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Steroidogenic Effects and Phytochemical Profile of Aqueous Extract of Tetracarpidium conophorum (Mull. Arg.) & Hutch Kernels in Male Rats
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作者 Herman Akassa Bonaventure Max Lazare Peneme +4 位作者 Constantin Moukouma dieu-merci bevel gallo mongo Rachie Osandze Arnaud Wilfrid Etou Ossibi Ange Antoine Abena 《Journal of Biosciences and Medicines》 2023年第10期156-167,共12页
The main aim of this study was to evaluate the steroidogenic effects and phytochemical profile of aqueous extract of Tetracarpidium conophorum in male rats. Assays of biochemical reproductive parameters (total cholest... The main aim of this study was to evaluate the steroidogenic effects and phytochemical profile of aqueous extract of Tetracarpidium conophorum in male rats. Assays of biochemical reproductive parameters (total cholesterol, serum testosterone, FSH and LH) were carried out using Cypress and ELISA kits respectively. The chemical screening of the extract was conducted through tube reactions, the principle of which involves adding a reagent to a quantity of the extract, and subsequently observing the resulting reactions such as precipitation and color change. The results obtained showed that oral administration of the aqueous extract of Tetracarpidium conophorum (250 and 500 mg/kg) produced a significant increase (p Tetracarpidium conophorum kernels at the doses studied produced a very significant decrease in total cholesterol levels (p Tetracarpidium conophorum kernels could have hypocholesterolemic and steroidogenic potential. A study of the aqueous extract of Tetracarpidium conophorum on semen quality and oxidative stress parameters deserves to be conducted. 展开更多
关键词 Tetracarpidium conophorum Steroidogenic Chemical Screaming
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Hypotensive Effects and Phytochemical Profile of Aqueous Extract and Fractions of Desmodium velutinun Leaves (Willd) D. C. (Fabaceae) in the Rat
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作者 Blondy Mboungou-Bouesse Arnaud Wilfrid Etou Ossibi +5 位作者 Elva Ngolo Romaric De Garde Elion Itou Béril Fabrice Mavouba dieu-merci bevel gallo mongo Gouollaly Tsiba Ange Antoine Abena 《Journal of Biosciences and Medicines》 CAS 2022年第8期100-109,共10页
Desmodium velutinum (D. velutinum) is a plant of the family Fabaceae used in traditional Congolese medicine for the treatment of high blood pressure (HBP) or hypertension (HT). The present work evaluated the hypotensi... Desmodium velutinum (D. velutinum) is a plant of the family Fabaceae used in traditional Congolese medicine for the treatment of high blood pressure (HBP) or hypertension (HT). The present work evaluated the hypotensive activity and determined the phytochemical profile of the aqueous extract and fractions of Desmodium velutinun (Willd) D. C. (Fabaceae) in the rat. The hypotensive effect of the aqueous extract and different fractions (F1, F2, F3 and F4) was evaluated at the dose of 2.5 mg/kg in normotensive rats anesthetized with 15% urethane at 1.5 g/kg, i.p. (intraperitoneally). Our results showed that the F3 fraction after administration caused a significant decrease in blood pressure and heart rate which remained higher than that of the aqueous extract and fractions (F1, F2 and F4). The richness in polyphenolic and flavonoid compounds as well as the separating capacity of the eluent used within the F3 fraction clearly justifies the beneficial effects of the latter on blood pressure and heart rate compared with the extract and fractions (F1, F2 and F4). In a second part we carried out the qualitative (thin-layer chromatography) and quantitative (total polyphenols and flavonoids determination) analysis. The chemical compounds remained dominated by the polyphenolic and flavonoid groups, the content of total polyphenols and total flavonoids meets the following increasing order: (extract, F1, F2, F3 and F4). The results obtained could certify the use of Desmodium velutinun in traditional Congolese medicine. 展开更多
关键词 HYPOTENSIVE FRACTION Desmodium velutinun PHYTOCHEMISTRY
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