In this paper, we describe resourceefficient hardware architectures for softwaredefined radio （SDR） frontends. These architectures are made efficient by using a polyphase channelizer that performs arbitrary sample r...In this paper, we describe resourceefficient hardware architectures for softwaredefined radio （SDR） frontends. These architectures are made efficient by using a polyphase channelizer that performs arbitrary sample rate changes, frequency selection, and bandwidth control. We discuss area, time, and power optimization for field programmable gate array （FPGA） based architectures in an Mpath polyphase filter bank with modified Npath polyphase filter. Such systems allow resampling by arbitrary ratios while simultaneously performing baseband aliasing from center frequencies at Nyquist zones that are not multiples of the output sample rate. A nonmaximally decimated polyphase filter bank, where the number of data loads is not equal to the number of M subfilters, processes M subfilters in a time period that is either less than or greater than the Mdataload ＇ s time period. We present a loadprocess architecture （LPA） and a runtime architecture （RA） （based on serial polyphase structure） which have different scheduling. In LPA, Nsubfilters are loaded, and then M subfilters are processed at a clock rate that is a multiple of the input data rate. This is necessary to meet the output time constraint of the down-sampled data. In RA, Msubfilters processes are efficiently scheduled within Ndataload time while simultaneously loading N subfilters. This requires reduced clock rates compared with LPA, and potentially less power is consumed. A polyphase filter bank that uses different resampling factors for maximally decimated, underdecimated, overdecimated, and combined upand downsampled scenarios is used as a case study, and an analysis of area, time, and power for their FPGA architectures is given. For resourceoptimized SDR frontends, RA is superior for reducing operating clock rates and dynamic power consumption. RA is also superior for reducing area resources, except when indices are prestored in LUTs.展开更多
This paper presents efficient processing engines for software-defined radio （SDR） front-ends. These engines, based on a polyphase channelizer, perform arbitrary sample-rate changes, frequency selection, and bandwidt...This paper presents efficient processing engines for software-defined radio （SDR） front-ends. These engines, based on a polyphase channelizer, perform arbitrary sample-rate changes, frequency selection, and bandwidth control. This paper presents an M-path polyphase filter bank based on a modified N-path polyphase filter. Such a system allows resampling by arbitrary ratios while performing baseband aliasing from center frequencies at Nyquist zones that are not multiples of the output sample rate. This resampling technique is based on sliding cyclic data load interacting with cyclic-shifted coefficients. A non-maximally-decimated polyphase filterbank （where the number of data loads is not equal to the number of M subfilters） processes M subfilters in a time period that is less than or greater than the M data loads. A polyphase filter bank with five different resampling modes is used as a case study for embedded resamp/ing in SDR front-ends. These modes are （i） maximally decimated, （ii） Under-decimated, （iii） over-decimated, and combined up- and down-sampling with （iv） single stride length, and （v） multiple stride lengths. These modes can be used to obtain any required rational sampling rate change in an SDR front-end based on a polyphase channelizer. They can also be used for translation to and from arbitrary center frequencies that are unrelated to the output sample rates.展开更多
In vitro chemosensitivity testing of short term primary glioma cultures derived from brain biopsies is still in the research phase and has not yet found a place in clinical use. The main reasons for this slow progress...In vitro chemosensitivity testing of short term primary glioma cultures derived from brain biopsies is still in the research phase and has not yet found a place in clinical use. The main reasons for this slow progression are the small amounts of tissue available and the lack of a suitably sensitive assay capable of use in the clinical setting. This study examines whether the MTS and ATP cell survival assays, which determine cytotoxicity via colorimetric and luminescence analysis respectively, could potentially fulfill this role. Primary glioma cultures were tested for chemosensitivity using the MTS and ATP assays and were found to be generally sensitive to cisplatin and paclitaxel but relatively resistant to carmustine and etoposide. For both assays, LD50 values lay in the range 2 - 130 μg/ml but in the vast majority of cases, those obtained by the ATP assay were markedly lower those obtained by the MTS assay. Moreover, at cell numbers less than 2000 in the cases of paclitaxel and carmustine and less than 4500 in the case of cisplatin, these drugs were generally indicated as ineffective against the glioma cultures tested by the MTS assay but effective against these cultures by the ATP assay. These data clearly demonstrate that the ATP assay is more sensitive when estimating small cell numbers generated by primary glioma cultures from brain biopsies and more reliably detects higher kill rates by anticancer drugs. This study also supports the feasibility of using the ATP assay for chemosensitivity testing in a clinical setting.展开更多
文摘In this paper, we describe resourceefficient hardware architectures for softwaredefined radio （SDR） frontends. These architectures are made efficient by using a polyphase channelizer that performs arbitrary sample rate changes, frequency selection, and bandwidth control. We discuss area, time, and power optimization for field programmable gate array （FPGA） based architectures in an Mpath polyphase filter bank with modified Npath polyphase filter. Such systems allow resampling by arbitrary ratios while simultaneously performing baseband aliasing from center frequencies at Nyquist zones that are not multiples of the output sample rate. A nonmaximally decimated polyphase filter bank, where the number of data loads is not equal to the number of M subfilters, processes M subfilters in a time period that is either less than or greater than the Mdataload ＇ s time period. We present a loadprocess architecture （LPA） and a runtime architecture （RA） （based on serial polyphase structure） which have different scheduling. In LPA, Nsubfilters are loaded, and then M subfilters are processed at a clock rate that is a multiple of the input data rate. This is necessary to meet the output time constraint of the down-sampled data. In RA, Msubfilters processes are efficiently scheduled within Ndataload time while simultaneously loading N subfilters. This requires reduced clock rates compared with LPA, and potentially less power is consumed. A polyphase filter bank that uses different resampling factors for maximally decimated, underdecimated, overdecimated, and combined upand downsampled scenarios is used as a case study, and an analysis of area, time, and power for their FPGA architectures is given. For resourceoptimized SDR frontends, RA is superior for reducing operating clock rates and dynamic power consumption. RA is also superior for reducing area resources, except when indices are prestored in LUTs.
文摘This paper presents efficient processing engines for software-defined radio （SDR） front-ends. These engines, based on a polyphase channelizer, perform arbitrary sample-rate changes, frequency selection, and bandwidth control. This paper presents an M-path polyphase filter bank based on a modified N-path polyphase filter. Such a system allows resampling by arbitrary ratios while performing baseband aliasing from center frequencies at Nyquist zones that are not multiples of the output sample rate. This resampling technique is based on sliding cyclic data load interacting with cyclic-shifted coefficients. A non-maximally-decimated polyphase filterbank （where the number of data loads is not equal to the number of M subfilters） processes M subfilters in a time period that is less than or greater than the M data loads. A polyphase filter bank with five different resampling modes is used as a case study for embedded resamp/ing in SDR front-ends. These modes are （i） maximally decimated, （ii） Under-decimated, （iii） over-decimated, and combined up- and down-sampling with （iv） single stride length, and （v） multiple stride lengths. These modes can be used to obtain any required rational sampling rate change in an SDR front-end based on a polyphase channelizer. They can also be used for translation to and from arbitrary center frequencies that are unrelated to the output sample rates.
文摘In vitro chemosensitivity testing of short term primary glioma cultures derived from brain biopsies is still in the research phase and has not yet found a place in clinical use. The main reasons for this slow progression are the small amounts of tissue available and the lack of a suitably sensitive assay capable of use in the clinical setting. This study examines whether the MTS and ATP cell survival assays, which determine cytotoxicity via colorimetric and luminescence analysis respectively, could potentially fulfill this role. Primary glioma cultures were tested for chemosensitivity using the MTS and ATP assays and were found to be generally sensitive to cisplatin and paclitaxel but relatively resistant to carmustine and etoposide. For both assays, LD50 values lay in the range 2 - 130 μg/ml but in the vast majority of cases, those obtained by the ATP assay were markedly lower those obtained by the MTS assay. Moreover, at cell numbers less than 2000 in the cases of paclitaxel and carmustine and less than 4500 in the case of cisplatin, these drugs were generally indicated as ineffective against the glioma cultures tested by the MTS assay but effective against these cultures by the ATP assay. These data clearly demonstrate that the ATP assay is more sensitive when estimating small cell numbers generated by primary glioma cultures from brain biopsies and more reliably detects higher kill rates by anticancer drugs. This study also supports the feasibility of using the ATP assay for chemosensitivity testing in a clinical setting.
