In recent years,the integrated development of the tea and tourism has become an important way to promote the rural revitalization of Tai'an tea-producing areas,but the state of industrial upgrading still needs to ...In recent years,the integrated development of the tea and tourism has become an important way to promote the rural revitalization of Tai'an tea-producing areas,but the state of industrial upgrading still needs to be improved.In order to better integrate tea and tourism in Tea Valley,this paper uses questionnaire and SWOT analysis to study.It found the following problems:(i)45.7%of tourists were interested in tea culture,but they know litle about it,and the integration of tea culture and tea tourism products is low.(i)50.54%of the tourists were interested in the tea picking experience project and wanted to add the tea food experience item.(ii)The acceptance of 45.7%of tourists to scenic spots was 1-2 h,which shows that the quality of transportation service facilities and personnel needs to be improved.Combined with the SWOT analysis,it is found that the scenic spot is rich in resources,convenient transportation,profound cultural heritage,and good govern-ment policy support conditions,which is suitable for the SO strategy(growth development strategy),so the scenic spot relies on internal ad-vantages and seizes external opportunities to develop the integration of tea and tourism.Based on the analysis results,it came up with the perti-nent recommendations for the key problems:(i)The infrastructure service is not well established.It is suggested that scenic spots should in-crease investment,regularly train service personnel to improve their quality,and improve transportation services,accommodation,catering and public service hardware facilities.(i)Tea tourism products are insufficient.It is suggested that tea tourism products should be innovatively designed and tea tourism experiential products and tourism commodities should be planned.(i)Tea culture and tourism lack organic combi-nation.It is recommended to deeply excavate tea culture,and take consideration of both spiritual and material aspects.The specific methods include building teahouses,Taishan Mountain(Mount Tai)tea culture throughout the whole process of tea production,development and pro-cessing,and AR tea culture experience hall can be built to make tourists feel tea culture from dfferent perspectives.(iv)The publicity is in-sufficient.Strategies should be made in three aspects:improving the Internet media,taking into account the traditional media,and expanding the market based on the surrounding areas.(v)The tea industry chain is short.It is recommended to add four new industrial chain designs of"tea+accommodation,tea+catering,tea+Intemet,tea+training",hoping to bring some inspiration and ideas to the managers of scenic spots.展开更多
The safe operating voltage and low volume variation of Li_(3)VO_(4)(LVO)make it an ideal anode material for lithium(Li)-ion batteries.However,the insufficient understanding of the inner storage mechanism hinders the d...The safe operating voltage and low volume variation of Li_(3)VO_(4)(LVO)make it an ideal anode material for lithium(Li)-ion batteries.However,the insufficient understanding of the inner storage mechanism hinders the design of LVO-based electrodes.Herein,we investigate,for the first time,the Li-ion storage activity in LVO via Cl doping.Moreover,N-doped C coating was simultaneously achieved in the Cl doping process,resulting in synergistically improved reaction kinetics.As a result,the as-prepared Cl-doped Li_(3)VO_(4) coated with N-doped C(Cl-LVO@NC)electrodes deliver a discharge capacity of 884.1 mAh/g after 200 cycles at 0.2 A/g,which is the highest among all of the LVO-based electrodes.The Cl-LVO@NC electrodes also exhibit high-capacity retention of 331.1 mAh/g at 8.0 A/g and full capacity recovery after 5 periods of rate testing over 400 cycles.After 5000 cycles at 4.0 A/g,the discharge capacity can be maintained at 423.2 mAh/g,which is superior to most LVO-based electrodes.The Li-ion storage activity in LVO via Cl doping and significant improvement in the high-rate Li-ion storage reported in this work can be used as references for the design of advanced LVO-based electrodes for high-power applications.展开更多
To improve the operation efficiency of the photovoltaic power station complementary power generation system,an optimal allocation model of the photovoltaic power station complementary power generation capacity based o...To improve the operation efficiency of the photovoltaic power station complementary power generation system,an optimal allocation model of the photovoltaic power station complementary power generation capacity based on PSO-BP is proposed.Particle Swarm Optimization and BP neural network are used to establish the forecasting model,the Markov chain model is used to correct the forecasting error of the model,and the weighted fitting method is used to forecast the annual load curve,to complete the optimal allocation of complementary generating capacity of photovoltaic power stations.The experimental results show that thismethod reduces the average loss of photovoltaic output prediction,improves the prediction accuracy and recall rate of photovoltaic output prediction,and ensures the effective operation of the power system.展开更多
[Objectives] To study the effect of "acupressure therapy" on anti-inflammatory mechanism in obesity-induced IR rats. [Methods] 10 rats were randomly selected and fed with normal diet as blank group, and the ...[Objectives] To study the effect of "acupressure therapy" on anti-inflammatory mechanism in obesity-induced IR rats. [Methods] 10 rats were randomly selected and fed with normal diet as blank group, and the remaining 30 rats were fed with high-fat diet for 8 weeks. The obesity-induced IR model was induced and divided into two groups: model group and acupressure group. The acupressure group was treated by "acupressure therapy" three times a week for 6 weeks;the model group was taken 3 times at the same time every week, and the supine binding experiment lasted for 10 min for 6 weeks. Morphological observation was carried out before and after the experiment, mainly observing the general conditions and body weight. After the last intervention, the animals were killed and samples were collected. Western Blot method was used to detect the expression of TNF-α and IL-6 protein in adipose tissue of the three groups. [Results] Compared with the blank group, the expression of TNF-α and IL-6 protein in adipose tissue of the model group increased significantly ( P <0.01);compared with the model group, the expression of TNF-α and IL-6 protein in adipose tissue of the acupressure group decreased significantly ( P <0.01). [Conclusions] After intervening in the obesity-induced IR rats with acupressure method, the status of insulin resistance in obese rats was improved by inhibiting the expression of inflammatory factors.展开更多
By reflecting on the current situation of the integration of excellent Chinese traditional culture into the training of acupuncture and massage professionals,this paper aims to carry out the research on the integratio...By reflecting on the current situation of the integration of excellent Chinese traditional culture into the training of acupuncture and massage professionals,this paper aims to carry out the research on the integration of excellent Chinese traditional culture into the training and education of acupuncture and massage.The specific implementation path includes early investigation and analysis,establishment of research objectives,formulation of teaching strategies,means and methods,empirical research on the process of teaching practice,teaching measurement and evaluation,and so on.Finally,it summarizes the connotation of the integration of excellent Chinese traditional culture into the training of acupuncture and massage professionals,in order to provide new ideas and methods for the integration of excellent Chinese traditional culture into the training and education of acupuncture and massage professionals.展开更多
At the end of 2019,the sudden outbreak of the COVID-19 epidemic brought great challenges to the world,and China's tourism industry suffered an unprecedented heavy blow.Exploring the impact of the epidemic on touri...At the end of 2019,the sudden outbreak of the COVID-19 epidemic brought great challenges to the world,and China's tourism industry suffered an unprecedented heavy blow.Exploring the impact of the epidemic on tourism consumption structure has become a research focus in the post-epidemic era.In this study,based on Shandong Tourism Statistics Handbook from 2018 to 2020,taking Shandong Province as an example,the changes of total tourism revenue and tourism consumption structure in Shandong Province before and after the COVID-19 epidemic were compared to predict the development of tourism in Shandong Province in the post-epidemic era and find out existing problems,and optimization paths were put forward for the development of tourism in Shandong Province in the post-epidemic era.展开更多
Tourism is gradually becoming one of the pillar industries of China s economy. Tourism resources are the premise and foundation of tourism development. It is of great significance to study the exploitation of tourism ...Tourism is gradually becoming one of the pillar industries of China s economy. Tourism resources are the premise and foundation of tourism development. It is of great significance to study the exploitation of tourism resources to promote the development of tourism. Jinan is famous for water, and Baimai Spring Park is a collection of springs in one place, with rich tourism resources. Coupled with the local government s attention to tourism, Baimai Spring Park, as a representative, has accumulated a rich tourism market foundation. With the support of policies, unique spring ecological and cultural resources and increasingly perfect location conditions, the high-quality development of tourism resources in Baimai Spring Park is particularly urgent. In this study, the present situation and problems of development of tourism resources in Baimai Spring Park were analyzed by questionnaire survey method, and corresponding optimization suggestions were put forward.展开更多
Objective Obstructive sleep apnea (OSA) is closely related to obesity, insulin resistance and inflammation. Secreted frizzled-related protein 5 (SFRP5) is a recently discovered adipokine. It is involved in insulin res...Objective Obstructive sleep apnea (OSA) is closely related to obesity, insulin resistance and inflammation. Secreted frizzled-related protein 5 (SFRP5) is a recently discovered adipokine. It is involved in insulin resistance and inflammation in obesity. This study aimed at evaluating the association between SFRP5and sleeping characteristics as well as biochemical parameters of OSA patients.Methods This was a prospective case control study. Nondiabetic OSA patients and controls were consecutively recruited and divided into three groups: OSA group, apnea–hypopnea Index (AHI)≥5/h; healthy controls with normal body mass index (BMI); obese controls without OSA, and BMI > 24.0 kg/m2. All participants underwent polysomnography (PSG). Plasma SFRP5 was examined using enzyme-linked immunosorbent assay (ELISA). Blood biochemical examinations, including fasting blood glucose (FBG), lipid profile, hypersensitive Creactive protein (hsCRP), were performed early in the morning after PSG. Patients with severe OSA were treated with nasal continuous positive airway pressure (nCPAP), and plasma SFRP5 was repeatedly measured for comparison.Results Sixty-eight subjects were enrolled in the study, including 38 patients of OSA, whose medium AHI was 58.70 /h (36.63, 71.15), 20 obese controls, and 10 healthy controls. The plasma SFRP5 level of OSA patients was not significantly different from that of healthy controls or obese controls. In OSA patients, SFRP5 level correlated positively with triglyceride level (r=0.447, P=0.005) and negatively with LDL-cholesterol level and HDLcholesterol level (r=?0.472 and P=0.003; r=?0.478 and P=0.002; respectively). SFRP5 level was not found correlating with FBG, AHI, or any of nocturnal hypoxia parameters. After overnight nCPAP treatment, plasma SFRP5 levels of OSA patients did not change significantly (t=1.557, P = 0.148) compared to that of pretreatment.Conclusions In nondiabetic OSA patients, plasma SFRP5 is associated with the lipid profile. However,no correlation was observed between SFRP5 and FBG or sleep parameters. The SFRP5 level of OSA patients did not differ from that of non-OSA individuals in our study.展开更多
Porphyromonas gingivalis(P.gingivalis),a key pathogen in periodontitis,has been shown to accelerate the progression of atherosclerosis(AS).However,the definite mechanisms remain elusive.Emerging evidence supports an a...Porphyromonas gingivalis(P.gingivalis),a key pathogen in periodontitis,has been shown to accelerate the progression of atherosclerosis(AS).However,the definite mechanisms remain elusive.Emerging evidence supports an association between mitochondrial dysfunction and AS.In our study,the impact of P.gingivalis on mitochondrial dysfunction and the potential mechanism were investigated.The mitochondrial morphology of EA.hy926 cells infected with P.gingivalis was assessed by transmission electron microscopy,mitochondrial staining,and quantitative analysis of the mitochondrial network.Fluorescence staining and flow cytometry analysis were performed to determine mitochondrial reactive oxygen species(mtROS)and mitochondrial membrane potential(MMP)levels.Cellular ATP production was examined by a luminescence assay kit.The expression of key fusion and fission proteins was evaluated by western blot and immunofluorescence.Mdivi-1,a specific Drp1 inhibitor,was used to elucidate the role of Drp1 in mitochondrial dysfunction.Our findings showed that P.gingivalis infection induced mitochondrial fragmentation,increased the mtROS levels,and decreased the MMP and ATP concentration in vascular endothelial cells.We observed upregulation of Drp1(Ser616)phosphorylation and translocation of Drp1 to mitochondria.Mdivi-1 blocked the mitochondrial fragmentation and dysfunction induced by P.gingivalis.Collectively,these results revealed that P.gingivalis infection promoted mitochondrial fragmentation and dysfunction,which was dependent on Drp1.Mitochondrial dysfunction may represent the mechanism by which P.gingivalis exacerbates atherosclerotic lesions.展开更多
Background:The Yangtze River floodplain provides important wintering habitats for Hooded Cranes(Grus monacha) in China.Fluctuations in the water level change foraging habitat and food availability,affecting their temp...Background:The Yangtze River floodplain provides important wintering habitats for Hooded Cranes(Grus monacha) in China.Fluctuations in the water level change foraging habitat and food availability,affecting their temporal-spatial patterns of foraging activities.It is of considerable importance to investigate the effect of these fluctuations on food availability for wintering Hooded Cranes and their foraging response to these changes.Understanding their behavior patterns is beneficial in protecting the wintering crane population and restoring their wintering habitats.Methods:A field survey of the winter behavior of cranes was carried out at Shengjin Lake from November in 2013 to April in 2014.Habitat variables,as well as the spatial distribution and behavior patterns of wintering cranes at their foraging sites during five stages of water level fluctuation were collected.Based on this data we analyzed the relationship of foraging behavior relative to water level fluctuations and habitat types.Results:The foraging habitats used by Hooded Cranes varied at the different water level stages.As the water level decreased,the use of meadows and mudflats increased.When the water dropped to its lowest level,the use by the Hooded Crane in the mudflats reached a peak.There were statistically significant differences in time budget in the three types of habitats over the five stages of the water level.In the mudflats,the foraging behavior and maintenance behavior varied significantly with the water level,while the alert behavior showed little variation.Analysis of a generalized linear model showed that the five water level stages and three habitat types had a significant effect on foraging behavior,while the combined effect of these two variables was significant on the foraging time budget and the length of foraging activity of the Hooded Crane.Conclusions:With the decrease in the water level,the use of mudflats by Hooded Cranes increased correspondingly.Food availability in different habitats was affected by changes in the water level.The Hooded Crane adjusted its foraging patterns and made full use of the three available types of habitat in order to acquire enough food in response to fluctuations in the water level.展开更多
This study investigated the effects of Yishendaluo decoction on the loss of blood-brain barrier integrity in mice exhibiting experimental autoimmune encephalomyelitis.To this end,we used real-time fluorescent quantita...This study investigated the effects of Yishendaluo decoction on the loss of blood-brain barrier integrity in mice exhibiting experimental autoimmune encephalomyelitis.To this end,we used real-time fluorescent quantitative PCR to measure the levels of mRNAs specific to the T cell markers CD4 and CD8,and the monocyte marker CD11b.In addition,we used Evans blue dye extravasation in the spinal cord and brain tissues to assess blood-brain barrier permeability.The results indicated that an increase in blood-brain barrier permeability was associated with an increase in CD4,CD8 and CD11b mRNA expression in experimental autoimmune encephalomyelitis mice.Yishendaluo decoction administration significantly reversed inflammatory cell accumulation in cerebral tissues of experimental autoimmune encephalomyelitis mice.展开更多
CD93 and GAIP-interacting protein,C termius(GIPC) have been shown to interactively alter phagocytic processes of immune cells.CD93 and GIPC expression and localization during central nervous system inflammation have n...CD93 and GAIP-interacting protein,C termius(GIPC) have been shown to interactively alter phagocytic processes of immune cells.CD93 and GIPC expression and localization during central nervous system inflammation have not yet been reported.In this study,we established a rat model of brain inflammation by lipopolysaccharide injection to the lateral ventricle.In the brain of rats with inflammation,western blots showed increased CD93 expression that decreased over time.GIPC expression was unaltered.Immunohistochemistry demonstrated extensive distribution of CD93 expression mainly in cell membranes in the cerebral cortex.After lipopolysaccharide stimulation,CD93 expression increased and then reduced,with distinct staining in the cytoplasm and nucleus.Double immunofluorescence staining in cerebral cortex of normal rats showed that CD93 and GIPC widely expressed in resting microglia and neurons.CD93 was mainly expressed in microglial and neuronal cell membranes,while GIPC was expressed in both cell membrane and cytoplasm.In the cerebral cortex at 9 hours after model establishment,CD93-immunoreactive signal diminished in microglial membrane,with cytoplasmic translocation and aggregation detected.GIPC localization was unaltered in neurons and microglia.These results are the first to demonstrate CD93 participation in pathophysiological processes of central nervous system inflammation.展开更多
The influence of a deep excavation on existing shield tunnels nearby is a vital issue in tunnelling engineering.Whereas,there lacks robust methods to predict excavation-induced tunnel displacements.In this study,an au...The influence of a deep excavation on existing shield tunnels nearby is a vital issue in tunnelling engineering.Whereas,there lacks robust methods to predict excavation-induced tunnel displacements.In this study,an auto machine learning(AutoML)-based approach is proposed to precisely solve the issue.Seven input parameters are considered in the database covering two physical aspects,namely soil property,and spatial characteristics of the deep excavation.The 10-fold cross-validation method is employed to overcome the scarcity of data,and promote model’s robustness.Six genetic algorithm(GA)-ML models are established as well for comparison.The results indicated that the proposed AutoML model is a comprehensive model that integrates efficiency and robustness.Importance analysis reveals that the ratio of the average shear strength to the vertical effective stress E_(ur)/σ′_(v),the excavation depth H,and the excavation width B are the most influential variables for the displacements.Finally,the AutoML model is further validated by practical engineering.The prediction results are in a good agreement with monitoring data,signifying that our model can be applied in real projects.展开更多
Forest tourist areas have an excellent ecological environment,which is conducive to people's physical and mental health.In this study,Fuzhou National Forest Park and Wuying National Forest Park were selected as ty...Forest tourist areas have an excellent ecological environment,which is conducive to people's physical and mental health.In this study,Fuzhou National Forest Park and Wuying National Forest Park were selected as typical representatives of the southern and northern forest parks,respectively,which were compared by qualitative and quantitative research methods from such five aspects as air quality,climate quality,water environment quality,acoustic environment quality and biological population in some forest areas.The results showed that Fuzhou National Forest Park has a concentration of negative oxygen ions much higher than Wuying National Forest Park,and is thus more conducive to people's health;and it has the characteristics of warm and comfortable climate throughout the year and high biodiversity,but the noise is 4.35 db higher than Wuying National Forest Park,and the water quality is slightly poorer than that of Wuying National Forest Park.And its DO value is about 3.89 smaller in autumn than in summer.In Wuying National Forest Park,the concentration of negative oxygen ions is 53.6% lower than Fuzhou National Forest Park,but it is also above the national standard.The climate is only comfortable in June-August,and is colder or cooler in other months.The water quality is better than that of Fuzhou National Forest Park.In particular,the PH value is about 0.38 lower than that of Fuzhou National Forest Park.It has its own unique biological characteristics.The number of tourists in summer is higher,resulting in higher noise in summer than in autumn.The two forest parks in the north and the south are both good places for people to relax and enjoy.展开更多
文摘In recent years,the integrated development of the tea and tourism has become an important way to promote the rural revitalization of Tai'an tea-producing areas,but the state of industrial upgrading still needs to be improved.In order to better integrate tea and tourism in Tea Valley,this paper uses questionnaire and SWOT analysis to study.It found the following problems:(i)45.7%of tourists were interested in tea culture,but they know litle about it,and the integration of tea culture and tea tourism products is low.(i)50.54%of the tourists were interested in the tea picking experience project and wanted to add the tea food experience item.(ii)The acceptance of 45.7%of tourists to scenic spots was 1-2 h,which shows that the quality of transportation service facilities and personnel needs to be improved.Combined with the SWOT analysis,it is found that the scenic spot is rich in resources,convenient transportation,profound cultural heritage,and good govern-ment policy support conditions,which is suitable for the SO strategy(growth development strategy),so the scenic spot relies on internal ad-vantages and seizes external opportunities to develop the integration of tea and tourism.Based on the analysis results,it came up with the perti-nent recommendations for the key problems:(i)The infrastructure service is not well established.It is suggested that scenic spots should in-crease investment,regularly train service personnel to improve their quality,and improve transportation services,accommodation,catering and public service hardware facilities.(i)Tea tourism products are insufficient.It is suggested that tea tourism products should be innovatively designed and tea tourism experiential products and tourism commodities should be planned.(i)Tea culture and tourism lack organic combi-nation.It is recommended to deeply excavate tea culture,and take consideration of both spiritual and material aspects.The specific methods include building teahouses,Taishan Mountain(Mount Tai)tea culture throughout the whole process of tea production,development and pro-cessing,and AR tea culture experience hall can be built to make tourists feel tea culture from dfferent perspectives.(iv)The publicity is in-sufficient.Strategies should be made in three aspects:improving the Internet media,taking into account the traditional media,and expanding the market based on the surrounding areas.(v)The tea industry chain is short.It is recommended to add four new industrial chain designs of"tea+accommodation,tea+catering,tea+Intemet,tea+training",hoping to bring some inspiration and ideas to the managers of scenic spots.
基金supported by the National Natural Science Foundation of China(No.52101262)Distinguished Youth Foundation of Hubei Province(2019CFA084)+1 种基金Educational offi ce of Hubei Province(Q20201201)the 111 project(D20015).
文摘The safe operating voltage and low volume variation of Li_(3)VO_(4)(LVO)make it an ideal anode material for lithium(Li)-ion batteries.However,the insufficient understanding of the inner storage mechanism hinders the design of LVO-based electrodes.Herein,we investigate,for the first time,the Li-ion storage activity in LVO via Cl doping.Moreover,N-doped C coating was simultaneously achieved in the Cl doping process,resulting in synergistically improved reaction kinetics.As a result,the as-prepared Cl-doped Li_(3)VO_(4) coated with N-doped C(Cl-LVO@NC)electrodes deliver a discharge capacity of 884.1 mAh/g after 200 cycles at 0.2 A/g,which is the highest among all of the LVO-based electrodes.The Cl-LVO@NC electrodes also exhibit high-capacity retention of 331.1 mAh/g at 8.0 A/g and full capacity recovery after 5 periods of rate testing over 400 cycles.After 5000 cycles at 4.0 A/g,the discharge capacity can be maintained at 423.2 mAh/g,which is superior to most LVO-based electrodes.The Li-ion storage activity in LVO via Cl doping and significant improvement in the high-rate Li-ion storage reported in this work can be used as references for the design of advanced LVO-based electrodes for high-power applications.
文摘To improve the operation efficiency of the photovoltaic power station complementary power generation system,an optimal allocation model of the photovoltaic power station complementary power generation capacity based on PSO-BP is proposed.Particle Swarm Optimization and BP neural network are used to establish the forecasting model,the Markov chain model is used to correct the forecasting error of the model,and the weighted fitting method is used to forecast the annual load curve,to complete the optimal allocation of complementary generating capacity of photovoltaic power stations.The experimental results show that thismethod reduces the average loss of photovoltaic output prediction,improves the prediction accuracy and recall rate of photovoltaic output prediction,and ensures the effective operation of the power system.
基金Supported by National Natural Science Foundation of China(82174525)Jilin Science and Technology Development Plan Project(YDZJ202201ZYTS195)+2 种基金Jilin Natural Science Foundation(YDZJ202301ZYTS469)Jilin Traditional Chinese Medicine Science and Technology Project in 2022(2022128)2023 Youth Outstanding Discipline Backbone Training Project of Changchun University of Chinese Medicine(202304).
文摘[Objectives] To study the effect of "acupressure therapy" on anti-inflammatory mechanism in obesity-induced IR rats. [Methods] 10 rats were randomly selected and fed with normal diet as blank group, and the remaining 30 rats were fed with high-fat diet for 8 weeks. The obesity-induced IR model was induced and divided into two groups: model group and acupressure group. The acupressure group was treated by "acupressure therapy" three times a week for 6 weeks;the model group was taken 3 times at the same time every week, and the supine binding experiment lasted for 10 min for 6 weeks. Morphological observation was carried out before and after the experiment, mainly observing the general conditions and body weight. After the last intervention, the animals were killed and samples were collected. Western Blot method was used to detect the expression of TNF-α and IL-6 protein in adipose tissue of the three groups. [Results] Compared with the blank group, the expression of TNF-α and IL-6 protein in adipose tissue of the model group increased significantly ( P <0.01);compared with the model group, the expression of TNF-α and IL-6 protein in adipose tissue of the acupressure group decreased significantly ( P <0.01). [Conclusions] After intervening in the obesity-induced IR rats with acupressure method, the status of insulin resistance in obese rats was improved by inhibiting the expression of inflammatory factors.
基金Supported by 2021 Scientific Research Project of National Chinese Medicine Examination(TC2021022)Research Project on Teaching Reform of Vocational and Adult Education in Jilin Province in 2022(2022ZCY295)+2 种基金2021 Higher Education Research Project of Jilin Institute of Higher Education(JGJX2021D170)the Thirteenth Five-Year Plan Project of Education and Science of Jilin Province in 2020(GH20169)2022 Higher Education Research Project of Jilin Institute of Higher Education(JGJX2022D129)。
文摘By reflecting on the current situation of the integration of excellent Chinese traditional culture into the training of acupuncture and massage professionals,this paper aims to carry out the research on the integration of excellent Chinese traditional culture into the training and education of acupuncture and massage.The specific implementation path includes early investigation and analysis,establishment of research objectives,formulation of teaching strategies,means and methods,empirical research on the process of teaching practice,teaching measurement and evaluation,and so on.Finally,it summarizes the connotation of the integration of excellent Chinese traditional culture into the training of acupuncture and massage professionals,in order to provide new ideas and methods for the integration of excellent Chinese traditional culture into the training and education of acupuncture and massage professionals.
文摘At the end of 2019,the sudden outbreak of the COVID-19 epidemic brought great challenges to the world,and China's tourism industry suffered an unprecedented heavy blow.Exploring the impact of the epidemic on tourism consumption structure has become a research focus in the post-epidemic era.In this study,based on Shandong Tourism Statistics Handbook from 2018 to 2020,taking Shandong Province as an example,the changes of total tourism revenue and tourism consumption structure in Shandong Province before and after the COVID-19 epidemic were compared to predict the development of tourism in Shandong Province in the post-epidemic era and find out existing problems,and optimization paths were put forward for the development of tourism in Shandong Province in the post-epidemic era.
文摘Tourism is gradually becoming one of the pillar industries of China s economy. Tourism resources are the premise and foundation of tourism development. It is of great significance to study the exploitation of tourism resources to promote the development of tourism. Jinan is famous for water, and Baimai Spring Park is a collection of springs in one place, with rich tourism resources. Coupled with the local government s attention to tourism, Baimai Spring Park, as a representative, has accumulated a rich tourism market foundation. With the support of policies, unique spring ecological and cultural resources and increasingly perfect location conditions, the high-quality development of tourism resources in Baimai Spring Park is particularly urgent. In this study, the present situation and problems of development of tourism resources in Baimai Spring Park were analyzed by questionnaire survey method, and corresponding optimization suggestions were put forward.
文摘Objective Obstructive sleep apnea (OSA) is closely related to obesity, insulin resistance and inflammation. Secreted frizzled-related protein 5 (SFRP5) is a recently discovered adipokine. It is involved in insulin resistance and inflammation in obesity. This study aimed at evaluating the association between SFRP5and sleeping characteristics as well as biochemical parameters of OSA patients.Methods This was a prospective case control study. Nondiabetic OSA patients and controls were consecutively recruited and divided into three groups: OSA group, apnea–hypopnea Index (AHI)≥5/h; healthy controls with normal body mass index (BMI); obese controls without OSA, and BMI > 24.0 kg/m2. All participants underwent polysomnography (PSG). Plasma SFRP5 was examined using enzyme-linked immunosorbent assay (ELISA). Blood biochemical examinations, including fasting blood glucose (FBG), lipid profile, hypersensitive Creactive protein (hsCRP), were performed early in the morning after PSG. Patients with severe OSA were treated with nasal continuous positive airway pressure (nCPAP), and plasma SFRP5 was repeatedly measured for comparison.Results Sixty-eight subjects were enrolled in the study, including 38 patients of OSA, whose medium AHI was 58.70 /h (36.63, 71.15), 20 obese controls, and 10 healthy controls. The plasma SFRP5 level of OSA patients was not significantly different from that of healthy controls or obese controls. In OSA patients, SFRP5 level correlated positively with triglyceride level (r=0.447, P=0.005) and negatively with LDL-cholesterol level and HDLcholesterol level (r=?0.472 and P=0.003; r=?0.478 and P=0.002; respectively). SFRP5 level was not found correlating with FBG, AHI, or any of nocturnal hypoxia parameters. After overnight nCPAP treatment, plasma SFRP5 levels of OSA patients did not change significantly (t=1.557, P = 0.148) compared to that of pretreatment.Conclusions In nondiabetic OSA patients, plasma SFRP5 is associated with the lipid profile. However,no correlation was observed between SFRP5 and FBG or sleep parameters. The SFRP5 level of OSA patients did not differ from that of non-OSA individuals in our study.
基金supported by grants from National Natural Science Foundation of China(NO.81970943,81870771)。
文摘Porphyromonas gingivalis(P.gingivalis),a key pathogen in periodontitis,has been shown to accelerate the progression of atherosclerosis(AS).However,the definite mechanisms remain elusive.Emerging evidence supports an association between mitochondrial dysfunction and AS.In our study,the impact of P.gingivalis on mitochondrial dysfunction and the potential mechanism were investigated.The mitochondrial morphology of EA.hy926 cells infected with P.gingivalis was assessed by transmission electron microscopy,mitochondrial staining,and quantitative analysis of the mitochondrial network.Fluorescence staining and flow cytometry analysis were performed to determine mitochondrial reactive oxygen species(mtROS)and mitochondrial membrane potential(MMP)levels.Cellular ATP production was examined by a luminescence assay kit.The expression of key fusion and fission proteins was evaluated by western blot and immunofluorescence.Mdivi-1,a specific Drp1 inhibitor,was used to elucidate the role of Drp1 in mitochondrial dysfunction.Our findings showed that P.gingivalis infection induced mitochondrial fragmentation,increased the mtROS levels,and decreased the MMP and ATP concentration in vascular endothelial cells.We observed upregulation of Drp1(Ser616)phosphorylation and translocation of Drp1 to mitochondria.Mdivi-1 blocked the mitochondrial fragmentation and dysfunction induced by P.gingivalis.Collectively,these results revealed that P.gingivalis infection promoted mitochondrial fragmentation and dysfunction,which was dependent on Drp1.Mitochondrial dysfunction may represent the mechanism by which P.gingivalis exacerbates atherosclerotic lesions.
基金supported by the National Natural Science Foundation of China(Grant no.31172117,31472020)the Graduate Student Innovation Research Projects of Anhui University(YQH100269)
文摘Background:The Yangtze River floodplain provides important wintering habitats for Hooded Cranes(Grus monacha) in China.Fluctuations in the water level change foraging habitat and food availability,affecting their temporal-spatial patterns of foraging activities.It is of considerable importance to investigate the effect of these fluctuations on food availability for wintering Hooded Cranes and their foraging response to these changes.Understanding their behavior patterns is beneficial in protecting the wintering crane population and restoring their wintering habitats.Methods:A field survey of the winter behavior of cranes was carried out at Shengjin Lake from November in 2013 to April in 2014.Habitat variables,as well as the spatial distribution and behavior patterns of wintering cranes at their foraging sites during five stages of water level fluctuation were collected.Based on this data we analyzed the relationship of foraging behavior relative to water level fluctuations and habitat types.Results:The foraging habitats used by Hooded Cranes varied at the different water level stages.As the water level decreased,the use of meadows and mudflats increased.When the water dropped to its lowest level,the use by the Hooded Crane in the mudflats reached a peak.There were statistically significant differences in time budget in the three types of habitats over the five stages of the water level.In the mudflats,the foraging behavior and maintenance behavior varied significantly with the water level,while the alert behavior showed little variation.Analysis of a generalized linear model showed that the five water level stages and three habitat types had a significant effect on foraging behavior,while the combined effect of these two variables was significant on the foraging time budget and the length of foraging activity of the Hooded Crane.Conclusions:With the decrease in the water level,the use of mudflats by Hooded Cranes increased correspondingly.Food availability in different habitats was affected by changes in the water level.The Hooded Crane adjusted its foraging patterns and made full use of the three available types of habitat in order to acquire enough food in response to fluctuations in the water level.
基金the National Natural Science Foundation of China, No. 30672692
文摘This study investigated the effects of Yishendaluo decoction on the loss of blood-brain barrier integrity in mice exhibiting experimental autoimmune encephalomyelitis.To this end,we used real-time fluorescent quantitative PCR to measure the levels of mRNAs specific to the T cell markers CD4 and CD8,and the monocyte marker CD11b.In addition,we used Evans blue dye extravasation in the spinal cord and brain tissues to assess blood-brain barrier permeability.The results indicated that an increase in blood-brain barrier permeability was associated with an increase in CD4,CD8 and CD11b mRNA expression in experimental autoimmune encephalomyelitis mice.Yishendaluo decoction administration significantly reversed inflammatory cell accumulation in cerebral tissues of experimental autoimmune encephalomyelitis mice.
基金supported by the National Natural Science Foundation of China,No.31170766the Nantong Municipal Social Undertakings Technological Innovation and Demonstration Project Foundation,No.HS2012032the Natural Science Pre-research Project Foundation of Nantong University in 2012,No.12ZY020
文摘CD93 and GAIP-interacting protein,C termius(GIPC) have been shown to interactively alter phagocytic processes of immune cells.CD93 and GIPC expression and localization during central nervous system inflammation have not yet been reported.In this study,we established a rat model of brain inflammation by lipopolysaccharide injection to the lateral ventricle.In the brain of rats with inflammation,western blots showed increased CD93 expression that decreased over time.GIPC expression was unaltered.Immunohistochemistry demonstrated extensive distribution of CD93 expression mainly in cell membranes in the cerebral cortex.After lipopolysaccharide stimulation,CD93 expression increased and then reduced,with distinct staining in the cytoplasm and nucleus.Double immunofluorescence staining in cerebral cortex of normal rats showed that CD93 and GIPC widely expressed in resting microglia and neurons.CD93 was mainly expressed in microglial and neuronal cell membranes,while GIPC was expressed in both cell membrane and cytoplasm.In the cerebral cortex at 9 hours after model establishment,CD93-immunoreactive signal diminished in microglial membrane,with cytoplasmic translocation and aggregation detected.GIPC localization was unaltered in neurons and microglia.These results are the first to demonstrate CD93 participation in pathophysiological processes of central nervous system inflammation.
基金supported by the National Natural Science Foundation of China(Grant Nos.51978517,52090082,and 52108381)Innovation Program of Shanghai Municipal Education Commission(Grant No.2019-01-07-00-07-456 E00051)Shanghai Science and Technology Committee Program(Grant Nos.21DZ1200601 and 20DZ1201404).
文摘The influence of a deep excavation on existing shield tunnels nearby is a vital issue in tunnelling engineering.Whereas,there lacks robust methods to predict excavation-induced tunnel displacements.In this study,an auto machine learning(AutoML)-based approach is proposed to precisely solve the issue.Seven input parameters are considered in the database covering two physical aspects,namely soil property,and spatial characteristics of the deep excavation.The 10-fold cross-validation method is employed to overcome the scarcity of data,and promote model’s robustness.Six genetic algorithm(GA)-ML models are established as well for comparison.The results indicated that the proposed AutoML model is a comprehensive model that integrates efficiency and robustness.Importance analysis reveals that the ratio of the average shear strength to the vertical effective stress E_(ur)/σ′_(v),the excavation depth H,and the excavation width B are the most influential variables for the displacements.Finally,the AutoML model is further validated by practical engineering.The prediction results are in a good agreement with monitoring data,signifying that our model can be applied in real projects.
基金Supported by National Natural Science Foundation of China(41907050)Natural Science Foundation of Shandong Province(ZR2019MD031)Scientific Research Projects in Colleges and Universities in Shandong Province(J18KA197)
文摘Forest tourist areas have an excellent ecological environment,which is conducive to people's physical and mental health.In this study,Fuzhou National Forest Park and Wuying National Forest Park were selected as typical representatives of the southern and northern forest parks,respectively,which were compared by qualitative and quantitative research methods from such five aspects as air quality,climate quality,water environment quality,acoustic environment quality and biological population in some forest areas.The results showed that Fuzhou National Forest Park has a concentration of negative oxygen ions much higher than Wuying National Forest Park,and is thus more conducive to people's health;and it has the characteristics of warm and comfortable climate throughout the year and high biodiversity,but the noise is 4.35 db higher than Wuying National Forest Park,and the water quality is slightly poorer than that of Wuying National Forest Park.And its DO value is about 3.89 smaller in autumn than in summer.In Wuying National Forest Park,the concentration of negative oxygen ions is 53.6% lower than Fuzhou National Forest Park,but it is also above the national standard.The climate is only comfortable in June-August,and is colder or cooler in other months.The water quality is better than that of Fuzhou National Forest Park.In particular,the PH value is about 0.38 lower than that of Fuzhou National Forest Park.It has its own unique biological characteristics.The number of tourists in summer is higher,resulting in higher noise in summer than in autumn.The two forest parks in the north and the south are both good places for people to relax and enjoy.
