BACKGROUND Liver injury is common in severe acute pancreatitis(SAP).Excessive autophagy often leads to an imbalance of homeostasis in hepatocytes,which induces lipid peroxidation and mitochondrial iron deposition and ...BACKGROUND Liver injury is common in severe acute pancreatitis(SAP).Excessive autophagy often leads to an imbalance of homeostasis in hepatocytes,which induces lipid peroxidation and mitochondrial iron deposition and ultimately leads to ferroptosis.Our previous study found that milk fat globule epidermal growth factor 8(MFG-E8)alleviates acinar cell damage during SAP via binding toαvβ3/5 integrins.MFG-E8 also seems to mitigate pancreatic fibrosis via inhibiting chaperone-mediated autophagy.AIM To speculate whether MFG-E8 could also alleviate SAP induced liver injury by restoring the abnormal autophagy flux.METHODS SAP was induced in mice by 2 hly intraperitoneal injections of 4.0 g/kg L-arginine or 7 hly injections of 50μg/kg cerulein plus lipopolysaccharide.mfge8-knockout mice were used to study the effect of MFG-E8 deficiency on SAPinduced liver injury.Cilengitide,a specificαvβ3/5 integrin inhibitor,was used to investigate the possible mechanism of MFG-E8.RESULTS The results showed that MFG-E8 deficiency aggravated SAP-induced liver injury in mice,enhanced autophagy flux in hepatocyte,and worsened the degree of ferroptosis.Exogenous MFG-E8 reduced SAP-induced liver injury in a dose-dependent manner.Mechanistically,MFG-E8 mitigated excessive autophagy and inhibited ferroptosis in liver cells.Cilengitide abolished MFG-E8’s beneficial effects in SAP-induced liver injury.CONCLUSION MFG-E8 acts as an endogenous protective mediator in SAP-induced liver injury.MFG-E8 alleviates the excessive autophagy and inhibits ferroptosis in hepatocytes by binding to integrinαVβ3/5.展开更多
Maritime radar and automatic identification systems (AIS), which are essential auxiliary equipment for navigation safety in the shipping industry, have played significant roles in maritime safety supervision. However,...Maritime radar and automatic identification systems (AIS), which are essential auxiliary equipment for navigation safety in the shipping industry, have played significant roles in maritime safety supervision. However, in practical applications, the information obtained by a single device is limited, and it is necessary to integrate the information of maritime radar and AIS messages to achieve better recognition effects. In this study, the D-S evidence theory is used to fusion the two kinds of heterogeneous information: maritime radar images and AIS messages. Firstly, the radar image and AIS message are processed to get the targets of interest in the same coordinate system. Then, the coordinate position and heading of targets are chosen as the indicators for judging target similarity. Finally, a piece of D-S evidence theory based on the information fusion method is proposed to match the radar target and the AIS target of the same ship. Particularly, the effectiveness of the proposed method has been validated and evaluated through several experiments, which proves that such a method is practical in maritime safety supervision.展开更多
Geothermal energy is a kind of renewable,sustainable and clean energy resource.Geothermal energy is abundant in carbonate reservoirs.However,low matrix permeability limits its exploitation.The super-critical carbon di...Geothermal energy is a kind of renewable,sustainable and clean energy resource.Geothermal energy is abundant in carbonate reservoirs.However,low matrix permeability limits its exploitation.The super-critical carbon dioxide(SC-CO_(2))jet fracturing is expected to efficiently stimulate the carbonate geothermal reservoirs and achieve the storage of CO_(2) simultaneously.In this paper,we established a transient seepage and fluid-thermo-mechanical coupled model to analyze the impact performance of sc-CO_(2) jet fracturing.The mesh-based parallel code coupling interface was employed to couple the fluid and solid domains by exchanging the data through the mesh interface.The physical properties change of sC-CO_(2) with temperature were considered in the numerical model.Results showed that SC-CO_(2) jet frac-turing is superior to water-jet fracturing with respect to jetting velocity,particle trajectory and pene-trability.Besides,stress distribution on the carbonate rock showed that the tensile and shear failure would more easily occur by SC-CO_(2) jet than that by water jet.Moreover,pressure and temperature control the jet field and seepage field of sC-CO_(2) simultaneously.Increasing the jet temperature can effectively enhance the impingement effect and seepage process by decreasing the viscosity and density of SC-CO_(2).The key findings are expected to provide a theoretical basis and design reference for applying SC-CO_(2) jet fracturing in carbonate geothermal reservoirs.展开更多
Objective: To investigate the relationship between platelet-derived growth factor-A (PDGF-A) and atrial fibrosis in patients who have developed atrial fibrillation (AF) secondary to rheumatic valvular disease. Methods...Objective: To investigate the relationship between platelet-derived growth factor-A (PDGF-A) and atrial fibrosis in patients who have developed atrial fibrillation (AF) secondary to rheumatic valvular disease. Methods: 84 selected patients participated in the current study who have developed rheumatic heart disease and were going to have a cardiac surgical operation. In the current study, whole subjects were divided into two group, they were atrial fibrillation (AF) group (the quantity is thirty-nine) and sinus rhythm (SR) group (the quantity is forty-five). Before the operation, complete clinical data was available for the whole patients. During the operation, the right atrial tissue (0.3 - 0.5 mm<sup>3</sup>) was disserted from every patient. Right atrial fibrosis was observed by Masson staining and the distribution of PDGF-A in right atrium specimen was observed by immunohistochemistry. RT-PCR techniques were applied to admeasure the mRNA expressions of PDGF-A in patients’ atrial tissue. At the same time, western-Blot techniques were employed to admeasure the protein expressions of PDGF-A. Results: In baseline clinical characteristics, in both AF group and SR group, there was no apparently difference between them (P > 0.05);compared with SR group, the diameters of left atrium and right atrium in AF group were apparently increased (P Conclusion: Atrial remodeling plays an important role in patients with valvular atrial fibrillation;PDGF-A in patients with AF was highly expressed in the right atrial, and was closely related with atrial fibrosis.展开更多
BACKGROUND:The resection and reconstruction of large vessels,including the portal vein,are frequently needed in tumor resection.Warm ischemia before reconstruction might have deleterious effects on the function of som...BACKGROUND:The resection and reconstruction of large vessels,including the portal vein,are frequently needed in tumor resection.Warm ischemia before reconstruction might have deleterious effects on the function of some vital organs and therefore,how to reconstruct the vessels quickly after resection is extremely important.The present study was to introduce a new type of magnetic compression anastomosis(MCA)device to establish a quick non-suture anastomosis of the portal vein after resection in canines.METHODS:The new MCA device consists of a pair of titanium alloy and neodymium-ferrum-boron magnet(Ti-Nd Fe B)composite rings.The Nd Fe B magnetic ring as a core of the device was hermetically sealed inside the biomedical titanium alloy case.Twelve canines were divided into two groups:a MCA group in which the end-to-end anastomoses was made with a new device after resection in the portal vein and a traditional manual suture(TMS)group consisted of 6 canines.The anastomosis time,anastomotic patency and quality were investigated at week 24 postoperatively.RESULTS:The portal vein was reconstructed successfully in all of the animals and they all survived.The duration of portal vein anastomosis was significantly shorter in the MCA group than in the TMS group(8.16±1.25 vs 36.24±2.17 min,P<0.05).Portography and ultrasound showed that the blood flow was normal without angiostenosis or thrombosis in all of the canines.Hematoxylin-eosin staining and electron microscope scanning showed in contrast to the TMS group,MCA anastomotic intimal was much smoother with more regularly arranged endothelial cells at week 24 postoperatively.展开更多
AIM: To investigate the optimal magnetic pressure and provide a theoretical basis for choledochojejunostomy magnetic compressive anastomosis(magnamosis).METHODS: Four groups of neodymium-iron-boron magnets with differ...AIM: To investigate the optimal magnetic pressure and provide a theoretical basis for choledochojejunostomy magnetic compressive anastomosis(magnamosis).METHODS: Four groups of neodymium-iron-boron magnets with different magnetic pressures of 0.1, 0.2, 0.3 and 0.4 MPa were used to complete the choledochojejunostomy magnamosis. Twenty-six young mongrel dogs were randomly divided into five groups: four groups with different magnetic pressures and 1 group with a hand-suture anastomosis. Serum bilirubin levels were measured in all groups before and 1 wk, 2 wk, 3 wk, 1 mo and 3 mo after surgery. Daily abdominal X-ray fluoroscopy was carried out postoperatively to detect the path and the excretion of the magnet. The animals were euthanized at 1 or 3 mo after the operation, the burst pressure was detected in each anastomosis, and the gross appearance and histology were compared according to the observation.RESULTS: The surgical procedures were all successfully performed in animals. However, animals of group D(magnetic pressure of 0.4 MPa) all experienced complications with bile leakage(4/4), whereas half of animals in group A(magnetic pressure of 0.1 MPa) experienced complications(3/6), 1 animal in the manual group E developed anastomotic stenosis, and animals in group B and group C(magnetic pressure of 0.2 MPa and 0.3 MPa, respectively) all healed well without complications. These results also suggested that the time required to form the stoma was inversely proportional to the magnetic pressure; however, the burst pressure of group A was smaller than those of the other groups at 1 mo(187.5 ± 17.7 vs 290 ± 10/296.7 ± 5.7/287.5 ± 3.5, P < 0.05); the remaining groups did not differ significantly. A histologic examination demonstrated obvious differences between the magnamosis groups and the hand-sewn group.CONCLUSION: We proved that the optimal range for choledochojejunostomy magnamosis is 0.2 MPa to 0.3 MPa, which will help to improve the clinical application of this technique in the future.展开更多
Geothermal energy is a precious resource,which is widely distributed,varied,and abundant.China has entered a period of rapid development of geothermal energy since 2010.As shallow geothermal energy promoting,the depth...Geothermal energy is a precious resource,which is widely distributed,varied,and abundant.China has entered a period of rapid development of geothermal energy since 2010.As shallow geothermal energy promoting,the depth of hydrothermal geothermal exploration is increasing.The quality of Hot Dry Rock (HDR)and related exploratory technologies are better developed and utilized.On the basis of geothermal development,this paper reviews the geothermal progress during the "12th Five-Year Plan",and summarizes the achievements of hydrothermal geothermal and hot dry rocks from geothermal survey and evaluation aspects.Finally,the authors predict the development trend of the future geothermal research to benefit geothermal and hot dry rock research.展开更多
The Beijing-Tianjin-Hebei region boasts rich geothermal resources and new achievements have been made in the exploration and development of geothermal resources in this region based on previous regional investigation....The Beijing-Tianjin-Hebei region boasts rich geothermal resources and new achievements have been made in the exploration and development of geothermal resources in this region based on previous regional investigation.In detail,geothermal reservoirs of Gaoyuzhuang Formation of Jixian System and Changcheng System in Xiongan New Area have been recently discovered,opening up the second space of geothermal resources;the calculation method of the recoverable resources of geothermal fluid with reinjection being considered has been improved in Beijing-Tianjin-Hebei region,and uniform comprehensive assessment of shallow geothermal energy,hydrothermal geothermal resources,and hot dry rocks(HDR)geothermal resources in the whole Beijing-Tianjin-Shijiazhuang region has been completed.The scientific research base for cascade development and utilization of geothermal resources in Beijing-Tianjin-Hebei region has applied hydraulic fracturing technology to the geothermal reservoirs in Gaoyuzhuang Formation.As a result,the production capacity doubled and two-stage cascade utilization composed of geothermal power generation and geothermal heating were realized,with the first-phase installed capacity of 280 kW and the geothermal heating is 30000 m2.In this way,a model of the exploration,development,and utilization of geothermal resources formed.Large-scale utilization has become the future trend of geothermal resource development in Beijing-Tianjin-Hebei region,and great efforts shall be made to achieve breakthroughs in reinjection technology,geothermal reservoir reconstruction technology,thermoelectric technology and underground heat exchange technology.展开更多
Guanzhong Basin is a typical medium-low temperature geothermal field mainly controlled by geo-pressure in the west of China.The characteristics of hydrogen and oxygen isotopes were used to analyze the flow and storage...Guanzhong Basin is a typical medium-low temperature geothermal field mainly controlled by geo-pressure in the west of China.The characteristics of hydrogen and oxygen isotopes were used to analyze the flow and storage modes of geothermal resources in the basin.In this paper,the basin was divided into six geotectonic units,where a total of 121 samples were collected from geothermal wells and surface water bodies for the analysis of hydrogen-oxygen isotopes.Analytical results show that the isotopic signatures of hydrogen and oxygen throughout Guanzhong Basin reveal a trend of gradual increase from the basin edge areas to the basin center.In terms of recharge systems,the area in the south edge belongs to the geothermal system of Qinling Mountain piedmont,while to the north of Weihe fault is the geothermal system of North mountain piedmont,where the atmospheric temperature is about 0.2℃-1.8℃in the recharge areas.The main factors that affect the geothermal waterδ18O drifting include the depth of geothermal reservoir and temperature of geothermal reservoir,lithological characteristics,water-rock interaction,geothermal reservoir environment and residence time.Theδ18O-δD relation shows that the main source is the meteoric water,together with some sedimentary water,but there are no deep magmatic water and mantle water which recharge the geothermal water in the basin.Through examining the distribution pattern of hydrogen-oxygen isotopic signatures,the groundwater circulation model of this basin can be divided into open circulation type,semi-open type,closed type and sedimentary type.This provides some important information for rational exploitation of the geothermal resources.展开更多
Objective: To investigate the expression of Platelet-derived growth factor receptor alpha (PDGFR-α) in patients who have valvular atrial fibrillation. Methods: In this research, eighty-four patients with rheumatic he...Objective: To investigate the expression of Platelet-derived growth factor receptor alpha (PDGFR-α) in patients who have valvular atrial fibrillation. Methods: In this research, eighty-four patients with rheumatic heart disease who were going to undertake cardiac surgery were included. The subjects were divided into two groups: the AF group and the sinus rhythm group, the quantities are 39 and 45 respectively. Before the surgery, baseline demographics, physical examination, routine laboratory testing, echocardiography, echocardiographic data and additional clinical data were available for all patients. The right atrial tissue of the subjects was separated during surgery, with an area of approximately 0.3 - 0.5 mm<sup>3</sup>. Immunofluorescence staining was used to analyze the distribution of PDGFR-α of atrial tissue. mRNA of PDGFR-α in atrial tissue were determined by real-time quantitative PCR (Polymerase Chain Reaction);Western-Blot technique was used to measure the protein of PDGFR-α in atrial tissue. Results: There were no significant differences (P > 0.05) in sex ratio, age, blood pressure, blood biochemistry, and other aspects of medical history between the two groups. However, the right and left atrium diameters in the AF group were markedly larger than those in the SR group (P α from right atrial tissue were obviously higher in the AF group than that in the SR group (P Conclusion: The expression of PDGFR-α in the right atrial tissue of patients with atrial fibrillation was found to be significantly higher.展开更多
AIM:To evaluate the anti-Helicobacter pylori (H.pylori) activity of 50 traditional Chinese herbal medicines in order to provide the primary evidence for their use in clinical practice.METHODS:A susceptibility test of ...AIM:To evaluate the anti-Helicobacter pylori (H.pylori) activity of 50 traditional Chinese herbal medicines in order to provide the primary evidence for their use in clinical practice.METHODS:A susceptibility test of water extract from 50 selected traditional Chinese herbal medicines for in vitro H.pylori Sydney strain 1 was performed with broth dilution method.Anti-H.pylori activity of the selected Chinese herbal medicines was evaluated according to their minimum inhibitory concentration (MIC).RESULTS:The water extract from Rhizoma Coptidis,Radix Scutellariae and Radix isatidis could significantly inhibit the H.pylori activity with their MIC less than 7.8 mg/mL,suggesting that traditional Chinese herbal medicines have anti-inflammatory and antibacterial effects and can thus be used in treatment of H.pylori infection.CONCLUSION:Rhizoma Coptidis,Radix Scutellariae and Radix isatidis are the potential sources for the synthesis of new drugs against H.pylori.展开更多
Based on the latest conventional–unconventional oil and gas databases and relevant reports,the distribution features of global tight oil were analyzed.A classification scheme of tight oil plays is proposed based on d...Based on the latest conventional–unconventional oil and gas databases and relevant reports,the distribution features of global tight oil were analyzed.A classification scheme of tight oil plays is proposed based on developed tight oil fields.Effective tight oil plays are defined by considering the exploiting practices of the past few years.Currently,potential tight oil areas are mainly distributed in 137 sets of shale strata in 84 basins,especially South America,North America,Russia,and North Africa.Foreland,craton,and continental rift basins dominate.In craton basins,tight oil mainly occurs in Paleozoic strata,while in continental rift basins,tight oil occurs in Paleozoic–Cenozoic strata.Tight oil mainly accumulates in the Cretaceous,Early Jurassic,Late Devonian,and Miocene,which correspond very well to six sets of globaldeveloped source rocks.Based on source–reservoir relationship,core data,and well-logging data,tight oil plays can be classified into eight types,above-source play,below-source play,beside-source play,in-source play,between-source play,in-source mud-dominated play,insource mud-subordinated play,and interbedded-source play.Specifically,between-source,interbedded-source,and in-source mud-subordinated plays are major targets for global tight oil development with high production.Incontrast,in-source mud-dominated and in-source plays are less satisfactory.展开更多
The Songke No.2 well (eastern hole)(referred to as Well SK-2),one of the "two wells and four holes"of the Deep Continental Scientific Drilling Engineering Project in the Songliao Basin,is in Anda City, Heilo...The Songke No.2 well (eastern hole)(referred to as Well SK-2),one of the "two wells and four holes"of the Deep Continental Scientific Drilling Engineering Project in the Songliao Basin,is in Anda City, Heilongjiang Province,and was officially completed on May 26,2018.Tlie scientific goals of Well SK-2 cover four aspects:paleoclimate research,resource and energy exploration,primary geological research, and development of deep earth exploration techniques.Since the official commencement of drilling in 2014,the Well SK-2 scientific drilling engineering team has organized and implemented drilling for coring,in situ logging,chemical analysis of core elements,and deep structural exploration around the well.Currently,the following preliminary scientific research progress has been made:4334.81 m in situ core data has been obtained;the centimeter-level high-resolution characterization of the most complete and continuous Cretaceous continental strata ever unearthed has been completed,and the standard profile of continental strata has been initially established;the unconventional natural gas resources and basin-type hot dry rocks in the deep Songliao Basin were found to have good prospects for exploration and development;the climatic evolutionary history of the Cretaceous continental strata was rebuilt for the first time,covering hundreds of thousands to millions of years,and the major events of Cretaceous climate fluctuations have been discovered;all these reveal strong evidence for the subduction and aggregation of paleo-ocean plates,providing a theoretical basis for the re-recognition of the genesis of the Songliao Basin and for deep earth oil and gas exploration.The implementation of the Deep Continental Scientific Drilling Engineering Project in the Songliao Basin is of great significance for exploring the mysteries of the Earth and solving major problems such as those related to the deep energy environment.It is a solid step along the road of "going deep into the Earth".展开更多
Endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD)are well-established therapeutics for gastrointestinal neoplasias,but complications after EMR/ESD,including bleeding and perforation,result in ...Endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD)are well-established therapeutics for gastrointestinal neoplasias,but complications after EMR/ESD,including bleeding and perforation,result in additional treatment morbidity and even threaten the lives of patients.Thus,designing biomaterials to treat gastric bleeding and wound healing after endoscopic treatment is highly desired and remains a challenge.Herein,a series of injectable pH-responsive selfhealing adhesive hydrogels based on acryloyl-6-aminocaproic acid(AA)and AA-g-N-hydroxysuccinimide(AA-NHS)were developed,and their great potential as endoscopic sprayable bioadhesive materials to efficiently stop hemorrhage and promote the wound healing process was further demonstrated in a swine gastric hemorrhage/wound model.The hydrogels showed a suitable gelation time,an autonomous and efficient self-healing capacity,hemostatic properties,and good biocompatibility.With the introduction of AA-NHS as a micro-cross-linker,the hydrogels exhibited enhanced adhesive strength.A swine gastric hemorrhage in vivo model demonstrated that the hydrogels showed good hemostatic performance by stopping acute arterial bleeding and preventing delayed bleeding.A gastric wound model indicated that the hydrogels showed excellent treatment effects with significantly enhanced wound healing with type I collagen deposition,α-SMA expression,and blood vessel formation.These injectable self-healing adhesive hydrogels exhibited great potential to treat gastric wounds after endoscopic treatment.展开更多
Highway constructions on the Qinghai-Tibet Plateau(QTP)face great challenges induced by the unique local environmental,geological,and engineering conditions.The large area of permafrost,great temperature variability,s...Highway constructions on the Qinghai-Tibet Plateau(QTP)face great challenges induced by the unique local environmental,geological,and engineering conditions.The large area of permafrost,great temperature variability,strong UV rays,and complex geological conditions are the major factors that adversely influence the longterm performance of pavement systems.Since 1960s,Chinese engineers and researchers have started conducting research on the QTP to enhance the performance and durability of pavement systems.The present paper provide a comprehensive review of challenge,research and practice of highway constructions on the QTP including the special environmental and geological conditions,history of highway constructions on the QTP,major challenges and the state-of-the-art technology of subgrade constructions on permafrost,developments of the pavement structures and materials,performance prediction and maintenance methods of pavement surfaces,and applications of the research achievements on the first expressway on the QTP(i.e.,Gongyu Expressway).Based on the comprehensive literature review,it can be found that(1)frost heave and thaw weakening induced subgrade disease and longitudinal cracks on the pavement surface are complex coupled water-thermal-load problems.Engineering solutions are focusing on active cooling and thermal insulation methods,which can help to reduce temperature variations in the subgrade and thus improving its stability,(2)the harsh environmental and construction conditions may reduce the early strength and induce premature damage of cement-treated base materials.Some field validations showed that geocell-reinforced or asphalt-treated flexible base materials can provide better long-term performance,(3)the large temperature variability and strong UV rays can significantly accelerate aging of asphalt binders and greatly reduce the service life of asphalt mixtures.Various binder modification methods were developed for improving their viscoelasticity and enhance the low-temperature cracking resistance of pavement surface materials but are still lack of field validation data and comparisons of their life cycle costs.Therefore,it is recommended that a demonstration research project build test sections to examine a range of pavement structures and materials,and compare their long-term performance and life cycle costs,which can serve as important reference for future highway constructions on the QTP.展开更多
The average size of the sand of dune in the vicinity of Tumen River is 0.12～0.30 mm, its standard deviation is 0.45～0.99 φ and the frequency cumulative distribution curve is divided into the single peak and the dou...The average size of the sand of dune in the vicinity of Tumen River is 0.12～0.30 mm, its standard deviation is 0.45～0.99 φ and the frequency cumulative distribution curve is divided into the single peak and the double peak. The Ski of the single peak is negative and the double peak is positive. There are two different areas in the plot of the Ski versus σi* It is shown that the sedimentary environment of the dunes is neritic deposit by the expressions of the grain-size parameters. All of the characters show that the sand dunes in Estuary of Tumen River may be the dunes of sea facies which were changed again by weathering and fluvialaction.展开更多
基金Supported by the National Natural Science Foundation of China,No.82100685the Scientific Research Fund of Xi’an Health Commission,No.2021yb08+1 种基金Scientific Research Fund of Xi’an Central Hospital,No.2022QN07Innovation Capability Support Plan of Xi’an Science and Technology Bureau,No.23YXYJ0097.
文摘BACKGROUND Liver injury is common in severe acute pancreatitis(SAP).Excessive autophagy often leads to an imbalance of homeostasis in hepatocytes,which induces lipid peroxidation and mitochondrial iron deposition and ultimately leads to ferroptosis.Our previous study found that milk fat globule epidermal growth factor 8(MFG-E8)alleviates acinar cell damage during SAP via binding toαvβ3/5 integrins.MFG-E8 also seems to mitigate pancreatic fibrosis via inhibiting chaperone-mediated autophagy.AIM To speculate whether MFG-E8 could also alleviate SAP induced liver injury by restoring the abnormal autophagy flux.METHODS SAP was induced in mice by 2 hly intraperitoneal injections of 4.0 g/kg L-arginine or 7 hly injections of 50μg/kg cerulein plus lipopolysaccharide.mfge8-knockout mice were used to study the effect of MFG-E8 deficiency on SAPinduced liver injury.Cilengitide,a specificαvβ3/5 integrin inhibitor,was used to investigate the possible mechanism of MFG-E8.RESULTS The results showed that MFG-E8 deficiency aggravated SAP-induced liver injury in mice,enhanced autophagy flux in hepatocyte,and worsened the degree of ferroptosis.Exogenous MFG-E8 reduced SAP-induced liver injury in a dose-dependent manner.Mechanistically,MFG-E8 mitigated excessive autophagy and inhibited ferroptosis in liver cells.Cilengitide abolished MFG-E8’s beneficial effects in SAP-induced liver injury.CONCLUSION MFG-E8 acts as an endogenous protective mediator in SAP-induced liver injury.MFG-E8 alleviates the excessive autophagy and inhibits ferroptosis in hepatocytes by binding to integrinαVβ3/5.
文摘Maritime radar and automatic identification systems (AIS), which are essential auxiliary equipment for navigation safety in the shipping industry, have played significant roles in maritime safety supervision. However, in practical applications, the information obtained by a single device is limited, and it is necessary to integrate the information of maritime radar and AIS messages to achieve better recognition effects. In this study, the D-S evidence theory is used to fusion the two kinds of heterogeneous information: maritime radar images and AIS messages. Firstly, the radar image and AIS message are processed to get the targets of interest in the same coordinate system. Then, the coordinate position and heading of targets are chosen as the indicators for judging target similarity. Finally, a piece of D-S evidence theory based on the information fusion method is proposed to match the radar target and the AIS target of the same ship. Particularly, the effectiveness of the proposed method has been validated and evaluated through several experiments, which proves that such a method is practical in maritime safety supervision.
基金the National Key R&D Program of China(No.2019YFB1504102).
文摘Geothermal energy is a kind of renewable,sustainable and clean energy resource.Geothermal energy is abundant in carbonate reservoirs.However,low matrix permeability limits its exploitation.The super-critical carbon dioxide(SC-CO_(2))jet fracturing is expected to efficiently stimulate the carbonate geothermal reservoirs and achieve the storage of CO_(2) simultaneously.In this paper,we established a transient seepage and fluid-thermo-mechanical coupled model to analyze the impact performance of sc-CO_(2) jet fracturing.The mesh-based parallel code coupling interface was employed to couple the fluid and solid domains by exchanging the data through the mesh interface.The physical properties change of sC-CO_(2) with temperature were considered in the numerical model.Results showed that SC-CO_(2) jet frac-turing is superior to water-jet fracturing with respect to jetting velocity,particle trajectory and pene-trability.Besides,stress distribution on the carbonate rock showed that the tensile and shear failure would more easily occur by SC-CO_(2) jet than that by water jet.Moreover,pressure and temperature control the jet field and seepage field of sC-CO_(2) simultaneously.Increasing the jet temperature can effectively enhance the impingement effect and seepage process by decreasing the viscosity and density of SC-CO_(2).The key findings are expected to provide a theoretical basis and design reference for applying SC-CO_(2) jet fracturing in carbonate geothermal reservoirs.
文摘Objective: To investigate the relationship between platelet-derived growth factor-A (PDGF-A) and atrial fibrosis in patients who have developed atrial fibrillation (AF) secondary to rheumatic valvular disease. Methods: 84 selected patients participated in the current study who have developed rheumatic heart disease and were going to have a cardiac surgical operation. In the current study, whole subjects were divided into two group, they were atrial fibrillation (AF) group (the quantity is thirty-nine) and sinus rhythm (SR) group (the quantity is forty-five). Before the operation, complete clinical data was available for the whole patients. During the operation, the right atrial tissue (0.3 - 0.5 mm<sup>3</sup>) was disserted from every patient. Right atrial fibrosis was observed by Masson staining and the distribution of PDGF-A in right atrium specimen was observed by immunohistochemistry. RT-PCR techniques were applied to admeasure the mRNA expressions of PDGF-A in patients’ atrial tissue. At the same time, western-Blot techniques were employed to admeasure the protein expressions of PDGF-A. Results: In baseline clinical characteristics, in both AF group and SR group, there was no apparently difference between them (P > 0.05);compared with SR group, the diameters of left atrium and right atrium in AF group were apparently increased (P Conclusion: Atrial remodeling plays an important role in patients with valvular atrial fibrillation;PDGF-A in patients with AF was highly expressed in the right atrial, and was closely related with atrial fibrosis.
基金supported by grants from the National Natural Science Foundation of China(30830099&81470896&81127005)the Science and Technology Co-ordinating Innovative Engineering Projects of Shaanxi Province(2014KTCQ03-05)
文摘BACKGROUND:The resection and reconstruction of large vessels,including the portal vein,are frequently needed in tumor resection.Warm ischemia before reconstruction might have deleterious effects on the function of some vital organs and therefore,how to reconstruct the vessels quickly after resection is extremely important.The present study was to introduce a new type of magnetic compression anastomosis(MCA)device to establish a quick non-suture anastomosis of the portal vein after resection in canines.METHODS:The new MCA device consists of a pair of titanium alloy and neodymium-ferrum-boron magnet(Ti-Nd Fe B)composite rings.The Nd Fe B magnetic ring as a core of the device was hermetically sealed inside the biomedical titanium alloy case.Twelve canines were divided into two groups:a MCA group in which the end-to-end anastomoses was made with a new device after resection in the portal vein and a traditional manual suture(TMS)group consisted of 6 canines.The anastomosis time,anastomotic patency and quality were investigated at week 24 postoperatively.RESULTS:The portal vein was reconstructed successfully in all of the animals and they all survived.The duration of portal vein anastomosis was significantly shorter in the MCA group than in the TMS group(8.16±1.25 vs 36.24±2.17 min,P<0.05).Portography and ultrasound showed that the blood flow was normal without angiostenosis or thrombosis in all of the canines.Hematoxylin-eosin staining and electron microscope scanning showed in contrast to the TMS group,MCA anastomotic intimal was much smoother with more regularly arranged endothelial cells at week 24 postoperatively.
基金the National Natural Science Foundation of China,No.51275387the Project of Development and Innovation Team of Ministry of Education,No.IRT1279the Science and Technology Co-ordination and Innovation Project,Shaanxi Province of China,No.2011KTCQ03-12
文摘AIM: To investigate the optimal magnetic pressure and provide a theoretical basis for choledochojejunostomy magnetic compressive anastomosis(magnamosis).METHODS: Four groups of neodymium-iron-boron magnets with different magnetic pressures of 0.1, 0.2, 0.3 and 0.4 MPa were used to complete the choledochojejunostomy magnamosis. Twenty-six young mongrel dogs were randomly divided into five groups: four groups with different magnetic pressures and 1 group with a hand-suture anastomosis. Serum bilirubin levels were measured in all groups before and 1 wk, 2 wk, 3 wk, 1 mo and 3 mo after surgery. Daily abdominal X-ray fluoroscopy was carried out postoperatively to detect the path and the excretion of the magnet. The animals were euthanized at 1 or 3 mo after the operation, the burst pressure was detected in each anastomosis, and the gross appearance and histology were compared according to the observation.RESULTS: The surgical procedures were all successfully performed in animals. However, animals of group D(magnetic pressure of 0.4 MPa) all experienced complications with bile leakage(4/4), whereas half of animals in group A(magnetic pressure of 0.1 MPa) experienced complications(3/6), 1 animal in the manual group E developed anastomotic stenosis, and animals in group B and group C(magnetic pressure of 0.2 MPa and 0.3 MPa, respectively) all healed well without complications. These results also suggested that the time required to form the stoma was inversely proportional to the magnetic pressure; however, the burst pressure of group A was smaller than those of the other groups at 1 mo(187.5 ± 17.7 vs 290 ± 10/296.7 ± 5.7/287.5 ± 3.5, P < 0.05); the remaining groups did not differ significantly. A histologic examination demonstrated obvious differences between the magnamosis groups and the hand-sewn group.CONCLUSION: We proved that the optimal range for choledochojejunostomy magnamosis is 0.2 MPa to 0.3 MPa, which will help to improve the clinical application of this technique in the future.
基金National Natural Science Foundation of China(4160227)China Geological Survey(DD20160207,DD20189112).
文摘Geothermal energy is a precious resource,which is widely distributed,varied,and abundant.China has entered a period of rapid development of geothermal energy since 2010.As shallow geothermal energy promoting,the depth of hydrothermal geothermal exploration is increasing.The quality of Hot Dry Rock (HDR)and related exploratory technologies are better developed and utilized.On the basis of geothermal development,this paper reviews the geothermal progress during the "12th Five-Year Plan",and summarizes the achievements of hydrothermal geothermal and hot dry rocks from geothermal survey and evaluation aspects.Finally,the authors predict the development trend of the future geothermal research to benefit geothermal and hot dry rock research.
基金This work is financially supported by the Special Fund for National Key Research and Development Program of China(2018YFC0604306)China Geological Survey project Survey and Assessment of Geothermal Energy in Xiongan New Area(DD20189112)Technology Innovation Center of Geothermal and Hot Dry Rock Exploration and Development,Ministry of Natural Resources.
文摘The Beijing-Tianjin-Hebei region boasts rich geothermal resources and new achievements have been made in the exploration and development of geothermal resources in this region based on previous regional investigation.In detail,geothermal reservoirs of Gaoyuzhuang Formation of Jixian System and Changcheng System in Xiongan New Area have been recently discovered,opening up the second space of geothermal resources;the calculation method of the recoverable resources of geothermal fluid with reinjection being considered has been improved in Beijing-Tianjin-Hebei region,and uniform comprehensive assessment of shallow geothermal energy,hydrothermal geothermal resources,and hot dry rocks(HDR)geothermal resources in the whole Beijing-Tianjin-Shijiazhuang region has been completed.The scientific research base for cascade development and utilization of geothermal resources in Beijing-Tianjin-Hebei region has applied hydraulic fracturing technology to the geothermal reservoirs in Gaoyuzhuang Formation.As a result,the production capacity doubled and two-stage cascade utilization composed of geothermal power generation and geothermal heating were realized,with the first-phase installed capacity of 280 kW and the geothermal heating is 30000 m2.In this way,a model of the exploration,development,and utilization of geothermal resources formed.Large-scale utilization has become the future trend of geothermal resource development in Beijing-Tianjin-Hebei region,and great efforts shall be made to achieve breakthroughs in reinjection technology,geothermal reservoir reconstruction technology,thermoelectric technology and underground heat exchange technology.
基金funded by National Key R&D Program of China(Grant No.2019YFB1504101)National Natural Science Foundation of China(No.41602271)China Geological Survey(No.DD20160207,DD20189112)。
文摘Guanzhong Basin is a typical medium-low temperature geothermal field mainly controlled by geo-pressure in the west of China.The characteristics of hydrogen and oxygen isotopes were used to analyze the flow and storage modes of geothermal resources in the basin.In this paper,the basin was divided into six geotectonic units,where a total of 121 samples were collected from geothermal wells and surface water bodies for the analysis of hydrogen-oxygen isotopes.Analytical results show that the isotopic signatures of hydrogen and oxygen throughout Guanzhong Basin reveal a trend of gradual increase from the basin edge areas to the basin center.In terms of recharge systems,the area in the south edge belongs to the geothermal system of Qinling Mountain piedmont,while to the north of Weihe fault is the geothermal system of North mountain piedmont,where the atmospheric temperature is about 0.2℃-1.8℃in the recharge areas.The main factors that affect the geothermal waterδ18O drifting include the depth of geothermal reservoir and temperature of geothermal reservoir,lithological characteristics,water-rock interaction,geothermal reservoir environment and residence time.Theδ18O-δD relation shows that the main source is the meteoric water,together with some sedimentary water,but there are no deep magmatic water and mantle water which recharge the geothermal water in the basin.Through examining the distribution pattern of hydrogen-oxygen isotopic signatures,the groundwater circulation model of this basin can be divided into open circulation type,semi-open type,closed type and sedimentary type.This provides some important information for rational exploitation of the geothermal resources.
文摘Objective: To investigate the expression of Platelet-derived growth factor receptor alpha (PDGFR-α) in patients who have valvular atrial fibrillation. Methods: In this research, eighty-four patients with rheumatic heart disease who were going to undertake cardiac surgery were included. The subjects were divided into two groups: the AF group and the sinus rhythm group, the quantities are 39 and 45 respectively. Before the surgery, baseline demographics, physical examination, routine laboratory testing, echocardiography, echocardiographic data and additional clinical data were available for all patients. The right atrial tissue of the subjects was separated during surgery, with an area of approximately 0.3 - 0.5 mm<sup>3</sup>. Immunofluorescence staining was used to analyze the distribution of PDGFR-α of atrial tissue. mRNA of PDGFR-α in atrial tissue were determined by real-time quantitative PCR (Polymerase Chain Reaction);Western-Blot technique was used to measure the protein of PDGFR-α in atrial tissue. Results: There were no significant differences (P > 0.05) in sex ratio, age, blood pressure, blood biochemistry, and other aspects of medical history between the two groups. However, the right and left atrium diameters in the AF group were markedly larger than those in the SR group (P α from right atrial tissue were obviously higher in the AF group than that in the SR group (P Conclusion: The expression of PDGFR-α in the right atrial tissue of patients with atrial fibrillation was found to be significantly higher.
基金Supported by The Cooperation Project in Industry,Education and Research of Guangdong Province and Ministry of Education of China,No.2009B090300280
文摘AIM:To evaluate the anti-Helicobacter pylori (H.pylori) activity of 50 traditional Chinese herbal medicines in order to provide the primary evidence for their use in clinical practice.METHODS:A susceptibility test of water extract from 50 selected traditional Chinese herbal medicines for in vitro H.pylori Sydney strain 1 was performed with broth dilution method.Anti-H.pylori activity of the selected Chinese herbal medicines was evaluated according to their minimum inhibitory concentration (MIC).RESULTS:The water extract from Rhizoma Coptidis,Radix Scutellariae and Radix isatidis could significantly inhibit the H.pylori activity with their MIC less than 7.8 mg/mL,suggesting that traditional Chinese herbal medicines have anti-inflammatory and antibacterial effects and can thus be used in treatment of H.pylori infection.CONCLUSION:Rhizoma Coptidis,Radix Scutellariae and Radix isatidis are the potential sources for the synthesis of new drugs against H.pylori.
文摘Based on the latest conventional–unconventional oil and gas databases and relevant reports,the distribution features of global tight oil were analyzed.A classification scheme of tight oil plays is proposed based on developed tight oil fields.Effective tight oil plays are defined by considering the exploiting practices of the past few years.Currently,potential tight oil areas are mainly distributed in 137 sets of shale strata in 84 basins,especially South America,North America,Russia,and North Africa.Foreland,craton,and continental rift basins dominate.In craton basins,tight oil mainly occurs in Paleozoic strata,while in continental rift basins,tight oil occurs in Paleozoic–Cenozoic strata.Tight oil mainly accumulates in the Cretaceous,Early Jurassic,Late Devonian,and Miocene,which correspond very well to six sets of globaldeveloped source rocks.Based on source–reservoir relationship,core data,and well-logging data,tight oil plays can be classified into eight types,above-source play,below-source play,beside-source play,in-source play,between-source play,in-source mud-dominated play,insource mud-subordinated play,and interbedded-source play.Specifically,between-source,interbedded-source,and in-source mud-subordinated plays are major targets for global tight oil development with high production.Incontrast,in-source mud-dominated and in-source plays are less satisfactory.
基金the Chinese Geological Survey Program (DD20160207,DD20189702)the National Natural Science Foundation of China (41474081).
文摘The Songke No.2 well (eastern hole)(referred to as Well SK-2),one of the "two wells and four holes"of the Deep Continental Scientific Drilling Engineering Project in the Songliao Basin,is in Anda City, Heilongjiang Province,and was officially completed on May 26,2018.Tlie scientific goals of Well SK-2 cover four aspects:paleoclimate research,resource and energy exploration,primary geological research, and development of deep earth exploration techniques.Since the official commencement of drilling in 2014,the Well SK-2 scientific drilling engineering team has organized and implemented drilling for coring,in situ logging,chemical analysis of core elements,and deep structural exploration around the well.Currently,the following preliminary scientific research progress has been made:4334.81 m in situ core data has been obtained;the centimeter-level high-resolution characterization of the most complete and continuous Cretaceous continental strata ever unearthed has been completed,and the standard profile of continental strata has been initially established;the unconventional natural gas resources and basin-type hot dry rocks in the deep Songliao Basin were found to have good prospects for exploration and development;the climatic evolutionary history of the Cretaceous continental strata was rebuilt for the first time,covering hundreds of thousands to millions of years,and the major events of Cretaceous climate fluctuations have been discovered;all these reveal strong evidence for the subduction and aggregation of paleo-ocean plates,providing a theoretical basis for the re-recognition of the genesis of the Songliao Basin and for deep earth oil and gas exploration.The implementation of the Deep Continental Scientific Drilling Engineering Project in the Songliao Basin is of great significance for exploring the mysteries of the Earth and solving major problems such as those related to the deep energy environment.It is a solid step along the road of "going deep into the Earth".
基金This work was jointly supported by the National Natural Science Foundation of China(grant Nos.:51973172,51673155,81201927,82002957 and 81672460)the National Key Research and Development Plan of China(No.2018YFC0115300)+5 种基金the State Key Laboratory for Mechanical Behavior of Materials,the World-Class Universities(Disciplines)the Characteristic Development Guidance Funds for the Central Universities,the Natural Science Foundation of Shaanxi Province(No.2020JC-03 and 2019TD-020)the Innovation Talent Promotion Plan of Shaanxi(No.2017KJXX-07)the Key Research and Development Program of Shaanxi Province(No.2019SF-012)the Opening Project of Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research,College of Stomatology,Xi’an Jiaotong University(No.2019LHM-KFKT008)Fundamental Research Funds for the Central Universities of China(No.xjj2018090).
文摘Endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD)are well-established therapeutics for gastrointestinal neoplasias,but complications after EMR/ESD,including bleeding and perforation,result in additional treatment morbidity and even threaten the lives of patients.Thus,designing biomaterials to treat gastric bleeding and wound healing after endoscopic treatment is highly desired and remains a challenge.Herein,a series of injectable pH-responsive selfhealing adhesive hydrogels based on acryloyl-6-aminocaproic acid(AA)and AA-g-N-hydroxysuccinimide(AA-NHS)were developed,and their great potential as endoscopic sprayable bioadhesive materials to efficiently stop hemorrhage and promote the wound healing process was further demonstrated in a swine gastric hemorrhage/wound model.The hydrogels showed a suitable gelation time,an autonomous and efficient self-healing capacity,hemostatic properties,and good biocompatibility.With the introduction of AA-NHS as a micro-cross-linker,the hydrogels exhibited enhanced adhesive strength.A swine gastric hemorrhage in vivo model demonstrated that the hydrogels showed good hemostatic performance by stopping acute arterial bleeding and preventing delayed bleeding.A gastric wound model indicated that the hydrogels showed excellent treatment effects with significantly enhanced wound healing with type I collagen deposition,α-SMA expression,and blood vessel formation.These injectable self-healing adhesive hydrogels exhibited great potential to treat gastric wounds after endoscopic treatment.
基金financial support provided by the National Key R&D Program of China(No.2021YFB2601000,2022YFE0101500)the National Science&Technology Pillar Program(No.2014BAG05B04)+4 种基金the National Natural Science Foundation of China(No.51708045,51878064,51908057,51978074,52178185,5217082105)The Shaanxi Natural Science Basic Research Program(No.2021JQ-249)the Major Science and Technology Project of Qinghai Province(No.2014-GX-A2A)the Fellowship of the China Postdoctoral Science Foundation(No.2021MD703885)the Special Found for Basic Scientific Research of Central College(No.300102218408).
文摘Highway constructions on the Qinghai-Tibet Plateau(QTP)face great challenges induced by the unique local environmental,geological,and engineering conditions.The large area of permafrost,great temperature variability,strong UV rays,and complex geological conditions are the major factors that adversely influence the longterm performance of pavement systems.Since 1960s,Chinese engineers and researchers have started conducting research on the QTP to enhance the performance and durability of pavement systems.The present paper provide a comprehensive review of challenge,research and practice of highway constructions on the QTP including the special environmental and geological conditions,history of highway constructions on the QTP,major challenges and the state-of-the-art technology of subgrade constructions on permafrost,developments of the pavement structures and materials,performance prediction and maintenance methods of pavement surfaces,and applications of the research achievements on the first expressway on the QTP(i.e.,Gongyu Expressway).Based on the comprehensive literature review,it can be found that(1)frost heave and thaw weakening induced subgrade disease and longitudinal cracks on the pavement surface are complex coupled water-thermal-load problems.Engineering solutions are focusing on active cooling and thermal insulation methods,which can help to reduce temperature variations in the subgrade and thus improving its stability,(2)the harsh environmental and construction conditions may reduce the early strength and induce premature damage of cement-treated base materials.Some field validations showed that geocell-reinforced or asphalt-treated flexible base materials can provide better long-term performance,(3)the large temperature variability and strong UV rays can significantly accelerate aging of asphalt binders and greatly reduce the service life of asphalt mixtures.Various binder modification methods were developed for improving their viscoelasticity and enhance the low-temperature cracking resistance of pavement surface materials but are still lack of field validation data and comparisons of their life cycle costs.Therefore,it is recommended that a demonstration research project build test sections to examine a range of pavement structures and materials,and compare their long-term performance and life cycle costs,which can serve as important reference for future highway constructions on the QTP.
文摘The average size of the sand of dune in the vicinity of Tumen River is 0.12～0.30 mm, its standard deviation is 0.45～0.99 φ and the frequency cumulative distribution curve is divided into the single peak and the double peak. The Ski of the single peak is negative and the double peak is positive. There are two different areas in the plot of the Ski versus σi* It is shown that the sedimentary environment of the dunes is neritic deposit by the expressions of the grain-size parameters. All of the characters show that the sand dunes in Estuary of Tumen River may be the dunes of sea facies which were changed again by weathering and fluvialaction.
