OBJECTIVE To evaluate the prospective association between cumulative resting heart rate(cumRHR)and rapid renal function decline(RRFD)in a cohort of individuals aged 60 and older.METHODS In the Tianjin Chronic Kidney D...OBJECTIVE To evaluate the prospective association between cumulative resting heart rate(cumRHR)and rapid renal function decline(RRFD)in a cohort of individuals aged 60 and older.METHODS In the Tianjin Chronic Kidney Disease Cohort Study,the individuals who underwent three consecutive physical examinations between 2014 and 2017,with estimated glomerular filtration rate(eGFR)greater than 60 mL/min per 1.73 m2 and aged 60 years or older were enrolled.A total of 27,564 patients were prospectively followed up from January 1,2017 to December 31,2020.The 3-year cumRHR was calculated.The primary outcome was RRFD,defined as an annualized decline in eGFR of 5 mL/min per 1.73 m2 or greater.Logistic and restricted spline regression models and subgroup analysis were used to investigate the association of cumRHR with RRFD after adjusting for all confounders.RESULTS During a median follow-up of 3.2 years,a total of 4,347(15.77%)subjects developed RRFD.In fully-adjusted models,compared with the lowest quartile of cumRHR,the odds ratio(OR)for the highest was 1.44(1.28–1.61),P<0.001.Furthermore,each 1-standard deviation(27.97 beats/min per year)increment in cumRHR was associated with a 17%(P<0.001)increased risk of RRFD,with a linear positive correlation(P for non-linear=0.803).Participants with a 3-year cumRHR≥207(beats/min)*year(equivalent to≥69 beats/min per year in 3 years)were found to be at a higher risk of RRFD.CONCLUSIONS The cumRHR is significantly associated with a higher risk of RRFD among older adults.These results might provide an effective goal for managing and delaying the decline of renal function in the older adults.展开更多
AIM: To examine the genetic profile of primary uveal melanoma(UM) as compared to UM in immune escape.·METHODS: Dendritic cells(DC) loaded with lysates of UM cells of high metastatic potential were used to stimula...AIM: To examine the genetic profile of primary uveal melanoma(UM) as compared to UM in immune escape.·METHODS: Dendritic cells(DC) loaded with lysates of UM cells of high metastatic potential were used to stimulate cytotoxic T-lymphocytes(CTLs). When CTLs co-cultured with the UM cells, most UM cells could be eliminated. Survival UM cells grew slowly and were considered to be survival variants and examined by a microarray analysis. These differential genes were analyzed further with Venn Diagrams and functions related to immune escape. We additionally examined transcriptional changes of manually selected survival variants of UM cells and of clinical UM samples by quantitative real-time polymerase chain reaction(q RT-PCR),and analyzed the correlation of these expressions and patients' survival.· RESULTS: Gene expression analyses revealed a marked up-regulation of SLAMF7 and CCL22 and a significant down-regulation of KRT10, FXYD3 and ABCC2.. The expression of these genes in the relapsed UM was significantly greater than those in primary UM.UM patients with overexpression of these genes had a shorter survival period as compared with those of their underexpression.· CONCLUSION: Gene expression, in particular of SLAMF7, CCL22, KRT10, FXYD3 and ABCC2, differed between primary UM cells and survival variants of UM cells.展开更多
This paper presents an efficient algorithm for generating a spherical multiple-cell(SMC)grid.The algorithm adopts a recursive loop structure and provides two refinement methods:(1)an arbitrary area refinement method a...This paper presents an efficient algorithm for generating a spherical multiple-cell(SMC)grid.The algorithm adopts a recursive loop structure and provides two refinement methods:(1)an arbitrary area refinement method and(2)a nearshore refinement method.Numerical experiments are carried out,and the results show that compared with the existing grid generation algorithm,this algorithm is more flexible and operable.展开更多
Since the 2018 National Education Conference in China,physical education has gained importance as a whole,and the development of physical literacy education and teaching has been promoted.In order to ensure high-quali...Since the 2018 National Education Conference in China,physical education has gained importance as a whole,and the development of physical literacy education and teaching has been promoted.In order to ensure high-quality physical education teaching in primary and secondary schools in the new era,it is necessary to take core literacy as the guide to further improve the level of physical education in primary and secondary schools.This article emphasizes the importance of physical education in primary and secondary schools in the new era and analyzes the need of primary and secondary schools for core literacy-oriented physical education.On this basis,targeted suggestions are proposed from three aspects:new concept,new technology,and new evaluation.展开更多
Iconic memory and short-term memory are not only crucial for perception and cognition,but also of great importance to mental health.Here,we first showed that both types of memory could be improved by improving limitin...Iconic memory and short-term memory are not only crucial for perception and cognition,but also of great importance to mental health.Here,we first showed that both types of memory could be improved by improving limiting processes in visual processing through perceptual learning.Normal adults were trained in a contrast detection task for ten days,with their higher-order aberrations(HOA)corrected in real-time.We found that the training improved not only their contrast sensitivity function(CSF),but also their iconic memory and baseline information maintenance for short-term memory,and the relationship between memory and CSF improvements could be well-predicted by an observer model.These results suggest that training the limiting component of a cognitive task with visual perceptual learning could improve visual cognition.They may also provide an empirical foundation for new therapies to treat people with poor sensory memory.展开更多
基金funded by Tianjin Science and Technology Major Special ProjectEngineering Public Health Science and Technology Major Special Project (No.21ZXGWSY00100)+5 种基金Tianjin Natural Science Foundation Key Projects (22JCZDJC00590,21JCQNJC00460)Tianjin Key Medical Discipline(Specialty) Construct Project (No.TJYXZDXK-032A)The Science and technology talent project of Tianjin Health Commission (No. RC20175)The Scientific Research Funding of Tianjin Medical University Chu Hsien-I Memorial Hospital (No.ZXY-ZDSYSZD-1)China International Medical Exchange Foundation Key Fund Project (No.Z-2017-26-1902)Tianjin Municipal Health Care Commission Scientific Research Fund Project (ZC20128)
文摘OBJECTIVE To evaluate the prospective association between cumulative resting heart rate(cumRHR)and rapid renal function decline(RRFD)in a cohort of individuals aged 60 and older.METHODS In the Tianjin Chronic Kidney Disease Cohort Study,the individuals who underwent three consecutive physical examinations between 2014 and 2017,with estimated glomerular filtration rate(eGFR)greater than 60 mL/min per 1.73 m2 and aged 60 years or older were enrolled.A total of 27,564 patients were prospectively followed up from January 1,2017 to December 31,2020.The 3-year cumRHR was calculated.The primary outcome was RRFD,defined as an annualized decline in eGFR of 5 mL/min per 1.73 m2 or greater.Logistic and restricted spline regression models and subgroup analysis were used to investigate the association of cumRHR with RRFD after adjusting for all confounders.RESULTS During a median follow-up of 3.2 years,a total of 4,347(15.77%)subjects developed RRFD.In fully-adjusted models,compared with the lowest quartile of cumRHR,the odds ratio(OR)for the highest was 1.44(1.28–1.61),P<0.001.Furthermore,each 1-standard deviation(27.97 beats/min per year)increment in cumRHR was associated with a 17%(P<0.001)increased risk of RRFD,with a linear positive correlation(P for non-linear=0.803).Participants with a 3-year cumRHR≥207(beats/min)*year(equivalent to≥69 beats/min per year in 3 years)were found to be at a higher risk of RRFD.CONCLUSIONS The cumRHR is significantly associated with a higher risk of RRFD among older adults.These results might provide an effective goal for managing and delaying the decline of renal function in the older adults.
基金Supported by National Natural Science Foundation of China(No.81570891No.81272981)+4 种基金the Beijing Municipal Administration of Hospitals'Ascent Plan(No.DFL20150201)Science&Technology Project of Beijing Municipal Science&Technology Commission(No.Z151100001615052)Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support(No.ZYLX201307)Beijing Natural Science Foundation(No.7151003)Advanced Health Care Professionals Development Project of Beijing Municipal Health Bureau(No.2014-2-003)
文摘AIM: To examine the genetic profile of primary uveal melanoma(UM) as compared to UM in immune escape.·METHODS: Dendritic cells(DC) loaded with lysates of UM cells of high metastatic potential were used to stimulate cytotoxic T-lymphocytes(CTLs). When CTLs co-cultured with the UM cells, most UM cells could be eliminated. Survival UM cells grew slowly and were considered to be survival variants and examined by a microarray analysis. These differential genes were analyzed further with Venn Diagrams and functions related to immune escape. We additionally examined transcriptional changes of manually selected survival variants of UM cells and of clinical UM samples by quantitative real-time polymerase chain reaction(q RT-PCR),and analyzed the correlation of these expressions and patients' survival.· RESULTS: Gene expression analyses revealed a marked up-regulation of SLAMF7 and CCL22 and a significant down-regulation of KRT10, FXYD3 and ABCC2.. The expression of these genes in the relapsed UM was significantly greater than those in primary UM.UM patients with overexpression of these genes had a shorter survival period as compared with those of their underexpression.· CONCLUSION: Gene expression, in particular of SLAMF7, CCL22, KRT10, FXYD3 and ABCC2, differed between primary UM cells and survival variants of UM cells.
基金The National Key Research and Development Program of China under contract No.2018YFC1407000.
文摘This paper presents an efficient algorithm for generating a spherical multiple-cell(SMC)grid.The algorithm adopts a recursive loop structure and provides two refinement methods:(1)an arbitrary area refinement method and(2)a nearshore refinement method.Numerical experiments are carried out,and the results show that compared with the existing grid generation algorithm,this algorithm is more flexible and operable.
文摘Since the 2018 National Education Conference in China,physical education has gained importance as a whole,and the development of physical literacy education and teaching has been promoted.In order to ensure high-quality physical education teaching in primary and secondary schools in the new era,it is necessary to take core literacy as the guide to further improve the level of physical education in primary and secondary schools.This article emphasizes the importance of physical education in primary and secondary schools in the new era and analyzes the need of primary and secondary schools for core literacy-oriented physical education.On this basis,targeted suggestions are proposed from three aspects:new concept,new technology,and new evaluation.
基金This work was supported by the National Natural Science Foundation of China(31970975)the Natural Science Foundation for Distinguished Young Scholars of Zhejiang Province,China(LR22H120001)+2 种基金the Scientific Instrument Developing Project of the Chinese Academy of Sciences(ZDKYYQ20200005)the National Science and Technology Innovation 2030 Major Program(2022ZD0204801)the Project of State Key Laboratory of Ophthalmology,Optometry and Vision Science,Wenzhou Medical University(J02-20210203).
文摘Iconic memory and short-term memory are not only crucial for perception and cognition,but also of great importance to mental health.Here,we first showed that both types of memory could be improved by improving limiting processes in visual processing through perceptual learning.Normal adults were trained in a contrast detection task for ten days,with their higher-order aberrations(HOA)corrected in real-time.We found that the training improved not only their contrast sensitivity function(CSF),but also their iconic memory and baseline information maintenance for short-term memory,and the relationship between memory and CSF improvements could be well-predicted by an observer model.These results suggest that training the limiting component of a cognitive task with visual perceptual learning could improve visual cognition.They may also provide an empirical foundation for new therapies to treat people with poor sensory memory.
