Background:Irritable bowel syndrome(IBS)substantially affects quality of life and requires early prevention.This study aimed to elucidate the relationships between IBS and daily behaviors,including sedentary behavior(...Background:Irritable bowel syndrome(IBS)substantially affects quality of life and requires early prevention.This study aimed to elucidate the relationships between IBS and daily behaviors,including sedentary behavior(SB),physical activity(PA),and sleep.In particular,it seeks to identify healthy behaviors to reduce IBS risk,which previous studies have rarely addressed.Methods:Daily behaviors were retrieved from self-reported data of 362,193 eligible UK Biobank participants.Incident cases were determined by self-report or health care data according to RomeⅣcriteria.Results:A total of 345,388 participants were IBS-free at baseline,during a median follow-up of 8.45 years,19,885 incident IBS cases were recorded.When examined individually,SB and shorter(≤7 h/day)or longer(>7 h/day)sleep duration were each positively associated with increased IBS risk,and PA was associated with lower IBS risk.The isotemporal substitution model suggested that replacing SB with other activities could provide further protective effects against IBS risk.Among people sleeping≤7 h/day,replacing 1 h of SB with equivalent light PA,vigorous PA,or sleep was associated with 8.1%(95%confidence interval(95%CI):0.901-0.937),5.8%(95%CI:0.896-0.991),and 9.2%(95%CI:0.885-0.932)reduced IBS risk,respectively.For people sleeping>7 h/day,light and vigorous PA were associated with a 4.8%(95%CI:0.926-0.978)and a 12.0%(95%CI:0.815-0.949)lower IBS risk,respectively.These benefits were mostly independent of genetic risk for IBS.Conclusion:SB and unhealthy sleep duration are risk factors for IBS.A promising way to mitigate IBS risk for individuals sleeping≤7 h/day and for those sleeping>7 h/day appears to be by replacing SB with adequate sleep or vigorous PA,respectively,regardless of the genetic predisposition of IBS.展开更多
Cholelithiasis is a common digestive disease affecting 10%to 15%of adults.It imposes significant global health and financial burdens.However,the pathogenesis of cholelithiasis involves several factors and is incomplet...Cholelithiasis is a common digestive disease affecting 10%to 15%of adults.It imposes significant global health and financial burdens.However,the pathogenesis of cholelithiasis involves several factors and is incompletely elucidated.In addition to genetic predisposition and hepatic hypersecretion,the pathogenesis of cholelithiasis might involve the gastrointestinal(GI)microbiome,consisting of microorganisms and their metabolites.High-throughput sequencing studies have elucidated the role of bile,gallstones,and the fecal microbiome in cholelithiasis,associating microbiota dysbiosis with gallstone formation.The GI microbiome may drive cholelithogenesis by regulating bile acid metabolism and related signaling pathways.This review examines the literature implicating the GI microbiome in cholelithiasis,specifically gallbladder stones,choledocholithiasis,and asymptomatic gallstones.We also discuss alterations of the GI microbiome and its influence on cholelithogenesis.展开更多
Mobile Edge Computing(MEC)and 5G technology allow clients to access computing resources at the network frontier,which paves the way for applying Mobile Augmented Reality(MAR)applications.Under the MEC paradigm,MAR cli...Mobile Edge Computing(MEC)and 5G technology allow clients to access computing resources at the network frontier,which paves the way for applying Mobile Augmented Reality(MAR)applications.Under the MEC paradigm,MAR clients can offload complex tasks to the MEC server and enhance the human perception of the world by merging the received virtual information with the real environment.However,the resource allocation problem arises as a critical challenge in circumstances where several MAR clients compete for limited resources at the network frontier.In this paper,we aim to design an online resource allocation scheme on the MEC server that takes both high quality of experience and good fairness performance for MAR clients into consideration.We first formulate this problem as a Markov decision process and tackle the challenge of applying the deep reinforcement learning paradigm.Then,we propose DRAM,a Deep reinforcement learning-based Resource allocation scheme for mobile Augmented reality service in MEC.We also propose a self-adaptive algorithm on the MAR client that is derived based on the analysis of the MAR service to tackle client adaptation problems.The simulation results demonstrated that DRAM can provide high quality of experience and simultaneously achieve good fairness performance by coordinating with clients’adaptation algorithms.展开更多
BACKGROUND Hereditary hemorrhagic telangiectasia(HHT)is an autosomal dominant genetic disorder with an incidence of approximately 1 in 5000 in the general population.It is characterized by vasodilation,which affects s...BACKGROUND Hereditary hemorrhagic telangiectasia(HHT)is an autosomal dominant genetic disorder with an incidence of approximately 1 in 5000 in the general population.It is characterized by vasodilation,which affects specific organs,such as the skin,mucous membranes,brain,lungs,gastrointestinal tract,liver,and others.However,HHT rarely involves the portal venous system to cause serious clinical compli-cations.CASE SUMMARY A 68-year-old woman was admitted to the emergency department due to four consecutive days of abdominal pain and bloody stool and was subsequently diagnosed with HHT.Computed tomography angiography confirmed the presence of an arteriovenous fistula(AVFs).Considering this specific manifestation,whole exome sequencing was performed.After a comprehensive evaluation,a selective superior mesenteric artery embolization was prioritized to avoid intestinal ischemia.The postoperative symptoms of the patient were quickly relieved.Unfortunately,two months post-procedure the patient died from intestinal necrosis and abdominal infection related to remaining AVFs.CONCLUSION For patients with diffuse superior mesenteric AVFs,selective mesenteric arterial embolization may lead to positive short-term outcomes.展开更多
The intestinal microbiota plays an important role in inflammatory bowel disease(IBD).The pathogenesis of IBD involves inappropriate ongoing activation of the mucosal immune system driven by abnormal intestinal microbi...The intestinal microbiota plays an important role in inflammatory bowel disease(IBD).The pathogenesis of IBD involves inappropriate ongoing activation of the mucosal immune system driven by abnormal intestinal microbiota in genetically predisposed individuals.However,there are still no definitive microbial pathogens linked to the onset of IBD.The composition and function of the intestinal microbiota and their metabolites are indeed disturbed in IBD patients.The special alterations of gut microbiota associated with IBD remain to be evaluated.The microbial interactions and hostmicrobe immune interactions are still not clarified.Limitations of present probiotic products in IBD are mainly due to modest clinical efficacy,few available strains and no standardized administration.Fecal microbiota transplantation(FMT)may restore intestinal microbial ho-meostasis,and preliminary data have shown the clinical efficacy of FMT on refractory IBD or IBD combined with Clostridium difficile infection.Additionally,synthetic microbiota transplantation with the defined composition of fecal microbiota is also a promising therapeutic approach for IBD.However,FMT-related barriers,including the mechanism of restoring gut microbiota,standardized donor screening,fecal material preparation and administration,and long-term safety should be resolved.The role of intestinal microbiota and FMT in IBD should be further investigated by metagenomic and metatranscriptomic analyses combined with germfree/human flora-associated animals and chemostat gut models.展开更多
The contact angles of distilled water and methanol solution on the wings of butterflies were determined by a visual contact angle measuring system. The scale structures of the wings were observed using scanning electr...The contact angles of distilled water and methanol solution on the wings of butterflies were determined by a visual contact angle measuring system. The scale structures of the wings were observed using scanning electron microscopy, The influence of the scale micro- and ultra-structure on the wettability was investigated. Results show that the contact angle of distilled water on the wing surfaces varies from 134.0° to 159.2°. High hydrophobicity is found in six species with contact angles greater than 150°. The wing surfaces of some species are not only hydrophobic but also resist the wetting by methanol solution with 55% concentration. Only two species in Parnassius can not resist the wetting because the micro-structure （spindle-like shape） and ultra-structure （pinnule-like shape） of the wing scales are remarkably different from that of other species. The concentration of methanol solution for the occurrence of spreading/wetting on the wing surfaces of different species varies from 70% to 95%. After wetting by methanol solution for 10 min, the distilled water contact angle on the wing surface increases by 0.8°-2.1°, showing the promotion of capacity against wetting by distilled water.展开更多
AIM: To evaluate the change in spectrum of gastric polyps in the Chinese population in the past ten years.METHODS: A total of 157902 consecutive patients undergoing esophagogastroduodenoscopy(EGD) from 2004 to 2013 in...AIM: To evaluate the change in spectrum of gastric polyps in the Chinese population in the past ten years.METHODS: A total of 157902 consecutive patients undergoing esophagogastroduodenoscopy(EGD) from 2004 to 2013 in a tertiary hospital were retrospectively reviewed using an EGD database.Endoscopic records of 4043 patients diagnosed with gastric polyps were recalled for analysis.Data including demographics,information on polyps such as location,pathological diagnosis,reflux esophagitis and Helicobacter pylori infection were obtained.We focused on epithelial polyps,especially hyperplastic polyps,fundic gland polyps and adenomas,and histological classification of specimens from biopsy and endoscopic polypectomy was performed by professional pathologists,based on the updated guidelines.To explore the age distribution of gastric polyps over time,we divided patients with polyps into four groups: A(aged < 30 years),B(aged 30-44 years),C(aged 45-59 years) and D(aged > 60 years).Differences in localization,age,and sex distribution of gastric polyps were analyzed by statistical software.RESULTS: A total of 157902 EGD procedures were performed in ten years at our digestive endoscopy center,of which 4043 cases were diagnosed with gastric polyps confirmed by pathology.There were 2574(63%) female and 1469(37%) male patients with an average age of 54.7 years.The overall prevalence of gastric polyps was 2.6%(4043/157902).Our database demonstrated a rising prevalence of gastric polyps over the decade,increasing from 1.0%(80/8025) to 4.70%(828/17787) between 2004 and 2013.There has been a change in the spectrum of gastric polyps with the frequencies of FGPs increasing from 19%(15/80) to 77%(638/828) and hyperplastic polyps decreasing from 65%(52/80) to 15%(123/828).Moreover,data on 1921 polyps in 828 patients diagnosed with gastric polyps in 2013 showed that FGP was the most common type in the current polyp spectrum,making up 81.3%(1562/1921).Location and age distribution of gastric polyps have also altered.The prevalence of polyps located in the antrum decreased from 37.5%(30/80) to 9.30%(77/828),with an increasing prevalence of polyps in the corpus,from 45%(36/80) to 64.25%(532/828).The constituent ratio of older patients(aged > 60 years) in the polyp population decreased from 62.5%(50/80) to 32.13%(266/828),while that of patients aged 45-60 years showed an increased trend.CONCLUSION: There was a shift change in the spectrum of gastric polyps in the Chinese population with altered location and age distribution in the past ten years.展开更多
AIM: To explore Chinese physicians' perceptions towards fecal microbiota transplantation(FMT) and to provide information and an assessment of FMT development in China.METHODS: A self-administered questionnaire was...AIM: To explore Chinese physicians' perceptions towards fecal microbiota transplantation(FMT) and to provide information and an assessment of FMT development in China.METHODS: A self-administered questionnaire was developed according to the FMT practice guidelines and was distributed to physicians in hospitals via Internet Research Electronic Data Capture(REDcap) software and electronic mails to assess their attitudes toward and knowledge of FMT. The questionnaire included a brief introduction of FMT that was followed by 20 questions. The participants were required to respond voluntarily, under the condition of anonymity and without compensation. Except for the fill-in-the-blank questions, all of the other questions were required in the REDcap data collection systems, and the emailed questionnaires were completed based on eligibility.RESULTS: Up to December 9, 2014, 844 eligible questionnaires were received out of the 980 distributed questionnaires, with a response rate of 86.1%. Among the participants, 87.3% were from tertiary hospitals, and there were 647(76.7%) gastroenterologists and 197(23.3%) physicians in other departments(nongastroenterologists). Gastroenterologists' awareness of FMT prior to the survey was much higher than non-gastroenterologists'(54.3 vs 16.5%, P < 0.001); however, acceptance of FMT was not statistically different(92.4 vs 87.1%, P = 0.1603). Major concerns of FMT included the following: acceptability to patients(79.2%), absence of guidelines(56.9%), and administration and ethics(46.5%). On the basis of understanding, the FMT indications preferred byphysicians were recurrent Clostridium difficile infection(86.7%), inflammatory bowel disease combined with Clostridium difficile infection(78.6%), refractory ulcerative colitis(70.9%), ulcerative colitis(65.4%), Crohn's disease(59.4%), chronic constipation(43.7%), irritable bowel syndrome(39.1%), obesity(28.1%) and type 2 diabetes(23.9%). For donor selection, the majority of physicians preferred individuals with a similar gut flora environment to the recipients. 76.6% of physicians chose lower gastrointestinal tract as the administration approach. 69.2% of physicians considered FMT a safe treatment. CONCLUSION: Chinese physicians have awareness and a high acceptance of FMT, especially gastroenterologists, which provides the grounds and conditions for the development of this novel treatment in China. Physicians' greatest concerns were patient acceptability and absence of guidelines.展开更多
AIM:To evaluate the diagnosis of different differentiated gastric intraepithelial neoplasia (IN) by magnifica-tion endoscopy combined with narrow-band imaging (ME-NBI) and confocal laser endomicroscopy (CLE). METHODS:...AIM:To evaluate the diagnosis of different differentiated gastric intraepithelial neoplasia (IN) by magnifica-tion endoscopy combined with narrow-band imaging (ME-NBI) and confocal laser endomicroscopy (CLE). METHODS:Eligible patients with suspected gastric IN lesions previously diagnosed by endoscopy in secondary hospitals and scheduled for further diagnosis and tratment were recruited for this study. Excluded from the study were patients who had liver cirrhosis, impaired renal function, acute gastrointestinal (GI) bleeding, coagulopathy, esophageal varices, jaundice, and GI post-surgery. Also excluded were those who were pregnant, breastfeeding, were younger than 18 years old, or were unable to provide informed consent. All patients had all mucus and bile cleared from their stom-achs. They then received upper GI endoscopy. When a mucosal lesion is found during observation with whitelight imaging, the lesion is visualized using maximal magnification, employing gradual movement of the tip of the endoscope to bring the image into focus. Saved images are analyzed. Confocal images were evaluated by two endoscopists (Huang J and Li MY), who were familiar with CLE, blinded to the related information about the lesions, and asked to classify each lesion as either a low grade dysplasia (LGD) or high grade dysplasia (HGD) according to given criteria. The results were compared with the final histopathologic diagnosis. ME-NBI images were evaluated by two endoscopists (Lu ZS and Ling-Hu EQ) who were familiar with NBI, blinded to the related information about the lesions and CLE images, and were asked to classify each lesion as a LGD or HGD according to the "microvascular pattern and surface pattern" classification system. The results were compared with the final histopathologic diagnosis. RESULTS: The study included 32 pathology-proven low grade gastric IN and 26 pathology-proven high grade gastric IN that were detected with any of the modalities. CLE and ME-NBI enabled clear visualization of the vascular microsurface patterns and microvascular structures of the gastric mucosa. The accuracy of the CLE and the ME-NBI diagnosis was 88% (95% CI:78%-98%) and 81% (95% CI: 69%-93%), respectively. The kappa coefficient of agreement between the histopathology and the in vivo CLE imaging was 0.755; between the histopathology and the in vivo CLE imaging was 0.615. McNemar's test (binomial distribution used) indicated that the agreement was significant (P < 0.05). When patients were diagnosed by MENBI with CLE, the overall accuracy of the diagnosis was 86.21% (95% CI:73%-96%), and the kappa coefficient of agreement was 0.713, according to McNemar's test (P < 0.05). CONCLUSION:Higher diagnostic accuracy, sensitivityand specificity of CLE over ME-NBI indicate the feasibility of these two techniques for the efficacious diagnostic classification of gastric IN.展开更多
Ni-based composite coatings incorporated with nano/micron SiC particles were fabricated via electrochemical co-deposition in Watts bath,followed by the evaluation of their mechanical and anti-corrosion properties.The ...Ni-based composite coatings incorporated with nano/micron SiC particles were fabricated via electrochemical co-deposition in Watts bath,followed by the evaluation of their mechanical and anti-corrosion properties.The micrographic observations suggest that the SiC particles with various sizes can be well incorporated to the Ni substrate.X-ray diffraction(XRD)patterns indicate that SiC particles with smaller sizes could weaken the preferential growth of Ni along(200)facet.In addition,it is found that the incorporated SiC particles with medium micron sizes(8 and 1.5μm)could significantly enhance the micro-hardness of the Ni composite coatings.Nevertheless,electrochemical measurements demonstrate that micron-sized SiC particles would weaken the corrosion resistance of Ni composite coatings ascribed to the structure defects induced.In contrast,the combined incorporation of nanosized(50 nm)SiC particles with medium micron(1.5μm)ones is capable of promoting the compactness of the composite coatings,which is beneficial to the long-term corrosion resistance with negligible micro-hardness loss.展开更多
BACKGROUND: The lack of widely-accepted guidelines for acute cholangitis largely lags behind the progress in medical and surgical technology and science for the management of acute cholangitis. This study aimed to ver...BACKGROUND: The lack of widely-accepted guidelines for acute cholangitis largely lags behind the progress in medical and surgical technology and science for the management of acute cholangitis. This study aimed to verify the Tokyo guidelines for the management of acute cholangitis and cholecystitis of 2007 edition (TG07) in patients with obstructive cholangitis due to benign and malignant diseases. METHODS: The patients were retrieved from our existing ERCP database. Final diagnosis of acute cholangitis was made by detecting purulent bile during biliary drainage. We examined and compared the guidelines concerning benign and malignant obstruction. RESULTS: In 120 patients in our study, 82 and 38 had benign and malignant biliary obstruction, respectively. Guidelines based diagnosis was made in 68 (82.9%), 36 (94.7%), and 104 (86.7%) patients with benign, malignant, and overall biliary obstruction, respectively, which were significantly higher than 44 (53.7%), 17 (44.7%), and 61 (50.8%) diagnosed by Charcot’s triad (P【0.001). Treatment consistent with the guidelines was offered to 58 (70.7%) patients with benign obstruction and15 (39.5%) patients with malignant obstruction (P=0.001). No significant association was observed between clinical compliance, guidelines-based severity grades and clinical outcomes. In the multivariate model, intrahepatic obstruction (OR=11.2, 95% CI: 1.55-226.9) and hypoalbuminemia (≤25.0 g/L; OR=17.3, 95% CI: 3.5-313.6) were independent risk factors for a 30-day mortality. CONCLUSIONS: The TG07 are more reliable than Charcot’s triad for the diagnosis of acute cholangitis albeit with limited prognostic values. Intrahepatic obstruction and hypoalbuminemia are new predictors of poor prognosis and need further assessment.展开更多
We investigate the granular flow states in a channel with bottleneck by molecular dynamics simulations.Our study is restricted only on a selected key area rather than on the whole system to focus on the flow propertie...We investigate the granular flow states in a channel with bottleneck by molecular dynamics simulations.Our study is restricted only on a selected key area rather than on the whole system to focus on the flow properties of a single granular state.A random force field is introduced to control the granular temperature.It is also pointed out that the flow rate in the granular flow can be correlated with the pressure,which leads us to carry out a comprehensive study similar to the classical study for general liquid-gas phase transition.Our results show that the dilute flow state and the dense flow state of the granules are similar to the gas state and the liquid state of general substances,respectively,and the properties of phase transition and critical phenomenon are also similar to those occurring in general substances.展开更多
Behaviors of C or O in bcc Fe and interactions of C-O and oxygen-carbon-vacancy(O-C-□) are investigated by first principles calculations. Octahedral interstitial site is the most stable position for an O atom in bcc ...Behaviors of C or O in bcc Fe and interactions of C-O and oxygen-carbon-vacancy(O-C-□) are investigated by first principles calculations. Octahedral interstitial site is the most stable position for an O atom in bcc Fe. The migration energy of an O atom in bcc Fe is 0.46 eV. The strength of O-Fe(1 nn) bond(0.32) is slightly greater than that of Fe-Fe metallic bond(0.26). Repulsive interactions of C-C, O-O, and C-O exist in bcc Fe. When the concentration of FIA(FIA refers to C or O) is relatively high, a vacancy can attract four FIAs and form stable FIAs-□ complex.展开更多
Cloud platforms could automatically scale underlying network resources up and down in response to changes in the traffic load.Such an auto-scaling mechanism can largely enhance the elasticity and scalability of cloud ...Cloud platforms could automatically scale underlying network resources up and down in response to changes in the traffic load.Such an auto-scaling mechanism can largely enhance the elasticity and scalability of cloud platforms.However,it may introduce new security threats.For example,the Yo-Yo attack is a newly disclosed attack against the cloud auto-scaling mechanism.Attackers periodically send bursts of traffic to cause the autoscaling mechanism to oscillate between the scale-up process and the scale-down process,which may result in significant performance degradation and economic loss.None of the prior work addressed the problem of mitigating such an attack.In this paper,we propose a Trust-based Adversarial Scanner Delaying(TASD)approach to effectively and proactively mitigate the Yo-Yo attack on the cloud auto-scaling mechanism.In TASD,we first propose to use the trust-based scheme to establish trust values for users,which is leveraged to identify adversarial requests.Trust values are updated by jointly considering the request mode and the auto-scaling status.Then,we aim to disable the condition under which the Yo-Yo attack takes effect by injecting certain delay,under the QoS constraints,to manipulate the response time of suspicious requests and deceive the attackers.Our extensive evaluation demonstrates that our approach achieves promising results,e.g.,it can detect at least 80%Yo-Yo adversarial users and reduce more than 41%malicious scale-ups.展开更多
The pressure in liquefied natural gas (LNG) storage tank continues to increase due to the heat transfer from ambient air to low temperature LNG, which raises safety concerns. Accordingly, there is increasing interest ...The pressure in liquefied natural gas (LNG) storage tank continues to increase due to the heat transfer from ambient air to low temperature LNG, which raises safety concerns. Accordingly, there is increasing interest to explore the technical approaches capable of recovering Boil-Off Gas (BOG) and even eliminating the ventilation of LNG storage tank. This research numerically analyzed the greenhouse gas emissions of the re-liquefaction of BOG using the following four approaches: 1) a Claude cycle driven by electrical motor with the electricity produced by burning coal;2) a Claude cycle driven by a gas turbine fuelled by BOG released;3) a Claude cycle driven by a SI engine fuelled by gasoline;4) burning nature gas directly released by BOG. The impact of heat transfer coefficient, LNG tank configuration, size, and percentage of LNG stored in tank on the rate of BOG and energy needed for the re-liquefaction of methane vapor were investigated. The greenhouse gas emissions (GGE) was examined and compared. The data presented in this paper provide guideline for the management of pressure development in LNG storage tank.展开更多
The consumption of cooling and heating energy and the methods of heating and cooling used in large public buildings are analyzed in this paper. A comparison between initial investment and operation costs of heat pump ...The consumption of cooling and heating energy and the methods of heating and cooling used in large public buildings are analyzed in this paper. A comparison between initial investment and operation costs of heat pump and traditional heating modes used in large public buildings is also introduced. A life cycle cost (LCC) mathematical model is established to analyze the main factors that affect the LCC including the advantages and disadvantages of heat pumps currently in use. Some suggestions about heating and cooling modes applied in large buildings in different geographical areas are given in this paper.展开更多
Established on the Intel Multi-Core Embedded platform, using 802.11 Wireless Network protocols as the communication medium, combining with Radio Frequency-Communication and Ultrasonic Ranging, imple-ment a mobile term...Established on the Intel Multi-Core Embedded platform, using 802.11 Wireless Network protocols as the communication medium, combining with Radio Frequency-Communication and Ultrasonic Ranging, imple-ment a mobile terminal system in an intellectualized building. It can provide its holder such functions: 1) Accurate Positioning 2) Intelligent Navigation 3) Video Monitoring 4) Wireless Communication. The inno-vative point for this paper is to apply the multi-core computing on the embedded system to promote its com-puting speed and give a real-time performance and apply this system into the indoor environment for the purpose of emergent event or rescuing.展开更多
Objective: To investigate whether glucose-6-phosphate isomerase (G6PI) antigen and anti-G6PI antibodies could be applied for the clinical diagnostic markers of rheumatoid arthritis (RA) and its associations with RA ac...Objective: To investigate whether glucose-6-phosphate isomerase (G6PI) antigen and anti-G6PI antibodies could be applied for the clinical diagnostic markers of rheumatoid arthritis (RA) and its associations with RA activity states. Methods: The levels of G6PI antigens and anti-G6PI Abs in sera from 176 RA patients in different states, 35 non-RA patients and 100 healthy donors and in synovia fluids from 33 patients and 11 non-RA patients were measured by ELISA. Results: The sensitivity and specificity of G6PI antigens in the RA patients were 75.0% and 93.3%, respectively. The levels of serum G6PI antigens in 176 RA patients were significantly higher than non-RA patients and the health controls. Especially, there was a significant difference between the active phase and the inactive phase in G6PI antigens levels. The levels of G6PI antigens in synovia fluid were also significantly higher in RA groups than in non-RA patients. With the values of the anti-G6PI Abs in sera, there were no marked differences among RA, non-RA patients and health controls. Also, there was no significant difference between the active phase and the inactive phase in RA patients. However, there were no significant differences of G6PI and anti-G6PI between RA patients and health controls in synovial fluid. Conclusions: G6PI is highly correlated with the activity states of RA, and could be applied for a clinical biomarker with high sensitivity and specificity for the diagnosis of RA.展开更多
This study was conducted to investigate and analyze Euphorbiaceae plant resources in Sanling Mountain Forest Park in Zhanjiang City,Guangdong Province.A plant resource development and utilization value evaluation syst...This study was conducted to investigate and analyze Euphorbiaceae plant resources in Sanling Mountain Forest Park in Zhanjiang City,Guangdong Province.A plant resource development and utilization value evaluation system was established by analytic hierarchy process(AHP)and used to comprehensively evaluate the development and utilization value of Euphorbiaceae plant resources in the area.The results showed that the comprehensive evaluation values of Sapium discolor,Sapium sebiferum,Flueggea virosa,Baccaurea ramiflora,Aleurites moluccana,Antidesma ghaesembilla,Phyllanthus emblica and Pedilanthus tithymaloides were greater than 2.65,performing well;the comprehensive evaluation values of Bridelia tomentosa,Glochidion puberum,Breynia fruticosa,Mallotus paniculatus,Mallotus repandus,Mallotus apelta and Alchornea trewioides were in the range of 1.9622-2.5964,performing ordinary;and the comprehensive evaluation values of Phyllanthus reticulatus,Ricinus communis,Croton crassifolius,and Sebastiania chamaelea were smaller than 1.96,which were relatively lower.S.discolor,S.sebiferum,F.virosa,B.ramiflora,A.moluccana,A.ghaesembilla,P.emblica and P.tithymaloides have great development value and can be developed and used in a planned and step-by-step manner,and Aporosa dioica and Euphorbia tirucalli with a lower comprehensive evaluation value but strong stress resistance and adaptability can be applied to the construction of ecological forests and shelter forests.展开更多
基金supported by grants from China CDC Key Laboratory of Environment and Population Health(2022-CKL-03)Peking University(BMU2021YJ044)supported by the General Program of National Natural Science Foundation of China(32170898)。
文摘Background:Irritable bowel syndrome(IBS)substantially affects quality of life and requires early prevention.This study aimed to elucidate the relationships between IBS and daily behaviors,including sedentary behavior(SB),physical activity(PA),and sleep.In particular,it seeks to identify healthy behaviors to reduce IBS risk,which previous studies have rarely addressed.Methods:Daily behaviors were retrieved from self-reported data of 362,193 eligible UK Biobank participants.Incident cases were determined by self-report or health care data according to RomeⅣcriteria.Results:A total of 345,388 participants were IBS-free at baseline,during a median follow-up of 8.45 years,19,885 incident IBS cases were recorded.When examined individually,SB and shorter(≤7 h/day)or longer(>7 h/day)sleep duration were each positively associated with increased IBS risk,and PA was associated with lower IBS risk.The isotemporal substitution model suggested that replacing SB with other activities could provide further protective effects against IBS risk.Among people sleeping≤7 h/day,replacing 1 h of SB with equivalent light PA,vigorous PA,or sleep was associated with 8.1%(95%confidence interval(95%CI):0.901-0.937),5.8%(95%CI:0.896-0.991),and 9.2%(95%CI:0.885-0.932)reduced IBS risk,respectively.For people sleeping>7 h/day,light and vigorous PA were associated with a 4.8%(95%CI:0.926-0.978)and a 12.0%(95%CI:0.815-0.949)lower IBS risk,respectively.These benefits were mostly independent of genetic risk for IBS.Conclusion:SB and unhealthy sleep duration are risk factors for IBS.A promising way to mitigate IBS risk for individuals sleeping≤7 h/day and for those sleeping>7 h/day appears to be by replacing SB with adequate sleep or vigorous PA,respectively,regardless of the genetic predisposition of IBS.
文摘Cholelithiasis is a common digestive disease affecting 10%to 15%of adults.It imposes significant global health and financial burdens.However,the pathogenesis of cholelithiasis involves several factors and is incompletely elucidated.In addition to genetic predisposition and hepatic hypersecretion,the pathogenesis of cholelithiasis might involve the gastrointestinal(GI)microbiome,consisting of microorganisms and their metabolites.High-throughput sequencing studies have elucidated the role of bile,gallstones,and the fecal microbiome in cholelithiasis,associating microbiota dysbiosis with gallstone formation.The GI microbiome may drive cholelithogenesis by regulating bile acid metabolism and related signaling pathways.This review examines the literature implicating the GI microbiome in cholelithiasis,specifically gallbladder stones,choledocholithiasis,and asymptomatic gallstones.We also discuss alterations of the GI microbiome and its influence on cholelithogenesis.
基金supported by the National Key R&D Program of China(2020YFB1807804,2020YFB1807800)the National Nat-ural Science Foundation of China(NSFC)(62001087,62072079,U20A20156).
文摘Mobile Edge Computing(MEC)and 5G technology allow clients to access computing resources at the network frontier,which paves the way for applying Mobile Augmented Reality(MAR)applications.Under the MEC paradigm,MAR clients can offload complex tasks to the MEC server and enhance the human perception of the world by merging the received virtual information with the real environment.However,the resource allocation problem arises as a critical challenge in circumstances where several MAR clients compete for limited resources at the network frontier.In this paper,we aim to design an online resource allocation scheme on the MEC server that takes both high quality of experience and good fairness performance for MAR clients into consideration.We first formulate this problem as a Markov decision process and tackle the challenge of applying the deep reinforcement learning paradigm.Then,we propose DRAM,a Deep reinforcement learning-based Resource allocation scheme for mobile Augmented reality service in MEC.We also propose a self-adaptive algorithm on the MAR client that is derived based on the analysis of the MAR service to tackle client adaptation problems.The simulation results demonstrated that DRAM can provide high quality of experience and simultaneously achieve good fairness performance by coordinating with clients’adaptation algorithms.
基金the Youth Independent Innovation Science Project of PLA General Hospital,No.22QNFC058.
文摘BACKGROUND Hereditary hemorrhagic telangiectasia(HHT)is an autosomal dominant genetic disorder with an incidence of approximately 1 in 5000 in the general population.It is characterized by vasodilation,which affects specific organs,such as the skin,mucous membranes,brain,lungs,gastrointestinal tract,liver,and others.However,HHT rarely involves the portal venous system to cause serious clinical compli-cations.CASE SUMMARY A 68-year-old woman was admitted to the emergency department due to four consecutive days of abdominal pain and bloody stool and was subsequently diagnosed with HHT.Computed tomography angiography confirmed the presence of an arteriovenous fistula(AVFs).Considering this specific manifestation,whole exome sequencing was performed.After a comprehensive evaluation,a selective superior mesenteric artery embolization was prioritized to avoid intestinal ischemia.The postoperative symptoms of the patient were quickly relieved.Unfortunately,two months post-procedure the patient died from intestinal necrosis and abdominal infection related to remaining AVFs.CONCLUSION For patients with diffuse superior mesenteric AVFs,selective mesenteric arterial embolization may lead to positive short-term outcomes.
文摘The intestinal microbiota plays an important role in inflammatory bowel disease(IBD).The pathogenesis of IBD involves inappropriate ongoing activation of the mucosal immune system driven by abnormal intestinal microbiota in genetically predisposed individuals.However,there are still no definitive microbial pathogens linked to the onset of IBD.The composition and function of the intestinal microbiota and their metabolites are indeed disturbed in IBD patients.The special alterations of gut microbiota associated with IBD remain to be evaluated.The microbial interactions and hostmicrobe immune interactions are still not clarified.Limitations of present probiotic products in IBD are mainly due to modest clinical efficacy,few available strains and no standardized administration.Fecal microbiota transplantation(FMT)may restore intestinal microbial ho-meostasis,and preliminary data have shown the clinical efficacy of FMT on refractory IBD or IBD combined with Clostridium difficile infection.Additionally,synthetic microbiota transplantation with the defined composition of fecal microbiota is also a promising therapeutic approach for IBD.However,FMT-related barriers,including the mechanism of restoring gut microbiota,standardized donor screening,fecal material preparation and administration,and long-term safety should be resolved.The role of intestinal microbiota and FMT in IBD should be further investigated by metagenomic and metatranscriptomic analyses combined with germfree/human flora-associated animals and chemostat gut models.
文摘The contact angles of distilled water and methanol solution on the wings of butterflies were determined by a visual contact angle measuring system. The scale structures of the wings were observed using scanning electron microscopy, The influence of the scale micro- and ultra-structure on the wettability was investigated. Results show that the contact angle of distilled water on the wing surfaces varies from 134.0° to 159.2°. High hydrophobicity is found in six species with contact angles greater than 150°. The wing surfaces of some species are not only hydrophobic but also resist the wetting by methanol solution with 55% concentration. Only two species in Parnassius can not resist the wetting because the micro-structure （spindle-like shape） and ultra-structure （pinnule-like shape） of the wing scales are remarkably different from that of other species. The concentration of methanol solution for the occurrence of spreading/wetting on the wing surfaces of different species varies from 70% to 95%. After wetting by methanol solution for 10 min, the distilled water contact angle on the wing surface increases by 0.8°-2.1°, showing the promotion of capacity against wetting by distilled water.
文摘AIM: To evaluate the change in spectrum of gastric polyps in the Chinese population in the past ten years.METHODS: A total of 157902 consecutive patients undergoing esophagogastroduodenoscopy(EGD) from 2004 to 2013 in a tertiary hospital were retrospectively reviewed using an EGD database.Endoscopic records of 4043 patients diagnosed with gastric polyps were recalled for analysis.Data including demographics,information on polyps such as location,pathological diagnosis,reflux esophagitis and Helicobacter pylori infection were obtained.We focused on epithelial polyps,especially hyperplastic polyps,fundic gland polyps and adenomas,and histological classification of specimens from biopsy and endoscopic polypectomy was performed by professional pathologists,based on the updated guidelines.To explore the age distribution of gastric polyps over time,we divided patients with polyps into four groups: A(aged < 30 years),B(aged 30-44 years),C(aged 45-59 years) and D(aged > 60 years).Differences in localization,age,and sex distribution of gastric polyps were analyzed by statistical software.RESULTS: A total of 157902 EGD procedures were performed in ten years at our digestive endoscopy center,of which 4043 cases were diagnosed with gastric polyps confirmed by pathology.There were 2574(63%) female and 1469(37%) male patients with an average age of 54.7 years.The overall prevalence of gastric polyps was 2.6%(4043/157902).Our database demonstrated a rising prevalence of gastric polyps over the decade,increasing from 1.0%(80/8025) to 4.70%(828/17787) between 2004 and 2013.There has been a change in the spectrum of gastric polyps with the frequencies of FGPs increasing from 19%(15/80) to 77%(638/828) and hyperplastic polyps decreasing from 65%(52/80) to 15%(123/828).Moreover,data on 1921 polyps in 828 patients diagnosed with gastric polyps in 2013 showed that FGP was the most common type in the current polyp spectrum,making up 81.3%(1562/1921).Location and age distribution of gastric polyps have also altered.The prevalence of polyps located in the antrum decreased from 37.5%(30/80) to 9.30%(77/828),with an increasing prevalence of polyps in the corpus,from 45%(36/80) to 64.25%(532/828).The constituent ratio of older patients(aged > 60 years) in the polyp population decreased from 62.5%(50/80) to 32.13%(266/828),while that of patients aged 45-60 years showed an increased trend.CONCLUSION: There was a shift change in the spectrum of gastric polyps in the Chinese population with altered location and age distribution in the past ten years.
基金Supported by Chinese PLA General Hospital,No.2014FCTSYS-2001 and No.2013FC-TSYS-1009National High-tech Research and Development Projects(863),No.2015AA020702National Natural Science Foundation of China,No.81402345
文摘AIM: To explore Chinese physicians' perceptions towards fecal microbiota transplantation(FMT) and to provide information and an assessment of FMT development in China.METHODS: A self-administered questionnaire was developed according to the FMT practice guidelines and was distributed to physicians in hospitals via Internet Research Electronic Data Capture(REDcap) software and electronic mails to assess their attitudes toward and knowledge of FMT. The questionnaire included a brief introduction of FMT that was followed by 20 questions. The participants were required to respond voluntarily, under the condition of anonymity and without compensation. Except for the fill-in-the-blank questions, all of the other questions were required in the REDcap data collection systems, and the emailed questionnaires were completed based on eligibility.RESULTS: Up to December 9, 2014, 844 eligible questionnaires were received out of the 980 distributed questionnaires, with a response rate of 86.1%. Among the participants, 87.3% were from tertiary hospitals, and there were 647(76.7%) gastroenterologists and 197(23.3%) physicians in other departments(nongastroenterologists). Gastroenterologists' awareness of FMT prior to the survey was much higher than non-gastroenterologists'(54.3 vs 16.5%, P < 0.001); however, acceptance of FMT was not statistically different(92.4 vs 87.1%, P = 0.1603). Major concerns of FMT included the following: acceptability to patients(79.2%), absence of guidelines(56.9%), and administration and ethics(46.5%). On the basis of understanding, the FMT indications preferred byphysicians were recurrent Clostridium difficile infection(86.7%), inflammatory bowel disease combined with Clostridium difficile infection(78.6%), refractory ulcerative colitis(70.9%), ulcerative colitis(65.4%), Crohn's disease(59.4%), chronic constipation(43.7%), irritable bowel syndrome(39.1%), obesity(28.1%) and type 2 diabetes(23.9%). For donor selection, the majority of physicians preferred individuals with a similar gut flora environment to the recipients. 76.6% of physicians chose lower gastrointestinal tract as the administration approach. 69.2% of physicians considered FMT a safe treatment. CONCLUSION: Chinese physicians have awareness and a high acceptance of FMT, especially gastroenterologists, which provides the grounds and conditions for the development of this novel treatment in China. Physicians' greatest concerns were patient acceptability and absence of guidelines.
文摘AIM:To evaluate the diagnosis of different differentiated gastric intraepithelial neoplasia (IN) by magnifica-tion endoscopy combined with narrow-band imaging (ME-NBI) and confocal laser endomicroscopy (CLE). METHODS:Eligible patients with suspected gastric IN lesions previously diagnosed by endoscopy in secondary hospitals and scheduled for further diagnosis and tratment were recruited for this study. Excluded from the study were patients who had liver cirrhosis, impaired renal function, acute gastrointestinal (GI) bleeding, coagulopathy, esophageal varices, jaundice, and GI post-surgery. Also excluded were those who were pregnant, breastfeeding, were younger than 18 years old, or were unable to provide informed consent. All patients had all mucus and bile cleared from their stom-achs. They then received upper GI endoscopy. When a mucosal lesion is found during observation with whitelight imaging, the lesion is visualized using maximal magnification, employing gradual movement of the tip of the endoscope to bring the image into focus. Saved images are analyzed. Confocal images were evaluated by two endoscopists (Huang J and Li MY), who were familiar with CLE, blinded to the related information about the lesions, and asked to classify each lesion as either a low grade dysplasia (LGD) or high grade dysplasia (HGD) according to given criteria. The results were compared with the final histopathologic diagnosis. ME-NBI images were evaluated by two endoscopists (Lu ZS and Ling-Hu EQ) who were familiar with NBI, blinded to the related information about the lesions and CLE images, and were asked to classify each lesion as a LGD or HGD according to the "microvascular pattern and surface pattern" classification system. The results were compared with the final histopathologic diagnosis. RESULTS: The study included 32 pathology-proven low grade gastric IN and 26 pathology-proven high grade gastric IN that were detected with any of the modalities. CLE and ME-NBI enabled clear visualization of the vascular microsurface patterns and microvascular structures of the gastric mucosa. The accuracy of the CLE and the ME-NBI diagnosis was 88% (95% CI:78%-98%) and 81% (95% CI: 69%-93%), respectively. The kappa coefficient of agreement between the histopathology and the in vivo CLE imaging was 0.755; between the histopathology and the in vivo CLE imaging was 0.615. McNemar's test (binomial distribution used) indicated that the agreement was significant (P < 0.05). When patients were diagnosed by MENBI with CLE, the overall accuracy of the diagnosis was 86.21% (95% CI:73%-96%), and the kappa coefficient of agreement was 0.713, according to McNemar's test (P < 0.05). CONCLUSION:Higher diagnostic accuracy, sensitivityand specificity of CLE over ME-NBI indicate the feasibility of these two techniques for the efficacious diagnostic classification of gastric IN.
基金This work was financially supported by National Natural Science Foundation of China(Nos.51901018 and 51771027)National Science and Technology Resources In-vestigation Program of China(No.2019FY101400)+3 种基金Funda-mental Research Funds for the Central Universities,China(Nos.FRF-MP-19-001 and FRF-AT-20-07)National Key Research and Development Program of China(No.2017YFB0702100)China Postdoctoral Science Foundation(No.2019M660456)Young Elite Scientists Sponsor-ship Program by China Association for Science and Techno-logy(YESS,No.2019QNRC001).
文摘Ni-based composite coatings incorporated with nano/micron SiC particles were fabricated via electrochemical co-deposition in Watts bath,followed by the evaluation of their mechanical and anti-corrosion properties.The micrographic observations suggest that the SiC particles with various sizes can be well incorporated to the Ni substrate.X-ray diffraction(XRD)patterns indicate that SiC particles with smaller sizes could weaken the preferential growth of Ni along(200)facet.In addition,it is found that the incorporated SiC particles with medium micron sizes(8 and 1.5μm)could significantly enhance the micro-hardness of the Ni composite coatings.Nevertheless,electrochemical measurements demonstrate that micron-sized SiC particles would weaken the corrosion resistance of Ni composite coatings ascribed to the structure defects induced.In contrast,the combined incorporation of nanosized(50 nm)SiC particles with medium micron(1.5μm)ones is capable of promoting the compactness of the composite coatings,which is beneficial to the long-term corrosion resistance with negligible micro-hardness loss.
文摘BACKGROUND: The lack of widely-accepted guidelines for acute cholangitis largely lags behind the progress in medical and surgical technology and science for the management of acute cholangitis. This study aimed to verify the Tokyo guidelines for the management of acute cholangitis and cholecystitis of 2007 edition (TG07) in patients with obstructive cholangitis due to benign and malignant diseases. METHODS: The patients were retrieved from our existing ERCP database. Final diagnosis of acute cholangitis was made by detecting purulent bile during biliary drainage. We examined and compared the guidelines concerning benign and malignant obstruction. RESULTS: In 120 patients in our study, 82 and 38 had benign and malignant biliary obstruction, respectively. Guidelines based diagnosis was made in 68 (82.9%), 36 (94.7%), and 104 (86.7%) patients with benign, malignant, and overall biliary obstruction, respectively, which were significantly higher than 44 (53.7%), 17 (44.7%), and 61 (50.8%) diagnosed by Charcot’s triad (P【0.001). Treatment consistent with the guidelines was offered to 58 (70.7%) patients with benign obstruction and15 (39.5%) patients with malignant obstruction (P=0.001). No significant association was observed between clinical compliance, guidelines-based severity grades and clinical outcomes. In the multivariate model, intrahepatic obstruction (OR=11.2, 95% CI: 1.55-226.9) and hypoalbuminemia (≤25.0 g/L; OR=17.3, 95% CI: 3.5-313.6) were independent risk factors for a 30-day mortality. CONCLUSIONS: The TG07 are more reliable than Charcot’s triad for the diagnosis of acute cholangitis albeit with limited prognostic values. Intrahepatic obstruction and hypoalbuminemia are new predictors of poor prognosis and need further assessment.
基金Supported by the National Natural Science Foundation of China under Grant Nos 10875166 and 11274355
文摘We investigate the granular flow states in a channel with bottleneck by molecular dynamics simulations.Our study is restricted only on a selected key area rather than on the whole system to focus on the flow properties of a single granular state.A random force field is introduced to control the granular temperature.It is also pointed out that the flow rate in the granular flow can be correlated with the pressure,which leads us to carry out a comprehensive study similar to the classical study for general liquid-gas phase transition.Our results show that the dilute flow state and the dense flow state of the granules are similar to the gas state and the liquid state of general substances,respectively,and the properties of phase transition and critical phenomenon are also similar to those occurring in general substances.
基金Project supported by the Fundamental Research Funds in Heilongjiang Provincial Universities,China(Grant No.135209204)
文摘Behaviors of C or O in bcc Fe and interactions of C-O and oxygen-carbon-vacancy(O-C-□) are investigated by first principles calculations. Octahedral interstitial site is the most stable position for an O atom in bcc Fe. The migration energy of an O atom in bcc Fe is 0.46 eV. The strength of O-Fe(1 nn) bond(0.32) is slightly greater than that of Fe-Fe metallic bond(0.26). Repulsive interactions of C-C, O-O, and C-O exist in bcc Fe. When the concentration of FIA(FIA refers to C or O) is relatively high, a vacancy can attract four FIAs and form stable FIAs-□ complex.
基金This research was partially supported by the Natural Science Foundation of China(61571098)Open Foundation of State Key Laboratory of Networking and Switching Technology(Beijing University of Posts and Telecommunications)(SKLNST-2016-2-24).
文摘Cloud platforms could automatically scale underlying network resources up and down in response to changes in the traffic load.Such an auto-scaling mechanism can largely enhance the elasticity and scalability of cloud platforms.However,it may introduce new security threats.For example,the Yo-Yo attack is a newly disclosed attack against the cloud auto-scaling mechanism.Attackers periodically send bursts of traffic to cause the autoscaling mechanism to oscillate between the scale-up process and the scale-down process,which may result in significant performance degradation and economic loss.None of the prior work addressed the problem of mitigating such an attack.In this paper,we propose a Trust-based Adversarial Scanner Delaying(TASD)approach to effectively and proactively mitigate the Yo-Yo attack on the cloud auto-scaling mechanism.In TASD,we first propose to use the trust-based scheme to establish trust values for users,which is leveraged to identify adversarial requests.Trust values are updated by jointly considering the request mode and the auto-scaling status.Then,we aim to disable the condition under which the Yo-Yo attack takes effect by injecting certain delay,under the QoS constraints,to manipulate the response time of suspicious requests and deceive the attackers.Our extensive evaluation demonstrates that our approach achieves promising results,e.g.,it can detect at least 80%Yo-Yo adversarial users and reduce more than 41%malicious scale-ups.
文摘The pressure in liquefied natural gas (LNG) storage tank continues to increase due to the heat transfer from ambient air to low temperature LNG, which raises safety concerns. Accordingly, there is increasing interest to explore the technical approaches capable of recovering Boil-Off Gas (BOG) and even eliminating the ventilation of LNG storage tank. This research numerically analyzed the greenhouse gas emissions of the re-liquefaction of BOG using the following four approaches: 1) a Claude cycle driven by electrical motor with the electricity produced by burning coal;2) a Claude cycle driven by a gas turbine fuelled by BOG released;3) a Claude cycle driven by a SI engine fuelled by gasoline;4) burning nature gas directly released by BOG. The impact of heat transfer coefficient, LNG tank configuration, size, and percentage of LNG stored in tank on the rate of BOG and energy needed for the re-liquefaction of methane vapor were investigated. The greenhouse gas emissions (GGE) was examined and compared. The data presented in this paper provide guideline for the management of pressure development in LNG storage tank.
文摘The consumption of cooling and heating energy and the methods of heating and cooling used in large public buildings are analyzed in this paper. A comparison between initial investment and operation costs of heat pump and traditional heating modes used in large public buildings is also introduced. A life cycle cost (LCC) mathematical model is established to analyze the main factors that affect the LCC including the advantages and disadvantages of heat pumps currently in use. Some suggestions about heating and cooling modes applied in large buildings in different geographical areas are given in this paper.
文摘Established on the Intel Multi-Core Embedded platform, using 802.11 Wireless Network protocols as the communication medium, combining with Radio Frequency-Communication and Ultrasonic Ranging, imple-ment a mobile terminal system in an intellectualized building. It can provide its holder such functions: 1) Accurate Positioning 2) Intelligent Navigation 3) Video Monitoring 4) Wireless Communication. The inno-vative point for this paper is to apply the multi-core computing on the embedded system to promote its com-puting speed and give a real-time performance and apply this system into the indoor environment for the purpose of emergent event or rescuing.
文摘Objective: To investigate whether glucose-6-phosphate isomerase (G6PI) antigen and anti-G6PI antibodies could be applied for the clinical diagnostic markers of rheumatoid arthritis (RA) and its associations with RA activity states. Methods: The levels of G6PI antigens and anti-G6PI Abs in sera from 176 RA patients in different states, 35 non-RA patients and 100 healthy donors and in synovia fluids from 33 patients and 11 non-RA patients were measured by ELISA. Results: The sensitivity and specificity of G6PI antigens in the RA patients were 75.0% and 93.3%, respectively. The levels of serum G6PI antigens in 176 RA patients were significantly higher than non-RA patients and the health controls. Especially, there was a significant difference between the active phase and the inactive phase in G6PI antigens levels. The levels of G6PI antigens in synovia fluid were also significantly higher in RA groups than in non-RA patients. With the values of the anti-G6PI Abs in sera, there were no marked differences among RA, non-RA patients and health controls. Also, there was no significant difference between the active phase and the inactive phase in RA patients. However, there were no significant differences of G6PI and anti-G6PI between RA patients and health controls in synovial fluid. Conclusions: G6PI is highly correlated with the activity states of RA, and could be applied for a clinical biomarker with high sensitivity and specificity for the diagnosis of RA.
基金Young Innovative Talents Project in Regular Institutions of Higher Learning in Guangdong Province(2016KQNCX231).
文摘This study was conducted to investigate and analyze Euphorbiaceae plant resources in Sanling Mountain Forest Park in Zhanjiang City,Guangdong Province.A plant resource development and utilization value evaluation system was established by analytic hierarchy process(AHP)and used to comprehensively evaluate the development and utilization value of Euphorbiaceae plant resources in the area.The results showed that the comprehensive evaluation values of Sapium discolor,Sapium sebiferum,Flueggea virosa,Baccaurea ramiflora,Aleurites moluccana,Antidesma ghaesembilla,Phyllanthus emblica and Pedilanthus tithymaloides were greater than 2.65,performing well;the comprehensive evaluation values of Bridelia tomentosa,Glochidion puberum,Breynia fruticosa,Mallotus paniculatus,Mallotus repandus,Mallotus apelta and Alchornea trewioides were in the range of 1.9622-2.5964,performing ordinary;and the comprehensive evaluation values of Phyllanthus reticulatus,Ricinus communis,Croton crassifolius,and Sebastiania chamaelea were smaller than 1.96,which were relatively lower.S.discolor,S.sebiferum,F.virosa,B.ramiflora,A.moluccana,A.ghaesembilla,P.emblica and P.tithymaloides have great development value and can be developed and used in a planned and step-by-step manner,and Aporosa dioica and Euphorbia tirucalli with a lower comprehensive evaluation value but strong stress resistance and adaptability can be applied to the construction of ecological forests and shelter forests.
