The study of clastic rock failure evolution under true triaxial stress is an important research topic;however,it is rarely studied systematically due to the limitation of monitoring technology.In this study,true triax...The study of clastic rock failure evolution under true triaxial stress is an important research topic;however,it is rarely studied systematically due to the limitation of monitoring technology.In this study,true triaxial compression tests were conducted on clastic rock specimens to investigate the effect of cementation and intermediate principal stress(s2)on the failure mechanism.The complete stressestrain curves were obtained,while the acoustic emission(AE)was monitored to indirectly evaluate the evo-lution of tensile and shear cracks,and crack evolution under true triaxial compression was imaged in real time by a high-speed camera.The results showed that the deformation and failure characteristics of clastic rock were closely related to the cementation type and intermediate principal stress.On the basis of the distribution characteristics of the ratio of rise time to amplitude(RA)and the average frequency(AF)of AE signals,tensile cracks of the contact cementation specimen propagated preferentially.Meanwhile,the enhancement of specimen cementation promoted the evolution of shear cracks,and the increase inσ_(2)promoted the evolution of tensile cracks.Moreover,the mesoscale cracking mechanism of clastic rock caused by cementation andσ_(2)under true triaxial compression was analyzed.The failure patterns of clastic rock under true triaxial compression were divided into three modes:structure-induced,structure-stress-induced and stress-induced failures.This study confirms the feasibility of high-speed camera technology in true triaxial testing,and has important implications for elucidating the disaster mechanism of deep tunnels in weak rocks.展开更多
The squeezing scenario in deep weak rock tunnels can hinder underground construction.However,due to the limitations of test technologies at hand,the real excavation stress path cannot be mimicked in the laboratory.Thu...The squeezing scenario in deep weak rock tunnels can hinder underground construction.However,due to the limitations of test technologies at hand,the real excavation stress path cannot be mimicked in the laboratory.Thus,the large deformation mechanism of deep weak rocks still remains unclear.For this,a true triaxial apparatus(TTA)to investigate the mechanical responses of deep weak rock under excavation stress paths in field and reveal the squeezing mechanism of deep tunnels is assembled and developed at Northeastern University,China.The apparatus can perform instantaneous unloading in s3 direction based on electromagnetism technology.In addition,uniform loading and deformation measurements can be carried out based on the proposed linked interlocking clamp and antifriction device,even if the sample has a strong dilatation deformation performance.Next,a bore trepanning is designed to capture noiseless acoustic emission(AE)signals for deep weak rock at a low threshold.Finally,two tests were are conducted using this instrument to preliminarily understand the failure and deformation features of deep weak rock based on fractured marble.The results show that the complete stressestrain curves of fractured marble have the characteristics of low strengths and large deformations,and the larger deformation and the more serious failure occur when the fractured marble enters the post-peak state after excavation.The results show that the developed apparatus is likely to be applicable for deep weak rock engineering.展开更多
Kidney disease is manifested in a wide variety of phenotypes,many of which have an important hereditary component.To delineate the genotypic and phenotypic spectrum of pediatric nephropathy,a multicenter registration ...Kidney disease is manifested in a wide variety of phenotypes,many of which have an important hereditary component.To delineate the genotypic and phenotypic spectrum of pediatric nephropathy,a multicenter registration system is being imple-mented based on the Chinese Children Genetic Kidney Disease Database(CCGKDD).In this study,all the patients with kidney and urological diseases were recruited from 2014 to 2020.Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features.The genetic diagnosis was confirmed in 883 of 2256(39.1%)patients from 23 provinces in China.Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome(SRNS,23.5%),glomerulonephritis(GN,32.2%),congenital anomalies of the kidney and urinary tract(CAKUT,21.2%),cystic renal disease(3.9%),renal calcinosis/stone(3.6%),tubulopathy(9.7%),and chronic kidney disease of unknown etiology(CKDu,5.8%).The pathogenic variants of 105 monogenetic disorders were identified.Ten distinct genomic disorders were identified as pathogenic copy number variants(CNVs)in 11 patients.The diagnostic yield differed by subgroups,and was highest in those with cystic renal disease(66.3%),followed by tubulopathy(58.4%),GN(57.7%),CKDu(43.5%),SRNS(29.2%),renal calcinosis/stone(29.3%)and CAKUT(8.6%).Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions.We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed.Our data demonstrate the utility of family-based exome sequencing,and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease.展开更多
基金financial support from the 111 Project(Grant No.B17009)the Liaoning Revitalization Talents Program(Grant No.XLYCYSZX1902).
文摘The study of clastic rock failure evolution under true triaxial stress is an important research topic;however,it is rarely studied systematically due to the limitation of monitoring technology.In this study,true triaxial compression tests were conducted on clastic rock specimens to investigate the effect of cementation and intermediate principal stress(s2)on the failure mechanism.The complete stressestrain curves were obtained,while the acoustic emission(AE)was monitored to indirectly evaluate the evo-lution of tensile and shear cracks,and crack evolution under true triaxial compression was imaged in real time by a high-speed camera.The results showed that the deformation and failure characteristics of clastic rock were closely related to the cementation type and intermediate principal stress.On the basis of the distribution characteristics of the ratio of rise time to amplitude(RA)and the average frequency(AF)of AE signals,tensile cracks of the contact cementation specimen propagated preferentially.Meanwhile,the enhancement of specimen cementation promoted the evolution of shear cracks,and the increase inσ_(2)promoted the evolution of tensile cracks.Moreover,the mesoscale cracking mechanism of clastic rock caused by cementation andσ_(2)under true triaxial compression was analyzed.The failure patterns of clastic rock under true triaxial compression were divided into three modes:structure-induced,structure-stress-induced and stress-induced failures.This study confirms the feasibility of high-speed camera technology in true triaxial testing,and has important implications for elucidating the disaster mechanism of deep tunnels in weak rocks.
基金the financial support from the 111 Project(Grant No.B17009)the Liao Ning Revitalization Talents Program(Grant No.XLYCYSZX1902).
文摘The squeezing scenario in deep weak rock tunnels can hinder underground construction.However,due to the limitations of test technologies at hand,the real excavation stress path cannot be mimicked in the laboratory.Thus,the large deformation mechanism of deep weak rocks still remains unclear.For this,a true triaxial apparatus(TTA)to investigate the mechanical responses of deep weak rock under excavation stress paths in field and reveal the squeezing mechanism of deep tunnels is assembled and developed at Northeastern University,China.The apparatus can perform instantaneous unloading in s3 direction based on electromagnetism technology.In addition,uniform loading and deformation measurements can be carried out based on the proposed linked interlocking clamp and antifriction device,even if the sample has a strong dilatation deformation performance.Next,a bore trepanning is designed to capture noiseless acoustic emission(AE)signals for deep weak rock at a low threshold.Finally,two tests were are conducted using this instrument to preliminarily understand the failure and deformation features of deep weak rock based on fractured marble.The results show that the complete stressestrain curves of fractured marble have the characteristics of low strengths and large deformations,and the larger deformation and the more serious failure occur when the fractured marble enters the post-peak state after excavation.The results show that the developed apparatus is likely to be applicable for deep weak rock engineering.
基金J.R.is supported by National Natural Science Foundation of China(NSFC-8182207)Shanghai Academic/Technology Research Leader(19XD1420600)Chinese Academy of Medical Sciences(2019-RC-HL_020).
文摘Kidney disease is manifested in a wide variety of phenotypes,many of which have an important hereditary component.To delineate the genotypic and phenotypic spectrum of pediatric nephropathy,a multicenter registration system is being imple-mented based on the Chinese Children Genetic Kidney Disease Database(CCGKDD).In this study,all the patients with kidney and urological diseases were recruited from 2014 to 2020.Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features.The genetic diagnosis was confirmed in 883 of 2256(39.1%)patients from 23 provinces in China.Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome(SRNS,23.5%),glomerulonephritis(GN,32.2%),congenital anomalies of the kidney and urinary tract(CAKUT,21.2%),cystic renal disease(3.9%),renal calcinosis/stone(3.6%),tubulopathy(9.7%),and chronic kidney disease of unknown etiology(CKDu,5.8%).The pathogenic variants of 105 monogenetic disorders were identified.Ten distinct genomic disorders were identified as pathogenic copy number variants(CNVs)in 11 patients.The diagnostic yield differed by subgroups,and was highest in those with cystic renal disease(66.3%),followed by tubulopathy(58.4%),GN(57.7%),CKDu(43.5%),SRNS(29.2%),renal calcinosis/stone(29.3%)and CAKUT(8.6%).Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions.We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed.Our data demonstrate the utility of family-based exome sequencing,and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease.
