Connectome mapping studies have documented a principal primary-to-transmodal gradient in the adult brain network,capturing a functional spectrum that ranges from perception and action to abstract cognition.However,how...Connectome mapping studies have documented a principal primary-to-transmodal gradient in the adult brain network,capturing a functional spectrum that ranges from perception and action to abstract cognition.However,how this gradient pattern develops and whether its development is linked to cognitive growth,topological reorganization,and gene expression profiles remain largely unknown.Using longitudinal resting-state functional magnetic resonance imaging data from 305 children(aged 6-14 years),we describe substantial changes in the primary-to-transmodal gradient between childhood and adolescence,including emergence as the principal gradient,expansion of global topography,and focal tuning in primary and default-mode regions.These gradient changes are mediated by developmental changes in network integration and segregation,and are associated with abstract processing functions such as working memory and expression levels of calcium ion regulated exocytosis and synaptic transmission-related genes.Our findings have implications for understanding connectome maturation principles in normal development and developmental disorders.展开更多
In this study, we aimed to （1） identify white matter （WM） deficits underlying the consciousness level in patients with disorders of consciousness （DOCs） using diffusion tensor imaging （DTI）, and （2） evaluate...In this study, we aimed to （1） identify white matter （WM） deficits underlying the consciousness level in patients with disorders of consciousness （DOCs） using diffusion tensor imaging （DTI）, and （2） evaluate the relationship between DTI metrics and clinical measures of the consciousness level in DOC patients. With a cohort of 8 comatose, 8 unresponsive wakefulness syndrome/ vegetative state, and 14 minimally conscious state patients and 25 patient controls, we performed group comparisons of the DTI metrics in 48 core WM regions of interest （ROIs）, and examined the clinical relevance using correlation analysis. We identified multiple abnormal WM ROIs in DOC patients compared with normal controls, and the DTI metrics in these ROIs were significantly correlated with clinical measures of the consciousness level. Therefore, our findings suggested that multiple WM tracts are involved in the impaired consciousness levels in DOC patients and demonstrated the clinical relevance of DTI for DOC patients.展开更多
Background Disruptive behaviors,including agitation,disinhibition,irritability,and aberrant motor behaviors,are commonly observed in patients with Alzheimer’s disease(AD).However,the neuroanatomical basis of these di...Background Disruptive behaviors,including agitation,disinhibition,irritability,and aberrant motor behaviors,are commonly observed in patients with Alzheimer’s disease(AD).However,the neuroanatomical basis of these disruptive behaviors is not fully understood.Objective To confirm the differences in cortical thickness and surface area between AD patients and healthy controls and to further investigate the features of cortical thickness and surface area associated with disruptive behaviors in patients with AD.Methods One hundred seventy-four participants(125 AD patients and 49 healthy controls)were recruited frommemory clinics at the Peking University Institute of Sixth Hospital.Disruptive behaviors,including agitation/aggression,disinhibition,irritability/lability,and aberrant motor activity subdomain scores,were evaluated using the Neuropsychiatry Inventory.Both whole-brain vertex-based and region-of-interest-based cortical thickness and surface area analyses were automatically conducted with the CIVET pipeline based on structural magnetic resonance images.Both group-based statistical comparisons and brain-behavior association analyses were performed using general linear models,with age,sex,and education level as covariables.Results Compared with healthy controls,the AD patients exhibited widespread reduced cortical thickness,with the most significant thinning located in the medial and lateral temporal and parietal cortex,and smaller surface areas in the left fusiform and left inferior temporal gyrus.High total scores of disruptive behaviors were significantly associated with cortical thinning in several regions that are involved in sensorimotor processing,language,and expression functions.The total score of disruptive behaviors did not show significant associations with surface areas.ConclusionWe highlight that disruptive behaviors in patientswith AD are selectively associated with cortical thickness abnormalities in sensory,motor,and language regions,which provides insights into neuroanatomical substrates underlying disruptive behaviors.These findings could lead to sensory,motor,and communication interventions for alleviating disruptive behaviors in patients with AD.展开更多
基金supported by the National Natural Science Foundation of China(31830034,82021004,81620108016,31221003,31521063,81671767,82071998,81971690,32130045,and 61761166004)Changjiang Scholar Professorship Award(T2015027)+3 种基金the National Key Research and Development Project of China(2018YFA0701402)Beijing Nova Program(Z191100001119023)the Beijing Brain Initiative of Beijing Municipal Science&Technology Commission(Z181100001518003)the Fundamental Research Funds for the Central Universities(2020NTST29)。
文摘Connectome mapping studies have documented a principal primary-to-transmodal gradient in the adult brain network,capturing a functional spectrum that ranges from perception and action to abstract cognition.However,how this gradient pattern develops and whether its development is linked to cognitive growth,topological reorganization,and gene expression profiles remain largely unknown.Using longitudinal resting-state functional magnetic resonance imaging data from 305 children(aged 6-14 years),we describe substantial changes in the primary-to-transmodal gradient between childhood and adolescence,including emergence as the principal gradient,expansion of global topography,and focal tuning in primary and default-mode regions.These gradient changes are mediated by developmental changes in network integration and segregation,and are associated with abstract processing functions such as working memory and expression levels of calcium ion regulated exocytosis and synaptic transmission-related genes.Our findings have implications for understanding connectome maturation principles in normal development and developmental disorders.
基金supported by the Natural Science Foundation of China (81571025)International Cooperation Project from Shanghai Science Foundation (18410711300)+13 种基金the National Science Foundation for Distinguished Young Scholars of China (81025013)National Basic Research Development Program (973 Program) of China (2012CB720700, 2010CB945500, 2012CB966300, and 2009CB941100)the National Natural Science Foundation of China (81322021)the Beijing Nova Program (Z121110002512032)the Project for National 985 Engineering of China (985III-YFX0102)the ‘‘Dawn Tracking’’ Program of Shanghai Education Commission (10GG01)the Shanghai Natural Science Foundation (08411952000 and 10ZR1405400)the National Natural Science Young Foundation in China (81201033)the grants of Shanghai Health Bureau (20114358)the National High-Technology Development Project (863 Project) of China (2015AA020501)the Program for New Century Excellent Talents in University of China (NCET-10-0356)the National Program for the Support of TopNotch Young Professionalssupported by the Michael Smith Foundation, the CRC, and the CIHRsupported by the China Scholarship Council
文摘In this study, we aimed to （1） identify white matter （WM） deficits underlying the consciousness level in patients with disorders of consciousness （DOCs） using diffusion tensor imaging （DTI）, and （2） evaluate the relationship between DTI metrics and clinical measures of the consciousness level in DOC patients. With a cohort of 8 comatose, 8 unresponsive wakefulness syndrome/ vegetative state, and 14 minimally conscious state patients and 25 patient controls, we performed group comparisons of the DTI metrics in 48 core WM regions of interest （ROIs）, and examined the clinical relevance using correlation analysis. We identified multiple abnormal WM ROIs in DOC patients compared with normal controls, and the DTI metrics in these ROIs were significantly correlated with clinical measures of the consciousness level. Therefore, our findings suggested that multiple WM tracts are involved in the impaired consciousness levels in DOC patients and demonstrated the clinical relevance of DTI for DOC patients.
基金This study is supported by the China High School Science Talent Program,which is jointly organized by China Association for Science&Technology(CAST)and Ministry of Education of the People’s Republic of China。
文摘Background Disruptive behaviors,including agitation,disinhibition,irritability,and aberrant motor behaviors,are commonly observed in patients with Alzheimer’s disease(AD).However,the neuroanatomical basis of these disruptive behaviors is not fully understood.Objective To confirm the differences in cortical thickness and surface area between AD patients and healthy controls and to further investigate the features of cortical thickness and surface area associated with disruptive behaviors in patients with AD.Methods One hundred seventy-four participants(125 AD patients and 49 healthy controls)were recruited frommemory clinics at the Peking University Institute of Sixth Hospital.Disruptive behaviors,including agitation/aggression,disinhibition,irritability/lability,and aberrant motor activity subdomain scores,were evaluated using the Neuropsychiatry Inventory.Both whole-brain vertex-based and region-of-interest-based cortical thickness and surface area analyses were automatically conducted with the CIVET pipeline based on structural magnetic resonance images.Both group-based statistical comparisons and brain-behavior association analyses were performed using general linear models,with age,sex,and education level as covariables.Results Compared with healthy controls,the AD patients exhibited widespread reduced cortical thickness,with the most significant thinning located in the medial and lateral temporal and parietal cortex,and smaller surface areas in the left fusiform and left inferior temporal gyrus.High total scores of disruptive behaviors were significantly associated with cortical thinning in several regions that are involved in sensorimotor processing,language,and expression functions.The total score of disruptive behaviors did not show significant associations with surface areas.ConclusionWe highlight that disruptive behaviors in patientswith AD are selectively associated with cortical thickness abnormalities in sensory,motor,and language regions,which provides insights into neuroanatomical substrates underlying disruptive behaviors.These findings could lead to sensory,motor,and communication interventions for alleviating disruptive behaviors in patients with AD.
