The overall structure of live pig supply chain was constructed based on theoretical study and practical investigation, and the performance evaluation sys- tem for supply chain was studied from two perspectives of time...The overall structure of live pig supply chain was constructed based on theoretical study and practical investigation, and the performance evaluation sys- tem for supply chain was studied from two perspectives of time and space and balanced score card （BSC）. From the space perspective and BSC, the performance evaluation system composed of four primary indicators （financial dimension, customer dimension, internal business dimension and innovation/learning perspective） and 26 secondary indicators. From the time perspective and BSC, the system could be divided into four stages, including formation stage, development stage, matu- rity stage and recession stage, with a total of 30 indicators.展开更多
文摘目的:采用网络药理学方法对川芎治疗心力衰竭的机制进行分析,为深入研究川芎在心力衰竭方面的作用奠定基础。方法:根据Therapeutic Target Database(TTD)、Online Mendelian Inheritance in Man(OMIM)、中药系统药理学数据库(TCMSP)检索关于心力衰竭的靶点,在中医药综合数据库(Symmap)中搜索关于心力衰竭胸胁刺痛症状的靶点,并结合Uniprot数据库剔除非人源靶点,获得心力衰竭及胸胁刺痛症状的人源靶点,并与Symmap查询的川芎OB值≥30化学成分所对应的人源靶点进行映射,进一步筛选活性成分。利用String数据库和Cytoscape 3.2.1软件将得到的川芎治疗心力衰竭的靶点构造PPI网络分析,采用The Database for Annotation,Visualization and Integrated Discovery(DAVID)数据库进行通路分析,并通过Cytoscape 3.2.1软件构建中药-靶点-成分网络图。结果:得到川芎治疗心力衰竭的靶点共12个,心力衰竭胸胁刺痛的靶点1个,川芎治疗心力衰竭对应的化学成分47个,12个靶点应用DAVID数据库进行KEGG通路分析,得到川芎治疗心力衰竭相关通路29个。结论:川芎通过抑制炎性反应、调控细胞凋亡、改善血管收缩功能等来改善心功能,治疗心力衰竭。
基金Supported by National Natural Science Funds(71462020)Humanities and Social Science Fund Project of Ministry of Education(12YJC630050)+3 种基金Soft Science Bidding Subject of Ministry of Agriculture(20140203)Soft Science Fund Project of Jiangxi Province(20141BBA10065)Science and Technology Project of Education Department of Jiangxi Province(GJJ13727)Humanities and Social Science Fund Project of Jiangxi Province(14GL06)
文摘The overall structure of live pig supply chain was constructed based on theoretical study and practical investigation, and the performance evaluation sys- tem for supply chain was studied from two perspectives of time and space and balanced score card （BSC）. From the space perspective and BSC, the performance evaluation system composed of four primary indicators （financial dimension, customer dimension, internal business dimension and innovation/learning perspective） and 26 secondary indicators. From the time perspective and BSC, the system could be divided into four stages, including formation stage, development stage, matu- rity stage and recession stage, with a total of 30 indicators.
