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机器人辅助腹腔镜自体组织补片修复输尿管狭窄中国专家共识 被引量:1
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作者 包军胜 范阳 +16 位作者 冯宁翰 葛光炬 葛京平 李兵 李新飞 李学松 刘龙飞 刘永达 罗光恒 王坤杰 王尉 王毅 肖行远 杨昆霖 杨晓剑 张雪培 朱宏建 《微创泌尿外科杂志》 2024年第2期93-99,共7页
近年来自体组织补片输尿管重建术成为上尿路重建的标准术式之一,并且在长段或多段输尿管狭窄重建中具有优势。为推动自体组织补片修复输尿管技术应用和围手术期准备、管理的规范化,本专家共识编写组于2024年1月组织国内专家就自体组织... 近年来自体组织补片输尿管重建术成为上尿路重建的标准术式之一,并且在长段或多段输尿管狭窄重建中具有优势。为推动自体组织补片修复输尿管技术应用和围手术期准备、管理的规范化,本专家共识编写组于2024年1月组织国内专家就自体组织补片技术的关键热点问题进行讨论并达成专家共识,内容包括自体组织补片的适应证,补片组织来源的选择(口腔黏膜补片,阑尾组织补片),围手术期评估和准备,手术过程要点及术后随访建议等。 展开更多
关键词 输尿管狭窄 自体组织补片 共识 口腔黏膜补片 阑尾组织补片
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Progress in the Study of the Hepatoprotective Effect of SGLT2i on NAFLD Patients with T2DM
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作者 fan yang Xiaoping Tan 《Journal of Biosciences and Medicines》 2024年第1期115-125,共11页
In recent years, the progress of NAFLD has become an important health problem, and the prevention or delay of progress in NAFLD is a major key point. Whether or not to combine T2MD, people are interested in the mechan... In recent years, the progress of NAFLD has become an important health problem, and the prevention or delay of progress in NAFLD is a major key point. Whether or not to combine T2MD, people are interested in the mechanisms and efficacy of SGLT2i for NAFLD. In this review, we summarized the current clinical research on SGLT2i for the combination of T2MD’s NAFLD patients, and the latest evidence of external or animal experiments. These evidences will help us to more accurately understand the protective effects of SGLT2i in NAFLD. Lifestyle changes are still essential to prevent and treat NAFLD, and for all kinds of drugs that treat NAFLD in clinical trials, SGLT2i may be one of the promising treatments. 展开更多
关键词 Sodium-Glucose Cotransporter-2 Inhibitors Non-Alcoholic Fatty Liver Disease Diabetes Mellitus
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基于多光谱辐射测温法的换能元桥区温度检测技术
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作者 李党娟 丁成皎 +3 位作者 樊洋 王可暄 万文博 苏俊宏 《火工品》 CAS CSCD 北大核心 2024年第5期84-90,共7页
火工品换能元起爆过程中桥区温度的全程化精确测量对于研究换能元的电热转换效率、表征火工品点火性能至关重要。本研究通过建立包含6个波长通道的多光谱辐射测温系统,实现了对换能元桥区辐射光谱信号的实时采集,并通过PS800-25一体化... 火工品换能元起爆过程中桥区温度的全程化精确测量对于研究换能元的电热转换效率、表征火工品点火性能至关重要。本研究通过建立包含6个波长通道的多光谱辐射测温系统,实现了对换能元桥区辐射光谱信号的实时采集,并通过PS800-25一体化标准黑体进行系统标定。针对桥区材料在起爆过程中经历的固态、液态到气态的相变,建立了最优化函数温度解算模型,避免了对光谱发射率模型的依赖,并通过罚函数法进行真温的优化求解。试验结果表明,该方法的测温精度在3%以内,可应用于碳基桥箔点火过程中桥区温度的检测。 展开更多
关键词 换能元 火工品 多光谱辐射测温 最优化函数温度解算 碳基桥箔
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机器人辅助腹腔镜治疗膀胱阴道瘘专家共识
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作者 傅斌 张大宏 +9 位作者 薛蔚 王坤杰 李兵 吴大鹏 韩邦旻 黄海 罗光恒 崔心刚 范阳 陈路遥 《微创泌尿外科杂志》 2024年第2期100-103,共4页
膀胱阴道瘘是指膀胱与阴道之间的异常通道,多为医源性造成,手术修补是主要治疗方式。随着机器人手术技术的普及,机器人辅助腹腔镜手术治疗膀胱阴道瘘在临床上的应用越来越广泛,为更好地规范及推广该项技术,特邀请国内泌尿外科领域专家,... 膀胱阴道瘘是指膀胱与阴道之间的异常通道,多为医源性造成,手术修补是主要治疗方式。随着机器人手术技术的普及,机器人辅助腹腔镜手术治疗膀胱阴道瘘在临床上的应用越来越广泛,为更好地规范及推广该项技术,特邀请国内泌尿外科领域专家,聚焦术前评估、手术步骤与要点及术后随访,形成了本专家共识。 展开更多
关键词 膀胱阴道瘘 机器人外科手术 腹腔镜 共识
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小学特殊需要学生考试调整实施模式的行动研究——以数学学科为例
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作者 魏寿洪 范洋 +1 位作者 顾珂菲 巨梓君 《北京联合大学学报》 CAS 2024年第6期79-86,共8页
特殊需要学生由于自身的身心障碍,在普通学校的考试中会遇到诸多困难,难以展示自己的真实学业水平,而考试调整是帮助特殊需要学生克服考试困难的重要途径。研究者采用行动研究法对3名特殊需要学生开展考试调整行动,从考试调整的需求评... 特殊需要学生由于自身的身心障碍,在普通学校的考试中会遇到诸多困难,难以展示自己的真实学业水平,而考试调整是帮助特殊需要学生克服考试困难的重要途径。研究者采用行动研究法对3名特殊需要学生开展考试调整行动,从考试调整的需求评估、策略匹配、组织实施与成效分析等方面总结出一套可操作的考试调整实施模式,以促进普通小学对特殊需要学生进行有效的学业评估。 展开更多
关键词 特殊需要学生 考试调整 学业评估
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基于口袋实验室的便携式直流可调电源
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作者 裴晓芳 范阳 +2 位作者 张甜梦 王硕 谈潘锋 《计算机与数字工程》 2024年第7期2201-2206,共6页
直流可调电源是实验室中常用的设备,为了方便学生开展课外实验,设计一种基于FPGA口袋实验室的直流可调电压源。该设计系统由口袋实验室模块、触摸显示屏模块以及直流可调电源模块组成,利用SOPC技术结合增量型PID算法实现电压的精确控制... 直流可调电源是实验室中常用的设备,为了方便学生开展课外实验,设计一种基于FPGA口袋实验室的直流可调电压源。该设计系统由口袋实验室模块、触摸显示屏模块以及直流可调电源模块组成,利用SOPC技术结合增量型PID算法实现电压的精确控制,并在Nios II中使用uC/OS II操作系统,移植uC/GUI图形界面,设计显示界面。系统测试结果表明,利用旋转编码器调节可实现0 V~23.7 V的电压输出,步近50 mV,输出误差低于1%,最大输出电流3 A,最大输出功率达到18 W,具有体积小巧、输出精度高、携带方便的特点。 展开更多
关键词 口袋实验室 直流可调电源 旋转编码器 SOPC 增量型PID UC/GUI
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基于层级和全局特征结合的蛋白质序列EC编号预测 被引量:1
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作者 杨帆 韩巧玲 +1 位作者 赵文迪 赵玥 《遗传》 CAS CSCD 北大核心 2024年第8期661-670,共10页
酶功能的识别对理解生命活动的机制、推进生命科学的发展有重要作用。然而现有的酶EC编号预测方法,并未充分利用蛋白质序列信息,在识别精度上仍有所不足。针对上述问题,本研究提出一种基于层级特征和全局特征的EC编号预测网络(EC number... 酶功能的识别对理解生命活动的机制、推进生命科学的发展有重要作用。然而现有的酶EC编号预测方法,并未充分利用蛋白质序列信息,在识别精度上仍有所不足。针对上述问题,本研究提出一种基于层级特征和全局特征的EC编号预测网络(EC number prediction network using hierarchical features and global features,ECPN-HFGF)。该方法首先通过残差网络提取蛋白质序列通用特征,并通过层级特征提取模块和全局特征提取模块进一步提取蛋白质序列的层级特征和全局特征,之后结合两种特征信息的预测结果,采用多任务学习框架,实现酶EC编号的精确预测。计算实验结果表明,ECPN-HFGF方法在蛋白质序列EC编号预测任务上性能最佳,宏观F1值和微观F1值分别达到95.5%和99.0%。ECPN-HFGF方法能有效结合蛋白质序列的层级特征和全局特征,快速准确预测蛋白质序列EC编号,比当前常用方法预测精确度更高,能够为酶学研究和酶工程应用的发展提供一种高效的思路和方法。 展开更多
关键词 酶功能预测 蛋白质序列 深度学习 层级多标签分类 全局特征
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间充质干细胞对糖尿病肾病小鼠lncRNA的干预及肾脏保护的可能机制 被引量:1
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作者 凡洋 李亚玲 +1 位作者 雷蕾 白彝华 《中国老年学杂志》 CAS 北大核心 2024年第7期1625-1632,共8页
目的 筛选糖尿病肾病(DN)小鼠模型中异常表达的长链非编码RNA(lncRNA),探索与间充质干细胞(MSC)干预可能的lncRNA是否对小鼠肾脏起保护作用及可能机制。方法 利用基因表达综合数据库(GEO)来源的转录组测序(RNAseq)数据,对DN小鼠RNAseq... 目的 筛选糖尿病肾病(DN)小鼠模型中异常表达的长链非编码RNA(lncRNA),探索与间充质干细胞(MSC)干预可能的lncRNA是否对小鼠肾脏起保护作用及可能机制。方法 利用基因表达综合数据库(GEO)来源的转录组测序(RNAseq)数据,对DN小鼠RNAseq数据与正常小鼠进行筛选,得到与DN相关的lncRNA并进行验证,得到上调前3名的lncRNA,选取变化最显著的lncRNA进行下一步实验。分离培养小鼠肾小管上皮细胞(mRTECs)及骨髓间充质干细胞(BMSC),分组培养mRTECs[对照组、高糖(HG)组、HG+BMSC组],四甲基偶氮唑蓝(MTT)检测各组mRTECs细胞增殖率,荧光定量PCR法检测各组mRTECs中胶原蛋白(collagen)Ⅰ、α-平滑肌肌动蛋白(SMA)、波形蛋白(vimentin)、E-钙黏蛋白(cadherin) mRNA表达。采用siRNA敲减mRTECs中lncRNA的表达,构建正确的pcDNA3.1(+)质粒扩大培养。分组培养mRTECs(对照组、NC组、lncRNA组;si-NC组、si-lncRNA组、HG组、HG+si-lncRNA组;HG+BMSC组、HG+BMSC+lncRNA组),Western印迹检测各组细胞中collagenⅠ、α-SMA、vimentin、E-cadherin蛋白表达。结果 上调前3位的lncRNA为lncRNA NONMMUG023935、lncRNA NONMMUG030287、lncRNA NONMMUG004302。mRTECS经HG处理后,细胞增殖率、collagenⅠ、α-SMA和vimentin及lncRNA NONMMUG023935、lncRNA NONMMUG030287、lncRNA NONMMUG004302表达显著上升,E-cadherin表达显著下降(P<0.05)。而加入BMSC的mRTECs经HG处理后,上述指标的结果相反(P<0.05)。根据上述3个lncRNA表达变化绝对值最大选取lncRNA NONMMUG023935进行后续实验。转染si-lncRNA-NONMMUG023935后,相对应的lncRNA-NONMMUG023935表达显著降低(P<0.01)。lncRNA NONMMUG023935过表达可促进对mRTECs的损伤(P<0.05),BMSC可通过下调lncRNA NONMMUG023935表达从而抑制对HG诱导的mRTECs的损伤(P<0.05)。结论 MSC可下调DN肾小管上皮细胞中lncRNA NONMMUG023935的表达,从而改善肾脏纤维化,这可能是MSC延缓DN进展的机制之一。 展开更多
关键词 糖尿病肾病 间充质干细胞 长链非编码RNA 上皮-间充质转化
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富含氧空位的由多金属氧簇辅助的银基异质结用于高效电催化固氮
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作者 陈昕煜 赵聪聪 +8 位作者 任静 李波 刘倩倩 李葳 杨帆 陆思琦 赵宇飞 颜力楷 臧宏瑛 《Chinese Journal of Catalysis》 SCIE CAS CSCD 2024年第7期209-218,共10页
目前工业产氨主要依赖传统的Haber-Bosch工艺,然而该工艺条件苛刻,需要高温(350-550℃)和高压(150-250bar),每年消耗全球能源供应的2%,同时排放4.5亿吨二氧化碳(占全球总排放量的1.6%).近年来,科研工作者致力于开发高效率、高选择性的... 目前工业产氨主要依赖传统的Haber-Bosch工艺,然而该工艺条件苛刻,需要高温(350-550℃)和高压(150-250bar),每年消耗全球能源供应的2%,同时排放4.5亿吨二氧化碳(占全球总排放量的1.6%).近年来,科研工作者致力于开发高效率、高选择性的固氮电催化剂,但是由于析氢反应的强烈竞争,目前已报道的氮还原催化剂仍然受到低法拉第效率和低氨产率的限制.因此,开发活性位点丰富、氮气吸附能力强、催化性能优异的氮还原电催化剂成为当务之急.贵金属催化剂由于其纳米结构中富含活性位点,并且金属表界面处具有较好的导电性,因此表现出较高的法拉第效率.而分子催化剂因可调的电子结构和明确的构效关系引起了广泛关注.多金属氧簇是一种典型的金属聚阴离子团簇,由氧原子连接的含氧多面体组成,且具备优异的氧化还原性能.因此,本课题组尝试将多金属氧簇分子引入到氮还原催化剂中,并探究其催化机理.本文选取了一个多金属氧簇为前驱体,在溶剂、还原剂和诱导剂共存时,通过一锅法合成了富含氧空位的AgPW_(11)/Ag纳米方块电催化剂.实验结果表明,富含氧空位的AgPW_(11)/Ag异质结催化剂在-0.2 V(vs.RHE)电位时表现出高达46.02±1.03μg h^(-1)mg^(-1)_(cat).的氨产率和34.07±0.16%的法拉第效率,催化反应能够稳定运行32h且性能未见衰减,显著优于银催化剂.随后系统地研究了AgPW_(11)/Ag催化剂的氮还原活性位点,发现异质结中的银单质为催化反应提供了高导电性的支持,而催化剂中的银氧簇具有较好的电子得失能力,有利于促进氮还原反应中的六电子转移过程.丰富的氧空位利于吸附氮气,也能协同提升AgPW_(11)/Ag对电化学氮还原的催化活性.密度泛函理论计算结果表明,在还原后的银氧簇中,银原子d轨道与氮气π*轨道之间的强相互作用激活了吸附的氮气,促进了第一个质子化过程:*N_(2)向*N-NH的转化(电化学决速步).综上,本工作建立了异质结催化剂的催化性能与其分子结构之间的构效关系,为开发多金属氧簇及其衍生物作为电催化剂提供了依据和思路. 展开更多
关键词 多酸 金属氧簇 电催化 氮还原 氧空位 密度泛函理论 异质结
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熔体过热和脉冲磁场协同处理对Mn_(5)Si_(3)增强Cu-35Zn-3Al合金显微组织、力学和耐磨性能的影响
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作者 李航 牛冬涛 +3 位作者 张忠涛 杨帆 王红霞 程伟丽 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2024年第3期918-934,共17页
研究熔体过热和脉冲磁场协同处理对Mn_(5)Si_(3)增强Cu-35Zn-3Al合金显微组织、力学和耐磨性能的影响。研究结果表明,协同处理促进了熔体中的溶质迁移以及Mn_(5)Si_(3)晶体生长的吸附动力学,抑制了六棱柱形貌Mn_(5)Si_(3)颗粒上孔洞的... 研究熔体过热和脉冲磁场协同处理对Mn_(5)Si_(3)增强Cu-35Zn-3Al合金显微组织、力学和耐磨性能的影响。研究结果表明,协同处理促进了熔体中的溶质迁移以及Mn_(5)Si_(3)晶体生长的吸附动力学,抑制了六棱柱形貌Mn_(5)Si_(3)颗粒上孔洞的形成。协同处理后热锻态合金的抗拉强度和伸长率分别提高了9.0%和66.5%,这是由于拉伸变形过程中不含孔洞的Mn_(5)Si_(3)颗粒断裂强度提高,产生的应力集中减小,因此失效方式由脆性解理断裂转变为从基体中拔出,颗粒和基体间的载荷传递作用增强。在承受摩擦时,协同处理后合金的磨损亚表层中Mn_(5)Si_(3)颗粒不易发生剪切断裂,抑制了裂纹扩展和材料剥落,因而产生的剥层磨损减小,合金耐磨性显著提高。 展开更多
关键词 复杂黄铜 Mn_(5)Si_(3)相 脉冲磁场 强化机理 耐磨性
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不同处理对油菜秸秆养分、纤维结构和硫苷含量的影响
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作者 杨代毅 樊杨 +6 位作者 屠焰 徐志宇 薛颖昊 孙元丰 王进 郝小燕 马涛 《生物技术通报》 CAS CSCD 北大核心 2024年第6期172-179,共8页
【目的】采用物理(膨化)和微生物(黑曲霉、枯草芽孢杆菌)处理油菜秸秆,并分析发酵后的营养物质含量、纤维结构和硫代葡萄糖苷含量,旨在提高油菜秸秆作为粗饲料在反刍动物上的饲用价值。【方法】试验设计6个组,分别为:油菜秸秆(M组,即对... 【目的】采用物理(膨化)和微生物(黑曲霉、枯草芽孢杆菌)处理油菜秸秆,并分析发酵后的营养物质含量、纤维结构和硫代葡萄糖苷含量,旨在提高油菜秸秆作为粗饲料在反刍动物上的饲用价值。【方法】试验设计6个组,分别为:油菜秸秆(M组,即对照组)、对照加黑曲霉(MA组)、对照加枯草芽孢杆菌(MB组)、对照膨化(PM组)、对照膨化加黑曲霉(PMA组)、对照膨化加枯草芽孢杆菌(PMB组)。【结果】与M组(2.60%)相比,其他各组的粗蛋白质含量显著增加(P<0.05),分别为3.16%(MA组)、3.24%(MB组)、3.31%(PM组)、4.02%(PMA组)、3.73%(PMB组);与M组(83.4%)相比,其他各组的中性洗涤纤维(NDF)含量显著降低(P<0.05),分别为81.6%(MA组)、80.3%(MB组)、80.4%(PM组)、77.3%(PMA组)、78.3%(PMB组)。MA组的结晶度(27.0%vs 25.3%)和比表面积(1.22 m2/g vs 1.19 m2/g)显著高于M组(P<0.05),氢键作用力减弱,聚合度与其他各组无显著差异(P>0.05);与M组(0.49μmol/g)相比,其他各组硫代葡萄糖苷含量显著降低(P<0.05),PMA组(0.24μmol/g)和PMB组(0.22μmol/g)样品的硫代葡萄糖苷含量差异不显著,但显著低于其他各组(P<0.05)。【结论】通过物理和微生物处理油菜秸秆能通过破坏纤维结构降低NDF水平,并减少抗营养因子硫代葡萄糖苷含量,从而改善其在反刍动物上的饲用价值。 展开更多
关键词 油菜秸秆 膨化 黑曲霉 枯草芽孢杆菌 纤维结构 硫代葡萄糖苷
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机器人辅助腹腔镜肾脏移植术专家共识
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作者 范阳 蔡明 +9 位作者 付迎欣 金海龙 江军 林涛 宋涂润 孙洵 王瀚锋 周晓峰 张旭 董隽 《微创泌尿外科杂志》 2024年第2期73-78,共6页
机器人辅助腹腔镜肾脏移植是器官移植领域微创手术的代表,国内外多个移植中心经验已证明其可行和安全。但在临床实践中,该术式适应证、禁忌证、手术方法、安全注意事项、并发症处理及手术疗效等关键问题亟需形成专家共识。为了进一步规... 机器人辅助腹腔镜肾脏移植是器官移植领域微创手术的代表,国内外多个移植中心经验已证明其可行和安全。但在临床实践中,该术式适应证、禁忌证、手术方法、安全注意事项、并发症处理及手术疗效等关键问题亟需形成专家共识。为了进一步规范和推广该项技术,该领域专家聚焦上述问题检索了相关证据,并通过会议讨论、德尔菲问卷调查等方法达成共识,供广大临床医师参考。 展开更多
关键词 肾脏移植 机器人外科手术 腹腔镜 微创手术 共识
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Role of albumin-bilirubin score in non-malignant liver disease 被引量:1
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作者 Shi-Xue Xu fan yang +2 位作者 Nan Ge Jin-Tao Guo Si-Yu Sun 《World Journal of Gastroenterology》 SCIE CAS 2024年第9期999-1004,共6页
The albumin-bilirubin(ALBI)score,which was proposed to assess the prognosis of patients with hepatocellular carcinoma,has gradually been extended to other liver diseases in recent years,including primary biliary chola... The albumin-bilirubin(ALBI)score,which was proposed to assess the prognosis of patients with hepatocellular carcinoma,has gradually been extended to other liver diseases in recent years,including primary biliary cholangitis,liver cirrhosis,hepatitis,liver transplantation,and liver injury.The ALBI score is often compared with classical scores such as the Child-Pugh and model for end-stage liver disease scores or other noninvasive prediction models.It is widely employed because of its immunity to subjective evaluation indicators and ease of obtaining detection indicators.An increasing number of studies have confirmed that it is highly accurate for assessing the prognosis of patients with chronic liver disease;additionally,it has demonstrated good predictive performance for outcomes beyond survival in patients with liver diseases,such as decompensation events.This article presents a review of the application of ALBI scores in various non-malignant liver diseases. 展开更多
关键词 Albumin-bilirubin score Liver cirrhosis Primary biliary cholangitis Hepatitis Liver transplantation Liver injury
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Ultraviolet‑Irradiated All‑Organic Nanocomposites with Polymer Dots for High‑Temperature Capacitive Energy Storage 被引量:1
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作者 Jiale Ding Yao Zhou +5 位作者 Wenhan Xu fan yang Danying Zhao Yunhe Zhang Zhenhua Jiang Qing Wang 《Nano-Micro Letters》 SCIE EI CSCD 2024年第3期398-406,共9页
Polymer dielectrics capable of operating efficiently at high electric fields and elevated temperatures are urgently demanded by next-generation electronics and electrical power systems.While inorganic fillers have bee... Polymer dielectrics capable of operating efficiently at high electric fields and elevated temperatures are urgently demanded by next-generation electronics and electrical power systems.While inorganic fillers have been extensively utilized to improved high-temperature capacitive performance of dielectric polymers,the presence of thermodynamically incompatible organic and inorganic components may lead to concern about the long-term stability and also complicate film processing.Herein,zero-dimensional polymer dots with high electron affinity are introduced into photoactive allyl-containing poly(aryl ether sulfone)to form the all-organic polymer composites for hightemperature capacitive energy storage.Upon ultraviolet irradiation,the crosslinked polymer composites with polymer dots are efficient in suppressing electrical conduction at high electric fields and elevated temperatures,which significantly reduces the high-field energy loss of the composites at 200℃.Accordingly,the ultraviolet-irradiated composite film exhibits a discharged energy density of 4.2 J cm^(−3)at 200℃.Along with outstanding cyclic stability of capacitive performance at 200℃,this work provides a promising class of dielectric materials for robust high-performance all-organic dielectric nanocomposites. 展开更多
关键词 High-temperature energy storage Polymer dots Ultraviolet irradiation All-organic composite dielectrics
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Reservoir characteristics and controlling factor of tight sandstone in Shuixigou Group in Taibei depression,Turpan-Hami basin 被引量:1
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作者 Tong Lin Xuan Chen +3 位作者 fan yang Hongguang Gou Mingyu Liu Runze yang 《Energy Geoscience》 EI 2024年第2期70-80,共11页
The positive structure belts surrounding the Taibei Sag,Turpan-Hami Basin,have been the main targets for oil and gas exploration for years and are now left with remaining resources scattering in reservoirs adjacent to... The positive structure belts surrounding the Taibei Sag,Turpan-Hami Basin,have been the main targets for oil and gas exploration for years and are now left with remaining resources scattering in reservoirs adjacent to source rocks in the sag,where the Shuixigou Group with substantial oil and gas potential constitutes the primary focus for near-source exploration.Consequently,characterization of development and key controlling factors of reservoir space becomes a must for future exploration in the area.This study investigates the development traits,genesis,and controlling factors of the Xishanyao and Sangonghe formations in the Shengbei and Qiudong Sub-sags of the Taibei Sag with techniques such as cast thin-section observation,porosity and permeability tests,high-pressure mercury injection,and saturation fluid NMR analysis of reservoir rocks.The findings reveal that the Shuixigou Group in the Taibei Sag consists of lithic sandstone.Reservoirs in the group are mostly poor in terms of physical properties,with undeveloped primary pores dominated by intergranular dissolved pores as a result of a strong compaction.Comparative analysis of key controlling factors of the Sangonghe Formation reveals significant distinctions in sandstone particle size,sand body thickness,genesis and distribution,provenance location,and source rock type between the Qiudong area and Shengbei area.Vertically,the coal seams of the Xishanyao Formation exhibit heightened development with shallower burial depth and lower maturity compared to those of the Sangonghe Formation.Consequently,this environment fosters the formation of organic acids,which have a stronger dissolution effect on minerals to develop secondary dissolution pores,and ultimately resulting in better reservoir physical properties.Overall,the reservoirs within the Qiudong area of the Taibei Sag demonstrate superior characteristics compared to those in the Shengbei area.Furthermore,the reservoir physical properties of the Xishanyao Formation are better than those of the Sangonghe Formation.The research findings will provide valuable guidance for the exploration and development of lithological oil and gas reservoirs within the Taibei Sag. 展开更多
关键词 Intergranular dissolved pore Organic acid dissolution Secondary dissolution pore Tight sandstone Shuixigou group Turpan-Hami basin
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Extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis through the transport of microRNA-29a 被引量:1
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作者 fan yang Wan-Qi Xiong +7 位作者 Chen-Zhi Li Ming-Jian Wu Xiu-Zhi Zhang Chun-Xiao Ran Zhen-Hao Li Yan Cui Bao-Yi Liu De-Wei Zhao 《World Journal of Stem Cells》 SCIE 2024年第2期191-206,共16页
BACKGROUND Knee osteoarthritis(KOA)is a common orthopedic condition with an uncertain etiology,possibly involving genetics and biomechanics.Factors like changes in chondrocyte microenvironment,oxidative stress,inflamm... BACKGROUND Knee osteoarthritis(KOA)is a common orthopedic condition with an uncertain etiology,possibly involving genetics and biomechanics.Factors like changes in chondrocyte microenvironment,oxidative stress,inflammation,and immune responses affect KOA development.Early-stage treatment options primarily target symptom relief.Mesenchymal stem cells(MSCs)show promise for treatment,despite challenges.Recent research highlights microRNAs(miRNAs)within MSC-released extracellular vesicles that can potentially promote cartilage regeneration and hinder KOA progression.This suggests exosomes(Exos)as a promising avenue for future treatment.While these findings emphasize the need for effective KOA progression management,further safety and efficacy validation for Exos is essential.AIM To explore miR-29a’s role in KOA,we’ll create miR-29a-loaded vesicles,testing for early treatment in rat models.METHODS Extraction of bone marrow MSC-derived extracellular vesicles,preparation of engineered vesicles loaded with miR-29a using ultrasonication,and identification using quantitative reverse transcription polymerase chain reaction;after establi-shing a rat model of KOA,rats were randomly divided into three groups:Blank control group injected with saline,normal extracellular vesicle group injected with normal extracellular vesicle suspension,and engineered extrace-llular vesicle group injected with engineered extracellular vesicle suspension.The three groups evaluation,histological detection,and immunohistochemical detection to compare and evaluate the progress of various forms of arthritis.RESULTS General behavioral observation results showed that the extracellular vesicle group and engineered extracellular vesicle group had better performance in all four indicators of pain,gait,joint mobility,and swelling compared to the blank control group.Additionally,the engineered extracellular vesicle group had better pain relief at 4 wk and better knee joint mobility at 8 wk compared to the normal extracellular vesicle group.Imaging examination results showed that the blank control group had the fastest progression of arthritis,the normal extracellular vesicle group had a relatively slower progression,and the engineered extracellular vesicle group had the slowest progression.Gross histological observation results showed that the blank control group had the most obvious signs of arthritis,the normal extracellular vesicle group showed signs of arthritis,and the engineered extracellular vesicle group showed no significant signs of arthritis.Using the Pelletier gross score evaluation,the engineered extracellular vesicle group had the slowest progression of arthritis.Results from two types of staining showed that the articular cartilage of rats in the normal extracellular vesicle and engineered extracellular vesicle groups was significantly better than that of the blank control group,and the engineered extracellular vesicle group had the best cartilage cell and joint surface condition.Immunohistochemical detection of type II collagen and proteoglycan showed that the extracellular matrix of cartilage cells in the normal extracellular vesicle and engineered extracellular vesicle groups was better than that of the blank control group.Compared to the normal extracellular vesicle group,the engineered extracellular vesicle group had a better regulatory effect on the extracellular matrix of cartilage cells.CONCLUSION Engineered Exos loaded with miR-29a can exert anti-inflammatory effects and maintain extracellular matrix stability,thereby protecting articular cartilage,and slowing the progression of KOA. 展开更多
关键词 EXOSOMES OSTEOARTHRITIS Mesenchymal stem cells MicroRNA-29a Intra-articular injection
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In situ U-Pb dating and trace elements of magmatic rutile from Mujicun Cu-Mo deposit,North China Craton:Insights into porphyry mineralization
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作者 fan yang Jing-wen Mao +4 位作者 Wei-dong Ren Jia-run Tu Gilby Jepson Si-yuan Meng Zhi-min Wang 《China Geology》 CAS CSCD 2024年第4期730-746,共17页
Porphyry Cu(Mo-Au)deposit is one of the most important types of copper deposit and usually formed under magmatic arc-related settings,whilst the Mujicun porphyry Cu-Mo deposit in North China Craton uncommonly generate... Porphyry Cu(Mo-Au)deposit is one of the most important types of copper deposit and usually formed under magmatic arc-related settings,whilst the Mujicun porphyry Cu-Mo deposit in North China Craton uncommonly generated within intra-continental settings.Although previous studies have focused on the age,origin and ore genesis of the Mujicun deposit,the ore-forming age,magma source and tectonic evolution remain controversial.Here,this study targeted rutile(TiO_(2))in the ore-hosting diorite porphyry from the Mujicun Cu-Mo deposit to conduct in situ U-Pb dating and trace element composition studies,with major views to determine the timing and magma evolution and to provide new insights into porphyry Cu-Mo metallogeny.Rutile trace element data show flat-like REE patterns characterized by relatively enrichment LREEs and depleted HREEs,which could be identified as magmatic rutile.Rutile U-Pb dating yields lower intercept ages of 139.3–138.4 Ma,interpreted as post magmatic cooling timing below about 500℃,which are consistent or slightly postdate with the published zircon U-Pb ages of diorite porphyry(144.1–141.7 Ma)and skarn(146.2 Ma;139.9 Ma)as well as the molybdenite Re-Os ages of molybdenum ores(144.8–140.0 Ma).Given that the overlap between the closure temperature of rutile U-Pb system and ore-forming temperature of the Mujicun deposit,this study suggests that the ore-forming ages of the Mujicun deposit can be constrained at 139.3–138.4 Ma,with temporal links to the late large-scale granitic magmatism at 138–126 Ma in the Taihang Orogen.Based on the Mg and Al contents in rutile,the magma of ore-hosting diorite porphyry was suggested to be derived from crust-mantle mixing components.In conjunction with previous studies in Taihang Orogen,this study proposes that the far-field effect and the rollback of the subducting Paleo-Pacific slab triggered lithospheric extension,asthenosphere upwelling,crust-mantle interaction and thermo-mechanical erosion,which jointly facilitated the formation of dioritic magmas during the Early Cretaceous.Subsequently,the dioritic magmas carrying crust-mantle mixing metallic materials were emplaced and precipitated at shallow positions along NNE-trending ore-controlling faults,eventually resulting in the formation of the Mujicun Cu-Mo deposit within an intracontinental extensional setting. 展开更多
关键词 Rutile U-Pb geochronology Rutile geochemistry Intra-continental porphyry mineralization Paleo-Pacific slab subduction Tectonic evolution Magma source Ore-forming age Mujicun Cu-Mo deposit Mineral exploration engineering North China Craton
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活性细胞骨架网络中的力传播
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作者 屈子杰 刘世琛 +7 位作者 Rosalind Wenshan Pan Heun Jin Lee Shahriar Shadkhoo fan yang David Larios 李春赫 Rob Phillips Matt Thomson 《医用生物力学》 CAS CSCD 北大核心 2024年第S01期401-401,共1页
在生物系统中,由驱动蛋白和丝蛋白构成的消耗能量的活性网络可以产生驱动力并作用于多种生物过程,包括细胞运动、形状变化和复制等。这种活性网络的功能不可或缺,然而,分子尺度蛋白的相互作用如何能够使力在微米尺度上进行组织和传递仍... 在生物系统中,由驱动蛋白和丝蛋白构成的消耗能量的活性网络可以产生驱动力并作用于多种生物过程,包括细胞运动、形状变化和复制等。这种活性网络的功能不可或缺,然而,分子尺度蛋白的相互作用如何能够使力在微米尺度上进行组织和传递仍然难以捉摸。本研究证明了微管的捆绑(增长)可以使活性物质系统在“全局力传递”相和“局部力耗散”相间相互转化。平均微管长度增加5倍会导致局部相到全局相的转变。转变后,力传播的长度尺度增加100倍并且力的大小增加了20倍。全局相下活性物质系统可产生(10 p N)力场,使包括细胞运输和液滴运动等应用成为可能。通过理论和模拟证明,即使存在少数长微管也可以诱导局部和全局相之间的逾渗转变,为细胞中的力传递提供调节机制。本研究结果揭示了细胞中力传导机制,并使活性材料应用于合成生物学和软机器人成为可能。 展开更多
关键词 驱动蛋白 微管 合成生物学 活性物质 活性材料 分子尺度 丝蛋白 力传递
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Esophageal cancer global burden profiles, trends, and contributors
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作者 Yi Teng Changfa Xia +9 位作者 Maomao Cao fan yang Xinxin Yan Siyi He Mengdi Cao Shaoli Zhang Qianru Li Nuopei Tan Jiachen Wang Wanqing Chen 《Cancer Biology & Medicine》 SCIE CAS CSCD 2024年第8期656-666,共11页
Objective:This study aimed to provide a comprehensive overview of the global burden of esophageal cancer(EC)and determine the temporal trends and factors influencing changes in the global burden.Methods:The latest inc... Objective:This study aimed to provide a comprehensive overview of the global burden of esophageal cancer(EC)and determine the temporal trends and factors influencing changes in the global burden.Methods:The latest incidence and mortality data for EC worldwide were obtained from GLOBALCAN 2022.The mortality and disability-adjusted life years(DALYs)rates for EC from 1990±2019 were sourced from the 2019 Global Burden of Diseases.Trends in EC mortality and DALYs attributable to 11 risk factors or clusters of risk were analyzed using the joinpoint regression model.The trends in age-related EC burden were assessed using a decomposition approach.Results:An estimated 511,054 new cases of EC were diagnosed in 2022 with 445,391 deaths worldwide.Approximately 75%of cases and deaths occurred in Asia.Nearly 50%of global EC deaths and DALYs were attributed to tobacco use in men in 2019,while 20%were attributed to high body mass index(BMI)in women.From 1990±2019,EC deaths and DALYs attributable to almost all risk factors had declining trends,while EC deaths and DALYs attributed to high BMI in men had upward trends.The age-related EC burden exhibited an upward trend driven by population growth and aging,which contributed to 307.4 thousand deaths and 7.2 million DALYs due to EC.Conclusions:The EC burden remains substantial worldwide.Effective tobacco and obesity control measures are critical for addressing the risk-attributable burden of EC.Population growth and aging pose challenges for EC prevention and control efforts. 展开更多
关键词 Esophageal cancer INCIDENCE MORTALITY disability-adjusted life years risk factors AGING TRENDS
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Temporal and environmental factors drive community structure and function of methanotrophs in volcanic forest soils
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作者 Rusong Chai Hongjie Cao +3 位作者 Qingyang Huang Lihong Xie fan yang Hongbin Yin 《Journal of Forestry Research》 SCIE EI CAS CSCD 2024年第2期1-13,共13页
Methanotrophs,organisms that obtain oxygen by oxidizing methane,are recognized as the only known biological sink for atmospheric CH_4,and forest soil methanotrophs play crucial roles in mitigating global warming.The s... Methanotrophs,organisms that obtain oxygen by oxidizing methane,are recognized as the only known biological sink for atmospheric CH_4,and forest soil methanotrophs play crucial roles in mitigating global warming.The succession patterns of methanotrophic communities and functions in Wudalianchi volcano forest soils could provide a basis for the study of evolutionary mechanisms between soil microorganisms,the environment,and carbon cycling of temperate forest ecosystems under climate change.In this study,the characteristics and drivers of methanotrophic community structure and function of two volcanic soils at different stages of development are analyzed,including an old volcano and a new volcano,which most recently erupted 300 years and 17-19×10^(5)years ago,respectively,and a non-volcano hills as control,based on space for time substitution and Miseq sequencing and bioinformation technology.The results showed that CH_(4) fluxes were significantly higher in old-stage volcano forest soils than new-stage forest soils and non-volcano forest soils.There were significant differences in the community composition and diversity of soil methanotrophs from different volcano forest soils.Methylococcus was the dominant genus in all soil samples.Additionally,the relative abundance of Methylococcus,along with Clonothrix,Methyloglobulus,Methylomagum,Methylomonas and Methylosarcina,were the important genera responsible for the differences in methanotrophic community structure in different volcano forest soils.The relative abundance of methanotroph belonging toγ-proteobacteria was significantly higher than that belonging toα-proteobacteria(P<0.05).Chao1,Shannon and Simpson indices of soil methanotrophic community were significantly lower in new-stage volcanos and were significantly affected by bulk density,total porosity,p H,nitrate,dissolved organic carbon and dissolved organic nitrogen.There were significant differences in community structure between new-stage and old-stage volcanoes.Bulk density and p H are important soil properties contributing to the divergence of methanotrophs community structure,and changes in soil properties due to soil development time are important factors driving differences in methanotrophs communities in Wudalianchi volcanic soils. 展开更多
关键词 METHANOTROPHS pmo A Soil development stage Volcanoes Forest soils
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