflexive process.Specific areas for policy interventions within each of these entry points have also been discussed in the paper.
文摘Regio-and stereoselective 1,3-dipolar cycloadditions of C-(3-indolyl)-N-phenylnitrone(10)were carried out with different mono-substituted,disubstituted and cyclic dipolarophiles under mono-mode microwave irradiation to obtain substituted 3-(indol-30-yl)-N-phenyl-isoxazolidines(16–22).Reactions of nitrone(10)with allenic esters under similar conditions afforded,via a domino process,bis-indole derivatives(23a–c)along with compounds 24 and 25.Similarly,reactions of C-(3-pyridyl)-N-phenylnitrone(26)with mono-substituted,disubstituted and cyclic dipolarophiles were carried out in refluxing dry toluene to obtain substituted 3-(30-pyridyl)-Nphenylisoxazolidines(27–34).Some of the compounds(16f,18b,23a,23c,27c and 29f)display significant cytotoxicity against a number of human cancer cell lines.
文摘Metalworking fluids are the portion of a big family of lubricants. Metalworking fluids have been widely used for cutting the metal and the most communal category of theses fluids are water mixing fluids. In this article, the methods of lubrication using during various operations of machining is presenting and also represent the various benefits of these functional fluids in machining with respect to surface finish, cutting force, temperature at the zone of cutting. The disadvantages and performance of various methods are discussed in terms of output variables and parameters of machining. From the various literatures, it can be reported that fluids of cutting which are made by the oil of vegetable, could be eco-friendly in machining mode with same in performance achieved after using the metalworking fluid which are based on mineral oil. The various lubrication methods are going to be finished because of less cooling rate.
