This editorial comments on an article published in a recent issue of World Journal of Gastroenterology,entitled“Association of low muscle strength with metabolic dysfunction-associated fatty liver disease:A nationwid...This editorial comments on an article published in a recent issue of World Journal of Gastroenterology,entitled“Association of low muscle strength with metabolic dysfunction-associated fatty liver disease:A nationwide study”.We focused on the association between muscle strength and the incidence of non-alcoholic fatty liver disease(NAFLD)and metabolic-associated fatty liver disease(MAFLD),as well as the mechanisms underlying the correlation and related clinical applications.NAFLD,which is now redefined as MAFLD,is one of the most common chronic liver diseases globally with an increasing prevalence and is characterized by malnutrition,which may contribute to decreased muscle strength.Reduction of muscle strength reportedly has a pathogenesis similar to that of NAFLD/MAFLD,including insulin resistance,inflammation,sedentary behavior,as well as insufficient vitamin D.Multiple studies have focused on the relationship between sarcopenia or muscle strength and NAFLD.However,studies investigating the relationship between muscle strength and MAFLD are limited.Owing to the shortage of specific medications for NAFLD/MAFLD treatment,early detection is essential.Furthermore,the relationship between muscle strength and NAFLD/MAFLD suggests that improvements in muscle strength may have an impact on disease prevention and may provide novel insights into treatments including dietary therapy,as well as tailored physical activity.展开更多
Hybrid Power-line/Visible-light Communication(HPVC)network has been one of the most promising Cooperative Communication(CC)technologies for constructing Smart Home due to its superior communication reliability and har...Hybrid Power-line/Visible-light Communication(HPVC)network has been one of the most promising Cooperative Communication(CC)technologies for constructing Smart Home due to its superior communication reliability and hardware efficiency.Current research on HPVC networks focuses on the performance analysis and optimization of the Physical(PHY)layer,where the Power Line Communication(PLC)component only serves as the backbone to provide power to light Emitting Diode(LED)devices.So designing a Media Access Control(MAC)protocol remains a great challenge because it allows both PLC and Visible Light Communication(VLC)components to operate data transmission,i.e.,to achieve a true HPVC network CC.To solve this problem,we propose a new HPC network MAC protocol(HPVC MAC)based on Carrier Sense Multiple Access/Collision Avoidance(CSMA/CA)by combining IEEE 802.15.7 and IEEE 1901 standards.Firstly,we add an Additional Assistance(AA)layer to provide the channel selection strategies for sensor stations,so that they can complete data transmission on the selected channel via the specified CSMA/CA mechanism,respectively.Based on this,we give a detailed working principle of the HPVC MAC,followed by the construction of a joint analytical model for mathematicalmathematical validation of the HPVC MAC.In the modeling process,the impacts of PHY layer settings(including channel fading types and additive noise feature),CSMA/CA mechanisms of 802.15.7 and 1901,and practical configurations(such as traffic rate,transit buffer size)are comprehensively taken into consideration.Moreover,we prove the proposed analytical model has the solvability.Finally,through extensive simulations,we characterize the HPVC MAC performance under different system parameters and verify the correctness of the corresponding analytical model with an average error rate of 4.62%between the simulation and analytical results.展开更多
Urea generation through electrochemical CO_(2) and NO_(3)~-co-reduction reaction(CO_(2)NO_(3)RR)is still limited by either the low selectivity or yield rate of urea.Herein,we report copper carbonate hydroxide(Cu_2(OH)...Urea generation through electrochemical CO_(2) and NO_(3)~-co-reduction reaction(CO_(2)NO_(3)RR)is still limited by either the low selectivity or yield rate of urea.Herein,we report copper carbonate hydroxide(Cu_2(OH)_2CO_(3))as an efficient CO_(2)NO_(3)RR electrocatalyst with an impressive urea Faradaic efficiency of45.2%±2.1%and a high yield rate of 1564.5±145.2μg h~(-1)mg_(cat)~(-1).More importantly,H_(2) evolution is fully inhibited on this electrocatalyst over a wide potential range between-0.3 and-0.8 V versus reversible hydrogen electrode.Our thermodynamic simulation reveals that the first C-N coupling follows a unique pathway on Cu_2(OH)_2CO_(3) by combining the two intermediates,~*COOH and~*NHO.This work demonstrates that high selectivity and yield rate of urea can be simultaneously achieved on simple Cu-based electrocatalysts in CO_(2)NO_(3)RR,and provide guidance for rational design of more advanced catalysts.展开更多
Structural instability in underground engineering,especially in coal-rock structures,poses significant safety risks.Thus,the development of an accurate monitoring method for the health of coal-rock bodies is crucial.T...Structural instability in underground engineering,especially in coal-rock structures,poses significant safety risks.Thus,the development of an accurate monitoring method for the health of coal-rock bodies is crucial.The focus of this work is on understanding energy evolution patterns in coal-rock bodies under complex conditions by using shear,splitting,and uniaxial compression tests.We examine the changes in energy parameters during various loading stages and the effects of various failure modes,resulting in an innovative energy dissipation-based health evaluation technique for coal.Key results show that coal bodies go through transitions between strain hardening and softening mechanisms during loading,indicated by fluctuations in elastic energy and dissipation energy density.For tensile failure,the energy profile of coal shows a pattern of “high dissipation and low accumulation” before peak stress.On the other hand,shear failure is described by “high accumulation and low dissipation” in energy trends.Different failure modes correlate with an accelerated increase in the dissipation energy before destabilization,and a significant positive correlation is present between the energy dissipation rate and the stress state of the coal samples.A novel mathematical and statistical approach is developed,establishing a dissipation energy anomaly index,W,which categorizes the structural health of coal into different danger levels.This method provides a quantitative standard for early warning systems and is adaptable for monitoring structural health in complex underground engineering environments,contributing to the development of structural health monitoring technology.展开更多
The control of oxygen is paramount in achieving high-performance titanium(Ti)parts by powder metallurgy such as metal in-jection molding(MIM).In this study,we purposely selected the Ti and Ti-6Al-4V powders as the ref...The control of oxygen is paramount in achieving high-performance titanium(Ti)parts by powder metallurgy such as metal in-jection molding(MIM).In this study,we purposely selected the Ti and Ti-6Al-4V powders as the reference materials since these two are the most representative Ti materials in the industry.Herein,hydride-dehydride(HDH)Ti powders were pre-oxidized to examine the ef-fect of oxygen variation on the characteristics of oxide layer on the particle surface and its resultant color feature.The results indicate that the thickness and Ti oxide level(Ti^(0)→Ti^(4+))of the oxide layer on the HDH Ti powders increased as the oxygen content increased,lead-ing to the transition of color appearance from grey,brown to blue.This work aids in the powder feedstock selection at the initial stage in powder metallurgy.In addition,the development of oxygen content was comprehensively studied during the MIM process using the gas-atomized(GA)Ti-6Al-4V powders.Particularly,the oxygen variation in the form of oxide layer,the change of oxygen content in the powders,and the relevant parts were investigated during the processes of kneading,injection,debinding,and sintering.The oxygen vari-ation was mainly concentrated in the sintering stage,and the content increased with the increase of sintering temperature.The variation of oxygen content during the MIM process demonstrates the crucial role of powder feedstock and sintering stage in controlling oxygen con-tent.This work provides a piece of valuable information on oxygen detecting,control,and manipulation for the powder and processing in the industry of Ti and its alloys by powder metallurgy.展开更多
The precise correction of atmospheric zenith tropospheric delay(ZTD)is significant for the Global Navigation Satellite System(GNSS)performance regarding positioning accuracy and convergence time.In the past decades,ma...The precise correction of atmospheric zenith tropospheric delay(ZTD)is significant for the Global Navigation Satellite System(GNSS)performance regarding positioning accuracy and convergence time.In the past decades,many empirical ZTD models based on whether the gridded or scattered ZTD products have been proposed and widely used in the GNSS positioning applications.But there is no comprehensive evaluation of these models for the whole China region,which features complicated topography and climate.In this study,we completely assess the typical empirical models,the IGGtropSH model(gridded,non-meteorology),the SHAtropE model(scattered,non-meteorology),and the GPT3 model(gridded,meteorology)using the Crustal Movement Observation Network of China(CMONOC)network.In general,the results show that the three models share consistent performance with RMSE/bias of 37.45/1.63,37.13/2.20,and 38.27/1.34 mm for the GPT3,SHAtropE and IGGtropSH model,respectively.However,the models had a distinct performance regarding geographical distribution,elevation,seasonal variations,and daily variation.In the southeastern region of China,RMSE values are around 50 mm,which are much higher than that in the western region,approximately 20 mm.The SHAtropE model exhibits better performance for areas with large variations in elevation.The GPT3 model and the IGGtropSH model are more stable across different months,and the SHAtropE model based on the GNSS data exhibits superior performance across various UTC epochs.展开更多
Translesion DNA synthesis(TLS)can bypass DNA lesions caused by chemotherapeutic drugs,which usually result in drug resistance.Given its key role in mutagenesis and cell survival after DNA damage,inhibition of the TLS ...Translesion DNA synthesis(TLS)can bypass DNA lesions caused by chemotherapeutic drugs,which usually result in drug resistance.Given its key role in mutagenesis and cell survival after DNA damage,inhibition of the TLS pathway has emerged as a potential target for improving the efficacy of DNA-damaging agents such as cisplatin(CDDP),a widely used anticancer agent.Unfortunately,few suitable natural TLS inhibitors have been reported.Here,we found that a triterpenoid compound Ganoboninketal C(26-3)from Ganoderma boninense,a traditional Chinese medicine,can impair CDDP-induced TLS polymerase eta(Polη)focus formation,PCNA monoubiquitination as well as mutagenesis.Moreover,26-3 can significantly sensitize tumor cells to CDDP killing and reduce the proportion of cancer stem cells in AGS and promote apoptosis after CDDP exposure.Interestingly,26-3 can also sensitize tumor cells to Gefitinib therapy.Mechanistically,through RNA-seq analysis,we found that 26-3 could abrogate the CDDP-induced upregulation of Polηand PIDD(p53-induced protein with a death domain),2 known factors promoting TLS pathway.Furthermore,we found that activating transcription factor 3 is a potential novel TLS modulator.Taken together,we have identified a natural TLS inhibitor 26-3,which can be potentially used as an adjuvant to improve clinical efficacy.展开更多
In recent years,the Fuxian area in the southeastern Ordos Basin has undergone significant exploration,with industrial gas flow tested in wells drilled into the Ordovician marine carbonates.Despite this,the gas accumul...In recent years,the Fuxian area in the southeastern Ordos Basin has undergone significant exploration,with industrial gas flow tested in wells drilled into the Ordovician marine carbonates.Despite this,the gas accumulation patterns of this area are not fully understood,posing challenges for further exploration.Our analysis of geological conditions indicates that the Ordovician Majiagou Formation in this area hosts two gas plays:one found in weathering crusts and the other found in interior of the formation.We investigated various typical gas reservoirs in the area,focusing on differentiating the geological conditions and factors controlling gas accumulation in the weathering-crust and interior gas reservoirs.The results suggest three primary gas accumulation patterns in the Majiagou Formation in the Fuxian area:(1)upper gas accumulation in weathering crusts,present in the high parts of landforms such as residual paleo-hills or buried paleo-platform(Pattern I);(2)the stereoscopic pattern with gas accumulation in both weathering crusts and strata interior,arising in high parts of landforms such as residual paleo-hills or buried paleo-platforms(Pattern II);(3)lower gas accumulation in strata interior,occurring in the upper reaches and on both sides of paleo-trenches(Pattern III).This study will serve as a geological basis for future exploration deployment in the Fuxian area.展开更多
The closed-loop flight control system of fly by wire is generally adopted in modern air-craft.Based on the frequency-domain stability analysis,the aeroservoelastic model of closedloop aircraft is established,and aeros...The closed-loop flight control system of fly by wire is generally adopted in modern air-craft.Based on the frequency-domain stability analysis,the aeroservoelastic model of closedloop aircraft is established,and aeroservoelastic stability parameterized calculation of design improvement is conducted after the preliminary analysis.The design variables are mounted location of integrated sensors and damping coefficientsζ_(1),ζ_(2) of notch filter,with stability margin of the system as design objective.Results indicate that aeroservoelastic margin of the aircraft in certain states is insufficient.While the mounted location of integrated sensors is adjusted,the system stability can be improved to certain extent.It’s more appropriate to mount the integrated sensors in the overlapping field between the nodal lines of vertical and lateral bending for the fuselage.The system stability is also significantly improved by adding notch filter,both gain margin and phase margin increase when the real number pairζ_(1)-ζ_(2) is located in the zone above the 45°diagonal ofζ_(1),ζ_(2) con-struction plane,and the farther theζ_(1)-ζ_(2) is from the 45°diagonal,the stronger the system stability.Also the decrease in the gain peak of frequency response and the enhancement of relative stability of the system are achieved by the appropriateζ_(1)-ζ_(2) of notch filter.展开更多
Purpose–This study aimed to facilitate a rapid evaluation of track service status and vehicle ride comfort based on car body acceleration.Consequently,a low-cost,data-driven approach was proposed for analyzing speed-...Purpose–This study aimed to facilitate a rapid evaluation of track service status and vehicle ride comfort based on car body acceleration.Consequently,a low-cost,data-driven approach was proposed for analyzing speed-related acceleration limits in metro systems.Design/methodology/approach–A portable sensing terminal was developed to realize easy and efficient detection of car body acceleration.Further,field measurements were performed on a 51.95-km metro line.Data from 272 metro sections were tested as a case study,and a quantile regression method was proposed to fit the control limits of the car body acceleration at different speeds using the measured data.Findings–First,the frequency statistics of the measured data in the speed-acceleration dimension indicated that the car body acceleration was primarily concentrated within the constant speed stage,particularly at speeds of 15.4,18.3,and 20.9 m/s.Second,resampling was performed according to the probability density distribution of car body acceleration for different speed domains to achieve data balance.Finally,combined with the traditional linear relationship between speed and acceleration,the statistical relationships between the speed and car body acceleration under different quantiles were determined.We concluded the lateral/vertical quantiles of 0.8989/0.9895,0.9942/0.997,and 0.9998/0.993 as being excellent,good,and qualified control limits,respectively,for the lateral and vertical acceleration of the car body.In addition,regression lines for the speedrelated acceleration limits at other quantiles(0.5,0.75,2s,and 3s)were obtained.Originality/value–The proposed method is expected to serve as a reference for further studies on speedrelated acceleration limits in rail transit systems.展开更多
Purpose–This study aims to analyze the development direction of track geometry inspection equipment for high-speed comprehensive inspection train in China.Design/methodology/approach–The development of track geometr...Purpose–This study aims to analyze the development direction of track geometry inspection equipment for high-speed comprehensive inspection train in China.Design/methodology/approach–The development of track geometry inspection equipment for highspeed comprehensive inspection train in China in the past 20 years can be divided into 3 stages.Track geometry inspection equipment 1.0 is the stage of analog signal.At the stage 1.0,the first priority is to meet the China’s railways basic needs of pre-operation joint debugging,safety assessment and daily dynamic inspection,maintenance and repair after operation.Track geometry inspection equipment 2.0 is the stage of digital signal.At the stage 2.0,it is important to improve stability and reliability of track geometry inspection equipment by upgrading the hardware sensors and improving software architecture.Track geometry inspection equipment 3.0 is the stage of lightweight.At the stage 3.0,miniaturization,low power consumption,self-running and green economy are co-developing on demand.Findings–The ability of track geometry inspection equipment for high-speed comprehensive inspection train will be expanded.The dynamic inspection of track stiffness changes will be studied under loaded and unloaded conditions in response to the track local settlement,track plate detachment and cushion plate failure.The dynamic measurement method of rail surface slope and vertical curve radius will be proposed,to reveal the changes in railway profile parameters of high-speed railways and the relationship between railway profile,track irregularity and subsidence of subgrade and bridges.The 200 m cut-off wavelength of track regularity will be researched to adapt to the operating speed of 400 km/h.Originality/value–The research can provide new connotations and requirements of track geometry inspection equipment for high-speed comprehensive inspection train in the new railway stage.展开更多
Objective:In this study,we investigated the composition of the intestinal microflora associated with Yang-deficiency and the function-specific members of this microflora.Method:Subjects with normal and Yang-deficient ...Objective:In this study,we investigated the composition of the intestinal microflora associated with Yang-deficiency and the function-specific members of this microflora.Method:Subjects with normal and Yang-deficient constitutions were recruited in Beijing,with 30 subjects in each group.Illumina high-throughput sequencing was used to sequence the DNA of their fecal bacteria in the 16S rRNA V3-V4 region.The species abundance and distribution of the intestinal microflora in each specimen were determined with a statistical analysis of these sequences.We identified an underlying taxonomic trend with nonparametric PCoA and other statistical techniques.Results:(1) Subjects with Yang-deficiency displayed more uneven abundances of the taxa in their intestinal microflora than the subjects with normal Yang;(2) several differences were observed in the proportions of certain bacterial groups between the Yang-deficient and control groups;and (3) the fallowing bacteria differed significantly between the two groups:(i) Brevundimonas,Leuconostoc,Turicibacter,Defluviitaleaceae incertae sedis,Rothia,and Butyricimonas were slightly higher in the Yang-deficient subjects,whereas (ii)Megasphaera,Ruminococcus,and Lachnospira were higher in the normal subjects than in the Yang-deficient subjects.展开更多
目的:探索重大公共卫生事件背景下医护人员心理状况研究现状、热点及未来发展趋势,为今后的研究提供参考依据。方法:检索2020-2022年在Web of Science核心合集数据库中以此次新冠疫情中医护人员心理状况为主题的文献,运用CiteSpace软件...目的:探索重大公共卫生事件背景下医护人员心理状况研究现状、热点及未来发展趋势,为今后的研究提供参考依据。方法:检索2020-2022年在Web of Science核心合集数据库中以此次新冠疫情中医护人员心理状况为主题的文献,运用CiteSpace软件对发文国家/地区、机构、作者及关键词进行可视化分析,并根据可视化图谱对该领域的研究进行分析与讨论。结果:共纳入文献792篇。该领域近3年的发文数量呈上升趋势;不同国家/地区、机构和作者之间的合作较少;研究热点包括医护人员心理健康的现状、影响因素及干预措施;对研究对象的扩展及对干预理论的探索成为该领域的发展趋势。结论:重大突发公共卫生事件背景下医护人员心理状况研究尚处于起步阶段,建议加强交流与合作,促进该领域研究的深化和发展,以提高医护人员心理健康,保障医疗卫生服务质量。展开更多
基金supported by the Jiangsu Province Industry–University–Research Project,China(No.BY20221160)the Postgraduate Research and Practice Innovation Program of Jiangsu Province,China(No.KYCX22_3798)+2 种基金the National Natural Science Foundation of China(No.52275339)the Key Research and Development Plan of the Ministry of Science and Technology,China(No.2023YFE0200400)the Science and Technology Project of Jiangsu Province,China(No.BZ2021053)。
基金Supported by National Natural Science Foundation of China,No.82000625the Doctoral Scientific Research Foundation of Liaoning Province,No.2020-BS-109.
文摘This editorial comments on an article published in a recent issue of World Journal of Gastroenterology,entitled“Association of low muscle strength with metabolic dysfunction-associated fatty liver disease:A nationwide study”.We focused on the association between muscle strength and the incidence of non-alcoholic fatty liver disease(NAFLD)and metabolic-associated fatty liver disease(MAFLD),as well as the mechanisms underlying the correlation and related clinical applications.NAFLD,which is now redefined as MAFLD,is one of the most common chronic liver diseases globally with an increasing prevalence and is characterized by malnutrition,which may contribute to decreased muscle strength.Reduction of muscle strength reportedly has a pathogenesis similar to that of NAFLD/MAFLD,including insulin resistance,inflammation,sedentary behavior,as well as insufficient vitamin D.Multiple studies have focused on the relationship between sarcopenia or muscle strength and NAFLD.However,studies investigating the relationship between muscle strength and MAFLD are limited.Owing to the shortage of specific medications for NAFLD/MAFLD treatment,early detection is essential.Furthermore,the relationship between muscle strength and NAFLD/MAFLD suggests that improvements in muscle strength may have an impact on disease prevention and may provide novel insights into treatments including dietary therapy,as well as tailored physical activity.
基金supported by the National Natural Science Foundation of China(No.61772386)National Key Research and Development Project(No.2018YFB1305001)Fundamental Research Funds for the Central Universities(No.KJ02072021-0119).
文摘Hybrid Power-line/Visible-light Communication(HPVC)network has been one of the most promising Cooperative Communication(CC)technologies for constructing Smart Home due to its superior communication reliability and hardware efficiency.Current research on HPVC networks focuses on the performance analysis and optimization of the Physical(PHY)layer,where the Power Line Communication(PLC)component only serves as the backbone to provide power to light Emitting Diode(LED)devices.So designing a Media Access Control(MAC)protocol remains a great challenge because it allows both PLC and Visible Light Communication(VLC)components to operate data transmission,i.e.,to achieve a true HPVC network CC.To solve this problem,we propose a new HPC network MAC protocol(HPVC MAC)based on Carrier Sense Multiple Access/Collision Avoidance(CSMA/CA)by combining IEEE 802.15.7 and IEEE 1901 standards.Firstly,we add an Additional Assistance(AA)layer to provide the channel selection strategies for sensor stations,so that they can complete data transmission on the selected channel via the specified CSMA/CA mechanism,respectively.Based on this,we give a detailed working principle of the HPVC MAC,followed by the construction of a joint analytical model for mathematicalmathematical validation of the HPVC MAC.In the modeling process,the impacts of PHY layer settings(including channel fading types and additive noise feature),CSMA/CA mechanisms of 802.15.7 and 1901,and practical configurations(such as traffic rate,transit buffer size)are comprehensively taken into consideration.Moreover,we prove the proposed analytical model has the solvability.Finally,through extensive simulations,we characterize the HPVC MAC performance under different system parameters and verify the correctness of the corresponding analytical model with an average error rate of 4.62%between the simulation and analytical results.
基金supported by the Research Grants Council(26206115,16304821 and 16309418)the Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)(SMSEGL20SC01)+2 种基金the Innovation and Technology Commission(grant no.ITC-CNERC14EG03)of the Hong Kong Special Administrative Regionthe Hong Kong Postdoctoral Fellowship Scheme(HKUST PDFS2021-4S12 and HKUST PDFS2021-6S08)the support from the Shenzhen fundamental research funding(JCYJ20210324115809026,20200925154115001,JCYJ20200109141216566)。
文摘Urea generation through electrochemical CO_(2) and NO_(3)~-co-reduction reaction(CO_(2)NO_(3)RR)is still limited by either the low selectivity or yield rate of urea.Herein,we report copper carbonate hydroxide(Cu_2(OH)_2CO_(3))as an efficient CO_(2)NO_(3)RR electrocatalyst with an impressive urea Faradaic efficiency of45.2%±2.1%and a high yield rate of 1564.5±145.2μg h~(-1)mg_(cat)~(-1).More importantly,H_(2) evolution is fully inhibited on this electrocatalyst over a wide potential range between-0.3 and-0.8 V versus reversible hydrogen electrode.Our thermodynamic simulation reveals that the first C-N coupling follows a unique pathway on Cu_2(OH)_2CO_(3) by combining the two intermediates,~*COOH and~*NHO.This work demonstrates that high selectivity and yield rate of urea can be simultaneously achieved on simple Cu-based electrocatalysts in CO_(2)NO_(3)RR,and provide guidance for rational design of more advanced catalysts.
基金financially supported by the National Natural Science Foundation of China(Nos.52011530037 and 51904019)。
文摘Structural instability in underground engineering,especially in coal-rock structures,poses significant safety risks.Thus,the development of an accurate monitoring method for the health of coal-rock bodies is crucial.The focus of this work is on understanding energy evolution patterns in coal-rock bodies under complex conditions by using shear,splitting,and uniaxial compression tests.We examine the changes in energy parameters during various loading stages and the effects of various failure modes,resulting in an innovative energy dissipation-based health evaluation technique for coal.Key results show that coal bodies go through transitions between strain hardening and softening mechanisms during loading,indicated by fluctuations in elastic energy and dissipation energy density.For tensile failure,the energy profile of coal shows a pattern of “high dissipation and low accumulation” before peak stress.On the other hand,shear failure is described by “high accumulation and low dissipation” in energy trends.Different failure modes correlate with an accelerated increase in the dissipation energy before destabilization,and a significant positive correlation is present between the energy dissipation rate and the stress state of the coal samples.A novel mathematical and statistical approach is developed,establishing a dissipation energy anomaly index,W,which categorizes the structural health of coal into different danger levels.This method provides a quantitative standard for early warning systems and is adaptable for monitoring structural health in complex underground engineering environments,contributing to the development of structural health monitoring technology.
基金financially supported by the National Key Research and Development Program of China(No.2021 YFB3701900)the National Natural Science Foundation Program of China(No.51971036)the Open Research Fund of State Key Laboratory of Mesoscience and Engineering(No.MESO-23-D07).
文摘The control of oxygen is paramount in achieving high-performance titanium(Ti)parts by powder metallurgy such as metal in-jection molding(MIM).In this study,we purposely selected the Ti and Ti-6Al-4V powders as the reference materials since these two are the most representative Ti materials in the industry.Herein,hydride-dehydride(HDH)Ti powders were pre-oxidized to examine the ef-fect of oxygen variation on the characteristics of oxide layer on the particle surface and its resultant color feature.The results indicate that the thickness and Ti oxide level(Ti^(0)→Ti^(4+))of the oxide layer on the HDH Ti powders increased as the oxygen content increased,lead-ing to the transition of color appearance from grey,brown to blue.This work aids in the powder feedstock selection at the initial stage in powder metallurgy.In addition,the development of oxygen content was comprehensively studied during the MIM process using the gas-atomized(GA)Ti-6Al-4V powders.Particularly,the oxygen variation in the form of oxide layer,the change of oxygen content in the powders,and the relevant parts were investigated during the processes of kneading,injection,debinding,and sintering.The oxygen vari-ation was mainly concentrated in the sintering stage,and the content increased with the increase of sintering temperature.The variation of oxygen content during the MIM process demonstrates the crucial role of powder feedstock and sintering stage in controlling oxygen con-tent.This work provides a piece of valuable information on oxygen detecting,control,and manipulation for the powder and processing in the industry of Ti and its alloys by powder metallurgy.
基金supported by the National Natural Science Foundation of China(42204022,52174160,52274169)Open Fund of Hubei Luojia Laboratory(230100031)+2 种基金the Open Fund of State Laboratory of Information Engineering in Surveying,Mapping and Remote Sensing,Wuhan University(23P02)the Fundamental Research Funds for the Central Universities(2023ZKPYDC10)China University of Mining and Technology-Beijing Innovation Training Program for College Students(202302014,202202023)。
文摘The precise correction of atmospheric zenith tropospheric delay(ZTD)is significant for the Global Navigation Satellite System(GNSS)performance regarding positioning accuracy and convergence time.In the past decades,many empirical ZTD models based on whether the gridded or scattered ZTD products have been proposed and widely used in the GNSS positioning applications.But there is no comprehensive evaluation of these models for the whole China region,which features complicated topography and climate.In this study,we completely assess the typical empirical models,the IGGtropSH model(gridded,non-meteorology),the SHAtropE model(scattered,non-meteorology),and the GPT3 model(gridded,meteorology)using the Crustal Movement Observation Network of China(CMONOC)network.In general,the results show that the three models share consistent performance with RMSE/bias of 37.45/1.63,37.13/2.20,and 38.27/1.34 mm for the GPT3,SHAtropE and IGGtropSH model,respectively.However,the models had a distinct performance regarding geographical distribution,elevation,seasonal variations,and daily variation.In the southeastern region of China,RMSE values are around 50 mm,which are much higher than that in the western region,approximately 20 mm.The SHAtropE model exhibits better performance for areas with large variations in elevation.The GPT3 model and the IGGtropSH model are more stable across different months,and the SHAtropE model based on the GNSS data exhibits superior performance across various UTC epochs.
基金supported by National Key Research and Development Program of China(2018YFA0108500)NSFC82341006,81673334,31970740,31801144,31800684 and 31701227+3 种基金Natural Science Foundation of Beijing(IS23071)Postdoctoral Research Foundation of China(2021M703206)Natural Science Foundation of Shanxi Province(202203021211155)the State Key Laboratory of Membrane Biology.
文摘Translesion DNA synthesis(TLS)can bypass DNA lesions caused by chemotherapeutic drugs,which usually result in drug resistance.Given its key role in mutagenesis and cell survival after DNA damage,inhibition of the TLS pathway has emerged as a potential target for improving the efficacy of DNA-damaging agents such as cisplatin(CDDP),a widely used anticancer agent.Unfortunately,few suitable natural TLS inhibitors have been reported.Here,we found that a triterpenoid compound Ganoboninketal C(26-3)from Ganoderma boninense,a traditional Chinese medicine,can impair CDDP-induced TLS polymerase eta(Polη)focus formation,PCNA monoubiquitination as well as mutagenesis.Moreover,26-3 can significantly sensitize tumor cells to CDDP killing and reduce the proportion of cancer stem cells in AGS and promote apoptosis after CDDP exposure.Interestingly,26-3 can also sensitize tumor cells to Gefitinib therapy.Mechanistically,through RNA-seq analysis,we found that 26-3 could abrogate the CDDP-induced upregulation of Polηand PIDD(p53-induced protein with a death domain),2 known factors promoting TLS pathway.Furthermore,we found that activating transcription factor 3 is a potential novel TLS modulator.Taken together,we have identified a natural TLS inhibitor 26-3,which can be potentially used as an adjuvant to improve clinical efficacy.
基金supported the National Natural Science Foundation of China(Nos.:U19B6003,U20B6001)the Class A Strategic Pilot Science and Technology Program of the Chinese Academy of Sciences(No.:XDA14000000)a project entitled Oil and Gas Enrichment Rules and Favorable Target Selection in the Iran-Iraq region initiated by the Sinopec Science and Technology Department.
文摘In recent years,the Fuxian area in the southeastern Ordos Basin has undergone significant exploration,with industrial gas flow tested in wells drilled into the Ordovician marine carbonates.Despite this,the gas accumulation patterns of this area are not fully understood,posing challenges for further exploration.Our analysis of geological conditions indicates that the Ordovician Majiagou Formation in this area hosts two gas plays:one found in weathering crusts and the other found in interior of the formation.We investigated various typical gas reservoirs in the area,focusing on differentiating the geological conditions and factors controlling gas accumulation in the weathering-crust and interior gas reservoirs.The results suggest three primary gas accumulation patterns in the Majiagou Formation in the Fuxian area:(1)upper gas accumulation in weathering crusts,present in the high parts of landforms such as residual paleo-hills or buried paleo-platform(Pattern I);(2)the stereoscopic pattern with gas accumulation in both weathering crusts and strata interior,arising in high parts of landforms such as residual paleo-hills or buried paleo-platforms(Pattern II);(3)lower gas accumulation in strata interior,occurring in the upper reaches and on both sides of paleo-trenches(Pattern III).This study will serve as a geological basis for future exploration deployment in the Fuxian area.
文摘The closed-loop flight control system of fly by wire is generally adopted in modern air-craft.Based on the frequency-domain stability analysis,the aeroservoelastic model of closedloop aircraft is established,and aeroservoelastic stability parameterized calculation of design improvement is conducted after the preliminary analysis.The design variables are mounted location of integrated sensors and damping coefficientsζ_(1),ζ_(2) of notch filter,with stability margin of the system as design objective.Results indicate that aeroservoelastic margin of the aircraft in certain states is insufficient.While the mounted location of integrated sensors is adjusted,the system stability can be improved to certain extent.It’s more appropriate to mount the integrated sensors in the overlapping field between the nodal lines of vertical and lateral bending for the fuselage.The system stability is also significantly improved by adding notch filter,both gain margin and phase margin increase when the real number pairζ_(1)-ζ_(2) is located in the zone above the 45°diagonal ofζ_(1),ζ_(2) con-struction plane,and the farther theζ_(1)-ζ_(2) is from the 45°diagonal,the stronger the system stability.Also the decrease in the gain peak of frequency response and the enhancement of relative stability of the system are achieved by the appropriateζ_(1)-ζ_(2) of notch filter.
基金the National Natural Science Foundation of China(NSFC)under No.52308473the National KeyR&DProgram under No.2022YFB2603301the China Postdoctoral Science Foundation funded project(Certificate Number:2023M743895).
文摘Purpose–This study aimed to facilitate a rapid evaluation of track service status and vehicle ride comfort based on car body acceleration.Consequently,a low-cost,data-driven approach was proposed for analyzing speed-related acceleration limits in metro systems.Design/methodology/approach–A portable sensing terminal was developed to realize easy and efficient detection of car body acceleration.Further,field measurements were performed on a 51.95-km metro line.Data from 272 metro sections were tested as a case study,and a quantile regression method was proposed to fit the control limits of the car body acceleration at different speeds using the measured data.Findings–First,the frequency statistics of the measured data in the speed-acceleration dimension indicated that the car body acceleration was primarily concentrated within the constant speed stage,particularly at speeds of 15.4,18.3,and 20.9 m/s.Second,resampling was performed according to the probability density distribution of car body acceleration for different speed domains to achieve data balance.Finally,combined with the traditional linear relationship between speed and acceleration,the statistical relationships between the speed and car body acceleration under different quantiles were determined.We concluded the lateral/vertical quantiles of 0.8989/0.9895,0.9942/0.997,and 0.9998/0.993 as being excellent,good,and qualified control limits,respectively,for the lateral and vertical acceleration of the car body.In addition,regression lines for the speedrelated acceleration limits at other quantiles(0.5,0.75,2s,and 3s)were obtained.Originality/value–The proposed method is expected to serve as a reference for further studies on speedrelated acceleration limits in rail transit systems.
基金supported by the National Natural Science Foundation of China(Grant No.52278465)Science and Technology Research and Development Plan of China Railway(Grant No.N2022G051)Key Project of China Academy of Railway Sciences(Grant No.2351JJ2401).
文摘Purpose–This study aims to analyze the development direction of track geometry inspection equipment for high-speed comprehensive inspection train in China.Design/methodology/approach–The development of track geometry inspection equipment for highspeed comprehensive inspection train in China in the past 20 years can be divided into 3 stages.Track geometry inspection equipment 1.0 is the stage of analog signal.At the stage 1.0,the first priority is to meet the China’s railways basic needs of pre-operation joint debugging,safety assessment and daily dynamic inspection,maintenance and repair after operation.Track geometry inspection equipment 2.0 is the stage of digital signal.At the stage 2.0,it is important to improve stability and reliability of track geometry inspection equipment by upgrading the hardware sensors and improving software architecture.Track geometry inspection equipment 3.0 is the stage of lightweight.At the stage 3.0,miniaturization,low power consumption,self-running and green economy are co-developing on demand.Findings–The ability of track geometry inspection equipment for high-speed comprehensive inspection train will be expanded.The dynamic inspection of track stiffness changes will be studied under loaded and unloaded conditions in response to the track local settlement,track plate detachment and cushion plate failure.The dynamic measurement method of rail surface slope and vertical curve radius will be proposed,to reveal the changes in railway profile parameters of high-speed railways and the relationship between railway profile,track irregularity and subsidence of subgrade and bridges.The 200 m cut-off wavelength of track regularity will be researched to adapt to the operating speed of 400 km/h.Originality/value–The research can provide new connotations and requirements of track geometry inspection equipment for high-speed comprehensive inspection train in the new railway stage.
文摘Objective:In this study,we investigated the composition of the intestinal microflora associated with Yang-deficiency and the function-specific members of this microflora.Method:Subjects with normal and Yang-deficient constitutions were recruited in Beijing,with 30 subjects in each group.Illumina high-throughput sequencing was used to sequence the DNA of their fecal bacteria in the 16S rRNA V3-V4 region.The species abundance and distribution of the intestinal microflora in each specimen were determined with a statistical analysis of these sequences.We identified an underlying taxonomic trend with nonparametric PCoA and other statistical techniques.Results:(1) Subjects with Yang-deficiency displayed more uneven abundances of the taxa in their intestinal microflora than the subjects with normal Yang;(2) several differences were observed in the proportions of certain bacterial groups between the Yang-deficient and control groups;and (3) the fallowing bacteria differed significantly between the two groups:(i) Brevundimonas,Leuconostoc,Turicibacter,Defluviitaleaceae incertae sedis,Rothia,and Butyricimonas were slightly higher in the Yang-deficient subjects,whereas (ii)Megasphaera,Ruminococcus,and Lachnospira were higher in the normal subjects than in the Yang-deficient subjects.
文摘目的:探索重大公共卫生事件背景下医护人员心理状况研究现状、热点及未来发展趋势,为今后的研究提供参考依据。方法:检索2020-2022年在Web of Science核心合集数据库中以此次新冠疫情中医护人员心理状况为主题的文献,运用CiteSpace软件对发文国家/地区、机构、作者及关键词进行可视化分析,并根据可视化图谱对该领域的研究进行分析与讨论。结果:共纳入文献792篇。该领域近3年的发文数量呈上升趋势;不同国家/地区、机构和作者之间的合作较少;研究热点包括医护人员心理健康的现状、影响因素及干预措施;对研究对象的扩展及对干预理论的探索成为该领域的发展趋势。结论:重大突发公共卫生事件背景下医护人员心理状况研究尚处于起步阶段,建议加强交流与合作,促进该领域研究的深化和发展,以提高医护人员心理健康,保障医疗卫生服务质量。
