BACKGROUND:Prolonged invasive respiratory support and extracorporeal membrane oxygenation(ECMO)in patients requiring urgent lung transplantation(ULTx)present signifi cant challenges to clinical practice due to severe ...BACKGROUND:Prolonged invasive respiratory support and extracorporeal membrane oxygenation(ECMO)in patients requiring urgent lung transplantation(ULTx)present signifi cant challenges to clinical practice due to severe underlying diseases and complex conditions.The aim of the study was to report the clinical outcomes of patients who received ULTx and followed the perioperative rehabilitation protocol implemented in a lung transplant center.METHODS:A retrospective analysis was conducted in ULTx patients who required preoperative invasive mechanical ventilation(IMV)and ECMO between January 2018 and January 2023.Data were retrieved from electronic medical records at our lung transplant center.RESULTS:Fourteen patients(mean age 57.43±10.97 years;12 males,2 females)underwent ULTx with bridging ECMO and IMV.The mean body mass index was 23.94±3.33 kg/m²,and the mean Acute Physiology and Chronic Health Evaluation(APACHE)II score was 21.50±3.96.The Nutritional Risk Screening 2002(NRS 2002)scores were≥3.ULTx was performed after an 8.5-day waiting period(interquartile interval[IQR]5.0-26.5 d).Following the surgeries,the average lengths of ECMO and IMV were 1.0(IQR 1.0-2.0)d and 5.0(IQR 3.0-7.3)d,respectively.The total length of hospital stay was 60.1±30.8 d,with an average intensive care unit stay of 38.3±22.9 d and post-operative hospitalization stay of 45.8±26.1 d.Two patients died within 30 d after ULTx,with a 30-day survival rate of 85.71%.CONCLUSION:Patients receiving ULTx showed an acceptable short-term survival rate,validating the practicality and safety of the treatment protocols implemented in our center.展开更多
BACKGROUND Radical gastrectomy(RG)is commonly used in the treatment of patients with gastric cancer(GC),but this procedure may lead to stress responses,postoperative cognitive dysfunction,and blood coagulation abnorma...BACKGROUND Radical gastrectomy(RG)is commonly used in the treatment of patients with gastric cancer(GC),but this procedure may lead to stress responses,postoperative cognitive dysfunction,and blood coagulation abnormalities in patients.AIM To investigate the influences of dexmedetomidine(DEX)on stress responses and postoperative cognitive and coagulation functions in patients undergoing RG under general anesthesia(GA).METHODS One hundred and two patients undergoing RG for GC under GA from February 2020 to February 2022 were retrospectively reviewed.Of these,50 patients had received conventional anesthesia intervention[control group(CG)]and 52 patients had received DEX in addition to routine anesthesia intervention[observation group(OG)].Inflammatory factor(IFs;tumor necrosis factor-α,TNF-α;interleukin-6,IL-6),stress responses(cortisol,Cor;adrenocorticotropic hormone,ACTH),cognitive function(CF;Mini-Mental State Examination,MMSE),neurological function(neuron-specific enolase,NSE;S100 calciumbinding protein B,S100B),and coagulation function(prothrombin time,PT;thromboxane B2,TXB2;fibrinogen,FIB)were compared between the two groups before surgery(T0),as well as at 6 h(T1)and 24 h(T2)after surgery.RESULTS Compared with T0,TNF-α,IL-6,Cor,ACTH,NSE,S100B,PT,TXB2,and FIB showed a significant increase in both groups at T1 and T2,but with even lower levels in OG vs CG.Both groups showed a significant reduction in the MMSE score at T1 and T2 compared with T0,but the MMSE score was notably higher in OG compared with CG.CONCLUSION In addition to a potent inhibitory effect on postoperative IFs and stress responses in GC patients undergoing RG under GA,DEX may also alleviate the coagulation dysfunction and improve the postoperative CF of these patients.展开更多
A blockchain-based power transaction method is proposed for Active Distribution Network(ADN),considering the poor security and high cost of a centralized power trading system.Firstly,the decentralized blockchain struc...A blockchain-based power transaction method is proposed for Active Distribution Network(ADN),considering the poor security and high cost of a centralized power trading system.Firstly,the decentralized blockchain structure of the ADN power transaction is built and the transaction information is kept in blocks.Secondly,considering the transaction needs between users and power suppliers in ADN,an energy request mechanism is proposed,and the optimization objective function is designed by integrating cost aware requests and storage aware requests.Finally,the particle swarm optimization algorithm is used for multi-objective optimal search to find the power trading scheme with the minimum power purchase cost of users and the maximum power sold by power suppliers.The experimental demonstration of the proposed method based on the experimental platform shows that when the number of participants is no more than 10,the transaction delay time is 0.2 s,and the transaction cost fluctuates at 200,000 yuan,which is better than other comparison methods.展开更多
In a high thrust-weight-ratio aero-engine,turbine blades are exposed to extremely high temperature and pressure which sets higher demands in the blade cooling technology.To boost film-cooling effectiveness,an accurate...In a high thrust-weight-ratio aero-engine,turbine blades are exposed to extremely high temperature and pressure which sets higher demands in the blade cooling technology.To boost film-cooling effectiveness,an accurate,efficient,and all-sided inspection of film cooling holes is urgently requested to ensure the quality of turbine blades.The tiny size of film-cooling holes adds to extreme difficulties in the inspection process both by contact and non-contact measurement.This paper proposed a non-contact measuring technique to cope with the inspection of turbine blades.A specially designed light-field camera with a small field of view and proper depth of field is applied to resolve a 3D geometry of film cooling holes.The technique uses one light field camera to capture images of the blade surface.3D lightfield reconstruction algoritm is applied and point cloud of the blade is generated.Due to the compactness of the non-contact single light-field imaging system,information inside the holes becomes attainable.By precisely controlling the relative pose of the camera to the blade surface,the device can obtain hole diamter and outlet angle with an accuracy of±0.03mm and±1°17’respectively.The average time consumed for reconstructing one film cooling hole is about 5 seconds.展开更多
Through a series of experiments using denitrifying phosphorus-accumulating sludge in sequencing batch reactors （SBRs）, the variations of the intracellular polymers during the anaerobic phosphorus release process at ...Through a series of experiments using denitrifying phosphorus-accumulating sludge in sequencing batch reactors （SBRs）, the variations of the intracellular polymers during the anaerobic phosphorus release process at different pH values were compared, the probable reasons for different performances of phosphorus removal were examined, and system operations in a typical cycle were investigated. The results show that the phosphorus removal rate was positively correlated with pH values in a range of 6.5-8.5. When the pH value was 8.0, the anaerobic phosphorus release rate and anoxic phosphorus uptake rate of the activated sludge were 20.95 mg/（g, h） and 23.29 mg/（g, h）, respectively; the mass fraction of poly-13-hydroxybutyrate （PHB） increased to 62.87 mg/g under anaerobic conditions; the mass fraction of polyphosphate was 92.67 mg/g under anoxic conditions; and the effluent concentration of total phosphorus （TP） was 1.47 mg/L. With the increase of pH, the mass fraction of acetic acid and PHB also increased, and the absorption rate of acetic acid was equal to the disintegration rate of polyphosphate. When the pH value was above 8.0, biological phosphorus removal was achieved by chemical phosphorus precipitation, and the phosphorus removal rate decreased.展开更多
Background:Administration of propofol,an intravenous anesthetic with antioxidant property,immediately at the onset of post-ischemic reperfusion(propofol postconditioning,P-PostC) has been shown to confer cardioprotect...Background:Administration of propofol,an intravenous anesthetic with antioxidant property,immediately at the onset of post-ischemic reperfusion(propofol postconditioning,P-PostC) has been shown to confer cardioprotection against ischemia–reperfusion(I/R) injury,while the underlying mechanism remains incompletely understood.The forkhead box O(FoxO) transcription factors are reported to play critical roles in activating cardiomyocyte survival signaling throughout the process of cellular injuries induced by oxidative stress and are also involved in hypoxic postconditioning mediated neuroprotection,however,the role of FoxO in postconditioning mediated protection in the heart and in particular in high glucose condition is unknown.Methods:Rat heart-derived H9c2 cells were exposed to high glucose(HG) for 48 h,then subjected to hypoxia/reoxygenation(H/R,composed of 8 h of hypoxia followed by 12 h of reoxygenation) in the absence or presence of postconditioning with various concentrations of propofol(P-PostC) at the onset of reoxygenation.After having identified the optical concentration of propofol,H9c2 cells were subjected to H/R and P-PostC in the absence or presence of FoxO1 or FoxO3a gene silencing to explore their roles in P-PostC mediated protection against apoptotic and autophagic cell deaths under hyperglycemia.Results:The results showed that HG with or without H/R decreased cell viability,increased lactate dehydrogenase(LDH) leakage and the production of reactive oxygen species(ROS) in H9c2 cells,all of which were significantly reversed by propofol(P-PostC),especially at the concentration of 25 μmol/L(P25)(P<0.05,NC vs.HG;HG vs.HG+HR;HG+HR+P12.5 or HG+HR+P25 or HG+HR+P50 vs.HG+HR).Moreover,we found that propofol(P25) decreased H9c2 cells apoptosis and autophagy that were concomitant with increased FoxO1 and FoxO3a expression(P<0.05,HG+HR+P25 vs.HG+HR).The protective effects of propofol(P25) against H/R injury were reversed by silencing FoxO1 or FoxO3a(P<0.05,HG+HR+P25 vs.HG+HR+P25+siRNA-1 or HG+HR+P25+siRNA-5).Conclusions:It is concluded that propofol postconditioning attenuated H9c2 cardiac cells apoptosis and autophagy induced by H/R injury through upregulating FoxO1 and FoxO3a under hyperglycemia.展开更多
The G2019S mutation of the leucine-rich repeat kinase 2(LRRK2)is the most common genetic cause of Parkinson's disease (PD).However,the molecular mechanisms of LRRK2 mutation contributing to the onset and progressi...The G2019S mutation of the leucine-rich repeat kinase 2(LRRK2)is the most common genetic cause of Parkinson's disease (PD).However,the molecular mechanisms of LRRK2 mutation contributing to the onset and progression of PD have not been fully illustrated.We generated HEK293 cells stably transfected with α-synuclein and investigated the effect of LRRK2 G2019S mutation on the degradation of α-synuclein.The lysosomal activity was assessed by the protein degradation of glyceraldehyde-3-phosphate dehydrogenase and ribonuclease A.It was found that α-synuclein was mainly degraded in lysosomes.LRRK2G2019S inhibited the degradation of α-synuclein,and promoted its aggregation.LRRK2G 2019S also decreased the activities of lysosomal enzymes including cathepsin B and cathepsin L.Furthermore,the inhibitory effect of LRRK2 G2019S on lysosomal functions did not depend on its kinase activity.These findings indicated that the inhibitory effect of LRRK2 G2019S on α-synuclein degradation could underlie the pathogenesis of aberrant α-synuclein aggregation in PD with LRRK2 mutation.展开更多
Enhancing ion conductance and controlling transport pathway in organic electrolyte could be used to modulate ionic kinetics to handle signals. In a Pt/Poly(3-hexylthiophene-2,5-diyl)/Polyethylene?Li CF3SO3/Pt hetero-j...Enhancing ion conductance and controlling transport pathway in organic electrolyte could be used to modulate ionic kinetics to handle signals. In a Pt/Poly(3-hexylthiophene-2,5-diyl)/Polyethylene?Li CF3SO3/Pt hetero-junction, the electrolyte layer handled at high temperature showed nano-fiber microstructures accompanied with greatly improved salt solubility. Ions with high mobility were confined in the nano-fibrous channels leading to the semiconducting polymer layer,which is favorable for modulating dynamic doping at the semiconducting polymer/electrolyte interface by pulse frequency.Such a device realized synaptic-like frequency selectivity, i.e., depression at low frequency stimulation but potentiation at high-frequency stimulation.展开更多
Recent innovations in nanomaterials inspire abundant novel tumor-targeting CRISPR-based gene therapies.However,the therapeutic efficiency of traditional targeted nanotherapeutic strategies is limited by that the bioma...Recent innovations in nanomaterials inspire abundant novel tumor-targeting CRISPR-based gene therapies.However,the therapeutic efficiency of traditional targeted nanotherapeutic strategies is limited by that the biomarkers vary in a spatiotemporal-dependent manner with tumor progression.Here,we propose a self-amplifying logic-gated gene editing strategy for gene/H_(2)O_(2)-mediated/starvation multimodal cancer therapy.In this approach,a hypoxia-degradable covalent-organic framework(COF) is synthesized to coat a-ZIF-8 in which glucose oxidase(GOx) and CRISPR system are packaged.To intensify intracellular redox dyshomeostasis,DNAzymes which can cleave catalase mRNA are loaded as well.When the nano system gets into the tumor,the weakly acidic and hypoxic microenvironment degrades the ZIF-8@COF to activate GOx,which amplifies intracellular H^(+)and hypoxia,accelerating the nanocarrier degradation to guarantee available CRISPR plasmid and GOx release in target cells.These tandem reactions deplete glucose and oxygen,leading to logic-gated-triggered gene editing as well as synergistic gene/H_(2)O_(2)-mediated/starvation therapy.Overall,this approach highlights the biocomputing-based CRISPR delivery and underscores the great potential of precise cancer therapy.展开更多
Urethral stricture is characterized by the chronic formation of fibrous tissue,leading to the narrowing of the urethral lumen.Despite the availability of various endoscopic treatments,the recurrence of urethral strict...Urethral stricture is characterized by the chronic formation of fibrous tissue,leading to the narrowing of the urethral lumen.Despite the availability of various endoscopic treatments,the recurrence of urethral strictures remains a common challenge.Postsurgery pharmacotherapy targeting tissue fibrosis is a promising option for reducing recurrence rates.Although drugs cannot replace surgery,they can be used as adjuvant therapies to improve outcomes.In this regard,many drugs have been proposed based on the mechanisms underlying the pathophysiology of urethral stricture.Ongoing studies have obtained substantial progress in treating urethral strictures,highlighting the potential for improved drug effectiveness through appropriate clinical delivery methods.Therefore,this review summarizes the latest researches on the mechanisms related to the pathophysiology of urethral stricture and the drugs to provide a theoretical basis and new insights for the effective use and future advancements in drug therapy for urethral stricture.展开更多
Inevitable geometric variations significantly affect the performance of turbines or even that of entire engines;thus,it is necessary to determine their actual characteristics and accurately estimate their impact on pe...Inevitable geometric variations significantly affect the performance of turbines or even that of entire engines;thus,it is necessary to determine their actual characteristics and accurately estimate their impact on performance.In this study,based on 1781 measured profiles of a typical turbine blade,the statistical characteristics of the geometric variations and the uncertainty impact are analyzed,and some commonly used uncertainty modelling methods based on Principal-Component Analysis(PCA)are verified.The geometric variations are found to be evident,asymmetric,and non-uniform,and the non-normality of the random distributions is non-negligible.The performance is notably affected,which is manifested as an overall offset,a notable scattering,and significant deterioration in several extreme cases.Additionally,it is demonstrated that the PCA reconstruction model is effective in characterizing major uncertainty characteristics of the geometric variations and their impact on the performance with almost the first 10 PCA modes.Based on a reasonable profile error and mean geometric deviation,the Gaussian assumption and stochasticprocess-based model are also found to be effective in predicting the mean values and standard deviations of the performance variations.However,they fail to predict the probability of some extreme cases with high loss.Finally,a Chi-square-based correction model is proposed to compensate for this deficiency.The present work can provide a useful reference for uncertainty analysis of the impact of geometric variations,and the corresponding uncertainty design of turbine blades.展开更多
Emulating the auditory sense is a significant challenge in terms of both integration and energy consumption for handling complicated spatiotemporal information.Here,we demonstrate how to utilize the chaotic dynamics o...Emulating the auditory sense is a significant challenge in terms of both integration and energy consumption for handling complicated spatiotemporal information.Here,we demonstrate how to utilize the chaotic dynamics of a threshold switching memristor,which usually acts as a leaky integrate and fire neuron in the neuromorphic network,to encode the frequency and amplitude in auditory information.We fabricate a Pd/Nb/NbOx/Nb/Pd memristor domi-nated by the Poole-Frankel conduction mechanism,set its state at the edge of chaos,and stimulate it using periodic perturbations.The memristor's responses to the perturbation frequencies can be categorized into three zones.Two are phase locking with linear phase-frequency rela tionships,and one has a hyper-bolic spike number-frequency relationship.The memristor system also enables intensity coding and tonotopy by modulating the response spikes in either the locked phase or spike number.Based on the emulation of these two features,the memristor system demonstrates sound location and frequency mixing.Our study suggests a novel routine for handling the auditory and visual senses using threshold-switching memristor arrays to enhance the efficiency of neuromorphic networks.展开更多
Benzene is a volatile organic compound that can seriously harm human health,while it can serve as a precursor to produce chemicals of more complex structures in chemical industry.Capturing benzene using adsorbents is ...Benzene is a volatile organic compound that can seriously harm human health,while it can serve as a precursor to produce chemicals of more complex structures in chemical industry.Capturing benzene using adsorbents is of great importance for human health,when the separation of hydrocarbons including benzene from crude oil was referred to as one of the“seven chemical separations to change the world”.In this work,we reported the efficient and selective separation of benzene from BTX and cyclohexane by hydrogen bonding self-assembly nonporous adaptive crystals AdaOH for the first time under mild and user-friendly conditions.Separation of benzene and cyclohexane(v/v=1:1)can be achieved by AdaOH with a purity of benzene up to 96.8%.Separation of BTX(v/v;benzene:toluene:o-xylene:m-xylene:pxylene=1:1:1:1:1)can be achieved by AdaOH with a purity of benzene increased from 20%to 82.9%.Our results suggest that separation of benzene using the activated AdaOH as a non-porous adaptive crystal for selectively and efficiently capturing benzene can solve the challenge in separation of benzene from other chemicals such as cyclohexane in chemical industry,and can be helpful for removal of benzene that is released from the vehicles to air.The advantages of commercially availability,easy preparation,high separation efficiency and selectivity for benzene might endow this material with enormous potential for practical uses in areas like petrochemical industry.展开更多
Squealer tip is widely used in turbines to reduce tip leakage loss.In typical turbine environment,the squealer tip leakage flow is affected by multiple factors such as the relative casing motion and the wide range of ...Squealer tip is widely used in turbines to reduce tip leakage loss.In typical turbine environment,the squealer tip leakage flow is affected by multiple factors such as the relative casing motion and the wide range of variable incidence angles.The development of experimental methods which can accurately model the real turbine environment and influencing factors is of great significance to study the squealer tip leakage flow mechanism.In the present paper,a low-speed turbine cascade test facility which can model the relative casing motion and wide range of variable incidence angles(-25°to 55°)is built.Based on the similarity criteria,a high-low speed similarity transformation method of the turbine cascade is established by considering the thickness of the turbine blade.A combined testing method of Particle Image Velocimetry(PIV)and local pressure measurement is proposed to obtain the complex flow structures within the tip cavity.The results show that the experimental method can successfully model the relative casing motion and the wide range of variable incidence angles.The low-speed cascade obtained by the similarity transformation can model the high-speed flow accurately.The measurement technique developed can obtain the complex flow field and successfully capture the scraping vortex within the squealer tip.展开更多
In this study,high Curie Temperature(T_(c))perovskite ceramics of optimized composition 0.55(0.1BiYbO_(3)-0.9PbTiO_(3))-0.45PbZrO_(3) with unique double orthorhombic main phases were prepared by a modified solgel meth...In this study,high Curie Temperature(T_(c))perovskite ceramics of optimized composition 0.55(0.1BiYbO_(3)-0.9PbTiO_(3))-0.45PbZrO_(3) with unique double orthorhombic main phases were prepared by a modified solgel method.Compared to the usual solid-state prepared sample,the sol-gel derived sample has a 1.6 times higher d_(33) of 325 pC/N,a 2.4 times higher remnant polarization,and a much better high temperature stability with similar depolarization temperature(T_(d))and T_(c).Comprehensive analysis of the xerogel prepared over a wide calcination temperature(T_(cal))range of 300-1000℃ revealed that perovskite structure appeared at only 400℃ and it became the main phase above 500℃.Comparison of XRD refinement results showed that calcination and sintering induced subtle and continuous phase transition,namely,the 400-900℃ calcined powders with coexisted tetragonal(P4mm)and orthorhombic(Pbam)phase changed to a rather stable double orthorhombic(Pmmm and Pbam)main phase in all the differently sintered ceramics,as similar to the 1000C calcined powders.The stable phase coexistence well explains the enhanced performance.The results also demonstrate that optimized sol-gel processing can provide high T_(c) ceramics with desirable multi-phase structure and significantly enhanced performance at a lower temperature.展开更多
The structure and morphology of A1 interdigital transducers as a function of Ni underlayer thickness were studied. The A1 （111） texture intensity increases first and then decreases as Ni underlayer thickness increas...The structure and morphology of A1 interdigital transducers as a function of Ni underlayer thickness were studied. The A1 （111） texture intensity increases first and then decreases as Ni underlayer thickness increases. 6-nm Ni underlayer results in the strongest A1 （111） texture with flattest surface, which exhibits almost 10 times longer life in electromigration measurement than those without Ni underlayer. 1.5 GHz surface acoustic wave filters fabri- cated with A1 film on 6-nm Ni underlayer also have improved power durability compared with those without Ni underlayer from 29.0 to 32.5 dBm. It is observed that those fine grains in the 6-nm Ni underlayer greatly enhance A1 （111） texture. Together with increased adhesion force, strong A1 （111） texture accounts for the improved resistance to electromigration and acoustomigration via the reduction of gains boundaries, resistivity, and fine grains at the interface, which is promising for high power surface acoustic wave filters.展开更多
All memristor neuromorphic networks have great potential and advantage in both technology and computational protocols for artificial intelligence.It is crucial to find suitable elementary units for both performing fea...All memristor neuromorphic networks have great potential and advantage in both technology and computational protocols for artificial intelligence.It is crucial to find suitable elementary units for both performing featured neuromorphic functions and fabrication in large scale.Here a simple memristive structure,Nb/HfOx/Pd,is proposed for this goal.Its two resistive switching mechanisms,Mott transition of NbO2 and oxygen vacancy(Vo)migration,can be controlled by modulating external bias directions.Negative bias activates reversible phase transition and restrains Vo filament formation to allow the memristor to mimic the firing action potential.Positive bias activates Vo filament formation and restrains the other to allow the memristor to mimic synaptic plasticity and learning protocols.The system can respond adaptively to naturally generated action potentials and modified synaptic signals from the same memristive structure.In addition,some special features related to signal encoding and recognition are discovered when the system is settled according to chaos circuit theory.Our study provides a novel approach for designing elementary units for neuromorphic computations.展开更多
A novel good water-soluble macrocycle containing two pyridinium moieties was synthesized in high yield.It could form 1:1 complexes with neutral guests containing naphthalene or phenyl units in water.The water-soluble ...A novel good water-soluble macrocycle containing two pyridinium moieties was synthesized in high yield.It could form 1:1 complexes with neutral guests containing naphthalene or phenyl units in water.The water-soluble macrocycle can selectively encapsulate naphthalene to form a 1:1 complex over a variety of polycyclic aromatic hydrocarbons.展开更多
Two novel [3]pseudorotaxanes can be selectively synthesized from four components through self-sorting processes, which provides a new strategy for the construction of a well-organized heteropolyrotaxane.
文摘BACKGROUND:Prolonged invasive respiratory support and extracorporeal membrane oxygenation(ECMO)in patients requiring urgent lung transplantation(ULTx)present signifi cant challenges to clinical practice due to severe underlying diseases and complex conditions.The aim of the study was to report the clinical outcomes of patients who received ULTx and followed the perioperative rehabilitation protocol implemented in a lung transplant center.METHODS:A retrospective analysis was conducted in ULTx patients who required preoperative invasive mechanical ventilation(IMV)and ECMO between January 2018 and January 2023.Data were retrieved from electronic medical records at our lung transplant center.RESULTS:Fourteen patients(mean age 57.43±10.97 years;12 males,2 females)underwent ULTx with bridging ECMO and IMV.The mean body mass index was 23.94±3.33 kg/m²,and the mean Acute Physiology and Chronic Health Evaluation(APACHE)II score was 21.50±3.96.The Nutritional Risk Screening 2002(NRS 2002)scores were≥3.ULTx was performed after an 8.5-day waiting period(interquartile interval[IQR]5.0-26.5 d).Following the surgeries,the average lengths of ECMO and IMV were 1.0(IQR 1.0-2.0)d and 5.0(IQR 3.0-7.3)d,respectively.The total length of hospital stay was 60.1±30.8 d,with an average intensive care unit stay of 38.3±22.9 d and post-operative hospitalization stay of 45.8±26.1 d.Two patients died within 30 d after ULTx,with a 30-day survival rate of 85.71%.CONCLUSION:Patients receiving ULTx showed an acceptable short-term survival rate,validating the practicality and safety of the treatment protocols implemented in our center.
基金Supported by Project of Guangxi Health and Health Commission,No.Z20201268。
文摘BACKGROUND Radical gastrectomy(RG)is commonly used in the treatment of patients with gastric cancer(GC),but this procedure may lead to stress responses,postoperative cognitive dysfunction,and blood coagulation abnormalities in patients.AIM To investigate the influences of dexmedetomidine(DEX)on stress responses and postoperative cognitive and coagulation functions in patients undergoing RG under general anesthesia(GA).METHODS One hundred and two patients undergoing RG for GC under GA from February 2020 to February 2022 were retrospectively reviewed.Of these,50 patients had received conventional anesthesia intervention[control group(CG)]and 52 patients had received DEX in addition to routine anesthesia intervention[observation group(OG)].Inflammatory factor(IFs;tumor necrosis factor-α,TNF-α;interleukin-6,IL-6),stress responses(cortisol,Cor;adrenocorticotropic hormone,ACTH),cognitive function(CF;Mini-Mental State Examination,MMSE),neurological function(neuron-specific enolase,NSE;S100 calciumbinding protein B,S100B),and coagulation function(prothrombin time,PT;thromboxane B2,TXB2;fibrinogen,FIB)were compared between the two groups before surgery(T0),as well as at 6 h(T1)and 24 h(T2)after surgery.RESULTS Compared with T0,TNF-α,IL-6,Cor,ACTH,NSE,S100B,PT,TXB2,and FIB showed a significant increase in both groups at T1 and T2,but with even lower levels in OG vs CG.Both groups showed a significant reduction in the MMSE score at T1 and T2 compared with T0,but the MMSE score was notably higher in OG compared with CG.CONCLUSION In addition to a potent inhibitory effect on postoperative IFs and stress responses in GC patients undergoing RG under GA,DEX may also alleviate the coagulation dysfunction and improve the postoperative CF of these patients.
基金supported by the Postdoctoral Research Funding Program of Jiangsu Province under Grant 2021K622C.
文摘A blockchain-based power transaction method is proposed for Active Distribution Network(ADN),considering the poor security and high cost of a centralized power trading system.Firstly,the decentralized blockchain structure of the ADN power transaction is built and the transaction information is kept in blocks.Secondly,considering the transaction needs between users and power suppliers in ADN,an energy request mechanism is proposed,and the optimization objective function is designed by integrating cost aware requests and storage aware requests.Finally,the particle swarm optimization algorithm is used for multi-objective optimal search to find the power trading scheme with the minimum power purchase cost of users and the maximum power sold by power suppliers.The experimental demonstration of the proposed method based on the experimental platform shows that when the number of participants is no more than 10,the transaction delay time is 0.2 s,and the transaction cost fluctuates at 200,000 yuan,which is better than other comparison methods.
基金Aero Engine Corporation of China(HFZL2020CXY014-1,HFZL2020CXY014-2)。
文摘In a high thrust-weight-ratio aero-engine,turbine blades are exposed to extremely high temperature and pressure which sets higher demands in the blade cooling technology.To boost film-cooling effectiveness,an accurate,efficient,and all-sided inspection of film cooling holes is urgently requested to ensure the quality of turbine blades.The tiny size of film-cooling holes adds to extreme difficulties in the inspection process both by contact and non-contact measurement.This paper proposed a non-contact measuring technique to cope with the inspection of turbine blades.A specially designed light-field camera with a small field of view and proper depth of field is applied to resolve a 3D geometry of film cooling holes.The technique uses one light field camera to capture images of the blade surface.3D lightfield reconstruction algoritm is applied and point cloud of the blade is generated.Due to the compactness of the non-contact single light-field imaging system,information inside the holes becomes attainable.By precisely controlling the relative pose of the camera to the blade surface,the device can obtain hole diamter and outlet angle with an accuracy of±0.03mm and±1°17’respectively.The average time consumed for reconstructing one film cooling hole is about 5 seconds.
基金supported by the Research Program of the Liaoning Educational Committee(Grant No.LJZ2016014)the Natural Science Foundation of Liaoning Province(Grant No.201501069)+1 种基金the Research Program of the Ministry of Housing and Urban-Rural Development(Grant No.2015-K7-007)the National Natural Science Foundation of China(Grants No.51776131 and 51678375)
文摘Through a series of experiments using denitrifying phosphorus-accumulating sludge in sequencing batch reactors （SBRs）, the variations of the intracellular polymers during the anaerobic phosphorus release process at different pH values were compared, the probable reasons for different performances of phosphorus removal were examined, and system operations in a typical cycle were investigated. The results show that the phosphorus removal rate was positively correlated with pH values in a range of 6.5-8.5. When the pH value was 8.0, the anaerobic phosphorus release rate and anoxic phosphorus uptake rate of the activated sludge were 20.95 mg/（g, h） and 23.29 mg/（g, h）, respectively; the mass fraction of poly-13-hydroxybutyrate （PHB） increased to 62.87 mg/g under anaerobic conditions; the mass fraction of polyphosphate was 92.67 mg/g under anoxic conditions; and the effluent concentration of total phosphorus （TP） was 1.47 mg/L. With the increase of pH, the mass fraction of acetic acid and PHB also increased, and the absorption rate of acetic acid was equal to the disintegration rate of polyphosphate. When the pH value was above 8.0, biological phosphorus removal was achieved by chemical phosphorus precipitation, and the phosphorus removal rate decreased.
基金supported by the National Natural Science Foundation of China grant (NSFC81970247)。
文摘Background:Administration of propofol,an intravenous anesthetic with antioxidant property,immediately at the onset of post-ischemic reperfusion(propofol postconditioning,P-PostC) has been shown to confer cardioprotection against ischemia–reperfusion(I/R) injury,while the underlying mechanism remains incompletely understood.The forkhead box O(FoxO) transcription factors are reported to play critical roles in activating cardiomyocyte survival signaling throughout the process of cellular injuries induced by oxidative stress and are also involved in hypoxic postconditioning mediated neuroprotection,however,the role of FoxO in postconditioning mediated protection in the heart and in particular in high glucose condition is unknown.Methods:Rat heart-derived H9c2 cells were exposed to high glucose(HG) for 48 h,then subjected to hypoxia/reoxygenation(H/R,composed of 8 h of hypoxia followed by 12 h of reoxygenation) in the absence or presence of postconditioning with various concentrations of propofol(P-PostC) at the onset of reoxygenation.After having identified the optical concentration of propofol,H9c2 cells were subjected to H/R and P-PostC in the absence or presence of FoxO1 or FoxO3a gene silencing to explore their roles in P-PostC mediated protection against apoptotic and autophagic cell deaths under hyperglycemia.Results:The results showed that HG with or without H/R decreased cell viability,increased lactate dehydrogenase(LDH) leakage and the production of reactive oxygen species(ROS) in H9c2 cells,all of which were significantly reversed by propofol(P-PostC),especially at the concentration of 25 μmol/L(P25)(P<0.05,NC vs.HG;HG vs.HG+HR;HG+HR+P12.5 or HG+HR+P25 or HG+HR+P50 vs.HG+HR).Moreover,we found that propofol(P25) decreased H9c2 cells apoptosis and autophagy that were concomitant with increased FoxO1 and FoxO3a expression(P<0.05,HG+HR+P25 vs.HG+HR).The protective effects of propofol(P25) against H/R injury were reversed by silencing FoxO1 or FoxO3a(P<0.05,HG+HR+P25 vs.HG+HR+P25+siRNA-1 or HG+HR+P25+siRNA-5).Conclusions:It is concluded that propofol postconditioning attenuated H9c2 cardiac cells apoptosis and autophagy induced by H/R injury through upregulating FoxO1 and FoxO3a under hyperglycemia.
基金the National Natura Science Foundation of China(NSFC)(No.81401051,No 81671051,and No.81501107).
文摘The G2019S mutation of the leucine-rich repeat kinase 2(LRRK2)is the most common genetic cause of Parkinson's disease (PD).However,the molecular mechanisms of LRRK2 mutation contributing to the onset and progression of PD have not been fully illustrated.We generated HEK293 cells stably transfected with α-synuclein and investigated the effect of LRRK2 G2019S mutation on the degradation of α-synuclein.The lysosomal activity was assessed by the protein degradation of glyceraldehyde-3-phosphate dehydrogenase and ribonuclease A.It was found that α-synuclein was mainly degraded in lysosomes.LRRK2G2019S inhibited the degradation of α-synuclein,and promoted its aggregation.LRRK2G 2019S also decreased the activities of lysosomal enzymes including cathepsin B and cathepsin L.Furthermore,the inhibitory effect of LRRK2 G2019S on lysosomal functions did not depend on its kinase activity.These findings indicated that the inhibitory effect of LRRK2 G2019S on α-synuclein degradation could underlie the pathogenesis of aberrant α-synuclein aggregation in PD with LRRK2 mutation.
基金supported by National Natural Science foundation of China (Grant Nos. 51371103 and 51231004)National Basic Research Program of China (Grant No. 2010CB832905)+1 种基金National Hi-tech (R&D) Project of China (Grant Nos. 2012AA03A706, 2013AA030801)the Research Project of Chinese Ministry of Education (No. 113007A)
文摘Enhancing ion conductance and controlling transport pathway in organic electrolyte could be used to modulate ionic kinetics to handle signals. In a Pt/Poly(3-hexylthiophene-2,5-diyl)/Polyethylene?Li CF3SO3/Pt hetero-junction, the electrolyte layer handled at high temperature showed nano-fiber microstructures accompanied with greatly improved salt solubility. Ions with high mobility were confined in the nano-fibrous channels leading to the semiconducting polymer layer,which is favorable for modulating dynamic doping at the semiconducting polymer/electrolyte interface by pulse frequency.Such a device realized synaptic-like frequency selectivity, i.e., depression at low frequency stimulation but potentiation at high-frequency stimulation.
基金financially supported by the National Natural Science Foundation of China(21874066,and 82073288)the National Key R&D Program of China(2019YFA0709200)+5 种基金the Key Research and Development Program of Jiangsu Province(BE2021373,China)Jiangsu Provincial Medical Key Discipline Cultivation Unit(JSDW202239,China)the Natural Science Foundation of Jiangsu Province(BK20200336,China)the Fundamental Research Funds for Central Universities(China)the Program for Innovative Talents and Entrepreneur in Jiangsu(China)Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX23_0146,China).
文摘Recent innovations in nanomaterials inspire abundant novel tumor-targeting CRISPR-based gene therapies.However,the therapeutic efficiency of traditional targeted nanotherapeutic strategies is limited by that the biomarkers vary in a spatiotemporal-dependent manner with tumor progression.Here,we propose a self-amplifying logic-gated gene editing strategy for gene/H_(2)O_(2)-mediated/starvation multimodal cancer therapy.In this approach,a hypoxia-degradable covalent-organic framework(COF) is synthesized to coat a-ZIF-8 in which glucose oxidase(GOx) and CRISPR system are packaged.To intensify intracellular redox dyshomeostasis,DNAzymes which can cleave catalase mRNA are loaded as well.When the nano system gets into the tumor,the weakly acidic and hypoxic microenvironment degrades the ZIF-8@COF to activate GOx,which amplifies intracellular H^(+)and hypoxia,accelerating the nanocarrier degradation to guarantee available CRISPR plasmid and GOx release in target cells.These tandem reactions deplete glucose and oxygen,leading to logic-gated-triggered gene editing as well as synergistic gene/H_(2)O_(2)-mediated/starvation therapy.Overall,this approach highlights the biocomputing-based CRISPR delivery and underscores the great potential of precise cancer therapy.
基金This work was supported by the Natural Science Foundation of Jiangxi Province,China(No.20202BABL206031 and No.20224BAB216024).
文摘Urethral stricture is characterized by the chronic formation of fibrous tissue,leading to the narrowing of the urethral lumen.Despite the availability of various endoscopic treatments,the recurrence of urethral strictures remains a common challenge.Postsurgery pharmacotherapy targeting tissue fibrosis is a promising option for reducing recurrence rates.Although drugs cannot replace surgery,they can be used as adjuvant therapies to improve outcomes.In this regard,many drugs have been proposed based on the mechanisms underlying the pathophysiology of urethral stricture.Ongoing studies have obtained substantial progress in treating urethral strictures,highlighting the potential for improved drug effectiveness through appropriate clinical delivery methods.Therefore,this review summarizes the latest researches on the mechanisms related to the pathophysiology of urethral stricture and the drugs to provide a theoretical basis and new insights for the effective use and future advancements in drug therapy for urethral stricture.
基金supported by the National Science and Technology Major Project, China (No. J2019-II-0012-0032)
文摘Inevitable geometric variations significantly affect the performance of turbines or even that of entire engines;thus,it is necessary to determine their actual characteristics and accurately estimate their impact on performance.In this study,based on 1781 measured profiles of a typical turbine blade,the statistical characteristics of the geometric variations and the uncertainty impact are analyzed,and some commonly used uncertainty modelling methods based on Principal-Component Analysis(PCA)are verified.The geometric variations are found to be evident,asymmetric,and non-uniform,and the non-normality of the random distributions is non-negligible.The performance is notably affected,which is manifested as an overall offset,a notable scattering,and significant deterioration in several extreme cases.Additionally,it is demonstrated that the PCA reconstruction model is effective in characterizing major uncertainty characteristics of the geometric variations and their impact on the performance with almost the first 10 PCA modes.Based on a reasonable profile error and mean geometric deviation,the Gaussian assumption and stochasticprocess-based model are also found to be effective in predicting the mean values and standard deviations of the performance variations.However,they fail to predict the probability of some extreme cases with high loss.Finally,a Chi-square-based correction model is proposed to compensate for this deficiency.The present work can provide a useful reference for uncertainty analysis of the impact of geometric variations,and the corresponding uncertainty design of turbine blades.
基金National Natural Science Foundation of China,Grant/Award Number:51972192。
文摘Emulating the auditory sense is a significant challenge in terms of both integration and energy consumption for handling complicated spatiotemporal information.Here,we demonstrate how to utilize the chaotic dynamics of a threshold switching memristor,which usually acts as a leaky integrate and fire neuron in the neuromorphic network,to encode the frequency and amplitude in auditory information.We fabricate a Pd/Nb/NbOx/Nb/Pd memristor domi-nated by the Poole-Frankel conduction mechanism,set its state at the edge of chaos,and stimulate it using periodic perturbations.The memristor's responses to the perturbation frequencies can be categorized into three zones.Two are phase locking with linear phase-frequency rela tionships,and one has a hyper-bolic spike number-frequency relationship.The memristor system also enables intensity coding and tonotopy by modulating the response spikes in either the locked phase or spike number.Based on the emulation of these two features,the memristor system demonstrates sound location and frequency mixing.Our study suggests a novel routine for handling the auditory and visual senses using threshold-switching memristor arrays to enhance the efficiency of neuromorphic networks.
基金the financial support from the National Natural Science Foundation of China(No.21602055)Natural Science Foundation of Hunan Province(No.2017JJ3094).
文摘Benzene is a volatile organic compound that can seriously harm human health,while it can serve as a precursor to produce chemicals of more complex structures in chemical industry.Capturing benzene using adsorbents is of great importance for human health,when the separation of hydrocarbons including benzene from crude oil was referred to as one of the“seven chemical separations to change the world”.In this work,we reported the efficient and selective separation of benzene from BTX and cyclohexane by hydrogen bonding self-assembly nonporous adaptive crystals AdaOH for the first time under mild and user-friendly conditions.Separation of benzene and cyclohexane(v/v=1:1)can be achieved by AdaOH with a purity of benzene up to 96.8%.Separation of BTX(v/v;benzene:toluene:o-xylene:m-xylene:pxylene=1:1:1:1:1)can be achieved by AdaOH with a purity of benzene increased from 20%to 82.9%.Our results suggest that separation of benzene using the activated AdaOH as a non-porous adaptive crystal for selectively and efficiently capturing benzene can solve the challenge in separation of benzene from other chemicals such as cyclohexane in chemical industry,and can be helpful for removal of benzene that is released from the vehicles to air.The advantages of commercially availability,easy preparation,high separation efficiency and selectivity for benzene might endow this material with enormous potential for practical uses in areas like petrochemical industry.
基金supported by the National Natural Science Foundation of China(No.51676005)。
文摘Squealer tip is widely used in turbines to reduce tip leakage loss.In typical turbine environment,the squealer tip leakage flow is affected by multiple factors such as the relative casing motion and the wide range of variable incidence angles.The development of experimental methods which can accurately model the real turbine environment and influencing factors is of great significance to study the squealer tip leakage flow mechanism.In the present paper,a low-speed turbine cascade test facility which can model the relative casing motion and wide range of variable incidence angles(-25°to 55°)is built.Based on the similarity criteria,a high-low speed similarity transformation method of the turbine cascade is established by considering the thickness of the turbine blade.A combined testing method of Particle Image Velocimetry(PIV)and local pressure measurement is proposed to obtain the complex flow structures within the tip cavity.The results show that the experimental method can successfully model the relative casing motion and the wide range of variable incidence angles.The low-speed cascade obtained by the similarity transformation can model the high-speed flow accurately.The measurement technique developed can obtain the complex flow field and successfully capture the scraping vortex within the squealer tip.
基金supported by the National Natural Science Foundation of China(Grant No.11574346)the Fundamental Research Funds for the Central Universities+1 种基金the Fund of Key Laboratory of Advanced Materials of Ministry of Education(Grant No.218AML07)the Open Foundation of the State Key Laboratory of New Ceramics and Fine Processing of Tsinghua University(KF201809).
文摘In this study,high Curie Temperature(T_(c))perovskite ceramics of optimized composition 0.55(0.1BiYbO_(3)-0.9PbTiO_(3))-0.45PbZrO_(3) with unique double orthorhombic main phases were prepared by a modified solgel method.Compared to the usual solid-state prepared sample,the sol-gel derived sample has a 1.6 times higher d_(33) of 325 pC/N,a 2.4 times higher remnant polarization,and a much better high temperature stability with similar depolarization temperature(T_(d))and T_(c).Comprehensive analysis of the xerogel prepared over a wide calcination temperature(T_(cal))range of 300-1000℃ revealed that perovskite structure appeared at only 400℃ and it became the main phase above 500℃.Comparison of XRD refinement results showed that calcination and sintering induced subtle and continuous phase transition,namely,the 400-900℃ calcined powders with coexisted tetragonal(P4mm)and orthorhombic(Pbam)phase changed to a rather stable double orthorhombic(Pmmm and Pbam)main phase in all the differently sintered ceramics,as similar to the 1000C calcined powders.The stable phase coexistence well explains the enhanced performance.The results also demonstrate that optimized sol-gel processing can provide high T_(c) ceramics with desirable multi-phase structure and significantly enhanced performance at a lower temperature.
基金financially supported by the National Key Research and Development Program of China(No. 2016YFB0402700)Beijing Science and Technology Project (No. D171100004617001).
文摘The structure and morphology of A1 interdigital transducers as a function of Ni underlayer thickness were studied. The A1 （111） texture intensity increases first and then decreases as Ni underlayer thickness increases. 6-nm Ni underlayer results in the strongest A1 （111） texture with flattest surface, which exhibits almost 10 times longer life in electromigration measurement than those without Ni underlayer. 1.5 GHz surface acoustic wave filters fabri- cated with A1 film on 6-nm Ni underlayer also have improved power durability compared with those without Ni underlayer from 29.0 to 32.5 dBm. It is observed that those fine grains in the 6-nm Ni underlayer greatly enhance A1 （111） texture. Together with increased adhesion force, strong A1 （111） texture accounts for the improved resistance to electromigration and acoustomigration via the reduction of gains boundaries, resistivity, and fine grains at the interface, which is promising for high power surface acoustic wave filters.
基金the National Natural Science Foundation of China(No.51972192).
文摘All memristor neuromorphic networks have great potential and advantage in both technology and computational protocols for artificial intelligence.It is crucial to find suitable elementary units for both performing featured neuromorphic functions and fabrication in large scale.Here a simple memristive structure,Nb/HfOx/Pd,is proposed for this goal.Its two resistive switching mechanisms,Mott transition of NbO2 and oxygen vacancy(Vo)migration,can be controlled by modulating external bias directions.Negative bias activates reversible phase transition and restrains Vo filament formation to allow the memristor to mimic the firing action potential.Positive bias activates Vo filament formation and restrains the other to allow the memristor to mimic synaptic plasticity and learning protocols.The system can respond adaptively to naturally generated action potentials and modified synaptic signals from the same memristive structure.In addition,some special features related to signal encoding and recognition are discovered when the system is settled according to chaos circuit theory.Our study provides a novel approach for designing elementary units for neuromorphic computations.
基金The authors are grateful for the financial support from the National Natural Science Foundation of China(Nos.21602055 and 51772091)Natural Science Foundation of Hunan Province(No.2017JJ3094)Research Foundation of Education Bureau of Hunan Province(No.18C1072).
文摘A novel good water-soluble macrocycle containing two pyridinium moieties was synthesized in high yield.It could form 1:1 complexes with neutral guests containing naphthalene or phenyl units in water.The water-soluble macrocycle can selectively encapsulate naphthalene to form a 1:1 complex over a variety of polycyclic aromatic hydrocarbons.
基金National Natural Science Foundation of China(No.21602055)Sci-Tech Innovation Teams in Universities of Hunan Province for financial support
文摘Two novel [3]pseudorotaxanes can be selectively synthesized from four components through self-sorting processes, which provides a new strategy for the construction of a well-organized heteropolyrotaxane.
