期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Enigmatic origin of hepatitis B virus:An ancient travelling companion or a recent encounter? 被引量:3
1
作者 Gianguglielmo Zehender Erika Ebranati +5 位作者 elena gabanelli Chiara Sorrentino Alessra Lo Presti Elisabetta Tanzi Massimo Ciccozzi Massimo Galli 《World Journal of Gastroenterology》 SCIE CAS 2014年第24期7622-7634,共13页
Hepatitis B virus(HBV)is the leading cause of liver disease and infects an estimated 240 million people worldwide.It is characterised by a high degree of genetic heterogeneity because of the use of a reverse transcrip... Hepatitis B virus(HBV)is the leading cause of liver disease and infects an estimated 240 million people worldwide.It is characterised by a high degree of genetic heterogeneity because of the use of a reverse transcriptase during viral replication.The ten genotypes(A-J)that have been described so far further segregate into a number of subgenotypes which have distinct ethno-geographic distribution.Genotypes A and D are ubiquitous and the most prevalent genotypes in Europe(mainly represented by subgenotypes D1-3 and A2);genotypes B and C are restricted to eastern Asia and Oceania;genotype E to central and western Africa;and genotypes H and F(classified into 4 subgenotypes)to Latin America and Alaska.This review summarises the data obtained by studying the global phylodynamics and phylogeography of HBV genotypes,particularly those concerning the origin and dispersion histories of genotypes A,D,E and F and their subgenotypes.The lack of any consensus concerning the HBV substitution rate and the conflicting data obtained using different calibration approaches make the time of origin and divergence of the various genotypes and subgenotypes largely uncertain.It is hypothesised that HBV evolutionary rates are time dependent,and that the changes depend on the main transmission routes of the genotypes and the dynamics of the infected populations. 展开更多
关键词 Hepatitis B virus genotypes and subgenotypes PHYLOGEOGRAPHY Population dynamics and epidemics Molecular epidemiology Hepatitis B virus phylodynamics
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部