Spinal cord injury-induced motor dysfunction is associated with neuroinflammation.Studies have shown that the triterpenoid lupenone,a natural product found in various plants,has a remarkable anti-inflammatory effect i...Spinal cord injury-induced motor dysfunction is associated with neuroinflammation.Studies have shown that the triterpenoid lupenone,a natural product found in various plants,has a remarkable anti-inflammatory effect in the context of chronic inflammation.However,the effects of lupenone on acute inflammation induced by spinal cord injury remain unknown.In this study,we established an impact-induced mouse model of spinal cord injury,and then treated the injured mice with lupenone(8 mg/kg,twice a day)by intrape ritoneal injection.We also treated BV2 cells with lipopolysaccharide and adenosine5’-triphosphate to simulate the inflammatory response after spinal cord injury.Our res ults showed that lupenone reduced IKBa activation and p65 nuclear translocation,inhibited NLRP3 inflammasome function by modulating nuclear factor kappa B,and enhanced the conve rsion of proinflammatory M1 mic roglial cells into anti-inflammatory M2 microglial cells.Furthermore,lupenone decreased NLRP3 inflammasome activation,NLRP3-induced mic roglial cell polarization,and microglia pyroptosis by inhibiting the nuclear factor kappa B pathway.These findings suggest that lupenone protects against spinal cord injury by inhibiting inflammasomes.展开更多
Cobalt carbide nanoparticles(NPs),as a typical carbide material,have attracted extensive attention in the fields of magnetism and electrochemistry.Herein,we adopted a modified solution route by pyrolysis long-chain am...Cobalt carbide nanoparticles(NPs),as a typical carbide material,have attracted extensive attention in the fields of magnetism and electrochemistry.Herein,we adopted a modified solution route by pyrolysis long-chain amines at high temperatures to obtain Co_(2)C NPs,in which different forms of Co NPs were used as precursors.The results reveal that no matter what the structure of the precursor and the type of long-chain amine,single-phase Co_(2)C NPs with good crystallinity are obtained.At the same time,carbonization of hexagonal close packed(hcp)cobalt as the precursor gives the materials high magnetic anisotropy,exhibiting a large coercivity(~1,300 Oe)on the nanoscale.In terms of catalytic properties,benefiting from intrinsically high activity of Co_(2)C NPs,the material demonstrates superior hydrogen evolution reaction(HER)performance,with optimal overpotential as low as 73 mV at the current density of 10 mA·cm^(-2).This provides new ideas for the further development of transition metal carbides(TMCs)and the improvement of their magnetic and electrocatalytic properties.展开更多
基金supported by the National Natural Science Foundation of China,Nos.81801226(to QK and XS)and 82101445(to XJ)。
文摘Spinal cord injury-induced motor dysfunction is associated with neuroinflammation.Studies have shown that the triterpenoid lupenone,a natural product found in various plants,has a remarkable anti-inflammatory effect in the context of chronic inflammation.However,the effects of lupenone on acute inflammation induced by spinal cord injury remain unknown.In this study,we established an impact-induced mouse model of spinal cord injury,and then treated the injured mice with lupenone(8 mg/kg,twice a day)by intrape ritoneal injection.We also treated BV2 cells with lipopolysaccharide and adenosine5’-triphosphate to simulate the inflammatory response after spinal cord injury.Our res ults showed that lupenone reduced IKBa activation and p65 nuclear translocation,inhibited NLRP3 inflammasome function by modulating nuclear factor kappa B,and enhanced the conve rsion of proinflammatory M1 mic roglial cells into anti-inflammatory M2 microglial cells.Furthermore,lupenone decreased NLRP3 inflammasome activation,NLRP3-induced mic roglial cell polarization,and microglia pyroptosis by inhibiting the nuclear factor kappa B pathway.These findings suggest that lupenone protects against spinal cord injury by inhibiting inflammasomes.
基金This work was supported by the National Natural Science Foundation of China(No.51872111)the Natural Science Foundation of Jilin Province(No.20190201253JC).
文摘Cobalt carbide nanoparticles(NPs),as a typical carbide material,have attracted extensive attention in the fields of magnetism and electrochemistry.Herein,we adopted a modified solution route by pyrolysis long-chain amines at high temperatures to obtain Co_(2)C NPs,in which different forms of Co NPs were used as precursors.The results reveal that no matter what the structure of the precursor and the type of long-chain amine,single-phase Co_(2)C NPs with good crystallinity are obtained.At the same time,carbonization of hexagonal close packed(hcp)cobalt as the precursor gives the materials high magnetic anisotropy,exhibiting a large coercivity(~1,300 Oe)on the nanoscale.In terms of catalytic properties,benefiting from intrinsically high activity of Co_(2)C NPs,the material demonstrates superior hydrogen evolution reaction(HER)performance,with optimal overpotential as low as 73 mV at the current density of 10 mA·cm^(-2).This provides new ideas for the further development of transition metal carbides(TMCs)and the improvement of their magnetic and electrocatalytic properties.
