目的评估磁共振T1WI信号强度比(signal intensity ratio on T1WI,SIR1)对多发性骨髓瘤(MM)骨盆病变治疗效果的评价价值.方法收集本院2017年12月至2019年5月间收治的多发性骨髓瘤患者25例;另选取健康志愿者10例作为正常对照组.采用1.5T...目的评估磁共振T1WI信号强度比(signal intensity ratio on T1WI,SIR1)对多发性骨髓瘤(MM)骨盆病变治疗效果的评价价值.方法收集本院2017年12月至2019年5月间收治的多发性骨髓瘤患者25例;另选取健康志愿者10例作为正常对照组.采用1.5T磁共振扫描仪对MM患者治疗前后进行骨盆MRI成像检查,结合骨髓穿刺结果,观察治疗前后MM患者骨盆磁共振信号变化,测量分析相应感兴趣区的T1WI信号噪声比(SIR1)的差异.结果25例MM患者经规范化疗后,14例接近完全缓解,11例患者未缓解.14例治疗后缓解者的骨髓信号T1WI上信号增高,T1WI骨盆骨髓SIR1值为(2.967±0.342),与正常对照组(3.126±0.342)比较,差异无统计学意义(P>0.05);11例化疗后未缓解者T1WI骨盆骨髓SIR1值为(1.896±0.521),与正常对照组(3.126±0.342)比较,差异有统计学意义(P<0.05).结论MR-SIR1可作为一种简便有效的定量评价MM疗效的无创性影像学检测手段.展开更多
Chemical cross-linking provides an effective avenue to reduce the conformational entropy of polypeptide chains and hence has become a popular method to induce or force structural formation in peptides and proteins.Rec...Chemical cross-linking provides an effective avenue to reduce the conformational entropy of polypeptide chains and hence has become a popular method to induce or force structural formation in peptides and proteins.Recently,other types of molecular constraints,especially photoresponsive linkers and functional groups,have also found increased use in a wide variety of applications.Herein,we provide a concise review of using various forms of molecular strategies to constrain proteins,thereby stabilizing their native states,gaining insight into their folding mechanisms,and/or providing a handle to trigger a conformational process of interest with light.The applications discussed here cover a wide range of topics,ranging from delineating the details of the protein folding energy landscape to controlling protein assembly and function.展开更多
文摘目的评估磁共振T1WI信号强度比(signal intensity ratio on T1WI,SIR1)对多发性骨髓瘤(MM)骨盆病变治疗效果的评价价值.方法收集本院2017年12月至2019年5月间收治的多发性骨髓瘤患者25例;另选取健康志愿者10例作为正常对照组.采用1.5T磁共振扫描仪对MM患者治疗前后进行骨盆MRI成像检查,结合骨髓穿刺结果,观察治疗前后MM患者骨盆磁共振信号变化,测量分析相应感兴趣区的T1WI信号噪声比(SIR1)的差异.结果25例MM患者经规范化疗后,14例接近完全缓解,11例患者未缓解.14例治疗后缓解者的骨髓信号T1WI上信号增高,T1WI骨盆骨髓SIR1值为(2.967±0.342),与正常对照组(3.126±0.342)比较,差异无统计学意义(P>0.05);11例化疗后未缓解者T1WI骨盆骨髓SIR1值为(1.896±0.521),与正常对照组(3.126±0.342)比较,差异有统计学意义(P<0.05).结论MR-SIR1可作为一种简便有效的定量评价MM疗效的无创性影像学检测手段.
基金supported by the National Institutes of Health(GM-065978,AG-039253)
文摘Chemical cross-linking provides an effective avenue to reduce the conformational entropy of polypeptide chains and hence has become a popular method to induce or force structural formation in peptides and proteins.Recently,other types of molecular constraints,especially photoresponsive linkers and functional groups,have also found increased use in a wide variety of applications.Herein,we provide a concise review of using various forms of molecular strategies to constrain proteins,thereby stabilizing their native states,gaining insight into their folding mechanisms,and/or providing a handle to trigger a conformational process of interest with light.The applications discussed here cover a wide range of topics,ranging from delineating the details of the protein folding energy landscape to controlling protein assembly and function.
