The traceability system can effectively reduce the food safety risks, however, it is confronted with various problems during its implementation. In this context, the paper carries out a case study of consumers in Weif...The traceability system can effectively reduce the food safety risks, however, it is confronted with various problems during its implementation. In this context, the paper carries out a case study of consumers in Weifang, Shandong Province, and studies their willingness to pay the traceable pork with different quality information. The results indicate that, the consumers show high expectations towards the introduction of traceability system, and they tend to buy the traceable pork only with breeding and slaughter information; their behaviors of purchase are greatly influenced by the following factors: the consumers education, age, income, attention on food safety and whether there are pregnant family members, etc..展开更多
Quantum steering in a global state allows an observer to remotely steer a subsystem into different ensembles by performing different local measurements on the other part. We show that, in general, this property cannot...Quantum steering in a global state allows an observer to remotely steer a subsystem into different ensembles by performing different local measurements on the other part. We show that, in general, this property cannot be perfectly cloned by any joint operation between a steered subsystem and a third system. Perfect cloning is viable if and only if the initial state is of zero discord. We also investigate the process of cloning the steered qubit of a Bell state using a universal cloning machine. Einstein–Podolsky–Rosen(EPR) steering, which is a type of quantum correlation existing in the states without a local-hidden-state model, is observed in the two copy subsystems. This contradicts the conclusion of no-cloning of quantum steering(EPR steering) [C. Y. Chiu et al.,npj Quantum Inf. 2, 16020(2016)] based on a mutual information criterion for EPR steering.展开更多
Despite recent progress in multiple myeloma(MM)treatments,most patients will relapse and require additional treatment.Intravenous daratumumab,a human IgGκmonoclonal antibody targeting CD38,has shown good efficacy in ...Despite recent progress in multiple myeloma(MM)treatments,most patients will relapse and require additional treatment.Intravenous daratumumab,a human IgGκmonoclonal antibody targeting CD38,has shown good efficacy in the treatment of MM.A subcutaneous version of daratumumab was formulated to reduce the burden of intravenous infusions.We aimed to investigate the efficacy and safety of subcutaneous daratumumab in Chinese patients with relapsed/refractory MM based on the demonstrated noninferiority of subcutaneous daratumumab to intravenous daratumumab,with a shorter administration time and reduced infusion-related reaction rate in global studies.This phase 1,multicenter study(MMY1010;ClinicalTrials.gov Identifier:NCT04121260)evaluated subcutaneous daratumumab in Chinese patients with relapsed/refractory MM after 1 prior line(n=1)or≥2 prior lines(n=20)of therapy,including a proteasome inhibitor and an immunomodulatory drug.Primary endpoints were pharmacokinetics and safety.Mean(standard deviation)maximum trough concentration of daratumumab was 826(335)μg/mL,which was consistent with prior studies of subcutaneous daratumumab and intravenous daratumumab.Safety was consistent with safety profiles observed in other daratumumab studies,with no new safety concerns identified.Incidences of infusion-related reactions and injection-site reactions were low and consistent with other subcutaneous daratumumab studies.At a median follow-up of 7.5 months,the overall response rate was 57.1%,with a very good partial response or better rate of 38.1%and complete response or better rate of 19.0%.Our results demonstrate a favorable benefit/risk profile of subcutaneous daratumumab in Chinese patients with relapsed/refractory MM,potentially impacting clinical administration of daratumumab in this population.展开更多
基金Supported by the Youth Project for Humanities and Social Sciences of Ministry of Education in 2012(12YJC630326 and 12XJJC790003)
文摘The traceability system can effectively reduce the food safety risks, however, it is confronted with various problems during its implementation. In this context, the paper carries out a case study of consumers in Weifang, Shandong Province, and studies their willingness to pay the traceable pork with different quality information. The results indicate that, the consumers show high expectations towards the introduction of traceability system, and they tend to buy the traceable pork only with breeding and slaughter information; their behaviors of purchase are greatly influenced by the following factors: the consumers education, age, income, attention on food safety and whether there are pregnant family members, etc..
基金supported by the National Natural Science Foundation of China (Grant Nos. 11675119, 11575125, and 11105097)。
文摘Quantum steering in a global state allows an observer to remotely steer a subsystem into different ensembles by performing different local measurements on the other part. We show that, in general, this property cannot be perfectly cloned by any joint operation between a steered subsystem and a third system. Perfect cloning is viable if and only if the initial state is of zero discord. We also investigate the process of cloning the steered qubit of a Bell state using a universal cloning machine. Einstein–Podolsky–Rosen(EPR) steering, which is a type of quantum correlation existing in the states without a local-hidden-state model, is observed in the two copy subsystems. This contradicts the conclusion of no-cloning of quantum steering(EPR steering) [C. Y. Chiu et al.,npj Quantum Inf. 2, 16020(2016)] based on a mutual information criterion for EPR steering.
文摘Despite recent progress in multiple myeloma(MM)treatments,most patients will relapse and require additional treatment.Intravenous daratumumab,a human IgGκmonoclonal antibody targeting CD38,has shown good efficacy in the treatment of MM.A subcutaneous version of daratumumab was formulated to reduce the burden of intravenous infusions.We aimed to investigate the efficacy and safety of subcutaneous daratumumab in Chinese patients with relapsed/refractory MM based on the demonstrated noninferiority of subcutaneous daratumumab to intravenous daratumumab,with a shorter administration time and reduced infusion-related reaction rate in global studies.This phase 1,multicenter study(MMY1010;ClinicalTrials.gov Identifier:NCT04121260)evaluated subcutaneous daratumumab in Chinese patients with relapsed/refractory MM after 1 prior line(n=1)or≥2 prior lines(n=20)of therapy,including a proteasome inhibitor and an immunomodulatory drug.Primary endpoints were pharmacokinetics and safety.Mean(standard deviation)maximum trough concentration of daratumumab was 826(335)μg/mL,which was consistent with prior studies of subcutaneous daratumumab and intravenous daratumumab.Safety was consistent with safety profiles observed in other daratumumab studies,with no new safety concerns identified.Incidences of infusion-related reactions and injection-site reactions were low and consistent with other subcutaneous daratumumab studies.At a median follow-up of 7.5 months,the overall response rate was 57.1%,with a very good partial response or better rate of 38.1%and complete response or better rate of 19.0%.Our results demonstrate a favorable benefit/risk profile of subcutaneous daratumumab in Chinese patients with relapsed/refractory MM,potentially impacting clinical administration of daratumumab in this population.
