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偏侧咀嚼对小鼠学习记忆能力的影响及相关机制研究 被引量:8
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作者 姜华 董宪喆 +5 位作者 胡园 马军利 封纯真 章巧 李晓星 刘洪臣 《口腔颌面修复学杂志》 2018年第5期280-284,共5页
目的:研究偏侧咀嚼对小鼠学习记忆的影响,探讨其与记忆相关的HPA轴及5-HT系统相关信号通路的作用机理。方法:采用拔除单侧下颌牙的方法建立偏侧咀嚼(包括左侧咀嚼和右侧咀嚼)小鼠模型,分别记录术后4周和8周小鼠的体重变化,morris水迷宫... 目的:研究偏侧咀嚼对小鼠学习记忆的影响,探讨其与记忆相关的HPA轴及5-HT系统相关信号通路的作用机理。方法:采用拔除单侧下颌牙的方法建立偏侧咀嚼(包括左侧咀嚼和右侧咀嚼)小鼠模型,分别记录术后4周和8周小鼠的体重变化,morris水迷宫测试小鼠术后4周和8周后学习记忆能力变化;放免法检测术后8周小鼠海马和皮层中HPA轴相关激素,HPLC法检测神经递质5-HT水平的变化。结果:偏侧咀嚼小鼠在术后4周和8周时体重与正常组均无显著差异;术后8周时,偏侧咀嚼小鼠游泳潜伏期较正常组均有显著延长,穿越平台次数减少;偏侧咀嚼小鼠海马区CRH和ACTH水平较正常对照组显著升高;偏侧咀嚼小鼠海马中5-H T水平显著降低。结论:偏侧咀嚼小鼠学习记忆能力降低,其机制与海马中5-H T系统中5-H T水平和海马和皮层等脑区HPA轴功能异常相关。 展开更多
关键词 偏侧咀嚼 学习记忆 5-HT系统 HPA轴
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单颗种植义齿咬合大脑激活区域初步研究
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作者 封纯真 顾斌 +3 位作者 胡楠 李金锋 姜华 刘洪臣 《口腔颌面修复学杂志》 2018年第3期139-143,共5页
目的:观察单颗种植义齿咬合时大脑的激活特点,并与自然牙咬合时大脑的激活区域进行对比分析。方法:选取健康种植义齿志愿者5例,确定种植义齿的邻牙为对照牙,浸润麻醉种植义齿及对照牙的对颌牙。采用功能性磁共振技术,采用静息-咬牙的bl... 目的:观察单颗种植义齿咬合时大脑的激活特点,并与自然牙咬合时大脑的激活区域进行对比分析。方法:选取健康种植义齿志愿者5例,确定种植义齿的邻牙为对照牙,浸润麻醉种植义齿及对照牙的对颌牙。采用功能性磁共振技术,采用静息-咬牙的block设计方法,采集每位受试者种植义齿及对照牙咬合时的功能性磁共振图像。分析种植义齿咬合时大脑的激活特点。根据文献报道,确定了初级感觉运动区、辅助运动区、脑岛、丘脑、前额叶和小脑等咀嚼相关区域为兴趣区域,研究被试在使用不同的牙咬合的情况下这六个区的信号变化情况。结果:种植义齿咬合时大脑激活区域与自然牙类似,激活了左额上回,双侧小脑、中央前回、中央后回、丘脑、脑岛、辅助运动区,但激活强度低、范围小。在六个兴趣区域,种植义齿的激活强度均小于自然牙。结论:种植义齿部分的建立了感觉运动反馈调节。在大脑咀嚼相关区域,种植义齿的激活范围和激活强度均小于自然牙。 展开更多
关键词 种植义齿 大脑激活区域 功能性磁共振成像
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Nuclear magnetic resonance T_2 spectrum:multifractal characteristics and pore structure evaluation 被引量:20
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作者 Yan Jian-Ping He Xu +4 位作者 Geng Bin Hu Qin-Hong feng chun-zhen Kou Xiao-Pan Li Xing-Wen 《Applied Geophysics》 SCIE CSCD 2017年第2期205-215,322,共12页
Pore structure characteristics are important to oil and gas exploration in complex low-permeability reservoirs. Using multifractal theory and nuclear magnetic resonance (NMR), we studied the pore structure of low-pe... Pore structure characteristics are important to oil and gas exploration in complex low-permeability reservoirs. Using multifractal theory and nuclear magnetic resonance (NMR), we studied the pore structure of low-permeability sandstone rocks from the 4th Member (Es4) of the Shahejie Formation in the south slope of the Dongying Sag. We used the existing pore structure data from petrophysics, core slices, and mercury injection tests to classify the pore structure into three categories and five subcategories. Then, the T2 spectra of samples with different pore structures were interpolated, and the one- and three-dimensional fractal dimensions and the multifractal spectrum were obtained. Parameters a (intensity of singularity) andf(a) (density of distribution) were extracted from the multifractal spectra. The differences in the three fractal dimensions suggest that the pore structure types correlate with a andf(a). The results calculated based on the multifractal spectrum is consistent with that of the core slices and mercury injection. Finally, the proposed method was applied to an actual logging profile to evaluate the pore structure of low-permeability sandstone reservoirs. 展开更多
关键词 NMR T2 spectrum MULTIFRACTAL INTERPOLATION pore structure PERMEABILITY SANDSTONE
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Lower Es3 in Zhanhua Sag, Jiyang Depression: a case study for lithofacies classification in lacustrine mud shale 被引量:11
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作者 Yan Jian-Ping He Xu +4 位作者 Hu Qin-Hong Liang Qiang Tang Hong-Ming feng chun-zhen Geng Bin 《Applied Geophysics》 SCIE CSCD 2018年第2期151-164,361,共15页
Oil and gas exploration in lacustrine mud shale has focused on laminated calcareous lithofacies rich in type Ⅰ or type Ⅱ1 organic matter, taking into account the mineralogy and bedding structure, and type and abunda... Oil and gas exploration in lacustrine mud shale has focused on laminated calcareous lithofacies rich in type Ⅰ or type Ⅱ1 organic matter, taking into account the mineralogy and bedding structure, and type and abundance of organic matter. Using the lower third member of the Shahejie Formation, Zhanhua Sag, Jiyang Depression as the target lithology, we applied core description, thin section observations, electron microscopy imaging, nuclear magnetic resonance, and fullbore formation microimager (FMI) to study the mud shale lithofacies and features. First, the lithofacies were classified by considering the bedding structure, lithology, and organic matter and then a lithofacies classification scheme of lacustrine mud shale was proposed. Second, we used optimal filtering of logging data to distinguish the lithologies. Because the fractals of logging data are good indicators of the bedding structure, gamma-ray radiation was used to optimize the structural identification. Total organic carbon content (TOC) and pyrolyzed hydrocarbons (S2) were calculated from the logging data, and the hydrogen index (HI) was obtained to identify the organic matter type of the different strata (HI vs Tmax). Finally, a method for shale lithofacies identification based on logging data is proposed for exploring mud shale reservoirs and sweet spots from continuous wellbore profiles. 展开更多
关键词 mud shale lithofacies FILTERING fractals LOGGING
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