Nonalcoholic fatty liver disease(NAFLD)is the most prevalent type of chronic liver disease.However,the disease is underappreciated as a remarkable chronic disorder as there are rare managing strategies.Several studies...Nonalcoholic fatty liver disease(NAFLD)is the most prevalent type of chronic liver disease.However,the disease is underappreciated as a remarkable chronic disorder as there are rare managing strategies.Several studies have focused on determining NAFLD-caused hepatocyte death to elucidate the disease pathoe-tiology and suggest functional therapeutic and diagnostic options.Pyroptosis,ferroptosis,and necroptosis are the main subtypes of non-apoptotic regulated cell deaths(RCDs),each of which represents particular characteristics.Considering the complexity of the findings,the present study aimed to review these types of RCDs and their contribution to NAFLD progression,and subsequently discuss in detail the role of necroptosis in the pathoetiology,diagnosis,and treatment of the disease.The study revealed that necroptosis is involved in the occurrence of NAFLD and its progression towards steatohepatitis and cancer,hence it has potential in diagnostic and therapeutic approaches.Nevertheless,further studies are necessary.展开更多
Objective:To determine whether adjuvant chemotherapy improves the prognoses in women with stage IC1 epithelial ovarian cancer(EOC).Methods:All eligible women diagnosed with stage IC1 EOC from 2003 to 2019 in Tongji Ho...Objective:To determine whether adjuvant chemotherapy improves the prognoses in women with stage IC1 epithelial ovarian cancer(EOC).Methods:All eligible women diagnosed with stage IC1 EOC from 2003 to 2019 in Tongji Hospital were included.Patient characteristics,tumor features,surgical types,and chemotherapeutic treatments were collected.Kaplan-Meier analysis and Cox regression analysis were performed to evaluate progression-free survival(PFS)and overall survival(OS).展开更多
To investigate whether sperm with low concentration and motility can impact preimplantation embryos and to analyze how the effects present under a time-lapse incubation system,2905 oocytes were collected from 219 coup...To investigate whether sperm with low concentration and motility can impact preimplantation embryos and to analyze how the effects present under a time-lapse incubation system,2905 oocytes were collected from 219 couples between January 2014 and December 2015.Patients were divided into three groups according to sperm quality.Morphokinetic parameters and six cleavage patterns in the initial three cleavages were evaluated using the Primo Vision system.Embryo quality and clinic outcomes such as implantation rate,pregnancy rate and live birth rate were measured.The results showed that the concentration and motility of sperm correlated strongly with the rate of 2PN embryos,good-quality embryos on D3,blastocysts on D5/6 and good quality embryos on D5/6.The time-lapse system recordings showed that compromised sperm quality could result in a significant delay in cc l and a decrease in cc2,and impact embryo developmental potential mainly through large fragments or/and blastomere fragmentation in the initial three cleavages.In conclusion,sperm with low concentration and motility can have paternal effects on preimplantation embryos.These paternal effects present both as changes in morphokinetic parameters and cleavage patterns,which occur as early as fertilization and may cause severe damage to the preimplantation embryos.展开更多
Smaller mesoscale eddies(SMEs)have an important effect on the transmission of ocean temperatures,salinity,energy,and marine biochemical processes.However,traditional altimeters,the dominant sensors used to identify an...Smaller mesoscale eddies(SMEs)have an important effect on the transmission of ocean temperatures,salinity,energy,and marine biochemical processes.However,traditional altimeters,the dominant sensors used to identify and track eddies,have made it challenging to observe SMEs accurately due to resolution limitations.Eddies drive local upwelling or downwelling,leaving signatures on sea surface temperatures(SSTs)and chlorophyll concentrations(Chls).SST can be observed by spaceborne infrared sensors,and Chl can be measured by ocean color remote sensing.Therefore,multisatellite observations provide an opportunity to obtain information to characterize SMEs.In this paper,an eddy detection algorithm based on SST and Chl images is proposed,which identifies eddies by characterizing the spatial and temporal distribution of SST and Chl data.The algorithm is applied to characterize and analyze SMEs in the Kuroshio Extension.Statistical results on their distribution and seasonal variability are shown,and the formation processes are preliminarily discussed.SMEs generation may be contributed by horizontal strain instability,the interaction of topographic obstacles and currents,and wind stress curl.展开更多
For the sake of mine water drainage and sustainable groundwater protection,the new approach of mine water deep geological storage(MWDGS)is highly necessary to save water resources in the semi-arid region of China.Howe...For the sake of mine water drainage and sustainable groundwater protection,the new approach of mine water deep geological storage(MWDGS)is highly necessary to save water resources in the semi-arid region of China.However,up to now,little academic research has been done on mine water geological storage.Given this situation,the hydrogeological feasibility of MWDGS was explored in Baotashan coarse sandstone(BCS)of Jurassic measure in Ordos Basin.The results show that the white-gray BCS with a fragile skeleton of quartz(41.4%),feldspar(21.1%),and clay minerals(16.4%)provides the potential variable-void for mine water;and its hydro-chemical type of BCS aquifer is CO_(3)-Na and Cl-Na.As the burial depth increases,the strong alkaline groundwater is in stagnant and poor recharge-runoff-discharge condition.The lab test shows that the pores whose diameter is over 10μm could be treated as the main storage of mine water;and the effective porosity varies from 1.36%to 3.46%.When mine water is injected,the strong hydrodynamics of mine water storage would change the permeability significantly and about 0.201%soluble solids would be dissolved.Partial clay minerals obstruct the pores and induce the saturated phase of high permeability to evolve into steady phase of lower permeability.Under the condition of nonhydraulic fracturing during continuous storage,the heterogeneous anisotropic medium obtained by Transition PRObability GeoStatistics(TPROGS)shows that the capacity of BCS aquifer is 0.455 to 1.226Mm^(3)for 1 km^(2)in the study area.The simulation shows that the groundwater mound in well-scale and mine-scale would be formed.The groundwater quality characteristics of“Three Zone”would occur around and gradually drop to approximate the original brine within 10 years.The hydrogeological feasibility reveals that this approach is useful for the well design and groundwater environment management during the mine water deep geological storage project in the Ordos basin.展开更多
Mooring arrays have been widely deployed in sustained ocean observation in high resolution to measure finer dynamic features of marine phenomena.However,the irregular posture changes and nonlinear response of moorings...Mooring arrays have been widely deployed in sustained ocean observation in high resolution to measure finer dynamic features of marine phenomena.However,the irregular posture changes and nonlinear response of moorings under the effect of ocean currents face huge challenges for the deployment of mooring arrays,which may cause the deviations of measurements and yield a vacuum of observation in the upper ocean.We developed a data-driven mooring simulation model based on LSTM(long short-term memory)neural network,coupling the ocean current with position data from moorings to predict the motion of moorings,including single-step output prediction and multi-step prediction.Based on the predictive information,the formation of the mooring array can be adjusted to improve the accuracy and integrity of measurements.Moreover,we proposed the cuckoo search(CS)optimization algorithm to tune the parameters of LSTM,which improves the robustness and generalization of the model.We utilize the datasets observed from moorings anchored in the Kuroshio Extension region to train and validate the simulation model.The experimental results demonstrate that the model can remarkably improve prediction accuracy and yield stable performance.Moreover,compared with other optimization algorithms,CS is more efficient and performs better in simulating the motion of moorings.展开更多
Formaldehyde(HCHO)has been identified as one of the most common indoor pollutions nowadays.Manganese oxides(MnO_(x))are considered to be a promising catalytic material used in indoor HCHO oxidation removal due to thei...Formaldehyde(HCHO)has been identified as one of the most common indoor pollutions nowadays.Manganese oxides(MnO_(x))are considered to be a promising catalytic material used in indoor HCHO oxidation removal due to their high catalytic activity,low-cost,and environmentally friendly.In this paper,the progress in developing MnO_(x)-based catalysts for HCHO removal is comprehensively reviewed for exploring the mechanisms of catalytic oxidation and catalytic deactivation.The catalytic oxidation mechanisms based on three typical theory models(Mars-van-Krevelen,Eley-Rideal and Langmuir-Hinshelwood)are discussed and summarized.Furthermore,the research status of catalytic deactivation,catalysts’regeneration and integrated application of MnO_(x)-based catalysts for indoor HCHO removal are detailed in the review.Finally,the technical challenges in developing MnO_(x)-based catalysts for indoor HCHO removal are analyzed and the possible research direction is also proposed for overcoming the challenges toward practical application of such catalysts.展开更多
Rice yield stability is a breeding goal,particularly for short-growth duration rice,but its underlying mechanisms remain unclear.In an attempt to identify the relationship between yield stability and source–sink char...Rice yield stability is a breeding goal,particularly for short-growth duration rice,but its underlying mechanisms remain unclear.In an attempt to identify the relationship between yield stability and source–sink characteristics in short-growth duration rice,a field experiment was conducted at three sites(Yueyang,Liuyang,and Hengyang)in 2021 and 2022.This study compared yield,yield components,source–sink characteristics,and their stability between two stable-yielding short-growth duration rice cultivars,Zhongzao 39(Z-39)and Lingliangyou 268(L-268),and two unstable-yielding short-growth duration rice cultivars,Zhongjiazao 17(Z-17)and Zhuliangyou 819(Z-819).The stability of agronomic parameters was represented by the coefficient of variation(CV).The respective CVs of yield in Z-17,Z-819,Z-39,and L-268 were 10.2%,10.1%,4.5%,and 5.7%in 2021 and 19.7%,15.0%,5.4%,and 6.5%in 2022.The respective CVs of grain weight were 6.3%,5.7%,3.4%,and 4.5%in Z-17,Z-819,Z-39,and L-268 in 2021,and 8.1%,6.3%,1.5%,and 0.8%in 2022.The mean source capacity per spikelet and pre-heading non-structural carbohydrate reserves per spikelet(NSC_(pre))were 7%–43%and7%–72%lower in Z-819 and Z-17than in L-268 and Z-39 in 2021 and 2022.The mean quantum yield of photosystem II photochemistry of leaf,leaf area index,and specific leaf weight of L-268 and Z-39 were higher than those of Z-819 and Z-17 at the heading stage.This study suggests that high NSC_(pre),caused by great leaf traits before heading,increases source capacity per spikelet and its stability,thereby increasing the stability of grain weight and yield.Increasing NSC_(pre)is critical for achieving grain weight and yield stability in short-growth duration rice.展开更多
Weeds occurred during the fallow season can well perform the function of carbon(C)capture due to receiving little human disturbance.This study aimed to evaluate the C capture potential of fallow weeds in rice(Oryza sa...Weeds occurred during the fallow season can well perform the function of carbon(C)capture due to receiving little human disturbance.This study aimed to evaluate the C capture potential of fallow weeds in rice(Oryza sativa L.)cropping systems.A six-region,two-year on-farm investigation and a three-year tillage experiment were conducted to estimate C capture in fallow weeds in rice cropping systems.The on-farm investigation showed that the average mean C capture by fallow weeds across six regions and two years reached 112 g m^(-2).The tillage experiment indicated that no-tillage practices increased C capture by fallow weeds by 80%on average as compared with conventional tillage.The results of this study not only contribute to an understanding of C capture potential of fallow weeds in rice cropping systems,but also provide a reference for including fallow weeds in the estimation of vegetative C sink.展开更多
基金supported by the International Research Center of Big Data for Sustainable Development Goals [grant number CBAS2022GSP01]the National Natural Science Foundation of China [grant numbers 42276203 and 42030406]+1 种基金the Natural Science Foundation of Shandong Province [grant number ZR2021MD001]the Laoshan Laboratory [grant number LSKJ202204302].
文摘Nonalcoholic fatty liver disease(NAFLD)is the most prevalent type of chronic liver disease.However,the disease is underappreciated as a remarkable chronic disorder as there are rare managing strategies.Several studies have focused on determining NAFLD-caused hepatocyte death to elucidate the disease pathoe-tiology and suggest functional therapeutic and diagnostic options.Pyroptosis,ferroptosis,and necroptosis are the main subtypes of non-apoptotic regulated cell deaths(RCDs),each of which represents particular characteristics.Considering the complexity of the findings,the present study aimed to review these types of RCDs and their contribution to NAFLD progression,and subsequently discuss in detail the role of necroptosis in the pathoetiology,diagnosis,and treatment of the disease.The study revealed that necroptosis is involved in the occurrence of NAFLD and its progression towards steatohepatitis and cancer,hence it has potential in diagnostic and therapeutic approaches.Nevertheless,further studies are necessary.
基金This study was supported by grants from the National Key Technology R&D Program of China(No.2019YFC1005200,No.2019YFC1005202 and2018YFC1002103)。
文摘Objective:To determine whether adjuvant chemotherapy improves the prognoses in women with stage IC1 epithelial ovarian cancer(EOC).Methods:All eligible women diagnosed with stage IC1 EOC from 2003 to 2019 in Tongji Hospital were included.Patient characteristics,tumor features,surgical types,and chemotherapeutic treatments were collected.Kaplan-Meier analysis and Cox regression analysis were performed to evaluate progression-free survival(PFS)and overall survival(OS).
基金This work was supported by grants from the National Key Technology R&D Program of China(No.2019YFC1005200,No.2019YFC1005202,and No.2018YFC1002103)Hubei Province Health and Family Planning Scientific Research Project of China(No.WJ2019M127).
文摘To investigate whether sperm with low concentration and motility can impact preimplantation embryos and to analyze how the effects present under a time-lapse incubation system,2905 oocytes were collected from 219 couples between January 2014 and December 2015.Patients were divided into three groups according to sperm quality.Morphokinetic parameters and six cleavage patterns in the initial three cleavages were evaluated using the Primo Vision system.Embryo quality and clinic outcomes such as implantation rate,pregnancy rate and live birth rate were measured.The results showed that the concentration and motility of sperm correlated strongly with the rate of 2PN embryos,good-quality embryos on D3,blastocysts on D5/6 and good quality embryos on D5/6.The time-lapse system recordings showed that compromised sperm quality could result in a significant delay in cc l and a decrease in cc2,and impact embryo developmental potential mainly through large fragments or/and blastomere fragmentation in the initial three cleavages.In conclusion,sperm with low concentration and motility can have paternal effects on preimplantation embryos.These paternal effects present both as changes in morphokinetic parameters and cleavage patterns,which occur as early as fertilization and may cause severe damage to the preimplantation embryos.
基金The Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology(Qingdao)under contract Nos 2022QNLM050301-4 and 2021WHZZB1705the National Natural Science Foundation of China under contract Nos 41527901 and 42030406the National Key R&D Program of China under contract No.2019YFD0901001。
文摘Smaller mesoscale eddies(SMEs)have an important effect on the transmission of ocean temperatures,salinity,energy,and marine biochemical processes.However,traditional altimeters,the dominant sensors used to identify and track eddies,have made it challenging to observe SMEs accurately due to resolution limitations.Eddies drive local upwelling or downwelling,leaving signatures on sea surface temperatures(SSTs)and chlorophyll concentrations(Chls).SST can be observed by spaceborne infrared sensors,and Chl can be measured by ocean color remote sensing.Therefore,multisatellite observations provide an opportunity to obtain information to characterize SMEs.In this paper,an eddy detection algorithm based on SST and Chl images is proposed,which identifies eddies by characterizing the spatial and temporal distribution of SST and Chl data.The algorithm is applied to characterize and analyze SMEs in the Kuroshio Extension.Statistical results on their distribution and seasonal variability are shown,and the formation processes are preliminarily discussed.SMEs generation may be contributed by horizontal strain instability,the interaction of topographic obstacles and currents,and wind stress curl.
基金Fundamental Research Funds for the Universities,Grant/Award Numbers:2020ZDPY0201,2022QN1061National Key Research and Development Project of China,Grant/Award Number:2019YFC1805400+1 种基金National Science Foundation of Jiangsu Province,Grant/Award Number:BK20210524National Natural Science Foundation,Grant/Award Number:42202268。
文摘For the sake of mine water drainage and sustainable groundwater protection,the new approach of mine water deep geological storage(MWDGS)is highly necessary to save water resources in the semi-arid region of China.However,up to now,little academic research has been done on mine water geological storage.Given this situation,the hydrogeological feasibility of MWDGS was explored in Baotashan coarse sandstone(BCS)of Jurassic measure in Ordos Basin.The results show that the white-gray BCS with a fragile skeleton of quartz(41.4%),feldspar(21.1%),and clay minerals(16.4%)provides the potential variable-void for mine water;and its hydro-chemical type of BCS aquifer is CO_(3)-Na and Cl-Na.As the burial depth increases,the strong alkaline groundwater is in stagnant and poor recharge-runoff-discharge condition.The lab test shows that the pores whose diameter is over 10μm could be treated as the main storage of mine water;and the effective porosity varies from 1.36%to 3.46%.When mine water is injected,the strong hydrodynamics of mine water storage would change the permeability significantly and about 0.201%soluble solids would be dissolved.Partial clay minerals obstruct the pores and induce the saturated phase of high permeability to evolve into steady phase of lower permeability.Under the condition of nonhydraulic fracturing during continuous storage,the heterogeneous anisotropic medium obtained by Transition PRObability GeoStatistics(TPROGS)shows that the capacity of BCS aquifer is 0.455 to 1.226Mm^(3)for 1 km^(2)in the study area.The simulation shows that the groundwater mound in well-scale and mine-scale would be formed.The groundwater quality characteristics of“Three Zone”would occur around and gradually drop to approximate the original brine within 10 years.The hydrogeological feasibility reveals that this approach is useful for the well design and groundwater environment management during the mine water deep geological storage project in the Ordos basin.
基金Supported by the Laoshan Laboratory (Nos.LSKJ202201302-5,LSKJ202201405-1,LSKJ202204304)。
文摘Mooring arrays have been widely deployed in sustained ocean observation in high resolution to measure finer dynamic features of marine phenomena.However,the irregular posture changes and nonlinear response of moorings under the effect of ocean currents face huge challenges for the deployment of mooring arrays,which may cause the deviations of measurements and yield a vacuum of observation in the upper ocean.We developed a data-driven mooring simulation model based on LSTM(long short-term memory)neural network,coupling the ocean current with position data from moorings to predict the motion of moorings,including single-step output prediction and multi-step prediction.Based on the predictive information,the formation of the mooring array can be adjusted to improve the accuracy and integrity of measurements.Moreover,we proposed the cuckoo search(CS)optimization algorithm to tune the parameters of LSTM,which improves the robustness and generalization of the model.We utilize the datasets observed from moorings anchored in the Kuroshio Extension region to train and validate the simulation model.The experimental results demonstrate that the model can remarkably improve prediction accuracy and yield stable performance.Moreover,compared with other optimization algorithms,CS is more efficient and performs better in simulating the motion of moorings.
基金the National Natural Science Foundation of China (NSFC,52070006)BeijingNova Program of Science and Technology (Z191100001119116).
文摘Formaldehyde(HCHO)has been identified as one of the most common indoor pollutions nowadays.Manganese oxides(MnO_(x))are considered to be a promising catalytic material used in indoor HCHO oxidation removal due to their high catalytic activity,low-cost,and environmentally friendly.In this paper,the progress in developing MnO_(x)-based catalysts for HCHO removal is comprehensively reviewed for exploring the mechanisms of catalytic oxidation and catalytic deactivation.The catalytic oxidation mechanisms based on three typical theory models(Mars-van-Krevelen,Eley-Rideal and Langmuir-Hinshelwood)are discussed and summarized.Furthermore,the research status of catalytic deactivation,catalysts’regeneration and integrated application of MnO_(x)-based catalysts for indoor HCHO removal are detailed in the review.Finally,the technical challenges in developing MnO_(x)-based catalysts for indoor HCHO removal are analyzed and the possible research direction is also proposed for overcoming the challenges toward practical application of such catalysts.
基金the National Natural Science Foundation of China(32001470)the Scientific Research Fund of Hunan Provincial Education Department(21B0184)The Science and Technology Innovation Program of Hunan province(2021RC3088).
文摘Rice yield stability is a breeding goal,particularly for short-growth duration rice,but its underlying mechanisms remain unclear.In an attempt to identify the relationship between yield stability and source–sink characteristics in short-growth duration rice,a field experiment was conducted at three sites(Yueyang,Liuyang,and Hengyang)in 2021 and 2022.This study compared yield,yield components,source–sink characteristics,and their stability between two stable-yielding short-growth duration rice cultivars,Zhongzao 39(Z-39)and Lingliangyou 268(L-268),and two unstable-yielding short-growth duration rice cultivars,Zhongjiazao 17(Z-17)and Zhuliangyou 819(Z-819).The stability of agronomic parameters was represented by the coefficient of variation(CV).The respective CVs of yield in Z-17,Z-819,Z-39,and L-268 were 10.2%,10.1%,4.5%,and 5.7%in 2021 and 19.7%,15.0%,5.4%,and 6.5%in 2022.The respective CVs of grain weight were 6.3%,5.7%,3.4%,and 4.5%in Z-17,Z-819,Z-39,and L-268 in 2021,and 8.1%,6.3%,1.5%,and 0.8%in 2022.The mean source capacity per spikelet and pre-heading non-structural carbohydrate reserves per spikelet(NSC_(pre))were 7%–43%and7%–72%lower in Z-819 and Z-17than in L-268 and Z-39 in 2021 and 2022.The mean quantum yield of photosystem II photochemistry of leaf,leaf area index,and specific leaf weight of L-268 and Z-39 were higher than those of Z-819 and Z-17 at the heading stage.This study suggests that high NSC_(pre),caused by great leaf traits before heading,increases source capacity per spikelet and its stability,thereby increasing the stability of grain weight and yield.Increasing NSC_(pre)is critical for achieving grain weight and yield stability in short-growth duration rice.
基金supported by the National Key R&D Program of China(2017YFD0301503).
文摘Weeds occurred during the fallow season can well perform the function of carbon(C)capture due to receiving little human disturbance.This study aimed to evaluate the C capture potential of fallow weeds in rice(Oryza sativa L.)cropping systems.A six-region,two-year on-farm investigation and a three-year tillage experiment were conducted to estimate C capture in fallow weeds in rice cropping systems.The on-farm investigation showed that the average mean C capture by fallow weeds across six regions and two years reached 112 g m^(-2).The tillage experiment indicated that no-tillage practices increased C capture by fallow weeds by 80%on average as compared with conventional tillage.The results of this study not only contribute to an understanding of C capture potential of fallow weeds in rice cropping systems,but also provide a reference for including fallow weeds in the estimation of vegetative C sink.
