Cough variant is a common disease of the respiratory system and can lead to a unique type of asthma.The disease has no obvious symptoms such as wheezing nor shortness of breath.Coughing is the main clinical symptom,as...Cough variant is a common disease of the respiratory system and can lead to a unique type of asthma.The disease has no obvious symptoms such as wheezing nor shortness of breath.Coughing is the main clinical symptom,as it causes airway hyper-responsiveness.Traditional Chinese medicine(TCM)has a unique understanding of this disease,and the effect is obvious after treatment,as it's based on symptom differentiation.This article takes the concept of“mild fluid retention”from“The Synopsis of the Golden Chamber”as an entry point,briefly describes the relationship between cough variant and mild fluid retention,as well as the diagnosis and treatment of Chinese medicine.展开更多
Compound Kushen Injection(CKI),as a clinical traditional Chinese medicine preparation,has prominent antitumor effect but with several side effects.A large number of studies have shown that CKI plays an antitumor role ...Compound Kushen Injection(CKI),as a clinical traditional Chinese medicine preparation,has prominent antitumor effect but with several side effects.A large number of studies have shown that CKI plays an antitumor role by regulating tumor cell proliferation,inducing tumor cell differentiation and apoptosis,inhibitrng tumor cell invasion and metastasis,reducing tumor angiogenesis,regulating the immunity,and so on.Clinically,CKI is widely used to treat various tumors,where it is often combined with surgery,chemotherapy,radiotherapy,targeted therapy,and other antitumor treatments.This article reviews the antitumor mechanism of CKI and the progress of its clinical application in order to provide a theoretical basis for further clinical application.展开更多
With the efficient development of social economy,as well as the acceleration of the pace of life,the incidence of hemorrhoids remains high all year round,occupying a relatively high incidence of anorectal diseases.The...With the efficient development of social economy,as well as the acceleration of the pace of life,the incidence of hemorrhoids remains high all year round,occupying a relatively high incidence of anorectal diseases.The author will sort out the four most representative theories of pathogenesis,and summarize and analyze them.Understanding the pathogenesis of hemorrhoids can give a deeper understanding of the nature of the disease,and it will help improve the accuracy of clinical diagnosis and treatment,which in turn is beneficial to the improvement of the cure rate.展开更多
1.Introduction Quenched Fe-C martensite is very strong but brittle due to su-persaturated carbon atoms located at octahedron sites[1].In order to improve the ductility,tempering is necessary.With increasing tempering ...1.Introduction Quenched Fe-C martensite is very strong but brittle due to su-persaturated carbon atoms located at octahedron sites[1].In order to improve the ductility,tempering is necessary.With increasing tempering temperature,the saturated carbon can be sequentially arranged as clusters,segregation into defects like dislocations and interfaces,transition carbides,and cementite[2].As a result,the strength is reduced and the ductility is improved predominantly due to the decreased amount of solid solution carbon[3].展开更多
This paper develops a novel optimization method oriented to the resilience of multiple Unmanned Aerial Vehicle(multi-UAV)formations to achieve rapid and accurate reconfiguration under random attacks.First,a resilience...This paper develops a novel optimization method oriented to the resilience of multiple Unmanned Aerial Vehicle(multi-UAV)formations to achieve rapid and accurate reconfiguration under random attacks.First,a resilience metric is applied to reflect the effect and rapidity of multi-UAV formation resisting random attacks.Second,an optimization model based on a parameter optimization problem to maximize the system resilience is established.Third,an Adaptive Learning-based Pigeon-Inspired Optimization(ALPIO)algorithm is designed to optimize the resilience value.Finally,typical formation topologies with six UAVs are investigated as a case study to verify the proposed approach.The experimental results indicate that the proposed scheme can achieve resilience optimization for a multi-UAV formation reconfiguration by increasing the system resilience values to 97.53%and 81.4%after random attacks.展开更多
Many variables affect the sealing performance, and their distribution characteristics are difficult to obtain with probabilistic methods owing to the high cost involved. Numerous problems in engineering are similar du...Many variables affect the sealing performance, and their distribution characteristics are difficult to obtain with probabilistic methods owing to the high cost involved. Numerous problems in engineering are similar due to the appearance of small-sample parameters. In this study, the sealing reliability of an aviation seal was defined as the research object, and an interval uncertainty method and multidimensional response surface were proposed to calculate the sealing reliability.Based on this, we first analyzed the failure mechanism of the aviation seal and established a leakage rate model. Then, based on the non-probabilistic interval model, an interval uncertainty method was proposed to construct the analytical model. With reference to the limit state equation from the structural reliability theory, the multidimensional response surface was used for fast calculation.Then, we chose the single-cylinder gas steering gear used in aircraft as the case study, its sealing reliability in working and non-working statuses were calculated, and the results were verified with the actual maintenance records. By analyzing the sensitivity of some variables, we can improve the sealing reliability of the aviation seal by improving the surface roughness only if the cost allows.Finally, we consider that the method proposed in this study realizes the application of smallsample uncertainty analysis in reliability analysis, and could provide a feasible way to solve the similar problems in engineering with multidimensional and small-sample parameters.展开更多
文摘Cough variant is a common disease of the respiratory system and can lead to a unique type of asthma.The disease has no obvious symptoms such as wheezing nor shortness of breath.Coughing is the main clinical symptom,as it causes airway hyper-responsiveness.Traditional Chinese medicine(TCM)has a unique understanding of this disease,and the effect is obvious after treatment,as it's based on symptom differentiation.This article takes the concept of“mild fluid retention”from“The Synopsis of the Golden Chamber”as an entry point,briefly describes the relationship between cough variant and mild fluid retention,as well as the diagnosis and treatment of Chinese medicine.
文摘Compound Kushen Injection(CKI),as a clinical traditional Chinese medicine preparation,has prominent antitumor effect but with several side effects.A large number of studies have shown that CKI plays an antitumor role by regulating tumor cell proliferation,inducing tumor cell differentiation and apoptosis,inhibitrng tumor cell invasion and metastasis,reducing tumor angiogenesis,regulating the immunity,and so on.Clinically,CKI is widely used to treat various tumors,where it is often combined with surgery,chemotherapy,radiotherapy,targeted therapy,and other antitumor treatments.This article reviews the antitumor mechanism of CKI and the progress of its clinical application in order to provide a theoretical basis for further clinical application.
文摘With the efficient development of social economy,as well as the acceleration of the pace of life,the incidence of hemorrhoids remains high all year round,occupying a relatively high incidence of anorectal diseases.The author will sort out the four most representative theories of pathogenesis,and summarize and analyze them.Understanding the pathogenesis of hemorrhoids can give a deeper understanding of the nature of the disease,and it will help improve the accuracy of clinical diagnosis and treatment,which in turn is beneficial to the improvement of the cure rate.
基金supported by the National Key R&D Program of China(2019YFA0706802)Shenzhen Science and Technology Program(CJGJZD20210408092602006)the Science and Technology Major Project of Henan Province(221100240400)。
基金National Natural Science Foundation of China(Nos.52271004 and 51901021).
文摘1.Introduction Quenched Fe-C martensite is very strong but brittle due to su-persaturated carbon atoms located at octahedron sites[1].In order to improve the ductility,tempering is necessary.With increasing tempering temperature,the saturated carbon can be sequentially arranged as clusters,segregation into defects like dislocations and interfaces,transition carbides,and cementite[2].As a result,the strength is reduced and the ductility is improved predominantly due to the decreased amount of solid solution carbon[3].
基金supported by the National Defense Pre-Research Foundation of China(No.61400020109).
文摘This paper develops a novel optimization method oriented to the resilience of multiple Unmanned Aerial Vehicle(multi-UAV)formations to achieve rapid and accurate reconfiguration under random attacks.First,a resilience metric is applied to reflect the effect and rapidity of multi-UAV formation resisting random attacks.Second,an optimization model based on a parameter optimization problem to maximize the system resilience is established.Third,an Adaptive Learning-based Pigeon-Inspired Optimization(ALPIO)algorithm is designed to optimize the resilience value.Finally,typical formation topologies with six UAVs are investigated as a case study to verify the proposed approach.The experimental results indicate that the proposed scheme can achieve resilience optimization for a multi-UAV formation reconfiguration by increasing the system resilience values to 97.53%and 81.4%after random attacks.
基金supported in part from the Fundamental Research Project funded by the Ministry of Industry and Information Technology of the People’s Republic of China
文摘Many variables affect the sealing performance, and their distribution characteristics are difficult to obtain with probabilistic methods owing to the high cost involved. Numerous problems in engineering are similar due to the appearance of small-sample parameters. In this study, the sealing reliability of an aviation seal was defined as the research object, and an interval uncertainty method and multidimensional response surface were proposed to calculate the sealing reliability.Based on this, we first analyzed the failure mechanism of the aviation seal and established a leakage rate model. Then, based on the non-probabilistic interval model, an interval uncertainty method was proposed to construct the analytical model. With reference to the limit state equation from the structural reliability theory, the multidimensional response surface was used for fast calculation.Then, we chose the single-cylinder gas steering gear used in aircraft as the case study, its sealing reliability in working and non-working statuses were calculated, and the results were verified with the actual maintenance records. By analyzing the sensitivity of some variables, we can improve the sealing reliability of the aviation seal by improving the surface roughness only if the cost allows.Finally, we consider that the method proposed in this study realizes the application of smallsample uncertainty analysis in reliability analysis, and could provide a feasible way to solve the similar problems in engineering with multidimensional and small-sample parameters.
