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肌肉注射可调控胰岛素基因对糖尿病小鼠降糖作用 被引量:3
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作者 李鸿 苏本利 +5 位作者 刘海霞 张雪扬 吕申 刘敏 纪晓 f.bosch 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2004年第3期278-282,共5页
为研究四环素调控的胰岛素表达载体肌肉直接注射后对实验性糖尿病小鼠的降糖作用 ,构建了质粒 prTA tet4 rhINS .以链脲佐菌素 (STZ)诱导Balb/C小鼠成糖尿病模型 ,30 0 μg质粒注射至小鼠的股部肌肉 ,并同时在饮水中加入不同浓度强力霉... 为研究四环素调控的胰岛素表达载体肌肉直接注射后对实验性糖尿病小鼠的降糖作用 ,构建了质粒 prTA tet4 rhINS .以链脲佐菌素 (STZ)诱导Balb/C小鼠成糖尿病模型 ,30 0 μg质粒注射至小鼠的股部肌肉 ,并同时在饮水中加入不同浓度强力霉素 (Dox) ,监测小鼠末梢血糖、体重 ,测定血清人胰岛素、C肽水平 .用RT PCR检测小鼠肌肉注射部位组织中人胰岛素原mRNA水平的表达情况 .结果表明 :质粒prTA tet4 rhINS注射后 ,给予Dox可显著降低糖尿病小鼠的血糖 ,血清人胰岛素、C肽水平相应升高 ,体重增加 .效果持续大约二周 .小鼠肌肉组织中有人胰岛素原mRNA表达 .降糖效果和基因表达程度随Dox浓度增加而增强 .质粒 prTA tet4 rhINS对STZ诱导的糖尿病小鼠高血糖起到明显的降低作用 .在糖尿病小鼠肌肉组织能很好地表达 ,并受Dox调控 . 展开更多
关键词 肌肉注射 胰岛素 基因 糖尿病小鼠 降糖作用 肌肉组织 表达 DOX 调控
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类氢铀离子的辐射电子俘获角分布研究
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作者 马新文 T.Sthlker +7 位作者 H.F.Beyer f.bosch O.Brinzanescu C.Kozhuharov P.H.Mokler T.Ludziejewski Z.Stachura A.Warczak 《原子核物理评论》 CAS CSCD 北大核心 2002年第2期131-135,共5页
分析了在重离子冷却储存环上测量的辐射电子俘获产生的X射线能谱 ,得出了K REC光子的相对微分角分布 ,通过与非相对论理论和全相对论理论的计算结果进行比较 ,从实验上证明了相对论重离子 原子碰撞中自旋翻转跃迁的存在 ,实验结果与全... 分析了在重离子冷却储存环上测量的辐射电子俘获产生的X射线能谱 ,得出了K REC光子的相对微分角分布 ,通过与非相对论理论和全相对论理论的计算结果进行比较 ,从实验上证明了相对论重离子 原子碰撞中自旋翻转跃迁的存在 ,实验结果与全相对论理论计算结果一致 .同时还证实 ,重离子体系本身的相对论性质对碰撞过程有重要影响 . 展开更多
关键词 类氢铀离子 辐射电子俘获 相对论效应 X射线角分布 重离子冷却储存环 原子 X射线能谱 碰撞 相互作用
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Resonant Transfer and Excitation Study for Hydrogen-like Uranium Ions
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作者 P.H.Mokler G.Bednarz +11 位作者 f.bosch A.Gumberidze S.Hagmann C.Kozhuharov D.liesen U.Popp D.Sierpowski Z.Stachura Th.Sthlken S.Tashennov S.Toleikis A.Warczak 《IMP & HIRFL Annual Report》 2001年第1期85-85,共1页
He-like ions are the simplest atomic system where the electron-electron interactions can be studied without any disturbance by further correlations. For heavy atomic systems the structure and dynamics differ significa... He-like ions are the simplest atomic system where the electron-electron interactions can be studied without any disturbance by further correlations. For heavy atomic systems the structure and dynamics differ significantly from those of light ions, and in this relativistic domain the current or magnetic interactions play an 展开更多
关键词 RELATIVISTIC Hydrogen disturbance excited SWITCHED URANIUM COINCIDENCE SKETCH initially INTERACTING
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State-selective Electron Capture Study for He-like Uranium Ions
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作者 Th.Sthlker f.bosch +5 位作者 O.Brinzancscu S.Fritsche C.Kozhuharov P.H.Mokler T.Ludziejewski A.Warczak 《IMP & HIRFL Annual Report》 2001年第1期86-86,共1页
Radiative Electron Capture (REC) and Non-radiative Electron Capture (NRC) are two main processes in relativistic ion-atom collisions, and the cross sections for REC and NRC processes are strongly dependent on target-Z... Radiative Electron Capture (REC) and Non-radiative Electron Capture (NRC) are two main processes in relativistic ion-atom collisions, and the cross sections for REC and NRC processes are strongly dependent on target-Z~[1]. For high-Z ions and relativistic collisions there are scarce experimental information on state- 展开更多
关键词 Electron RELATIVISTIC SECTIONS RADIATIVE scarce capture PROJECTILE helium COINCIDENCE collision
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2-5 Data Analysis of the Schottky Mass Measurements of 152Sm Fragments
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作者 Yan Xinliang K.Blaum +24 位作者 Yu.A.Litvinov f.bosch C.Brandau Chen Lixin H.Geissel R.Knobel C.Kozhuharov J.Kurcewicz S.A.Litvinov G.Munzenberg C.Nociforo F.Nolden W.R.Pla M.S.Sanjari C.Scheidenberger M.Steck Sun Baohua Tu Xiaolin Wang Meng H.Weick N.Winckler M.Winkler Xu Hushan Zhang Yuhu Zhou Xiaohong 《IMP & HIRFL Annual Report》 2014年第1期35-36,共2页
Precision mass measurements of neutron-deficient 152Sm projectile fragments were conducted in 2005 at theFRS-ESR facility at GSI Helmholtz centre[1, 2], employing the time-resolved Schottky Mass Spectrometry[3]. A new... Precision mass measurements of neutron-deficient 152Sm projectile fragments were conducted in 2005 at theFRS-ESR facility at GSI Helmholtz centre[1, 2], employing the time-resolved Schottky Mass Spectrometry[3]. A newmass evaluation method has been developed in the data analysis. The systematic error in the mass determinationwas significantly reduced with the new method[4].Exotic nuclei, produced by projectile fragmentation of a 615 AMeV 152Sm primary beam in a 4.009 g/cm2beryllium target, were transmitted and B-separated by the fragment separator FRS and then injected and storedin the experimental storage ring ESR. In ESR the electron-cooling process was continuously applied to the storedions. To first order approximation, the revolution-frequencies (f) of the stored ions in the ESR are related to theirvelocities (v) and mass-to-charge ratios (m=q) of the ions in rest frame: 展开更多
关键词 SCHOTTKY MASS MEASUREMENTS
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Polarization Measurements in Radiative Electron Capture into High-Z Ions
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作者 f.bosch A.Gumberidze +13 位作者 S.Hagmann C.Kozhuharov Th.Krings A.OrsicMuthig D.Protic D.Sierpowski U.Spillmann Z.Stachura A.Warczak MaXinwen S.Tachenov Th.Stoehlker D.Banas H.F.Beyer 《近代物理研究所和兰州重离子加速器实验室年报:英文版》 2002年第1期77-77,共1页
Recently, there has been great interest in the linear polarization of photons produced by radiative electron capture (REC, the time reversed photoionization in ion-atom collisions). No such data are available for the ... Recently, there has been great interest in the linear polarization of photons produced by radiative electron capture (REC, the time reversed photoionization in ion-atom collisions). No such data are available for the high-Z regime till now. By using high efficiency by by a new generation of segmented germanium detectors that have energy as well as position resolution this field can be investigated experimentally. The 展开更多
关键词 高电荷态离子 俘获电子辐射 极化测量 散射截面 观测角 原子物理学 能量谱
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Two-electron QED Studies for Helium-like Uranium
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作者 MaXinwen Th.Stoehlker +17 位作者 A.Gumberidze H.F.Beyer G.Bednarz f.bosch CaiXiaohong S.Fritzsche S.Hagmann C.Kozhuharov O.Klepper D.Liesen P.H.Mokler D.Sierpowski Z.Stachura M.Steck A.Surzhykov S.Toleikis A.Warczak Y.Zou 《近代物理研究所和兰州重离子加速器实验室年报:英文版》 2002年第1期75-75,共1页
The study of structure of few-electron heavy ions is of important interest due to the strong field effects. Helium-like ions are the simplest atomic multi-body systems. A considerable improved precision has been made ... The study of structure of few-electron heavy ions is of important interest due to the strong field effects. Helium-like ions are the simplest atomic multi-body systems. A considerable improved precision has been made in both theory and experiments recently. The experiment exploits the radiative recombination (RR) transitions into the vacant 1 s shell of bare and H-like ions. In this process, the energy carried by the emitted photon is the energy difference between the initial and final electron state, hω=Ekin+EB. For bare 展开更多
关键词 类氦铀离子 双电子QED效应 强场作用 少电子重离子结构研究 原子物理学 基态电子 冷却电子
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Exclusive Population of n=2 S-states in He-like Uranium by Ionization Process
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作者 Ma Xinwen D.Banas +14 位作者 Th.Sthlker H.F.Beyer f.bosch A.Br(?)uning-Demian A.Gumberidze S.Hagmann C.Kozhuharov P.H.Mokler R.Mann A.Orsic Muthig D.Sierpowski U.Spillmann S.Tachenov Z.Stachura A.Warczak 《近代物理研究所和兰州重离子加速器实验室年报:英文版》 2002年第1期76-76,共1页
K-shell ionization for Li-like uranium ions in collisions with a N2 target was performed at the ESR storage ring. We found surprisingly that in such close encounters the 2 s electron remain almost unaffected by the co... K-shell ionization for Li-like uranium ions in collisions with a N2 target was performed at the ESR storage ring. We found surprisingly that in such close encounters the 2 s electron remain almost unaffected by the collisions. A dedicated experimental study was conducted by using Li-like uranium ions at an initial energy of 378 MeV/u in order to manifest the situation. In Fig.1 a typical spectrum is shown registered by a Ge(i) 展开更多
关键词 碰撞电离 类氦铀离子 超选择布居 S态 原子物理学 X射线衍射光谱分析 辐射强度
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Strong Alignment Observed in Resonant Transfer and Excitation for U^(91+) on H_2
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作者 MaXinwen P.H.Mokler +7 位作者 f.bosch A.Gumberidze C.Kozhuharov D.Liesen D.Sierpowski Z.Stachura Th.Stohlker A.Warczak 《近代物理研究所和兰州重离子加速器实验室年报:英文版》 2003年第1期91-91,共1页
For the heaviest and simplest atomic system resonant transfer and excitation involving the innermost shell shave been investigated . We measured for H-like U^91.+ projectiles the KLjLj-RTE Using a H(2) gas target prov... For the heaviest and simplest atomic system resonant transfer and excitation involving the innermost shell shave been investigated . We measured for H-like U^91.+ projectiles the KLjLj-RTE Using a H(2) gas target providing the narrowest possible Compton profile for atomically confined quasi-free target electrons. We studied the emission patterns of the cascade decay of doubly excited He-like U90^+ ions where the first hypersatellite (Kαi-H) and the second satellite (Kαi′-S) transitions are energetically separated . Although the REC cascadecontributions to the satellite lines (Kαi′-S) dominate, the RTE contributions could be isolated. In particular,the hypersatellite (Kαi-H) transitions are free of REC contributions - neglecting possible small interference effects. 展开更多
关键词 准自由目标电子 铀离子 能量独立 散射模型 原子物理学
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