期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Disposition and Metabolism of 1 -Nitropropane in Rats and Chimpanzees
1
作者 MARGRET HAAS-JOBELIUS FRIEDHELM KORTE f.coulston 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 1989年第3期249-264,共16页
The metabolic fate of 1 -nitropropane (1-NP) has not been previously reported. In this study male rats and chimpanzees were given single doses of 40 mg/kg ip and 5 mg/kg iv 1-[1-^(14)C]NP, respectively. The quantitati... The metabolic fate of 1 -nitropropane (1-NP) has not been previously reported. In this study male rats and chimpanzees were given single doses of 40 mg/kg ip and 5 mg/kg iv 1-[1-^(14)C]NP, respectively. The quantitative extent of urinary and fecal elimination was similar in both species. The rats excreted 16.5% ofthedosein urine and 1.7% in feces. For chimpanzees the respective values were 14.8 and 1.2%. Experiments with rats demonstrated that the major route of elimination was by exhalation. With a total elimination via the lungs of 72.6%, rats expired 10.3% of the dose as unchanged 1-NP. Five polar metabolites were isolated from the urine of chimpanzees. The two major metabolites were identified as 3-hydroxypropionic acid and 7V-methyl-N-2-(methylsulfinyl)ethylpropionic acid amide (NMPA). Both substances were also excreted in rat urine. The two identified metabolites indicate that 1-NP was degraded to propionic acid, part of which was modified to 3-hydroxypropionic acid or NMPA. A hypothetical pathway for the biochemical generation of NMPA is suggested.(c)1989 Academic Press, Inc. 展开更多
关键词 PPM Nitropropane in Rats and Chimpanzees Disposition and Metabolism of 1
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部