Objective:A protein-based leaking-proof theranostic nanoplatform for dual-modality imaging-guided tumor photodynamic therapy(PDT)has been designed.Impact Statement:A site-specific conjugation of chlorin e6(Ce6)to ferr...Objective:A protein-based leaking-proof theranostic nanoplatform for dual-modality imaging-guided tumor photodynamic therapy(PDT)has been designed.Impact Statement:A site-specific conjugation of chlorin e6(Ce6)to ferrimagnetic ferritin(MFtn-Ce6)has been constructed to address the challenge of unexpected leakage that often occurs during small-molecule drug delivery.Introduction:PDT is one of the most promising approaches for tumor treatment,while a delivery system is typically required for hydrophobic photosensitizers.However,the nonspecific distribution and leakage of photosensitizers could lead to insufficient drug accumulation in tumor sites.Methods:An engineered ferritin was generated for site-specific conjugation of Ce6 to obtain a leaking-proof delivery system,and a ferrimagnetic core was biomineralized in the cavity of ferritin,resulting in a fluorescent ferrimagnetic ferritin nanoplatform(MFtn-Ce6).The distribution and tumor targeting of MFtn-Ce6 can be detected by magnetic resonance imaging(MRI)and fluorescence imaging(FLI).Results:MFtn-Ce6 showed effective dual-modality MRI and FLI.A prolonged in vivo circulation and increased tumor accumulation and retention of photosensitizer was observed.The time-dependent distribution of MFtn-Ce6 can be precisely tracked in real time to find the optimal time window for PDT treatment.The colocalization of ferritin and the iron oxide core confirms the high stability of the nanoplatform in vivo.The results showed that mice treated with MFtn-Ce6 exhibited marked tumor-suppressive activity after laser irradiation.Conclusion:The ferritin-based leaking-proof nanoplatform can be used for the efficient delivery of the photosensitizer to achieve an enhanced therapeutic effect.This method established a general approach for the dual-modality imagingguided tumor delivery of PDT agents.展开更多
The stimulated Brillouin scattering phase conjugation mirror (SBS-PCM) based on liquid media is widely used in high-power laser systems due to its robust thermal load capacity, high energy conversion efficiency and im...The stimulated Brillouin scattering phase conjugation mirror (SBS-PCM) based on liquid media is widely used in high-power laser systems due to its robust thermal load capacity, high energy conversion efficiency and improved beam quality. Nevertheless, with an increase in the pump repetition rate, thermally-induced blooming and optical breakdown can emerge, leading to distortions in the Stokes beam. In this study, we delved into the thermal effects in liquid SBS-PCMs employing hydrodynamic analysis, establishing a relationship between beam profile distortion and the thermal convection field. We calculated the temperature and convection velocity distribution based on the pump light parameters and recorded the corresponding beam profiles. The intensities of the beam profiles were modulated in alignment with the convection directions, reaching a velocity peak of 2.85 mm/s at a pump pulse repetition rate of 250 Hz. The residual sum of squares (RSS) was employed to quantify the extent of beam profile distortion relative to a Gaussian distribution. The RSS escalated to 7.8, in contrast to 0.7 of the pump light at a pump pulse repetition rate of 500 Hz. By suppressing thermal convection using a high-viscosity medium, we effectively mitigated beam distortion. The RSS was reduced to 0.7 at a pump pulse repetition rate of 500 Hz, coinciding with a twentyfold increase in viscosity, thereby enhancing the beam quality. By integrating hydrodynamic analysis, we elucidated and mitigated distortion with targeted solutions. Our research offers an interdisciplinary perspective on studying thermal effects and contributes to the application of SBS-PCMs in high-repetition-rate laser systems by unveiling the mechanism of photothermal effects.展开更多
This study analyzes the linewidth narrowing characteristics of free-space-running Brillouin lasers and investigates the approaches to achieve linewidth compression and power enhancement simultaneously.The results show...This study analyzes the linewidth narrowing characteristics of free-space-running Brillouin lasers and investigates the approaches to achieve linewidth compression and power enhancement simultaneously.The results show that the Stokes linewidth behavior in a free-space-running Brillouin laser cavity is determined by the phase diffusion of the pump and the technical noise of the system.Experimentally,a Stokes light output with a power of 22.5 W and a linewidth of 3.2 kHz was obtained at a coupling mirror reflectivity of 96%,which is nearly 2.5 times compressed compared with the linewidth of the pump(7.36 kHz).In addition,the theorical analysis shows that at a pump power of 60Wand a coupling mirror reflectivity of 96%,a Stokes output with a linewidth of 1.6 kHz and up to 80%optical conversion efficiency can be achieved by reducing the insertion loss of the intracavity.This study provides a promising technical route to achieve high-power ultra-narrow linewidth special wavelength laser radiations.展开更多
A new low_temperature anomalous magnetism at about 29 K for the oxygen doped (Eu 1- x Y x ) 2CuO 4 and Sm 2CuO 4, prepared under high pressure, has been investigated. This anomaly originated from different mechanisms ...A new low_temperature anomalous magnetism at about 29 K for the oxygen doped (Eu 1- x Y x ) 2CuO 4 and Sm 2CuO 4, prepared under high pressure, has been investigated. This anomaly originated from different mechanisms to weak ferromagnetism (WF) behavior of T′ phase, and should be assigned to the ferromagnetic clusters formed by doped holes.展开更多
基金This work was supported by the National Key R&D Program of China(2020YFA0710700 and 2017YFA0505400)the National Natural Science Foundation of China(52021002,21877103,22177109,and 32101121)+2 种基金Users with Excellence Program of Hefei Science Center CAS(2020HSC-UE016)the Fundamental Research Funds for the Central Universities(WK3450000007)Suzhou Scientific and Technological Project(SYG202017).
文摘Objective:A protein-based leaking-proof theranostic nanoplatform for dual-modality imaging-guided tumor photodynamic therapy(PDT)has been designed.Impact Statement:A site-specific conjugation of chlorin e6(Ce6)to ferrimagnetic ferritin(MFtn-Ce6)has been constructed to address the challenge of unexpected leakage that often occurs during small-molecule drug delivery.Introduction:PDT is one of the most promising approaches for tumor treatment,while a delivery system is typically required for hydrophobic photosensitizers.However,the nonspecific distribution and leakage of photosensitizers could lead to insufficient drug accumulation in tumor sites.Methods:An engineered ferritin was generated for site-specific conjugation of Ce6 to obtain a leaking-proof delivery system,and a ferrimagnetic core was biomineralized in the cavity of ferritin,resulting in a fluorescent ferrimagnetic ferritin nanoplatform(MFtn-Ce6).The distribution and tumor targeting of MFtn-Ce6 can be detected by magnetic resonance imaging(MRI)and fluorescence imaging(FLI).Results:MFtn-Ce6 showed effective dual-modality MRI and FLI.A prolonged in vivo circulation and increased tumor accumulation and retention of photosensitizer was observed.The time-dependent distribution of MFtn-Ce6 can be precisely tracked in real time to find the optimal time window for PDT treatment.The colocalization of ferritin and the iron oxide core confirms the high stability of the nanoplatform in vivo.The results showed that mice treated with MFtn-Ce6 exhibited marked tumor-suppressive activity after laser irradiation.Conclusion:The ferritin-based leaking-proof nanoplatform can be used for the efficient delivery of the photosensitizer to achieve an enhanced therapeutic effect.This method established a general approach for the dual-modality imagingguided tumor delivery of PDT agents.
基金supported by the National Natural Science Foundation of China (Nos. 61927815 and 62075056)the Natural Science Foundation of Tianjin City (No. 22JCYBJC01100)+2 种基金the Natural Science Foundation of Hebei Province (No. F2023202063)the Funds for Basic Scientific Research of Hebei University of Technology (No. JBKYTD2201)support from the Shijiazhuang Overseas Talents Introduction Project (No. 20230004)
文摘The stimulated Brillouin scattering phase conjugation mirror (SBS-PCM) based on liquid media is widely used in high-power laser systems due to its robust thermal load capacity, high energy conversion efficiency and improved beam quality. Nevertheless, with an increase in the pump repetition rate, thermally-induced blooming and optical breakdown can emerge, leading to distortions in the Stokes beam. In this study, we delved into the thermal effects in liquid SBS-PCMs employing hydrodynamic analysis, establishing a relationship between beam profile distortion and the thermal convection field. We calculated the temperature and convection velocity distribution based on the pump light parameters and recorded the corresponding beam profiles. The intensities of the beam profiles were modulated in alignment with the convection directions, reaching a velocity peak of 2.85 mm/s at a pump pulse repetition rate of 250 Hz. The residual sum of squares (RSS) was employed to quantify the extent of beam profile distortion relative to a Gaussian distribution. The RSS escalated to 7.8, in contrast to 0.7 of the pump light at a pump pulse repetition rate of 500 Hz. By suppressing thermal convection using a high-viscosity medium, we effectively mitigated beam distortion. The RSS was reduced to 0.7 at a pump pulse repetition rate of 500 Hz, coinciding with a twentyfold increase in viscosity, thereby enhancing the beam quality. By integrating hydrodynamic analysis, we elucidated and mitigated distortion with targeted solutions. Our research offers an interdisciplinary perspective on studying thermal effects and contributes to the application of SBS-PCMs in high-repetition-rate laser systems by unveiling the mechanism of photothermal effects.
基金the National Natural Science Foundation of China(No.61927815)the Natural Science Foundation of Tianjin City(Nos.22JCYBJC01100 and 20JCZDJC00430)+4 种基金the Shijiazhuang Overseas Talents Introduction Project(No.20230004)the Program of State Key Laboratory of Quantum Optics and Quantum Optics Devices(No.KF202201)Funds for Basic Scientific Research of Hebei University of Technology(No.JBKYTD2201)D.J.acknowledges the support from the Postgraduate Innovation Ability Training Program of Hebei Province(No.CXZZBS2021030)R.P.M.acknowledges the support from the Asian Office of Aerospace Research and Development(AOARD).
文摘This study analyzes the linewidth narrowing characteristics of free-space-running Brillouin lasers and investigates the approaches to achieve linewidth compression and power enhancement simultaneously.The results show that the Stokes linewidth behavior in a free-space-running Brillouin laser cavity is determined by the phase diffusion of the pump and the technical noise of the system.Experimentally,a Stokes light output with a power of 22.5 W and a linewidth of 3.2 kHz was obtained at a coupling mirror reflectivity of 96%,which is nearly 2.5 times compressed compared with the linewidth of the pump(7.36 kHz).In addition,the theorical analysis shows that at a pump power of 60Wand a coupling mirror reflectivity of 96%,a Stokes output with a linewidth of 1.6 kHz and up to 80%optical conversion efficiency can be achieved by reducing the insertion loss of the intracavity.This study provides a promising technical route to achieve high-power ultra-narrow linewidth special wavelength laser radiations.
文摘A new low_temperature anomalous magnetism at about 29 K for the oxygen doped (Eu 1- x Y x ) 2CuO 4 and Sm 2CuO 4, prepared under high pressure, has been investigated. This anomaly originated from different mechanisms to weak ferromagnetism (WF) behavior of T′ phase, and should be assigned to the ferromagnetic clusters formed by doped holes.
