The autonomic nervous system plays a crucial role in regulating bone metabolism,with sympathetic activation stimulating bone resorption and inhibiting bone formation.We found that fractures lead to increased sympathet...The autonomic nervous system plays a crucial role in regulating bone metabolism,with sympathetic activation stimulating bone resorption and inhibiting bone formation.We found that fractures lead to increased sympathetic tone,enhanced osteoclast resorption,decreased osteoblast formation,and thus hastened systemic bone loss in ovariectomized(OVX)mice.However,the combined administration of parathyroid hormone(PTH)and theβ-receptor blocker propranolol dramatically promoted systemic bone formation and osteoporotic fracture healing in OVX mice.The effect of this treatment is superior to that of treatment with PTH or propranolol alone.In vitro,the sympathetic neurotransmitter norepinephrine(NE)suppressed PTH-induced osteoblast differentiation and mineralization,which was rescued by propranolol.Moreover,NE decreased the PTH-induced expression of Runx2 but enhanced the expression of Rankl and the effect of PTH-stimulated osteoblasts on osteoclastic differentiation,whereas these effects were reversed by propranolol.Furthermore,PTH increased the expression of the circadian clock gene Bmal1,which was inhibited by NE-βAR signaling.Bmal1 knockdown blocked the rescue effect of propranolol on the NE-induced decrease in PTHstimulated osteoblast differentiation.Taken together,these results suggest that propranolol enhances the anabolic effect of PTH in preventing systemic bone loss following osteoporotic fracture by blocking the negative effects of sympathetic signaling on PTH anabolism.展开更多
From the mid-19th century to the end of the 20th century, photographic plates served as the primary detectors for astronomical observations. Astronomical photographic observations in China began in 1901, and over a ce...From the mid-19th century to the end of the 20th century, photographic plates served as the primary detectors for astronomical observations. Astronomical photographic observations in China began in 1901, and over a century, a total of approximately 30,000 astronomical photographic plates were captured. These historical plates play an irreplaceable role in conducting long-term, time-domain astronomical research. To preserve and explore these valuable original astronomical observational data, Shanghai Astronomical Observatory has organized the transportation of plates, taken during nighttime observations from various stations across the country, to the Sheshan Plate Archive for centralized preservation. For the first time, plate information statistics were calculated. On this basis, the plates were cleaned and digitally scanned, and finally digitized images were acquired for 29,314 plates. In this study, using Gaia DR2 as the reference star catalog, astrometric processing was carried out successfully on 15,696 single-exposure plates, including object extraction, stellar identification,and plate model computation. As a result, for long focal length telescopes, such as the 40 cm double-tube refractor telescope, the 1.56 m reflector telescope at Shanghai Astronomical Observatory, and the 1m reflecting telescope at Yunnan Astronomical Observatory, the astrometric accuracy obtained for their plates is approximately 0."1–0."3. The distribution of astrometric accuracy for medium and short focal length telescopes ranges from 0."3 to 1."0. The relevant data of this batch of plates, including digitized images and a stellar catalog of the plates, are archived and released by the National Astronomical Data Center. Users can access and download plate data based on keywords such as station, telescope, observation year, and observed celestial coordinates.展开更多
The China Space Station Telescope(CSST)is a two-meter space telescope with multiple back-end instruments.The Fine Guidance Sensor(FGS)is an essential subsystem of the CSST Precision Image Stability System to ensure th...The China Space Station Telescope(CSST)is a two-meter space telescope with multiple back-end instruments.The Fine Guidance Sensor(FGS)is an essential subsystem of the CSST Precision Image Stability System to ensure the required absolute pointing accuracy and line-of-sight stabilization.In this study,we construct the Main Guide Star Catalog for FGS.To accomplish this,we utilize the information about the FGS and object information from the Gaia Data Release 3.We provide an FGS instrument magnitude and exclude variables,binaries,and high proper motion stars from the catalog to ensure uniform FGS guidance capabilities.Subsequently,we generate a HEALPix index,which provides a hierarchical tessellation of the celestial sphere,and employ the Voronoi algorithm to achieve a homogeneous distribution of stars across the catalog.This distribution ensures adequate coverage and sampling of the sky.The performance of the CSST guide star catalog was assessed by simulating the field of view of the FGS according to the CSST mock survey strategy catalog.The analysis of the results indicates that this catalog provides adequate coverage and accuracy.The catalog's performance meets the FGS requirements,ensuring the functioning of the FGS and its guidance capabilities.展开更多
The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of ...The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.展开更多
A large ground-based optical/infrared telescope is being planned for a world-class astronomical site in China.The cloud-free night percentage is the primary meteorological consideration for evaluating candidate sites....A large ground-based optical/infrared telescope is being planned for a world-class astronomical site in China.The cloud-free night percentage is the primary meteorological consideration for evaluating candidate sites.The data from GMS and NOAA satellites and the MODIS instrument were utilized in this research,covering the period from 1996 to 2015.Our data analysis benefits from overlapping results from different independent teams as well as a uniform analysis of selected sites using GMS+NOAA data.Although significant ground-based monitoring is needed to validate these findings,we identify three different geographical regions with a high percentage of cloud-free conditions(~83%on average),which is slightly lower than at Mauna Kea and Cerro Armazones(~85%on average)and were chosen for the large international projects TMT and ELT respectively.Our study finds evidence that cloud distributions and the seasonal changes affected by the prevailing westerly winds and summer monsoons reduce the cloud cover in areas influenced by the westerlies.This is consistent with the expectations from climate change models and is suggestive that most of the identified sites will have reduced cloud cover in the future.展开更多
Based on previous site testing and satellite cloud data,Ali,Daocheng and Muztagh-ata have been selected as candidate sites for the Large Optical/Infrared Telescope(LOT) in China.We present the data collection,processi...Based on previous site testing and satellite cloud data,Ali,Daocheng and Muztagh-ata have been selected as candidate sites for the Large Optical/Infrared Telescope(LOT) in China.We present the data collection,processing,management and quality analysis for our site testing based on using similar hardware.We analyze meteorological data,seeing,background light,cloud and precipitable water vapor data from 2017 March 10 to 2019 March 10.We also investigated the relative usefulness of our all-sky camera data in comparison to that from the meteorological TERRA satellite data based on a night-by-night comparison of the correlation and consistency between them.We find a 6% discrepancy arising from a wide range of factors.展开更多
LAMOST Data Release 5,covering 17000 deg^(2) from-10°to 80°in declination,contains 9 million co-added low-resolution spectra of celestial objects,each spectrum combined from repeat exposure of two to tens of...LAMOST Data Release 5,covering 17000 deg^(2) from-10°to 80°in declination,contains 9 million co-added low-resolution spectra of celestial objects,each spectrum combined from repeat exposure of two to tens of times during Oct 2011 to Jun 2017.In this paper,we present the spectra of individual exposures for all the objects in LAMOST Data Release 5.For each spectrum,the equivalent width of 60lines from 11 different elements are calculated with a new method combining the actual line core and fitted line wings.For stars earlier than F type,the Balmer lines are fitted with both emission and absorption profiles once two components are detected.Radial velocity of each individual exposure is measured by minimizing χ^(2) between the spectrum and its best template.The database for equivalent widths of spectral lines and radial velocities of individual spectra are available online.Radial velocity uncertainties with different stellar type and signal-to-noise ratio are quantified by comparing different exposure of the same objects.We notice that the radial velocity uncertainty depends on the time lag between observations.For stars observed in the same day and with signal-to-noise ratio higher than 20,the radial velocity uncertainty is below 5 km s^(-1),and increases to 10 km s^(-1) for stars observed in different nights.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.82330078,81874010)the National Key Research and Development Program(Grant Nos.2020YFC2009004,2021YFC2501700).
文摘The autonomic nervous system plays a crucial role in regulating bone metabolism,with sympathetic activation stimulating bone resorption and inhibiting bone formation.We found that fractures lead to increased sympathetic tone,enhanced osteoclast resorption,decreased osteoblast formation,and thus hastened systemic bone loss in ovariectomized(OVX)mice.However,the combined administration of parathyroid hormone(PTH)and theβ-receptor blocker propranolol dramatically promoted systemic bone formation and osteoporotic fracture healing in OVX mice.The effect of this treatment is superior to that of treatment with PTH or propranolol alone.In vitro,the sympathetic neurotransmitter norepinephrine(NE)suppressed PTH-induced osteoblast differentiation and mineralization,which was rescued by propranolol.Moreover,NE decreased the PTH-induced expression of Runx2 but enhanced the expression of Rankl and the effect of PTH-stimulated osteoblasts on osteoclastic differentiation,whereas these effects were reversed by propranolol.Furthermore,PTH increased the expression of the circadian clock gene Bmal1,which was inhibited by NE-βAR signaling.Bmal1 knockdown blocked the rescue effect of propranolol on the NE-induced decrease in PTHstimulated osteoblast differentiation.Taken together,these results suggest that propranolol enhances the anabolic effect of PTH in preventing systemic bone loss following osteoporotic fracture by blocking the negative effects of sympathetic signaling on PTH anabolism.
基金supported by the Shanghai Science and Technology Innovation Action Plan(grant No.21511104100)the Global Common Challenge Special Project(grant No.018GJHZ2023110GC)the China National Key Basic Research Program(grant No.2012FY120500)。
文摘From the mid-19th century to the end of the 20th century, photographic plates served as the primary detectors for astronomical observations. Astronomical photographic observations in China began in 1901, and over a century, a total of approximately 30,000 astronomical photographic plates were captured. These historical plates play an irreplaceable role in conducting long-term, time-domain astronomical research. To preserve and explore these valuable original astronomical observational data, Shanghai Astronomical Observatory has organized the transportation of plates, taken during nighttime observations from various stations across the country, to the Sheshan Plate Archive for centralized preservation. For the first time, plate information statistics were calculated. On this basis, the plates were cleaned and digitally scanned, and finally digitized images were acquired for 29,314 plates. In this study, using Gaia DR2 as the reference star catalog, astrometric processing was carried out successfully on 15,696 single-exposure plates, including object extraction, stellar identification,and plate model computation. As a result, for long focal length telescopes, such as the 40 cm double-tube refractor telescope, the 1.56 m reflector telescope at Shanghai Astronomical Observatory, and the 1m reflecting telescope at Yunnan Astronomical Observatory, the astrometric accuracy obtained for their plates is approximately 0."1–0."3. The distribution of astrometric accuracy for medium and short focal length telescopes ranges from 0."3 to 1."0. The relevant data of this batch of plates, including digitized images and a stellar catalog of the plates, are archived and released by the National Astronomical Data Center. Users can access and download plate data based on keywords such as station, telescope, observation year, and observed celestial coordinates.
基金the support by National Key R&D Program of China(No.2022YFF0503403,2022YFF0711500)the support of National Natural Science Foundation of China(NSFC,grant Nos.11988101,12073047,12273077,12022306,12373048,12263005)+3 种基金the support from the Ministry of Science and Technology of China(Nos.2020SKA0110100)the science research grants from the China Manned Space Project(Nos.CMS-CSST-2021-B01,CMSCSST-2021-A01)CAS Project for Young Scientists in Basic Research(No.YSBR-062)the support from K.C.Wong Education Foundation。
文摘The China Space Station Telescope(CSST)is a two-meter space telescope with multiple back-end instruments.The Fine Guidance Sensor(FGS)is an essential subsystem of the CSST Precision Image Stability System to ensure the required absolute pointing accuracy and line-of-sight stabilization.In this study,we construct the Main Guide Star Catalog for FGS.To accomplish this,we utilize the information about the FGS and object information from the Gaia Data Release 3.We provide an FGS instrument magnitude and exclude variables,binaries,and high proper motion stars from the catalog to ensure uniform FGS guidance capabilities.Subsequently,we generate a HEALPix index,which provides a hierarchical tessellation of the celestial sphere,and employ the Voronoi algorithm to achieve a homogeneous distribution of stars across the catalog.This distribution ensures adequate coverage and sampling of the sky.The performance of the CSST guide star catalog was assessed by simulating the field of view of the FGS according to the CSST mock survey strategy catalog.The analysis of the results indicates that this catalog provides adequate coverage and accuracy.The catalog's performance meets the FGS requirements,ensuring the functioning of the FGS and its guidance capabilities.
基金funded by the National Basic Research Program of China (973 Program, 2014CB845700)the National Natural Science Foundation of China (Grant Nos. 11390371)Funding for the project has been provided by the National Development and Reform Commission
文摘The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.
基金partly supported by the Operation,Maintenance and Upgrading Fund for Astronomical Telescopes and Facility Instruments,budgeted from the Ministry of Finance of China(MOF)and administered by the Chinese Academy of Sciences(CAS)supported by the National Natural Science Foundation of China(Grant Nos.11573054,11703065,11603044 and 11873081)+1 种基金support from a CAS PIFIUK STFC grant ST/R006598/1。
文摘A large ground-based optical/infrared telescope is being planned for a world-class astronomical site in China.The cloud-free night percentage is the primary meteorological consideration for evaluating candidate sites.The data from GMS and NOAA satellites and the MODIS instrument were utilized in this research,covering the period from 1996 to 2015.Our data analysis benefits from overlapping results from different independent teams as well as a uniform analysis of selected sites using GMS+NOAA data.Although significant ground-based monitoring is needed to validate these findings,we identify three different geographical regions with a high percentage of cloud-free conditions(~83%on average),which is slightly lower than at Mauna Kea and Cerro Armazones(~85%on average)and were chosen for the large international projects TMT and ELT respectively.Our study finds evidence that cloud distributions and the seasonal changes affected by the prevailing westerly winds and summer monsoons reduce the cloud cover in areas influenced by the westerlies.This is consistent with the expectations from climate change models and is suggestive that most of the identified sites will have reduced cloud cover in the future.
基金partly supported by the Operation,Maintenance and Upgrading Fund for Astronomical Telescopes and Facility Instruments,budgeted from the Ministry of Finance of China (MOF) and administered by the Chinese Academy of Sciences (CAS)supported by the National NaturalScience Foundation of China (Grant Nos.11573054,11703065,11603044 and 11873081)HRAJ acknowledges support from a CAS PIFI and UK STFC grant ST/R006598/1。
文摘Based on previous site testing and satellite cloud data,Ali,Daocheng and Muztagh-ata have been selected as candidate sites for the Large Optical/Infrared Telescope(LOT) in China.We present the data collection,processing,management and quality analysis for our site testing based on using similar hardware.We analyze meteorological data,seeing,background light,cloud and precipitable water vapor data from 2017 March 10 to 2019 March 10.We also investigated the relative usefulness of our all-sky camera data in comparison to that from the meteorological TERRA satellite data based on a night-by-night comparison of the correlation and consistency between them.We find a 6% discrepancy arising from a wide range of factors.
基金support of the National Key R&D Program of China(2019YFA0405000)the National Natural Science Foundation of China(NSFC)(Grant Nos.12090040 and 12090041)+4 种基金the support of NSFC(Grant No.11973054)the support of the Youth Innovation Promotion Association of Chinese Academy of Sciences(id.2020060)supported by Cultivation Project for LAMOST Scientific PayoffResearch Achievement of CAMS-CASFunding for the project has been provided by the National Development and Reform Commission。
文摘LAMOST Data Release 5,covering 17000 deg^(2) from-10°to 80°in declination,contains 9 million co-added low-resolution spectra of celestial objects,each spectrum combined from repeat exposure of two to tens of times during Oct 2011 to Jun 2017.In this paper,we present the spectra of individual exposures for all the objects in LAMOST Data Release 5.For each spectrum,the equivalent width of 60lines from 11 different elements are calculated with a new method combining the actual line core and fitted line wings.For stars earlier than F type,the Balmer lines are fitted with both emission and absorption profiles once two components are detected.Radial velocity of each individual exposure is measured by minimizing χ^(2) between the spectrum and its best template.The database for equivalent widths of spectral lines and radial velocities of individual spectra are available online.Radial velocity uncertainties with different stellar type and signal-to-noise ratio are quantified by comparing different exposure of the same objects.We notice that the radial velocity uncertainty depends on the time lag between observations.For stars observed in the same day and with signal-to-noise ratio higher than 20,the radial velocity uncertainty is below 5 km s^(-1),and increases to 10 km s^(-1) for stars observed in different nights.
