Medicinal plants of Moraceae family have been well-recognized traditionally due to their versatile applications in various fields including agriculture, cosmetic and food as well as in pharmaceutical industries. Their...Medicinal plants of Moraceae family have been well-recognized traditionally due to their versatile applications in various fields including agriculture, cosmetic and food as well as in pharmaceutical industries. Their biomedical and medicinal importance is reflected from their broad range of pharmacological activities for treatment of various inflammatory conditions, cancer, infectious diseases, and gastrointestinal disorders. The present review was aimed to summarize and critically discuss the biomedical implications of Morus species, their bioactive compounds, and phytochemicals. Bioactivity guided fractionation of these medicinal plants revealed that different types of bioactive phytochemicals and secondary metabolites such as steroids, saponins, alkaloids, glycosides and phenolic compounds including terpenoids, flavonoids, anthocyanins and tannins were present. The critical analysis of the literature revealed that the aqueous, methanolic, and ethanolic extracts of Morus species and their bioactive compounds exhibit remarkable anti-oxidative,anti-diabetic, anti-stress, nephroprotective, antimicrobial, anti-mutagenic, anticancer,anxiolytic, hepatoprotective, anthelmintic, antimicrobial, immune-modulatory and cholesterol lowering effects. Based on the literature review and bioactivity guided investigation of Morus species and their phytomedicinal effects, we anticipate that these herbal products hold excellent potential for future research.展开更多
Objective: To investigate the hepatoprotective efficacy of cranberry extract(CBE)against carbon tetrachloride(CCl4)-induced hepatic injury using in-vivo animal model.Methods: The hepatoprotective efficacy of CBE(200 a...Objective: To investigate the hepatoprotective efficacy of cranberry extract(CBE)against carbon tetrachloride(CCl4)-induced hepatic injury using in-vivo animal model.Methods: The hepatoprotective efficacy of CBE(200 and 400 mg/kg) was investigated against CCl4(4 m L/kg)-induced hepatotoxicity, elevated liver enzymes [ALT(alanine aminotransferase), AST(aspartate aminotransferase), and alkaline phosphatase(ALP)],and total protein(TP) contents in the serum. Moreover, CBE-aided antioxidant defense against hepatotoxic insult of CCl4 was measured by evaluating a number of anti-oxidative biomarkers including reduced glutathione(GSH), superoxide dismutase(SOD), catalase(CAT), and malondialdehyde(MDA) in the serum by using spectrophotometric analyses.Results: Results showed that the exposure of experimental animals to CCl4 did induce significant hepatotoxicity compared to the non-induced(untreated) group. The oral administration of CBE demonstrated a significant dose-dependent alleviation in the liver enzymes(AST, ALT, and ALP), increased antioxidant defense(GSH, SOD, and CAT),and reduced MDA levels in the serum of treated animals compared to the animals without treatment. The resulting data showed that the administration of CBE decreased the serum levels of ALT, AST, and ALP compared to the CCl4-induced group.Conclusions: The resulting data evidenced that CBE exhibits promising hepatoprotective potential against the chemical induced hepatotoxicity, maintains homeostasis in liver enzymes, and can provide significant antioxidant defense against free radicals-induced oxidative stress.展开更多
Objective:To evaluate correlation between the levels of vitamin D and male infertility as well as to determine the efficacy of vitamin D in improving the male fertility by up-regulating the levels of testosterone and ...Objective:To evaluate correlation between the levels of vitamin D and male infertility as well as to determine the efficacy of vitamin D in improving the male fertility by up-regulating the levels of testosterone and spermatogenesis.Methods: In the present study, 130 male patients (aged 25-70 years) having fertility defects were screened and 145 healthy individuals were taken as control. All human subjects were screened for 4-hydroxynonenal, isoprostane-F2α, 8-hydroxy-2′-deoxyguanosine, vitamin D, luteinizing hormone, follicle stimulating hormone, testosterones, malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase, and nitric oxide.Results: The screening analysis revealed that the levels of luteinizing hormone, follicle stimulating hormone, and testosterone were lower in male infertile subjects compared to healthy subjects. Similarly, the levels of vitamin D [(17.17 ± 2.30) ng/mL] and calcium[(6.29 ± 0.31) mg/dL] were significantly lower in infertile groups compared to the normal healthy groups. Moreover, the study revealed that the levels of superoxide dismutase, catalase, and glutathione peroxidase were significantly higher in healthy subjects compared to the infertile subjects.Conclusions:Vitamin D exhibits strong relevance to male fertility by maintaining the levels of sex hormones (luteinizing hormone, follicle stimulating hormone, and testosterone), up-regulating the antioxidant defense (superoxide dismutase, catalase, and glutathione peroxidase), and down-regulating the oxidative stress (malondialdehyde, nitric oxide, and inducible nitric oxide synthase species).展开更多
BACKGROUND Although panic buying(PB)is a ubiquitous behavior,it became prominent during the coronavirus disease 2019 pandemic.However,studies are inadequate to explore the different aspects of it,even though it covers...BACKGROUND Although panic buying(PB)is a ubiquitous behavior,it became prominent during the coronavirus disease 2019 pandemic.However,studies are inadequate to explore the different aspects of it,even though it covers several perspectives of life and academic domains.AIM To assess the research that have been conducted on PB.METHODS A search was conducted to identify the articles in PubMed,PubMed Central,Scopus,and Google Scholar using the search term“panic buying”on November 15,2020.A total of 104 articles was extracted from the initial search.After removing duplicates and initial and full-text screening,42 articles were included in the study.We only considered peer-reviewed published articles that can be downloaded in a full portable document format.Articles published in other languages and preprints were excluded.RESULTS Among the 42 articles,27 were original contributions,6 were correspondences,3 were commentaries,3 were review articles,and there was one each for editorial,opinion,and discussion type of articles.Several domains have been researched such as psychology,responsible factors,supply chain,management,disaster preparedness,e-commerce,consumer behavior,marketing,prevention strategies,media,social network,economics,personality,and engineering.Authors from several disciplines,such as psychiatry,management,economics,business,sales and marketing,consumer behavior,public health,communication,information management,sociology,engineering,business administration,psychology,nursing,health economics,food policy,epidemiology,and community health,have been studied it.Definition,causative model,econometric model,controlling strategy,and measuring instrument have been reported.A total of 18 papers had cross-country collaboration,and ten were funded projects.Most of the authors were affiliated with the institutions of Australia,Bangladesh,China,India,Singapore,and the United States.CONCLUSION PB is a relatively newer concept to get the attention of the research community.Further robust studies with replication of the findings are warranted to explore,predict,and control during crises.展开更多
Objective: The present study explored the effects of the combined herbal therapy consisting of curcumin(CUR) and Fructus Ligustri Lucidi(FLL) on aspects of bone regeneration.Methods: Prior to analyzing the ability of ...Objective: The present study explored the effects of the combined herbal therapy consisting of curcumin(CUR) and Fructus Ligustri Lucidi(FLL) on aspects of bone regeneration.Methods: Prior to analyzing the ability of this novel combined herbal therapy to promote aspects of bone regeneration, its cytotoxicity was determined using MC3 T3-E1 cells(pre-osteoblast model). Cell proliferation was evaluated using phase-contrast microscopy and cell differentiation was estimated using alkaline phosphatase activity. The effect of the combined herbal therapy(CUR + FLL) was also assessed in terms of mineralization in the extracellular matrix(ECM) of cultured cells. Further, to explore the molecular mechanisms of bone formation, time-dependent expression of bone-regulating protein biomarkers was also evaluated.Results: Combined herbal therapy(CUR + FLL) significantly upregulated the viability, proliferation and differentiation of MC3 T3-E1 cells compared to the monotherapy of CUR or FLL. The magnitude of ECM mineralization(calcium deposition) was also higher in MC3 T3-E1 cells treated with combined therapy.The time-dependent expression of bone-forming protein biomarkers revealed that the tendency of expression of these bone-regulating proteins was remarkably higher in cells treated with combined therapy.Conclusion: The co-administration of CUR and FLL had superior promotion of elements of bone regeneration in cultured cells, thus could be a promising alternative herbal therapy for the management of bone erosive disorders such as osteoporosis.展开更多
基金Universiti Teknologi MARA for providing LESTARI grant(600-IRMI/DANA 5/3/LESTARI(0007/2016))and support in writing the present review article.
文摘Medicinal plants of Moraceae family have been well-recognized traditionally due to their versatile applications in various fields including agriculture, cosmetic and food as well as in pharmaceutical industries. Their biomedical and medicinal importance is reflected from their broad range of pharmacological activities for treatment of various inflammatory conditions, cancer, infectious diseases, and gastrointestinal disorders. The present review was aimed to summarize and critically discuss the biomedical implications of Morus species, their bioactive compounds, and phytochemicals. Bioactivity guided fractionation of these medicinal plants revealed that different types of bioactive phytochemicals and secondary metabolites such as steroids, saponins, alkaloids, glycosides and phenolic compounds including terpenoids, flavonoids, anthocyanins and tannins were present. The critical analysis of the literature revealed that the aqueous, methanolic, and ethanolic extracts of Morus species and their bioactive compounds exhibit remarkable anti-oxidative,anti-diabetic, anti-stress, nephroprotective, antimicrobial, anti-mutagenic, anticancer,anxiolytic, hepatoprotective, anthelmintic, antimicrobial, immune-modulatory and cholesterol lowering effects. Based on the literature review and bioactivity guided investigation of Morus species and their phytomedicinal effects, we anticipate that these herbal products hold excellent potential for future research.
基金the Institute of Molecular Biology and Biotechnology (IMBB), University of Lahore for providing resources and financial support
文摘Objective: To investigate the hepatoprotective efficacy of cranberry extract(CBE)against carbon tetrachloride(CCl4)-induced hepatic injury using in-vivo animal model.Methods: The hepatoprotective efficacy of CBE(200 and 400 mg/kg) was investigated against CCl4(4 m L/kg)-induced hepatotoxicity, elevated liver enzymes [ALT(alanine aminotransferase), AST(aspartate aminotransferase), and alkaline phosphatase(ALP)],and total protein(TP) contents in the serum. Moreover, CBE-aided antioxidant defense against hepatotoxic insult of CCl4 was measured by evaluating a number of anti-oxidative biomarkers including reduced glutathione(GSH), superoxide dismutase(SOD), catalase(CAT), and malondialdehyde(MDA) in the serum by using spectrophotometric analyses.Results: Results showed that the exposure of experimental animals to CCl4 did induce significant hepatotoxicity compared to the non-induced(untreated) group. The oral administration of CBE demonstrated a significant dose-dependent alleviation in the liver enzymes(AST, ALT, and ALP), increased antioxidant defense(GSH, SOD, and CAT),and reduced MDA levels in the serum of treated animals compared to the animals without treatment. The resulting data showed that the administration of CBE decreased the serum levels of ALT, AST, and ALP compared to the CCl4-induced group.Conclusions: The resulting data evidenced that CBE exhibits promising hepatoprotective potential against the chemical induced hepatotoxicity, maintains homeostasis in liver enzymes, and can provide significant antioxidant defense against free radicals-induced oxidative stress.
文摘Objective:To evaluate correlation between the levels of vitamin D and male infertility as well as to determine the efficacy of vitamin D in improving the male fertility by up-regulating the levels of testosterone and spermatogenesis.Methods: In the present study, 130 male patients (aged 25-70 years) having fertility defects were screened and 145 healthy individuals were taken as control. All human subjects were screened for 4-hydroxynonenal, isoprostane-F2α, 8-hydroxy-2′-deoxyguanosine, vitamin D, luteinizing hormone, follicle stimulating hormone, testosterones, malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase, and nitric oxide.Results: The screening analysis revealed that the levels of luteinizing hormone, follicle stimulating hormone, and testosterone were lower in male infertile subjects compared to healthy subjects. Similarly, the levels of vitamin D [(17.17 ± 2.30) ng/mL] and calcium[(6.29 ± 0.31) mg/dL] were significantly lower in infertile groups compared to the normal healthy groups. Moreover, the study revealed that the levels of superoxide dismutase, catalase, and glutathione peroxidase were significantly higher in healthy subjects compared to the infertile subjects.Conclusions:Vitamin D exhibits strong relevance to male fertility by maintaining the levels of sex hormones (luteinizing hormone, follicle stimulating hormone, and testosterone), up-regulating the antioxidant defense (superoxide dismutase, catalase, and glutathione peroxidase), and down-regulating the oxidative stress (malondialdehyde, nitric oxide, and inducible nitric oxide synthase species).
文摘BACKGROUND Although panic buying(PB)is a ubiquitous behavior,it became prominent during the coronavirus disease 2019 pandemic.However,studies are inadequate to explore the different aspects of it,even though it covers several perspectives of life and academic domains.AIM To assess the research that have been conducted on PB.METHODS A search was conducted to identify the articles in PubMed,PubMed Central,Scopus,and Google Scholar using the search term“panic buying”on November 15,2020.A total of 104 articles was extracted from the initial search.After removing duplicates and initial and full-text screening,42 articles were included in the study.We only considered peer-reviewed published articles that can be downloaded in a full portable document format.Articles published in other languages and preprints were excluded.RESULTS Among the 42 articles,27 were original contributions,6 were correspondences,3 were commentaries,3 were review articles,and there was one each for editorial,opinion,and discussion type of articles.Several domains have been researched such as psychology,responsible factors,supply chain,management,disaster preparedness,e-commerce,consumer behavior,marketing,prevention strategies,media,social network,economics,personality,and engineering.Authors from several disciplines,such as psychiatry,management,economics,business,sales and marketing,consumer behavior,public health,communication,information management,sociology,engineering,business administration,psychology,nursing,health economics,food policy,epidemiology,and community health,have been studied it.Definition,causative model,econometric model,controlling strategy,and measuring instrument have been reported.A total of 18 papers had cross-country collaboration,and ten were funded projects.Most of the authors were affiliated with the institutions of Australia,Bangladesh,China,India,Singapore,and the United States.CONCLUSION PB is a relatively newer concept to get the attention of the research community.Further robust studies with replication of the findings are warranted to explore,predict,and control during crises.
文摘Objective: The present study explored the effects of the combined herbal therapy consisting of curcumin(CUR) and Fructus Ligustri Lucidi(FLL) on aspects of bone regeneration.Methods: Prior to analyzing the ability of this novel combined herbal therapy to promote aspects of bone regeneration, its cytotoxicity was determined using MC3 T3-E1 cells(pre-osteoblast model). Cell proliferation was evaluated using phase-contrast microscopy and cell differentiation was estimated using alkaline phosphatase activity. The effect of the combined herbal therapy(CUR + FLL) was also assessed in terms of mineralization in the extracellular matrix(ECM) of cultured cells. Further, to explore the molecular mechanisms of bone formation, time-dependent expression of bone-regulating protein biomarkers was also evaluated.Results: Combined herbal therapy(CUR + FLL) significantly upregulated the viability, proliferation and differentiation of MC3 T3-E1 cells compared to the monotherapy of CUR or FLL. The magnitude of ECM mineralization(calcium deposition) was also higher in MC3 T3-E1 cells treated with combined therapy.The time-dependent expression of bone-forming protein biomarkers revealed that the tendency of expression of these bone-regulating proteins was remarkably higher in cells treated with combined therapy.Conclusion: The co-administration of CUR and FLL had superior promotion of elements of bone regeneration in cultured cells, thus could be a promising alternative herbal therapy for the management of bone erosive disorders such as osteoporosis.
