Four heavyweight guests in the field of public health gathered together.No-bel Laureate Jules A Hoffmann,Academician George Fu Gao,Professor Chris Walzer and Professor Jiahai Lu discussed how to deal with global publi...Four heavyweight guests in the field of public health gathered together.No-bel Laureate Jules A Hoffmann,Academician George Fu Gao,Professor Chris Walzer and Professor Jiahai Lu discussed how to deal with global public health crises,such as the recent coronavirus disease 2019(COVID-19)pandemic,as well as the role of international organizations.The concept of“One Health”emerged as the latest approach to disease prevention and control.This concept emphasizes the intertwined health of humans,animals and the environment.The experts shared their thoughts and insights on how humanity can address emerging global public health crises through international cooperation.展开更多
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)continues to pose a significant threat to the world,as it continually evolves and gives rise to multiple variants and sub-variants.Recently,the Omicron EG.5 l...Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)continues to pose a significant threat to the world,as it continually evolves and gives rise to multiple variants and sub-variants.Recently,the Omicron EG.5 linage,which was first detected in Indonesia on 17 February 2023,has raised concerns due to its increased prevalence and extended immune escape properties,according to the risk analysis by the World Health Organization(WHO)[1].As of 3 October 2023,EG.5 and its sub-linages have been reported in 83 countries with shared 49,008 genome sequences in GISAID database(https://gisaid.org/hcov19-variants/).EG.5 has become the dominant strain in the United States according to Centers for Disease Control and Prevention(CDC),accounting for 29.4%of SARS-CoV-2 infections(https://covid.cdc.gov/covid-data-tracker/#variant-proportions).展开更多
Respiratory syncytial virus(RSV)is one of the leading pathogens that cause lower respiratory tract infections in infants and the elderly.Passive immunoprophylaxis with monoclonal antibody(mAb)has been approved to prev...Respiratory syncytial virus(RSV)is one of the leading pathogens that cause lower respiratory tract infections in infants and the elderly.Passive immunoprophylaxis with monoclonal antibody(mAb)has been approved to prevent morbidity and mortality from RSV infection in infants.Here we report the isolation of two neutralizing mAbs against RSV from convalescent children by prefusion form of fusion(F)glycoprotein as bait.One mAb RV11 exhibited good potency in neutralization of RSV strains from both A and B subtypes in cell-based assay,and protected mice from RSV infection in vivo.An RV11 escape mutant was identified,which contains an S443P mutation in F protein.Crystal structure showed the RV11 bound to a conserved prefusion epitope across the antigenic sites IV and V of the F glycoprotein.RV11 showed a strong synergistic effect when combined with two RSV antivirals,an F-targeting small molecular inhibitor ziresovir and a siteØneutralizing mAb D25(the parental mAb for nirsevimab).The study extended our knowledge to the neutralizing and protective epitopes of RSV,and the mAb RV11 deserves further development for clinical translation.展开更多
Zika virus infections,previously found associated with microcephaly in newborns and GuillainBarréSyndrome in humans,might also lead to male infertility in mice,as researchers revealed on November 22,2016,in an ar...Zika virus infections,previously found associated with microcephaly in newborns and GuillainBarréSyndrome in humans,might also lead to male infertility in mice,as researchers revealed on November 22,2016,in an article published online in Cell,as the result from a joint research by the research groups led by Prof.George Fu Gao from the institute of Microbiology,Chinese Academy of Sciences(IMCAS),and Prof.LI Xiangdong from the China Agricultural University(CAU).展开更多
As Professor Jiaxi Lu,the former president of the Chinese Academy of Sciences(CAS),said,“Academic journals are both the‘tail’and the‘head’of a dragon”[1].Professor Zuoyan Zhu,former editor-in-chief of both Scien...As Professor Jiaxi Lu,the former president of the Chinese Academy of Sciences(CAS),said,“Academic journals are both the‘tail’and the‘head’of a dragon”[1].Professor Zuoyan Zhu,former editor-in-chief of both Science China and Science Bulletin,also once said,“Let Chinese scientific journals grow along with scientific research in China”[2].Academic journals are important carriers for the exchange and dissemination of innovation and achievement in science and are important gardens for the training of scientific talent;also,they play an important role in carrying out an evaluation of academic work.Medical journals are an important component of the academic journal sphere,not only because they account for onethird of academic journals but also because they are directly related to human health。展开更多
The coronavirus disease 2019(COVID-19)pandemic remains a significant global health challenge.Older adults are the population at high risk of developing severe COVID-19 or death[1–3].To date,dozens of vaccines for pro...The coronavirus disease 2019(COVID-19)pandemic remains a significant global health challenge.Older adults are the population at high risk of developing severe COVID-19 or death[1–3].To date,dozens of vaccines for prototype severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)have received emergency use authorization or conditional marketing approval in many countries[4].ZF2001,a protein subunit vaccine comprising two copies of tandem receptor-binding domain(RBD)from prototype SARS-CoV-2(HB-02 strain)[5,6],has demonstrated safety and immunogenicity in populations aged 3–17 and 18–59 after three doses of vaccination[7,8].Moreover,it has shown good efficacy in the prevention of symptomatic COVID-19 caused by infections from the alpha,kappa,and delta variants after a six-month follow-up for adults beyond 18 years of age in a phase 3 trial[9].ZF2001 was safe and well-tolerated in a large cohort of adults(R18 years of age),and the incidence of adverse events was lower among the participants 60 years of age or older than among those aged 18–59[9].However,its durability and immunogenicity in individuals 60 years of age and older have not been reported and need further investigation.Here,we reported the phase 1 trial of ZF2001 in adults aged 60 or older in China to determine the safety,tolerability,and immunogenicity of ZF2001 in older populations after short(1 month)-and long(6 months)-term follow-up.Moreover,we conducted a post-hoc analysis of serum samples to assess their neutralization capacity against omicron variants.展开更多
Climate change is one of the biggest issues facing humanity.Governments,private sectors,nongovernmental organizations,and individuals are working daily to find solutions to counter andmitigate its influence.An underdi...Climate change is one of the biggest issues facing humanity.Governments,private sectors,nongovernmental organizations,and individuals are working daily to find solutions to counter andmitigate its influence.An underdiscussed issue is the effect that climate has on health,and the impact that environmental and atmospheric change can have on communities,medical care access,and ecology.Here,AlanDangour from theWellcomeTrustmediates a discussion between George Fu Gao,hLife Editor-in-Chief,and the former Director-General of Chinese Center for Disease Control and Prevention,Desta Lakewfrom African Medical and Research Foundation,and Alaa Murabit from the Gates Foundation,on this area of health and climate.They discuss how a changing climate can affect health,thework that has already been done to address these problems,and the innovations and steps that need to be made to fully tackle climate-related health issues,with a consensus that health should be at the center of all considerations.展开更多
Dear Editor,The spread of antibiotic resistance genes among bacteria is a serious and growing threat to global health (Peleg and Hoopet,2010).One emerging case is transferable genes found in bacteria-encoding enzymes ...Dear Editor,The spread of antibiotic resistance genes among bacteria is a serious and growing threat to global health (Peleg and Hoopet,2010).One emerging case is transferable genes found in bacteria-encoding enzymes resistant to colistin.Colistin is a cationic polypeptide antibiotic with broadspectrum activity against Gram-negative bacteria through interactions with the lipid A moiety of bacterial lipopoly-saccharide(LPS),subsequently destroying the cell envelope.During late 2015,a plasmid-mediated gene,mcr-1,was first reported from Escherichia coli(E.coli)in China to confer resistance to colistin(Liu et a1.,2016),and detected world-wide soon afterwards(Gao et a1.,2016;Hu et a1.,2016).展开更多
Coronaviruses(Co Vs)have brought serious threats to humans,particularly severe acute respiratory syndrome coronavirus 2(SARS-Co V-2),which continually evolves into multiple variants.These variants,especially Omicron,r...Coronaviruses(Co Vs)have brought serious threats to humans,particularly severe acute respiratory syndrome coronavirus 2(SARS-Co V-2),which continually evolves into multiple variants.These variants,especially Omicron,reportedly escape therapeutic antibodies and vaccines,indicating an urgent need for new antivirals with pan-SARS-Co V-2 inhibitory activity.We previously reported that a peptide fusion inhibitor,P3,targeting heptad repeated-1(HR1)of SARS-Co V-2 spike(S)protein,could inhibit viral infections.Here,we further designed multiple derivatives of the P3 based on structural analysis and found that one derivative,the P315V3,showed the most efficient antiviral activity against SARS-Co V-2 variants and several other sarbecoviruses,as well as other human-Co Vs(HCo Vs).P315V3 also exhibited effective prophylactic efficacy against the SARS-Co V-2 Delta and Omicron variants in mice via intranasal administration.These results suggest that P315V3,which is in PhaseⅡclinical trial,is promising for further development as a nasal pan-SARS-Co V-2 or pan-Co Vs inhibitor to prevent or treat CoV diseases.展开更多
Scientific journals are platforms for communication between authors and readers,and also among readers and the wider public.To promote health science and related medical science fields,we are pleased to announce the l...Scientific journals are platforms for communication between authors and readers,and also among readers and the wider public.To promote health science and related medical science fields,we are pleased to announce the launch of a transdisciplinary journal named hLife,which combines the ideas of a healthier,happier and harmonious life together.hLife is a peer-reviewed,open-access monthly journal published online,sponsored by the Institute of Microbiology,Chinese Academy of Sciences,in cooperation with the Chinese Society of Biotechnology and the Shanghai Immune Therapy Institute.The editorial board consists of around 60 scientists from 12 countries or regions worldwide,among them two Nobel Laureates.Now,hLife is one of the“high starting point journals”of the Chinese Action Plan for Journal Excellence.展开更多
Brazilian president Luiz Inacio Lula da Silva’s visit to China in April 2023 was an opportunity to elevate health cooperation between the two countries to scientific and technological cooperation standards,exemplifie...Brazilian president Luiz Inacio Lula da Silva’s visit to China in April 2023 was an opportunity to elevate health cooperation between the two countries to scientific and technological cooperation standards,exemplified by the China-Brazil Earth Resources Satellite(CBERS).The satellite programme can be traced back to the Basic Agreement on Scientific and Technological Cooperation signed by the two nations in 1982(https://www.planalto.gov.br/ccivil03/decreto/1990-1994/d0638.htm).This framework serves as a reference for health cooperation between Chinese science and health institutions and the Oswaldo Cruz Foundation(Fiocruz),the Brazilian Minister of Health’s core industrial and research facility.展开更多
Alphaviruses are a group of important viruses that cause significant diseases in humans.Among them,Semliki Forest vi-rus(SFV)not only causes symptoms such as joint pain but also infects neuron cells and induces enceph...Alphaviruses are a group of important viruses that cause significant diseases in humans.Among them,Semliki Forest vi-rus(SFV)not only causes symptoms such as joint pain but also infects neuron cells and induces encephalitis in rodents.Recently,the very-low-density lipoprotein receptor(VLDLR)was identified as the cellular receptor for SFV entry.In this study,we present the cryo-electron microscopy structure of SFV bound to human VLDLR.VLDLR targets E1-DIII region of SFV using its membrane-distal LDLR class A(LA)repeats.Structural and functional analyses emphasize the synergistic role of multiple VLDLR repeats in the SFV entry.Remarkably,VLDLR’s binding mode to SFV closely mirrors that of minor group human rhinoviruses but differs significantly from other alphaviruses’interactions with receptors in the canyon re-gion of the E protein.We also assessed SFV binding to VLDLR or apolipoprotein E receptor 2(ApoER2)proteins in horses and mosquitoes and revealed their use of multiple but different LA repeats for binding.Our findings illuminate SFV’s cross-species infectivity,offering insights into potential antiviral strategies against alphavirus infections.展开更多
Many severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)–related coronaviruses have been discovered,constituting potential threats to human health.However,it remains unclear whether the currently available va...Many severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)–related coronaviruses have been discovered,constituting potential threats to human health.However,it remains unclear whether the currently available vaccines are effective against these coronaviruses.Here,we constructed a wild-type mouse model to evaluate pathogenicity of the SARS-CoV-2-related pangolin coronavirus GX/P2V/2017 and neutralization efficacy of the approved tandemrepeat SARS-CoV-2 spike receptor-binding domain(RBD)vaccine ZF2001.We found that ZF2001-induced cross-reactive and cross-neutralizing antibodies against GX/P2V/2017,and the vaccination alleviated the pathological lung damage caused by GX/P2V/2017 in mice.These results indicate that RBD may work as a promising candidate for pan-coronavirus vaccine development.展开更多
Leptin receptor(LepR)signaling plays an essential role in balancing food intake and energy expenditure.The architec-ture of LepR signaling assembly is critical for its function.In this study,we determined the structur...Leptin receptor(LepR)signaling plays an essential role in balancing food intake and energy expenditure.The architec-ture of LepR signaling assembly is critical for its function.In this study,we determined the structures of three distinct conformations of human leptin–LepR using cryo-electron microscopy at resolutions of 3.88,3.77,and 3.58Å.Both 2:2 and 3:3 stoichiometric assemblies were observed,and the complexes exhibited asymmetric open conformations.Lep-tin undergoes substantial rearrangement of its flexible regions to accommodate binding to LepR.The assembled leptin–LepR complexes connect through a“hand-in-hand”geometry.The open,interlocked 3:3 trimeric assembly results from the engagement of a third leptin–LepR heterodimer with a 2:2 dimer.The asymmetric geometry of LepR is substantially distinct from that of other gp130 cytokine homologs,and that may be due to the twisted and rigid interface between the D3 and D4 domains.These results highlight the distinct engagement of leptin with LepR and provide important insights into the structural plasticity of LepR-signaling assemblies.展开更多
Duck egg drop syndrome virus(DEDSV) is a newly emerging pathogenic flavivirus isolated from ducks in China.DEDSV infection mainly results in severe egg drop syndrome in domestic poultry,which leads to huge economic lo...Duck egg drop syndrome virus(DEDSV) is a newly emerging pathogenic flavivirus isolated from ducks in China.DEDSV infection mainly results in severe egg drop syndrome in domestic poultry,which leads to huge economic losses.Thus,the discovery of ways and means to combat DEDSV is urgent.Since 2010,a remarkable amount of progress concerning DEDSV research has been achieved.Here,we review current knowledge on the epidemiology,symptomatology,and pathology of DEDSV.A detailed dissection of the viral genome and polyprotein sequences,comparative analysis of viral antigenicity and the corresponding potential immunity against the virus are also summarized.Current findings indicate that DEDSV should be a distinct species from Tembusu virus.Moreover,the adaption of DEDSV in wildlife and its high homology to pathogenic flaviviruses(e.g.,West Nile virus,Japanese encephalitis virus,and dengue virus),illustrate its reemergence and potential to become a zoonotic pathogen that should not be overlooked.Detailed insight into the antigenicity and corresponding immunity against the virus is of clear significance for the development of vaccines and antiviral drugs specific for DEDSV.展开更多
文摘Four heavyweight guests in the field of public health gathered together.No-bel Laureate Jules A Hoffmann,Academician George Fu Gao,Professor Chris Walzer and Professor Jiahai Lu discussed how to deal with global public health crises,such as the recent coronavirus disease 2019(COVID-19)pandemic,as well as the role of international organizations.The concept of“One Health”emerged as the latest approach to disease prevention and control.This concept emphasizes the intertwined health of humans,animals and the environment.The experts shared their thoughts and insights on how humanity can address emerging global public health crises through international cooperation.
基金supported by the National Key R&D Program of China(2023YFC0871300 and 2022YFC2303403)the National Natural Science Foundation of China(82225021)Q.W.is supported by the Chinese Academy of Sciences(YSBR-010 and Y2022037).
文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)continues to pose a significant threat to the world,as it continually evolves and gives rise to multiple variants and sub-variants.Recently,the Omicron EG.5 linage,which was first detected in Indonesia on 17 February 2023,has raised concerns due to its increased prevalence and extended immune escape properties,according to the risk analysis by the World Health Organization(WHO)[1].As of 3 October 2023,EG.5 and its sub-linages have been reported in 83 countries with shared 49,008 genome sequences in GISAID database(https://gisaid.org/hcov19-variants/).EG.5 has become the dominant strain in the United States according to Centers for Disease Control and Prevention(CDC),accounting for 29.4%of SARS-CoV-2 infections(https://covid.cdc.gov/covid-data-tracker/#variant-proportions).
基金supported by the National Natural Science Foundation of China(NSFC)(81991494 and 82122031)the National Key R&D Program of China(2020YFA0907100)+3 种基金the Chinese Academy of Sciences(YSBR-010)the CAMS Innovation Fund for Medical Sciences(CIFMS)(2019-I2M-5-026)Beijing Natural Science Foundation(L222076)L.D.is supported by the Youth Innovation Promotion Association CAS,China(2018113).
文摘Respiratory syncytial virus(RSV)is one of the leading pathogens that cause lower respiratory tract infections in infants and the elderly.Passive immunoprophylaxis with monoclonal antibody(mAb)has been approved to prevent morbidity and mortality from RSV infection in infants.Here we report the isolation of two neutralizing mAbs against RSV from convalescent children by prefusion form of fusion(F)glycoprotein as bait.One mAb RV11 exhibited good potency in neutralization of RSV strains from both A and B subtypes in cell-based assay,and protected mice from RSV infection in vivo.An RV11 escape mutant was identified,which contains an S443P mutation in F protein.Crystal structure showed the RV11 bound to a conserved prefusion epitope across the antigenic sites IV and V of the F glycoprotein.RV11 showed a strong synergistic effect when combined with two RSV antivirals,an F-targeting small molecular inhibitor ziresovir and a siteØneutralizing mAb D25(the parental mAb for nirsevimab).The study extended our knowledge to the neutralizing and protective epitopes of RSV,and the mAb RV11 deserves further development for clinical translation.
文摘Zika virus infections,previously found associated with microcephaly in newborns and GuillainBarréSyndrome in humans,might also lead to male infertility in mice,as researchers revealed on November 22,2016,in an article published online in Cell,as the result from a joint research by the research groups led by Prof.George Fu Gao from the institute of Microbiology,Chinese Academy of Sciences(IMCAS),and Prof.LI Xiangdong from the China Agricultural University(CAU).
文摘As Professor Jiaxi Lu,the former president of the Chinese Academy of Sciences(CAS),said,“Academic journals are both the‘tail’and the‘head’of a dragon”[1].Professor Zuoyan Zhu,former editor-in-chief of both Science China and Science Bulletin,also once said,“Let Chinese scientific journals grow along with scientific research in China”[2].Academic journals are important carriers for the exchange and dissemination of innovation and achievement in science and are important gardens for the training of scientific talent;also,they play an important role in carrying out an evaluation of academic work.Medical journals are an important component of the academic journal sphere,not only because they account for onethird of academic journals but also because they are directly related to human health。
基金This work is funded by Anhui Zhifei Longcom Biopharmaceutical,National Key R&D Program of China(2021YFA1300803)the National Natural Science Foundation of China(82122031)We thank the staff of the Biosafety Level 3 Laboratory(Institute of Microbiology,Chinese Academy of Sciences)for their help in live virus experiments,Yawen Liu for her help in pseudovirus experiments,and Grammarly for text improvement.
文摘The coronavirus disease 2019(COVID-19)pandemic remains a significant global health challenge.Older adults are the population at high risk of developing severe COVID-19 or death[1–3].To date,dozens of vaccines for prototype severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)have received emergency use authorization or conditional marketing approval in many countries[4].ZF2001,a protein subunit vaccine comprising two copies of tandem receptor-binding domain(RBD)from prototype SARS-CoV-2(HB-02 strain)[5,6],has demonstrated safety and immunogenicity in populations aged 3–17 and 18–59 after three doses of vaccination[7,8].Moreover,it has shown good efficacy in the prevention of symptomatic COVID-19 caused by infections from the alpha,kappa,and delta variants after a six-month follow-up for adults beyond 18 years of age in a phase 3 trial[9].ZF2001 was safe and well-tolerated in a large cohort of adults(R18 years of age),and the incidence of adverse events was lower among the participants 60 years of age or older than among those aged 18–59[9].However,its durability and immunogenicity in individuals 60 years of age and older have not been reported and need further investigation.Here,we reported the phase 1 trial of ZF2001 in adults aged 60 or older in China to determine the safety,tolerability,and immunogenicity of ZF2001 in older populations after short(1 month)-and long(6 months)-term follow-up.Moreover,we conducted a post-hoc analysis of serum samples to assess their neutralization capacity against omicron variants.
文摘Climate change is one of the biggest issues facing humanity.Governments,private sectors,nongovernmental organizations,and individuals are working daily to find solutions to counter andmitigate its influence.An underdiscussed issue is the effect that climate has on health,and the impact that environmental and atmospheric change can have on communities,medical care access,and ecology.Here,AlanDangour from theWellcomeTrustmediates a discussion between George Fu Gao,hLife Editor-in-Chief,and the former Director-General of Chinese Center for Disease Control and Prevention,Desta Lakewfrom African Medical and Research Foundation,and Alaa Murabit from the Gates Foundation,on this area of health and climate.They discuss how a changing climate can affect health,thework that has already been done to address these problems,and the innovations and steps that need to be made to fully tackle climate-related health issues,with a consensus that health should be at the center of all considerations.
基金supported by the Chinese Academy of Sciences (CAS) Strategic Priority Research Program (XDB08020100)the External Cooperation Program of Chinese Academy of Sciences (153211KYSB20160001)the National Key Plan for Scientific Research and Development of China (2016YFD0500305)
文摘Dear Editor,The spread of antibiotic resistance genes among bacteria is a serious and growing threat to global health (Peleg and Hoopet,2010).One emerging case is transferable genes found in bacteria-encoding enzymes resistant to colistin.Colistin is a cationic polypeptide antibiotic with broadspectrum activity against Gram-negative bacteria through interactions with the lipid A moiety of bacterial lipopoly-saccharide(LPS),subsequently destroying the cell envelope.During late 2015,a plasmid-mediated gene,mcr-1,was first reported from Escherichia coli(E.coli)in China to confer resistance to colistin(Liu et a1.,2016),and detected world-wide soon afterwards(Gao et a1.,2016;Hu et a1.,2016).
基金supported by the National Key R&D Program of China(2022YFC2303403)the National Natural Science Foundation of China(82225021 and 32171428)the CAS Young Scientists in Basic Research(YSBR-010)。
基金This work was supported by the Ministry of Science and Technology of the People’s Republic of China(2022YFC2303403 and 2021YFA1301404)CAS Project for Young Scientists in Basic Research(YSBR-010)+2 种基金National Natural Science Foundation of China(82225021 and 81830050)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB29040203)the Youth Innovation Promotion Association,CAS(Y2022037).
基金the Ministry of Science and Technology of the People’s Republic of China(2023YFC0871300 and 2022YFC2604103)the National Natural Science Foundation of China(82225021)+3 种基金Science and Technology Program of Shenzhen,China(JSGG20220606140800001)Research&Development Project in Key Areas of Guangdong Province(2022B1111060001)the Science and Technology Planning Project of Guangdong Province of China(2021B1212030009)the Chinese Academy of Sciences(YSBR-010 and Y2022037)。
文摘Coronaviruses(Co Vs)have brought serious threats to humans,particularly severe acute respiratory syndrome coronavirus 2(SARS-Co V-2),which continually evolves into multiple variants.These variants,especially Omicron,reportedly escape therapeutic antibodies and vaccines,indicating an urgent need for new antivirals with pan-SARS-Co V-2 inhibitory activity.We previously reported that a peptide fusion inhibitor,P3,targeting heptad repeated-1(HR1)of SARS-Co V-2 spike(S)protein,could inhibit viral infections.Here,we further designed multiple derivatives of the P3 based on structural analysis and found that one derivative,the P315V3,showed the most efficient antiviral activity against SARS-Co V-2 variants and several other sarbecoviruses,as well as other human-Co Vs(HCo Vs).P315V3 also exhibited effective prophylactic efficacy against the SARS-Co V-2 Delta and Omicron variants in mice via intranasal administration.These results suggest that P315V3,which is in PhaseⅡclinical trial,is promising for further development as a nasal pan-SARS-Co V-2 or pan-Co Vs inhibitor to prevent or treat CoV diseases.
文摘Scientific journals are platforms for communication between authors and readers,and also among readers and the wider public.To promote health science and related medical science fields,we are pleased to announce the launch of a transdisciplinary journal named hLife,which combines the ideas of a healthier,happier and harmonious life together.hLife is a peer-reviewed,open-access monthly journal published online,sponsored by the Institute of Microbiology,Chinese Academy of Sciences,in cooperation with the Chinese Society of Biotechnology and the Shanghai Immune Therapy Institute.The editorial board consists of around 60 scientists from 12 countries or regions worldwide,among them two Nobel Laureates.Now,hLife is one of the“high starting point journals”of the Chinese Action Plan for Journal Excellence.
基金supported by the National Natural Science Foundation of China(92169113)the CAS Project for Young Scientists in Basic Research(YSBR-010)+1 种基金the National Key R&D Program of China(2022YFC2302900)the Key Research Program of Frontier Sciences of CAS(ZDBS-LY-SM025)。
基金supported by the National Key R&D Program of China(2022YFE0210300,2022YFC2303401,2016YFD0500300,2021YFC0863300,and 2021YFC2300101)the National Natural Science Foundation of China(32070407)the special fund for Science and Technology Innovation Teams of Shanxi Province(202204051001022)。
文摘Brazilian president Luiz Inacio Lula da Silva’s visit to China in April 2023 was an opportunity to elevate health cooperation between the two countries to scientific and technological cooperation standards,exemplified by the China-Brazil Earth Resources Satellite(CBERS).The satellite programme can be traced back to the Basic Agreement on Scientific and Technological Cooperation signed by the two nations in 1982(https://www.planalto.gov.br/ccivil03/decreto/1990-1994/d0638.htm).This framework serves as a reference for health cooperation between Chinese science and health institutions and the Oswaldo Cruz Foundation(Fiocruz),the Brazilian Minister of Health’s core industrial and research facility.
基金supported by the National Natural Science Foundation of China (82072290,82122040,and 32100129)supported by CAS Project for Young Scientists in Basic Research (YSBR-010)the Youth Innovation Promotion Association CAS (Y2021033).
文摘Alphaviruses are a group of important viruses that cause significant diseases in humans.Among them,Semliki Forest vi-rus(SFV)not only causes symptoms such as joint pain but also infects neuron cells and induces encephalitis in rodents.Recently,the very-low-density lipoprotein receptor(VLDLR)was identified as the cellular receptor for SFV entry.In this study,we present the cryo-electron microscopy structure of SFV bound to human VLDLR.VLDLR targets E1-DIII region of SFV using its membrane-distal LDLR class A(LA)repeats.Structural and functional analyses emphasize the synergistic role of multiple VLDLR repeats in the SFV entry.Remarkably,VLDLR’s binding mode to SFV closely mirrors that of minor group human rhinoviruses but differs significantly from other alphaviruses’interactions with receptors in the canyon re-gion of the E protein.We also assessed SFV binding to VLDLR or apolipoprotein E receptor 2(ApoER2)proteins in horses and mosquitoes and revealed their use of multiple but different LA repeats for binding.Our findings illuminate SFV’s cross-species infectivity,offering insights into potential antiviral strategies against alphavirus infections.
基金supported by the National Key R&D Program of China(2022YFC2303403 and 2021YFC0863400)the National Natural Science Foundation of China(NSFC 82225021 and 32000127)+1 种基金Q.W.is supported by the Youth Innovation Promotion Association CAS(Y2022037)G.F.G.is supported by the Yanqi Lake Meeting organized by the Academic Divisions of CAS.
文摘Many severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)–related coronaviruses have been discovered,constituting potential threats to human health.However,it remains unclear whether the currently available vaccines are effective against these coronaviruses.Here,we constructed a wild-type mouse model to evaluate pathogenicity of the SARS-CoV-2-related pangolin coronavirus GX/P2V/2017 and neutralization efficacy of the approved tandemrepeat SARS-CoV-2 spike receptor-binding domain(RBD)vaccine ZF2001.We found that ZF2001-induced cross-reactive and cross-neutralizing antibodies against GX/P2V/2017,and the vaccination alleviated the pathological lung damage caused by GX/P2V/2017 in mice.These results indicate that RBD may work as a promising candidate for pan-coronavirus vaccine development.
基金sup-ported by the National Key Research and Development Program of China (grant numbers 2020YFA0509202).
文摘Leptin receptor(LepR)signaling plays an essential role in balancing food intake and energy expenditure.The architec-ture of LepR signaling assembly is critical for its function.In this study,we determined the structures of three distinct conformations of human leptin–LepR using cryo-electron microscopy at resolutions of 3.88,3.77,and 3.58Å.Both 2:2 and 3:3 stoichiometric assemblies were observed,and the complexes exhibited asymmetric open conformations.Lep-tin undergoes substantial rearrangement of its flexible regions to accommodate binding to LepR.The assembled leptin–LepR complexes connect through a“hand-in-hand”geometry.The open,interlocked 3:3 trimeric assembly results from the engagement of a third leptin–LepR heterodimer with a 2:2 dimer.The asymmetric geometry of LepR is substantially distinct from that of other gp130 cytokine homologs,and that may be due to the twisted and rigid interface between the D3 and D4 domains.These results highlight the distinct engagement of leptin with LepR and provide important insights into the structural plasticity of LepR-signaling assemblies.
基金supported by the National Basic Research Program of China,Ministry of Science and Technology of China (2011CB504703)National Natural Science Foundation of China (81021003)Gao George Fu is a leading principal investigator of the NSFC Innovative Research Group
文摘Duck egg drop syndrome virus(DEDSV) is a newly emerging pathogenic flavivirus isolated from ducks in China.DEDSV infection mainly results in severe egg drop syndrome in domestic poultry,which leads to huge economic losses.Thus,the discovery of ways and means to combat DEDSV is urgent.Since 2010,a remarkable amount of progress concerning DEDSV research has been achieved.Here,we review current knowledge on the epidemiology,symptomatology,and pathology of DEDSV.A detailed dissection of the viral genome and polyprotein sequences,comparative analysis of viral antigenicity and the corresponding potential immunity against the virus are also summarized.Current findings indicate that DEDSV should be a distinct species from Tembusu virus.Moreover,the adaption of DEDSV in wildlife and its high homology to pathogenic flaviviruses(e.g.,West Nile virus,Japanese encephalitis virus,and dengue virus),illustrate its reemergence and potential to become a zoonotic pathogen that should not be overlooked.Detailed insight into the antigenicity and corresponding immunity against the virus is of clear significance for the development of vaccines and antiviral drugs specific for DEDSV.
