Age-related hearing loss(AHL),or presbycusis,is the most common neurodegenerative disorder and top communication deficit of the aged population.Genetic predisposition is one of the major factors in the development of ...Age-related hearing loss(AHL),or presbycusis,is the most common neurodegenerative disorder and top communication deficit of the aged population.Genetic predisposition is one of the major factors in the development of AHL.Generally,AHL is associated with an age-dependent loss of sensory hair cells,spiral ganglion neurons and stria vascularis cells in the inner ear.Although the mechanisms leading to genetic hearing loss are not completely understood,caspase-family proteases function as important signals in the inner ear pathology.It is now accepted that mouse models are the best tools to study the mechanism of genetic hearing loss or AHL.Here,we provide a brief review of recent studies on hearing improvement in mouse models of AHL by anti-apoptotic treatment.展开更多
基金supported by National Natural Science Foundation of China (No. 81271092, 81570927)Scientific and Technological Developing Grant in Shandong Province (2014GSF118083)+1 种基金Scientific and Technological Developing Grant for Medicine and Health in Shandong Province (2015WS0507)Research Initiation Grant of Binzhou Medical University (BY2012KYQD01, BY2013KYQD15)
文摘Age-related hearing loss(AHL),or presbycusis,is the most common neurodegenerative disorder and top communication deficit of the aged population.Genetic predisposition is one of the major factors in the development of AHL.Generally,AHL is associated with an age-dependent loss of sensory hair cells,spiral ganglion neurons and stria vascularis cells in the inner ear.Although the mechanisms leading to genetic hearing loss are not completely understood,caspase-family proteases function as important signals in the inner ear pathology.It is now accepted that mouse models are the best tools to study the mechanism of genetic hearing loss or AHL.Here,we provide a brief review of recent studies on hearing improvement in mouse models of AHL by anti-apoptotic treatment.
