Purpose:Following the typical features of the grey-rhino event as predictability and profound influence,we attempt to find a special pattern called the grey-rhino in eminent technologies via patent analysis.Design/met...Purpose:Following the typical features of the grey-rhino event as predictability and profound influence,we attempt to find a special pattern called the grey-rhino in eminent technologies via patent analysis.Design/methodology/approach:We propose to combine triadic patent families and technology life cycle to define the grey-rhino model.Firstly,we design the indicator rhino-index Rh=ST/SP and descriptor sequence{Rh},where ST and SP are the accumulative number of triadic patent families and all patent families respectively for a specific technology.Secondly,according to the two typical features of the grey-rhino event,a grey-rhino is defined as a technology that meets both qualitative and quantitative conditions.Qualitatively,this technology has a profound influence.Quantitatively,in the emerging stage,Rh≥Rae,where Rae is the average level of the proportion of triadic patent families.Finally,this model is verified in three datasets,namely Encyclopedia Britannica’s list for the greatest inventions(EB technologies for short),MIT breakthrough technologies(MIT technologies)and Derwent Manual Code technologies(MAN technologies).Findings:The result shows that there are 64.71%EB technologies and 50.00%MIT technologies meeting the quantitative standard of the grey-rhino model,but only 14.71%MAN technologies fit the quantitative standard.This falling trend indicates the quantitative standard of the grey-rhino model is reasonable.EB technologies and MIT technologies have profound influence on society,which means they satisfy the qualitative standard of the grey-rhino model.Hence,64.71%EB technologies and 50.00%MIT technologies are grey-rhinos.In 14.71%MAN technologies meeting the quantitative standard,we make some qualitative judgments and deem U11-A01A,U12-A01A1A,and W01-A01A as grey-rhino technologies.In addition,grey-rhinos and non-grey-rhinos have some differences.Rh values of grey-rhinos have a downward trend,while Rh values of non-grey-rhinos have a contrary trend.Rh values of grey-rhinos are scattered relatively in the early stage and centralize gradually,but non-grey-rhinos do not have this feature.Research limitations:There are four main limitations.First,if a technology satisfies the quantitative standard of the model,it is likely to be a grey-rhino but expert judgments are necessary.Second,we don’t know why it will be eminent,which involves technical contents.Thirdly,we did not consider the China National Intellectual Property Administration(CNIPA)and the German Patent and Trademark Office(DPMA)which also play important roles in worldwide patents,so we hope to expand our study to the CNIPA and the DPMA.Furthermore,we did not compare the rhino-index with other patent indicators.Practical implications:If a technology meets the quantitative standard,this can be seen as early warning signals and the technology may become a grey-rhino in the future,which can catch people’s attention in the emerging stage and make people seize the technical opportunity early.Originality/value:We define and verify a new pattern called the grey-rhino model in eminent technologies.展开更多
本文在数据驱动与知识整合研究视野中,依据Web of Science收录文献的学科分布数据,指出图书情报学尚不是智库和大数据研究的核心学科,进而思考图书情报学跨界拓展的有效方向。以逻辑分析法发现在DIKW概念链上统合数据智能和知识发现作...本文在数据驱动与知识整合研究视野中,依据Web of Science收录文献的学科分布数据,指出图书情报学尚不是智库和大数据研究的核心学科,进而思考图书情报学跨界拓展的有效方向。以逻辑分析法发现在DIKW概念链上统合数据智能和知识发现作为有效方向的合理性,提出在数据智能和知识发现交互作用下图书情报学跨界拓展三大重点:(1)面向知识发现的数据智能,(2)融通数据智能的知识发现,(3)学术评价综合应用。建议发挥图书情报学在"软科学、硬技术"分界中的核心比较优势,以数据智能和知识发现形成图书情报学跨界拓展特色方向,整合为数据—学术—创造(DAC)。图4。表1。参考文献18。展开更多
Purpose:We attempt to find out whether OA or TA really affects the dissemination of scientific discoveries.Design/methodology/approach:We design the indicators,hot-degree,and R-index to indicate a topic OA or TA advan...Purpose:We attempt to find out whether OA or TA really affects the dissemination of scientific discoveries.Design/methodology/approach:We design the indicators,hot-degree,and R-index to indicate a topic OA or TA advantages.First,according to the OA classification of the Web of Science(WoS),we collect data from the WoS by downloading OA and TA articles,letters,and reviews published in Nature and Science during 2010–2019.These papers are divided into three broad disciplines,namely biomedicine,physics,and others.Then,taking a discipline in a journal and using the classical Latent Dirichlet Allocation(LDA)to cluster 100 topics of OA and TA papers respectively,we apply the Pearson correlation coefficient to match the topics of OA and TA,and calculate the hot-degree and R-index of every OA-TA topic pair.Finally,characteristics of the discipline can be presented.In qualitative comparison,we choose some high-quality papers which belong to Nature remarkable papers or Science breakthroughs,and analyze the relations between OA/TA and citation numbers.Findings:The result shows that OA hot-degree in biomedicine is significantly greater than that of TA,but significantly less than that of TA in physics.Based on the R-index,it is found that OA advantages exist in biomedicine and TA advantages do in physics.Therefore,the dissemination of average scientific discoveries in all fields is not necessarily affected by OA or TA.However,OA promotes the spread of important scientific discoveries in high-quality papers.Research limitations:We lost some citations by ignoring other open sources such as arXiv and bioArxiv.Another limitation came from that Nature employs some strong measures for access-promoting subscription-based articles,on which the boundary between OA and TA became fuzzy.Practical implications:It is useful to select hot topics in a set of publications by the hotdegree index.The finding comprehensively reflects the differences of OA and TA in different disciplines,which is a useful reference when researchers choose the publishing way as OA or TA.Originality/value:We propose a new method,including two indicators,to explore and measure OA or TA advantages.展开更多
The core of triad philosophy consists of triad ontology, triad epistemology, and triad axiology based on triad logic. The triad ontology is characterized by objective knowledge (Li), objective matter (Ch’i), and subj...The core of triad philosophy consists of triad ontology, triad epistemology, and triad axiology based on triad logic. The triad ontology is characterized by objective knowledge (Li), objective matter (Ch’i), and subjective spirit (Hs’in);triad epistemology by experiencing, studying, and thinking;and triad axiology by honesty, charity, and forgiveness. The idea could merge Western and Eastern thoughts into one philosophical system.展开更多
Purpose:To reveal the research hotpots and relationship among three research hot topics in b iomedicine,namely CRISPR,iPS(induced Pluripotent Stem)cell and Synthetic biology.Design/methodology/approach:We set up their...Purpose:To reveal the research hotpots and relationship among three research hot topics in b iomedicine,namely CRISPR,iPS(induced Pluripotent Stem)cell and Synthetic biology.Design/methodology/approach:We set up their keyword co-occurrence networks with using three indicators and information visualization for metric analysis.Findings:The results reveal the main research hotspots in the three topics are different,but the overlapping keywords in the three topics indicate that they are mutually integrated and interacted each other.Research limitations:All analyses use keywords,without any other forms.Practical implications:We try to find the information distribution and structure of these three hot topics for revealing their research status and interactions,and for promoting biomedical developments.Originality/value:We chose the core keywords in three research hot topics in biomedicine by using h-index.展开更多
Purpose： Applying SSCI journals of library and information science （LIS） as the research sample, we explore the feasibility of measuring academic journals＇ yearly social impact by using altmetric indicators. Desig...Purpose： Applying SSCI journals of library and information science （LIS） as the research sample, we explore the feasibility of measuring academic journals＇ yearly social impact by using altmetric indicators. Design/methodology/approach： Using a sample of 66 SSCI joumals in LIS published in 2013, statistics regarding journal mentions in social media and other online tools were retrieved from Altmetric.com and meanwhile citation data was also collected from JCR and Scopus. Based on the method of principal component analysis, data was analyzed for associations between the altmetric and traditional metrics to demonstrate the effect ofaltmetric indicators on measuring academic j oumals＇ yearly impact. Findings： The Spearman＇s rank correlation test results show that altmetric indicators and traditional citation counts were significantly correlated, indicating that altmetrics can be used to measure a journal＇s yearly social impact. Research limitations： The time frame of data collected from Altmetric.com may not be consistent with that of JCR and Scopus citation data. Practical implications： A new method is provided based on altmetrics for evaluating the social impact of academic journals, which can be applied to design new indicators of short-term journal impact. Originality value： In this paper, we have established a method for evaluating the social impact of academic journals based on altmetric indictors. Altmetrics can be complementary to traditional citation metrics in assessing a journal＇s impact within a year or even in a shorter period of time.展开更多
Purpose:Using the metaphor of"unicorn,"we identify the scientific papers and technical patents characterized by the informetric feature of very high citations in the first ten years after publishing,which ma...Purpose:Using the metaphor of"unicorn,"we identify the scientific papers and technical patents characterized by the informetric feature of very high citations in the first ten years after publishing,which may provide a new pattern to understand very high impact works in science and technology.Design/methodology/approach:When we set CT as the total citations of papers or patents in the first ten years after publication,with CT≥5,000 for scientific"unicorn"and CT≥500 for technical"unicorn,"we have an absolute standard for identifying scientific and technical"unicorn"publications.Findings:We identify 165 scientific"unicorns"in 14,301,875 WoS papers and 224 technical"unicorns"in 13,728,950 DII patents during 2001–2012.About 50%of"unicorns"belong to biomedicine,in which selected cases are individually discussed.The rare"unicorns"increase following linear model,the fitting data show 95%confidence with the RMSE of scientific"unicorn"is 0.2127 while the RMSE of technical"unicorn"is 0.0923.Research limitations:A"unicorn"is a pure quantitative consideration without concerning its quality,and"potential unicorns"as CT≤5,000 for papers and CT≤500 for patents are left in future studies.Practical implications:Scientific and technical"unicorns"provide a new pattern to understand high-impact works in science and technology.The"unicorn"pattern supplies a concise approach to identify very high-impact scientific papers and technical patents.Originality/value:The"unicorn"pattern supplies a concise approach to identify very high impact scientific papers and technical patents.展开更多
Purpose： To comprehensively evaluate the overall performance of a group or an individual in both bibliometrics and patentometrics. Design/methodology/approach： Trace metrics were applied to the top 30 universities i...Purpose： To comprehensively evaluate the overall performance of a group or an individual in both bibliometrics and patentometrics. Design/methodology/approach： Trace metrics were applied to the top 30 universities in the2014 Academic Ranking of World Universities（ARWU） — computer sciences, the top 30 ESI highly cited papers in the computer sciences field in 2014, as well as the top 30 assignees and the top 30 most cited patents in the National Bureau of Economic Research（NBER） computer hardware and software category.Findings： We found that, by applying trace metrics, the research or marketing impact efficiency, at both group and individual levels, was clearly observed. Furthermore, trace metrics were more sensitive to the different publication-citation distributions than the average citation and h-index were.Research limitations： Trace metrics considered publications with zero citations as negative contributions. One should clarify how he/she evaluates a zero-citation paper or patent before applying trace metrics.Practical implications： Decision makers could regularly examinine the performance of their university/company by applying trace metrics and adjust their policies accordingly.Originality/value： Trace metrics could be applied both in bibliometrics and patentometrics and provide a comprehensive view. Moreover, the high sensitivity and unique impact efficiency view provided by trace metrics can facilitate decision makers in examining and adjusting their policies.展开更多
Mankind holds creation as a special human property contributing knowledge and culture.Both design and research belong to creative activities.While research focuses on new findings following the rule of truth,design pa...Mankind holds creation as a special human property contributing knowledge and culture.Both design and research belong to creative activities.While research focuses on new findings following the rule of truth,design pays more attention to new designed works following the rule of beauty.Three philosophical principles for design are suggested as ABC principles:A.Design approaches beauty;B.Design balances science and art;C.Design concerns culture.Three types of design are practically discussed,including 2D art or symbol design,3D engineering or product design,and nD program or form design.展开更多
Spiritual ontology,Buddhist epistemology,and theological axiology construct a spirit philosophy,where spiritual ontology sets up an ontological foundation,Buddhist epistemology provides a practical method,and theologi...Spiritual ontology,Buddhist epistemology,and theological axiology construct a spirit philosophy,where spiritual ontology sets up an ontological foundation,Buddhist epistemology provides a practical method,and theological axiology contributes a living ethics.While spirit philosophy covers spiritual ontology,Buddhist epistemology,and theological axiology,spirit philosophy links to Buddhism and theology and then introduces a popular philosophy toward the good.This is a mellow philosophical system.展开更多
Congenital heart disease(CHD)is one of the most common causes of major birth defects,with a prevalence of 1%.Although an increasing number of studies have reported the etiology of CHD,the findings scattered throughout...Congenital heart disease(CHD)is one of the most common causes of major birth defects,with a prevalence of 1%.Although an increasing number of studies have reported the etiology of CHD,the findings scattered throughout the literature are difficult to retrieve and utilize in research and clinical practice.We therefore developed CHDbase,an evidence-based knowledgebase of CHD-related genes and clinical manifestations manually curated from 1114 publications,linking 1124 susceptibility genes and 3591 variations to more than 300 CHD types and related syndromes.Metadata such as the information of each publication and the selected population and samples,the strategy of studies,and the major findings of studies were integrated with each item of the research record.We also integrated functional annotations through parsing50 databases/tools to facilitate the interpretation of these genes and variations in disease pathogenicity.We further prioritized the significance of these CHD-related genes with a gene interaction network approach and extracted a core CHD sub-network with 163 genes.The clear genetic landscape of CHD enables the phenotype classification based on the shared genetic origin.Overall,CHDbase provides a comprehensive and freely available resource to study CHD susceptibilities,supporting a wide range of users in the scientific and medical communities.CHDbase is accessible at http://chddb.fwgenetics.org.展开更多
Assessing quantity or quality of academic articles are two completely different evaluation orientations.Obviously,quantity never represents quality and vice versa.In general,the quantitative research aims at the group...Assessing quantity or quality of academic articles are two completely different evaluation orientations.Obviously,quantity never represents quality and vice versa.In general,the quantitative research aims at the groups,mainly through the bibliometric indicators,to realize the statistical evaluation of the quantity,while the quality analysis aims at individuals.展开更多
基金This work is supported by the National Natural Science Foundation of China(Grant No.71673131).
文摘Purpose:Following the typical features of the grey-rhino event as predictability and profound influence,we attempt to find a special pattern called the grey-rhino in eminent technologies via patent analysis.Design/methodology/approach:We propose to combine triadic patent families and technology life cycle to define the grey-rhino model.Firstly,we design the indicator rhino-index Rh=ST/SP and descriptor sequence{Rh},where ST and SP are the accumulative number of triadic patent families and all patent families respectively for a specific technology.Secondly,according to the two typical features of the grey-rhino event,a grey-rhino is defined as a technology that meets both qualitative and quantitative conditions.Qualitatively,this technology has a profound influence.Quantitatively,in the emerging stage,Rh≥Rae,where Rae is the average level of the proportion of triadic patent families.Finally,this model is verified in three datasets,namely Encyclopedia Britannica’s list for the greatest inventions(EB technologies for short),MIT breakthrough technologies(MIT technologies)and Derwent Manual Code technologies(MAN technologies).Findings:The result shows that there are 64.71%EB technologies and 50.00%MIT technologies meeting the quantitative standard of the grey-rhino model,but only 14.71%MAN technologies fit the quantitative standard.This falling trend indicates the quantitative standard of the grey-rhino model is reasonable.EB technologies and MIT technologies have profound influence on society,which means they satisfy the qualitative standard of the grey-rhino model.Hence,64.71%EB technologies and 50.00%MIT technologies are grey-rhinos.In 14.71%MAN technologies meeting the quantitative standard,we make some qualitative judgments and deem U11-A01A,U12-A01A1A,and W01-A01A as grey-rhino technologies.In addition,grey-rhinos and non-grey-rhinos have some differences.Rh values of grey-rhinos have a downward trend,while Rh values of non-grey-rhinos have a contrary trend.Rh values of grey-rhinos are scattered relatively in the early stage and centralize gradually,but non-grey-rhinos do not have this feature.Research limitations:There are four main limitations.First,if a technology satisfies the quantitative standard of the model,it is likely to be a grey-rhino but expert judgments are necessary.Second,we don’t know why it will be eminent,which involves technical contents.Thirdly,we did not consider the China National Intellectual Property Administration(CNIPA)and the German Patent and Trademark Office(DPMA)which also play important roles in worldwide patents,so we hope to expand our study to the CNIPA and the DPMA.Furthermore,we did not compare the rhino-index with other patent indicators.Practical implications:If a technology meets the quantitative standard,this can be seen as early warning signals and the technology may become a grey-rhino in the future,which can catch people’s attention in the emerging stage and make people seize the technical opportunity early.Originality/value:We define and verify a new pattern called the grey-rhino model in eminent technologies.
文摘本文在数据驱动与知识整合研究视野中,依据Web of Science收录文献的学科分布数据,指出图书情报学尚不是智库和大数据研究的核心学科,进而思考图书情报学跨界拓展的有效方向。以逻辑分析法发现在DIKW概念链上统合数据智能和知识发现作为有效方向的合理性,提出在数据智能和知识发现交互作用下图书情报学跨界拓展三大重点:(1)面向知识发现的数据智能,(2)融通数据智能的知识发现,(3)学术评价综合应用。建议发挥图书情报学在"软科学、硬技术"分界中的核心比较优势,以数据智能和知识发现形成图书情报学跨界拓展特色方向,整合为数据—学术—创造(DAC)。图4。表1。参考文献18。
文摘Purpose:We attempt to find out whether OA or TA really affects the dissemination of scientific discoveries.Design/methodology/approach:We design the indicators,hot-degree,and R-index to indicate a topic OA or TA advantages.First,according to the OA classification of the Web of Science(WoS),we collect data from the WoS by downloading OA and TA articles,letters,and reviews published in Nature and Science during 2010–2019.These papers are divided into three broad disciplines,namely biomedicine,physics,and others.Then,taking a discipline in a journal and using the classical Latent Dirichlet Allocation(LDA)to cluster 100 topics of OA and TA papers respectively,we apply the Pearson correlation coefficient to match the topics of OA and TA,and calculate the hot-degree and R-index of every OA-TA topic pair.Finally,characteristics of the discipline can be presented.In qualitative comparison,we choose some high-quality papers which belong to Nature remarkable papers or Science breakthroughs,and analyze the relations between OA/TA and citation numbers.Findings:The result shows that OA hot-degree in biomedicine is significantly greater than that of TA,but significantly less than that of TA in physics.Based on the R-index,it is found that OA advantages exist in biomedicine and TA advantages do in physics.Therefore,the dissemination of average scientific discoveries in all fields is not necessarily affected by OA or TA.However,OA promotes the spread of important scientific discoveries in high-quality papers.Research limitations:We lost some citations by ignoring other open sources such as arXiv and bioArxiv.Another limitation came from that Nature employs some strong measures for access-promoting subscription-based articles,on which the boundary between OA and TA became fuzzy.Practical implications:It is useful to select hot topics in a set of publications by the hotdegree index.The finding comprehensively reflects the differences of OA and TA in different disciplines,which is a useful reference when researchers choose the publishing way as OA or TA.Originality/value:We propose a new method,including two indicators,to explore and measure OA or TA advantages.
文摘The core of triad philosophy consists of triad ontology, triad epistemology, and triad axiology based on triad logic. The triad ontology is characterized by objective knowledge (Li), objective matter (Ch’i), and subjective spirit (Hs’in);triad epistemology by experiencing, studying, and thinking;and triad axiology by honesty, charity, and forgiveness. The idea could merge Western and Eastern thoughts into one philosophical system.
基金the National Natural Science Foundation of China Grant 71673131 for financial support
文摘Purpose:To reveal the research hotpots and relationship among three research hot topics in b iomedicine,namely CRISPR,iPS(induced Pluripotent Stem)cell and Synthetic biology.Design/methodology/approach:We set up their keyword co-occurrence networks with using three indicators and information visualization for metric analysis.Findings:The results reveal the main research hotspots in the three topics are different,but the overlapping keywords in the three topics indicate that they are mutually integrated and interacted each other.Research limitations:All analyses use keywords,without any other forms.Practical implications:We try to find the information distribution and structure of these three hot topics for revealing their research status and interactions,and for promoting biomedical developments.Originality/value:We chose the core keywords in three research hot topics in biomedicine by using h-index.
基金supported by the National Natural Science Foundation of China(Grant No.:71173187)the China Major Key Project of National Social Science Foundation(Grant No.:12&ZD221)
文摘Purpose： Applying SSCI journals of library and information science （LIS） as the research sample, we explore the feasibility of measuring academic journals＇ yearly social impact by using altmetric indicators. Design/methodology/approach： Using a sample of 66 SSCI joumals in LIS published in 2013, statistics regarding journal mentions in social media and other online tools were retrieved from Altmetric.com and meanwhile citation data was also collected from JCR and Scopus. Based on the method of principal component analysis, data was analyzed for associations between the altmetric and traditional metrics to demonstrate the effect ofaltmetric indicators on measuring academic j oumals＇ yearly impact. Findings： The Spearman＇s rank correlation test results show that altmetric indicators and traditional citation counts were significantly correlated, indicating that altmetrics can be used to measure a journal＇s yearly social impact. Research limitations： The time frame of data collected from Altmetric.com may not be consistent with that of JCR and Scopus citation data. Practical implications： A new method is provided based on altmetrics for evaluating the social impact of academic journals, which can be applied to design new indicators of short-term journal impact. Originality value： In this paper, we have established a method for evaluating the social impact of academic journals based on altmetric indictors. Altmetrics can be complementary to traditional citation metrics in assessing a journal＇s impact within a year or even in a shorter period of time.
基金National Natural Science Foundation of China Grant No.71673131Jiangsu Key Laboratory Fundsupport from the International Joint Informatics Laboratory operated cooperatively by the University of Illinois at Urbana-Champaign,USA and Nanjing University,China。
文摘Purpose:Using the metaphor of"unicorn,"we identify the scientific papers and technical patents characterized by the informetric feature of very high citations in the first ten years after publishing,which may provide a new pattern to understand very high impact works in science and technology.Design/methodology/approach:When we set CT as the total citations of papers or patents in the first ten years after publication,with CT≥5,000 for scientific"unicorn"and CT≥500 for technical"unicorn,"we have an absolute standard for identifying scientific and technical"unicorn"publications.Findings:We identify 165 scientific"unicorns"in 14,301,875 WoS papers and 224 technical"unicorns"in 13,728,950 DII patents during 2001–2012.About 50%of"unicorns"belong to biomedicine,in which selected cases are individually discussed.The rare"unicorns"increase following linear model,the fitting data show 95%confidence with the RMSE of scientific"unicorn"is 0.2127 while the RMSE of technical"unicorn"is 0.0923.Research limitations:A"unicorn"is a pure quantitative consideration without concerning its quality,and"potential unicorns"as CT≤5,000 for papers and CT≤500 for patents are left in future studies.Practical implications:Scientific and technical"unicorns"provide a new pattern to understand high-impact works in science and technology.The"unicorn"pattern supplies a concise approach to identify very high-impact scientific papers and technical patents.Originality/value:The"unicorn"pattern supplies a concise approach to identify very high impact scientific papers and technical patents.
基金the National Natural Science Foundation of China (Grant No.: 71173187)Jiangsu Key Laboratory Fund for financial support
文摘Purpose： To comprehensively evaluate the overall performance of a group or an individual in both bibliometrics and patentometrics. Design/methodology/approach： Trace metrics were applied to the top 30 universities in the2014 Academic Ranking of World Universities（ARWU） — computer sciences, the top 30 ESI highly cited papers in the computer sciences field in 2014, as well as the top 30 assignees and the top 30 most cited patents in the National Bureau of Economic Research（NBER） computer hardware and software category.Findings： We found that, by applying trace metrics, the research or marketing impact efficiency, at both group and individual levels, was clearly observed. Furthermore, trace metrics were more sensitive to the different publication-citation distributions than the average citation and h-index were.Research limitations： Trace metrics considered publications with zero citations as negative contributions. One should clarify how he/she evaluates a zero-citation paper or patent before applying trace metrics.Practical implications： Decision makers could regularly examinine the performance of their university/company by applying trace metrics and adjust their policies accordingly.Originality/value： Trace metrics could be applied both in bibliometrics and patentometrics and provide a comprehensive view. Moreover, the high sensitivity and unique impact efficiency view provided by trace metrics can facilitate decision makers in examining and adjusting their policies.
文摘Mankind holds creation as a special human property contributing knowledge and culture.Both design and research belong to creative activities.While research focuses on new findings following the rule of truth,design pays more attention to new designed works following the rule of beauty.Three philosophical principles for design are suggested as ABC principles:A.Design approaches beauty;B.Design balances science and art;C.Design concerns culture.Three types of design are practically discussed,including 2D art or symbol design,3D engineering or product design,and nD program or form design.
文摘Spiritual ontology,Buddhist epistemology,and theological axiology construct a spirit philosophy,where spiritual ontology sets up an ontological foundation,Buddhist epistemology provides a practical method,and theological axiology contributes a living ethics.While spirit philosophy covers spiritual ontology,Buddhist epistemology,and theological axiology,spirit philosophy links to Buddhism and theology and then introduces a popular philosophy toward the good.This is a mellow philosophical system.
基金This work was supported by the Young Scientists Fund of the National Natural Science Foundation of China(Grant No.31801103)the Chinese Academy of Medical Sciences Initiative for Innovative Medicine(Grant No.2016-I2M-1-016).We acknowledge Dr.Adam Yongxin Ye at Harvard Medical School,Boston Children’s Hospital for his support and contribution to the project,and Dr.Ge Gao at Peking University for assistance with database comparison.
文摘Congenital heart disease(CHD)is one of the most common causes of major birth defects,with a prevalence of 1%.Although an increasing number of studies have reported the etiology of CHD,the findings scattered throughout the literature are difficult to retrieve and utilize in research and clinical practice.We therefore developed CHDbase,an evidence-based knowledgebase of CHD-related genes and clinical manifestations manually curated from 1114 publications,linking 1124 susceptibility genes and 3591 variations to more than 300 CHD types and related syndromes.Metadata such as the information of each publication and the selected population and samples,the strategy of studies,and the major findings of studies were integrated with each item of the research record.We also integrated functional annotations through parsing50 databases/tools to facilitate the interpretation of these genes and variations in disease pathogenicity.We further prioritized the significance of these CHD-related genes with a gene interaction network approach and extracted a core CHD sub-network with 163 genes.The clear genetic landscape of CHD enables the phenotype classification based on the shared genetic origin.Overall,CHDbase provides a comprehensive and freely available resource to study CHD susceptibilities,supporting a wide range of users in the scientific and medical communities.CHDbase is accessible at http://chddb.fwgenetics.org.
文摘Assessing quantity or quality of academic articles are two completely different evaluation orientations.Obviously,quantity never represents quality and vice versa.In general,the quantitative research aims at the groups,mainly through the bibliometric indicators,to realize the statistical evaluation of the quantity,while the quality analysis aims at individuals.
