In this study, the effects of particle size distribution （PSD）, chemical composition and pore structure of petroleum coke on the slurryability of petroleum coke water slurry （PCWS） were investigated. Four petroleu...In this study, the effects of particle size distribution （PSD）, chemical composition and pore structure of petroleum coke on the slurryability of petroleum coke water slurry （PCWS） were investigated. Four petroleum cokes were studied, and they showed completely different slurryability. The solid concentration at fixed viscosity （i.e. apparent viscosity of 1000 mPa） （SCFV） of four PCWSs is different from each other, with the highest value of 70.9%, and lowest of 62.1%. The apparent viscosity of the four PCWSs all increased with an increase of the solid concentration. The results showed that the PSD, inherent moisture content, specific surface area and pore volume of petroleum coke were key factors to affect the slurryability. The slurryability was enhanced with increasing PSD range and particle packing fraction, and with decreasing inherent moisture content, specific surface area and pore volume.展开更多
目的:运用网络药理学方法分析荜茇调控铁死亡治疗肺癌的作用机制。方法:通过中药系统药理学数据库与分析平台(traditional Chinese medicine systems pharmacology database and analysis platform,TCMSP)、Genecards数据库获得荜茇活...目的:运用网络药理学方法分析荜茇调控铁死亡治疗肺癌的作用机制。方法:通过中药系统药理学数据库与分析平台(traditional Chinese medicine systems pharmacology database and analysis platform,TCMSP)、Genecards数据库获得荜茇活性成分及相关靶点、肺癌相关疾病靶点并取交集靶点。通过Cytoscape 3.8.0构建“药物-成分-疾病-靶点”网络,分析其作用机制。通过String数据库构建蛋白质互作网络(protein-protein interaction networks,PPI),筛选荜茇治疗肺癌的核心靶点,通过R软件进行基因本体(gene ontology,GO)功能富集分析和京都基因与基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)信号通路富集分析。通过FerrDb数据库检索调控铁死亡的基因,最终分析荜茇活性成分、肺癌和铁死亡三者之间关系。通过肿瘤基因组图谱(the cancer genome atlas,TCGA)数据库分析基因差异表达情况。结果:从TCMSP中获取荜茇有效活性成分15种,靶点158个;从GeneCards数据库获取肺癌相关基因23469个;获得荜茇治疗肺癌的关键靶点68个;从FerrDb数据库获得259个与铁死亡相关的基因;预测得到以IL-6、NOX1、NOX3、PTGS2和G6PD 5个荜茇调控铁死亡治疗肺癌的可能作用靶标,通过分析以上基因在正常与肿瘤组织表达中存在显著差异。结论:荜茇可能通过IL-6、NOX1、NOX3、PTGS2、G6PD 5个基因起到调控铁死亡治疗肺癌的作用。展开更多
基金the financial support from National Key Basic Research Program Project (No. 2010CB227001)
文摘In this study, the effects of particle size distribution （PSD）, chemical composition and pore structure of petroleum coke on the slurryability of petroleum coke water slurry （PCWS） were investigated. Four petroleum cokes were studied, and they showed completely different slurryability. The solid concentration at fixed viscosity （i.e. apparent viscosity of 1000 mPa） （SCFV） of four PCWSs is different from each other, with the highest value of 70.9%, and lowest of 62.1%. The apparent viscosity of the four PCWSs all increased with an increase of the solid concentration. The results showed that the PSD, inherent moisture content, specific surface area and pore volume of petroleum coke were key factors to affect the slurryability. The slurryability was enhanced with increasing PSD range and particle packing fraction, and with decreasing inherent moisture content, specific surface area and pore volume.
文摘目的:运用网络药理学方法分析荜茇调控铁死亡治疗肺癌的作用机制。方法:通过中药系统药理学数据库与分析平台(traditional Chinese medicine systems pharmacology database and analysis platform,TCMSP)、Genecards数据库获得荜茇活性成分及相关靶点、肺癌相关疾病靶点并取交集靶点。通过Cytoscape 3.8.0构建“药物-成分-疾病-靶点”网络,分析其作用机制。通过String数据库构建蛋白质互作网络(protein-protein interaction networks,PPI),筛选荜茇治疗肺癌的核心靶点,通过R软件进行基因本体(gene ontology,GO)功能富集分析和京都基因与基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)信号通路富集分析。通过FerrDb数据库检索调控铁死亡的基因,最终分析荜茇活性成分、肺癌和铁死亡三者之间关系。通过肿瘤基因组图谱(the cancer genome atlas,TCGA)数据库分析基因差异表达情况。结果:从TCMSP中获取荜茇有效活性成分15种,靶点158个;从GeneCards数据库获取肺癌相关基因23469个;获得荜茇治疗肺癌的关键靶点68个;从FerrDb数据库获得259个与铁死亡相关的基因;预测得到以IL-6、NOX1、NOX3、PTGS2和G6PD 5个荜茇调控铁死亡治疗肺癌的可能作用靶标,通过分析以上基因在正常与肿瘤组织表达中存在显著差异。结论:荜茇可能通过IL-6、NOX1、NOX3、PTGS2、G6PD 5个基因起到调控铁死亡治疗肺癌的作用。
