期刊文献+
共找到5篇文章
< 1 >
每页显示 20 50 100
From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world 被引量:52
1
作者 Dimitrios Dimitroulis Christos Damaskos +12 位作者 Serena Valsami Spyridon Davakis Nikolaos Garmpis Eleftherios Spartalis Antonios Athanasiou demetrios moris Stratigoula Sakellariou Stylianos Kykalos Gerasimos Tsourouflis Anna Garmpi Ioanna Delladetsima Konstantinos Kontzoglou Gregory Kouraklis 《World Journal of Gastroenterology》 SCIE CAS 2017年第29期5282-5294,共13页
Hepatocellular carcinoma(HCC) is the most frequent primary liver malignancy and the third cause of cancer-related death in the Western Countries. The well-established causes of HCC are chronic liver infections such as... Hepatocellular carcinoma(HCC) is the most frequent primary liver malignancy and the third cause of cancer-related death in the Western Countries. The well-established causes of HCC are chronic liver infections such as hepatitis B virus or chronic hepatitis C virus, nonalcoholic fatty liver disease, consumption of aflatoxins and tobacco smocking. Clinical presentation varies widely; patients can be asymptomatic while symptomatology extends from right upper abdominal quadrant paint and weight loss to obstructive jaundice and lethargy. Imaging is the first key and one of the most important aspects at all stages of diagnosis, therapy and follow-up of patients with HCC. The Barcelona Clinic Liver Cancer Staging System remains the most widely classification system used for HCC management guidelines. Up until now, HCC remains a challenge to early diagnose, and treat effectively; treating management is focused on hepatic resection, orthotopic liver transplantation, ablative therapies, chemoembolization and systemic therapies with cytotocix drugs, and targeted agents. This review article describes the current evidence on epidemiology, symptomatology, diagnosis and treatment of hepatocellular carcinoma. 展开更多
关键词 HEPATOCELLULAR Cancer EPIDEMIOLOGY TREATMENT DIAGNOSIS STAGING Transplantation
下载PDF
Mechanistic insights of rapid liver regeneration after associating liver partition and portal vein ligation for stage hepatectomy 被引量:2
2
作者 demetrios moris Spyridon Vernadakis +4 位作者 Alexandros Papalampros Michail Vailas Nikolaos Dimitrokallis Athanasios Petrou Dimitrios Dimitroulis 《World Journal of Gastroenterology》 SCIE CAS 2016年第33期7613-7624,共12页
AIM To highlight the potential mechanisms of regeneration in the Associating Liver Partition and Portal vein ligation for Stage hepatectomy models(clinical and experimental) that could unlock the myth behind the extra... AIM To highlight the potential mechanisms of regeneration in the Associating Liver Partition and Portal vein ligation for Stage hepatectomy models(clinical and experimental) that could unlock the myth behind the extraordinary capability of the liver for regeneration,which would help in designing new therapeutic options for the regenerative drive in difficult setup,such as chronic liver diseases. Associating Liver Partition and Portal vein ligation for Stage hepatectomy has been recently advocated to induce rapid future liver remnant hypertrophy that significantly shortens the time for the second stage hepatectomy. The introduction of Associating Liver Partition and Portal vein ligation for Stage hepatectomy in the surgical armamentarium of therapeutic tools for liver surgeons represented a real breakthrough in the history of liver surgery. METHODS A comprehensive literature review of Associating Liver Partition and Portal vein ligation for Stage hepatectomy and its utility in liver regeneration is performed. RESULTS Liver regeneration after Associating Liver Partition and Portal vein ligation for Stage hepatectomy is a combination of portal flow changes and parenchymal transection that generate a systematic response inducing hepatocyte proliferation and remodeling. CONCLUSION Associating Liver Partition and Portal vein ligation for Stage hepatectomy represents a real breakthrough in the history of liver surgery because it offers rapid liver regeneration potential that facilitate resection of liver tumors that were previously though unresectable. The jury is still out though in terms of safety,efficacy and oncological outcomes. As far as Associating Liver Partition and Portal vein ligation for Stage hepatectomy-induced liver regeneration is concerned,further research on the field should focus on the role of nonparenchymal cells in liver regeneration as well as on the effect of Associating Liver Partition and Portal vein ligation for Stage hepatectomy in liver regeneration in the setup of parenchymal liver disease. 展开更多
关键词 LIVER regeneration Associating LIVER PARTITION with PORTAL VEIN LIGATION for staged HEPATECTOMY PORTAL VEIN embolization PORTAL VEIN LIGATION LIVER transection
下载PDF
Effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats: What we know so far? 被引量:5
3
作者 antonios athanasiou eleftherios spartalis +4 位作者 mairead hennessy michael spartalis demetrios moris christos damaskos emmanouil pikoulis 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2018年第1期91-92,共2页
To the editor:We read with great interest the article entitled "Comparative study of the effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats" by Ulmer et al.[1]... To the editor:We read with great interest the article entitled "Comparative study of the effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats" by Ulmer et al.[1].The aim of this study was to analyse the impact of terlipressin ver- 展开更多
关键词 Effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats What we know so far
下载PDF
Novel approaches for the treatment of ventricular tachycardia 被引量:2
4
作者 Michael Spartalis Eleftherios Spartalis +7 位作者 Eleni Tzatzaki Diamantis I Tsilimigras demetrios moris Christos Kontogiannis Efthimios Livanis Dimitrios C Iliopoulos Vassilis Voudris George N Theodorakis 《World Journal of Cardiology》 CAS 2018年第7期52-59,共8页
Ventricular tachycardia(VT) is a crucial cause of sudden cardiac death(SCD) and a primary cause of mortality and morbidity in patients with structural cardiac disease. VT includes clinical disorders varying from benig... Ventricular tachycardia(VT) is a crucial cause of sudden cardiac death(SCD) and a primary cause of mortality and morbidity in patients with structural cardiac disease. VT includes clinical disorders varying from benign to lifethreatening. Most life-threatening episodes are correlated with coronary artery disease, but the risk of SCD varies in certain populations, with various underlying heart conditions, specific family history, and genetic variants. The targets of VT management are symptom alleviation, improved quality of life, reduced implantable cardioverter defibrillator shocks, prevention of reduction of left ventricular function, reduced risk of SCD, and improved overall survival. Antiarrhythmic drug therapy and endocardial catheter ablation remains the cornerstone of guideline-endorsed VT treatment strategies in patients with structural cardiac abnormalities. Novel strategies such as epicardial ablation, surgical cryoablation, transcoronary alcohol ablation, pre-procedural imaging, and stereotactic ablative radiotherapy are an appealing area of res-earch. In this review, we gathered all recent advances in innovative therapies as well as experimental evidence focusing on different aspects of VT treatment that could be significant for future favorable clinical applications. 展开更多
关键词 VENTRICULAR TACHYCARDIA CATHETER ablation EPICARDIAL SUDDEN cardiac death NOVEL techniques Substrate
下载PDF
Role of platelet-rich plasma in ischemic heart disease: An update on the latest evidence 被引量:1
5
作者 Eleftherios Spartalis Periklis Tomos +6 位作者 demetrios moris Antonios Athanasiou Charalampos Markakis Michael D Spartalis Theodore Troupis Dimitrios Dimitroulis Despina Perrea 《World Journal of Cardiology》 CAS 2015年第10期665-670,共6页
Myocardial infarction is the most common cause of congestive heart failure. Novel strategies such as directly reprogramming cardiac fibroblasts into cardiomyocytes are an exciting area of investigation for repair of i... Myocardial infarction is the most common cause of congestive heart failure. Novel strategies such as directly reprogramming cardiac fibroblasts into cardiomyocytes are an exciting area of investigation for repair of injured myocardial tissue. The ultimate goal is to rebuild functional myocardium by transplanting exogenous stem cells or by activating native stem cells to induce endogenous repair. Cell-based myocardial restoration, however, has not penetrated broad clinical practice yet. Plateletrich plasma, an autologous fractionation of whole blood containing high concentrations of growth factors, has been shown to safely and effectively enhance healing and angiogenesis primarily by reparative cell signaling. In this review, we collected all recent advances in novel therapies as well as experimental evidence demonstrating the role of platelet-rich plasma in ischemic heart disease, focusing on aspects that might be important for future successful clinical application. 展开更多
关键词 Platelet-rich plasma ISCHEMIC HEART disease Myocar
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部