To enhance the anesthetic efficacy and reduce toxic side effects,a strategy is proposed involving the utilization of general anesthetics of Propofol(Pro)and Eto-midate(Eto)to synergistic inhibition GABA receptors simul...To enhance the anesthetic efficacy and reduce toxic side effects,a strategy is proposed involving the utilization of general anesthetics of Propofol(Pro)and Eto-midate(Eto)to synergistic inhibition GABA receptors simultaneously.Four-in-one molecular aggregates were prepared to implement this strategy,which comprised of Pro and Eto with the bridging molecule monoglyceride monooleate(GMO)and sur-factant F127 through intermolecular forces.The blood-brain barrier(BBB)targeted lactoferrin(LF)is affixed to their surface,obtaining thefinal molecular aggregates.By employing lactoferrin enrich aggregates to the BBB,followed by ultrasound combine microbubbles to open the BBB,a remarkable 4.5-fold enhancement in brain drug delivery was achieved.The molecular aggregates group maintained sta-ble parameters of heart rate,diastolic blood pressure,and systolic blood pressure.A notable increase of more than twice therapeutic index(TI)value was observed,implying their higher anesthesia efficiency and reduced toxicity.Electroencephalo-gram(EEG)experiments demonstrate a significant elevation in the proportion of θ waves from 28%to 80%for aggregates,accompanied by a nearlyfivefold reduc-tion in the proportion ofθwaves,meaning a significant improvement in synergistic anesthesia effectiveness(interaction index 0.289)with lower drug dosage.Further-more,mouse immunofluorescence brain slice experiments suggest Pro and Eto enter the GABA receptor simultaneously,resulting in synergistic inhibition of GABA receptors.展开更多
We carefully read the review article,which compared three types of ablation therapies such as radiofrequency ablation(RFA),high-intensity focused ultrasound(HIFU),and microwave ablation(MWA)for Barcelona clinic liver ...We carefully read the review article,which compared three types of ablation therapies such as radiofrequency ablation(RFA),high-intensity focused ultrasound(HIFU),and microwave ablation(MWA)for Barcelona clinic liver cancer(BCLC)stage 0 and A(early-stage)hepatocellular carcinoma(HCC)patients with cirrhosis by Cheung et al.(1)published in 2021 in Hepatobiliary Surgery and Nutrition.This manuscript well described the principles,indications,and limitations of these ablation systems in detail(1).We would like to provide several comments.展开更多
基金Young Top-notch Talents of“High-level Talents Special Support Program”of Shaanxi ProvinceNational Natural Science Foundation of China,Grant/Award Numbers:81971290,82102074。
文摘To enhance the anesthetic efficacy and reduce toxic side effects,a strategy is proposed involving the utilization of general anesthetics of Propofol(Pro)and Eto-midate(Eto)to synergistic inhibition GABA receptors simultaneously.Four-in-one molecular aggregates were prepared to implement this strategy,which comprised of Pro and Eto with the bridging molecule monoglyceride monooleate(GMO)and sur-factant F127 through intermolecular forces.The blood-brain barrier(BBB)targeted lactoferrin(LF)is affixed to their surface,obtaining thefinal molecular aggregates.By employing lactoferrin enrich aggregates to the BBB,followed by ultrasound combine microbubbles to open the BBB,a remarkable 4.5-fold enhancement in brain drug delivery was achieved.The molecular aggregates group maintained sta-ble parameters of heart rate,diastolic blood pressure,and systolic blood pressure.A notable increase of more than twice therapeutic index(TI)value was observed,implying their higher anesthesia efficiency and reduced toxicity.Electroencephalo-gram(EEG)experiments demonstrate a significant elevation in the proportion of θ waves from 28%to 80%for aggregates,accompanied by a nearlyfivefold reduc-tion in the proportion ofθwaves,meaning a significant improvement in synergistic anesthesia effectiveness(interaction index 0.289)with lower drug dosage.Further-more,mouse immunofluorescence brain slice experiments suggest Pro and Eto enter the GABA receptor simultaneously,resulting in synergistic inhibition of GABA receptors.
基金supported by the National Natural Science Foundation of China(No.82102074)Key Science and Technology Program of Shaanxi Province of China(No.2022SF-320).
文摘We carefully read the review article,which compared three types of ablation therapies such as radiofrequency ablation(RFA),high-intensity focused ultrasound(HIFU),and microwave ablation(MWA)for Barcelona clinic liver cancer(BCLC)stage 0 and A(early-stage)hepatocellular carcinoma(HCC)patients with cirrhosis by Cheung et al.(1)published in 2021 in Hepatobiliary Surgery and Nutrition.This manuscript well described the principles,indications,and limitations of these ablation systems in detail(1).We would like to provide several comments.
