Background Low alanine aminotransaminase (LALT) levels may be seen in patients with inflammatory bowel disease (IBD),but there has been no study about the frequency and its clinical significance.We aimed to analyze th...Background Low alanine aminotransaminase (LALT) levels may be seen in patients with inflammatory bowel disease (IBD),but there has been no study about the frequency and its clinical significance.We aimed to analyze the frequency of LALT,and its clinical significance in children with IBD.Methods The study included the 89 patients with IBD without hepatobiliary involvement.LALT was defined as ALT levels < 5 U/L.Demographic and clinical findings and outcome of the patients with and without LALT were compared.Results LALT was found 47.1% of the patients.At initial examination,it was more common in female patients (92.3 vs.41.3%,P < 0.001) and patients with CD (57.7 vs.30.2%,P=0.01).75% of the patients with penetrating Crohn's disease (CD) had LALT (P=0.002).Hemoglobin (10.4±2.1 vs.11.7± 1.9 g/dL,P=0.01),folic acid (5.2±3.3 vs.8.6±5.9 ng/mL,P =0.02) and serum albumin levels (3.6 ± 0.8 vs.4.7 ± 5 g/dL,P =0.002) were significantly low in patients with LALT.LALT was associted with the disease relapse within 2 weeks in 12 of the 16 patients with LALT whereas it was seen in 16 of the 73 patients without LALT during the follow-up (75 vs.21.9%,P < 0.001).Additionally,steroid dependency was more common in patients with LALT during the follow-up (62.5 vs.12.3%,P<0.001).Conclusions LALT is common in children with IBD especially in CD and associated with low hemoglobin,albumin and folic acid levels.It may be a marker of relapse and steroid dependency.展开更多
Background:This study was undertaken to evaluate demographics,clinical manifestations,laboratoryfi ndings and outcomes of children with inflammatory bowel disease(IBD)in Turkey.Methods:We analyzed the medical records ...Background:This study was undertaken to evaluate demographics,clinical manifestations,laboratoryfi ndings and outcomes of children with inflammatory bowel disease(IBD)in Turkey.Methods:We analyzed the medical records of 127 children diagnosed with IBD(under 18 years old)between January 2004 and January 2012 in 8 pediatric gastroenterology centers.Results:Of the 127 patients,90(70.9%)suffered from ulcerative colitis(UC),29(22.8%)from Crohn's disease(CD),and 8(6.3%)from IBD unclassified.The mean age of the 127 patients was 11.6±4.1 years,and 11.8%of the patients were below 5 years old.Of the patients,49.6%were male,and males were more predominant in patients with CD than in those with UC(72.4%vs.42.2%,P=0.008;a male/female ratio of 2.62 in CD,P=0.0016).Approximately one fifth of the patients had extra-intestinal manifestations and 13.3%of the patients had associated diseases.Extraintestinal manifestations and associated diseases were more common in early onset disease[P=0.017,odds ratio(OR)=4.02;P=0.03,OR=4.1].Of the patients,15%had normal laboratory parameters including anemia,high platelet count,hypoalbuminemia,hypoferritinemia,and high sedimentation rate.Area under receiver operation characteristics was used to predict pancolitis in patients with UC.The values of C-reactive protein,sedimentation rate and pediatric ulcerative colitis activity were 0.61(P=0.06),0.66(P=0.01)and 0.76(P=0.0001),respectively.Four(4.4%)patients with UC underwent colectomy,andfi nally two(1.5%,95%confidence interval:0-3.7%)patients died from primary disease or complications.Conclusions:IBD is an increasing clinical entity in Turkey.Features of IBD are similar to those in other populations,but prospective multicenter studies are needed to analyze the true incidence of IBD in Turkish children.展开更多
文摘Background Low alanine aminotransaminase (LALT) levels may be seen in patients with inflammatory bowel disease (IBD),but there has been no study about the frequency and its clinical significance.We aimed to analyze the frequency of LALT,and its clinical significance in children with IBD.Methods The study included the 89 patients with IBD without hepatobiliary involvement.LALT was defined as ALT levels < 5 U/L.Demographic and clinical findings and outcome of the patients with and without LALT were compared.Results LALT was found 47.1% of the patients.At initial examination,it was more common in female patients (92.3 vs.41.3%,P < 0.001) and patients with CD (57.7 vs.30.2%,P=0.01).75% of the patients with penetrating Crohn's disease (CD) had LALT (P=0.002).Hemoglobin (10.4±2.1 vs.11.7± 1.9 g/dL,P=0.01),folic acid (5.2±3.3 vs.8.6±5.9 ng/mL,P =0.02) and serum albumin levels (3.6 ± 0.8 vs.4.7 ± 5 g/dL,P =0.002) were significantly low in patients with LALT.LALT was associted with the disease relapse within 2 weeks in 12 of the 16 patients with LALT whereas it was seen in 16 of the 73 patients without LALT during the follow-up (75 vs.21.9%,P < 0.001).Additionally,steroid dependency was more common in patients with LALT during the follow-up (62.5 vs.12.3%,P<0.001).Conclusions LALT is common in children with IBD especially in CD and associated with low hemoglobin,albumin and folic acid levels.It may be a marker of relapse and steroid dependency.
文摘Background:This study was undertaken to evaluate demographics,clinical manifestations,laboratoryfi ndings and outcomes of children with inflammatory bowel disease(IBD)in Turkey.Methods:We analyzed the medical records of 127 children diagnosed with IBD(under 18 years old)between January 2004 and January 2012 in 8 pediatric gastroenterology centers.Results:Of the 127 patients,90(70.9%)suffered from ulcerative colitis(UC),29(22.8%)from Crohn's disease(CD),and 8(6.3%)from IBD unclassified.The mean age of the 127 patients was 11.6±4.1 years,and 11.8%of the patients were below 5 years old.Of the patients,49.6%were male,and males were more predominant in patients with CD than in those with UC(72.4%vs.42.2%,P=0.008;a male/female ratio of 2.62 in CD,P=0.0016).Approximately one fifth of the patients had extra-intestinal manifestations and 13.3%of the patients had associated diseases.Extraintestinal manifestations and associated diseases were more common in early onset disease[P=0.017,odds ratio(OR)=4.02;P=0.03,OR=4.1].Of the patients,15%had normal laboratory parameters including anemia,high platelet count,hypoalbuminemia,hypoferritinemia,and high sedimentation rate.Area under receiver operation characteristics was used to predict pancolitis in patients with UC.The values of C-reactive protein,sedimentation rate and pediatric ulcerative colitis activity were 0.61(P=0.06),0.66(P=0.01)and 0.76(P=0.0001),respectively.Four(4.4%)patients with UC underwent colectomy,andfi nally two(1.5%,95%confidence interval:0-3.7%)patients died from primary disease or complications.Conclusions:IBD is an increasing clinical entity in Turkey.Features of IBD are similar to those in other populations,but prospective multicenter studies are needed to analyze the true incidence of IBD in Turkish children.
