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Single vs double antiplatelet therapy in acute coronary syndrome: Predictors of bleeding after coronary artery bypass grafting
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作者 Vincenzo Tarzia Giacomo Bortolussi +5 位作者 Edward Buratto Carla Paolini Carlo Dal Lin Giulio Rizzoli Tomaso Bottio gino gerosa 《World Journal of Cardiology》 CAS 2015年第9期571-578,共8页
AIM:To investigate the contribution of anti-platelet therapy and derangements of pre-operative classical coagulation and thromboelastometry parameters to major bleeding post-coronary artery bypass grafting(CABG).METHO... AIM:To investigate the contribution of anti-platelet therapy and derangements of pre-operative classical coagulation and thromboelastometry parameters to major bleeding post-coronary artery bypass grafting(CABG).METHODS:Two groups of CABG patients were studied:Group A,treated with aspirin alone(n=50),and Group B treated with aspirin and clopidogrel(n=50).Both had similar preoperative,clinical,biologic characteristics and operative management.Classic coagulation parameters and rotational thromboelastometry(ROTEM)profiles were determined preoperatively for both groups and the same heparin treatment was administered.ROTEM profiles(INTEM and EXTEM assays)were analyzed,both for traditional parameters,and thrombin generation potential,expressed by area-under-curve(AUC).RESULTS:There was no significant difference betweenrates of major bleeding between patients treated with aspirin alone,compared with those treated with aspirin and clopidogrel(12%vs 16%,P=0.77).In the 14 cases of major bleeding,pre-operative classic coagulation and traditional ROTEM parameters were comparable.Conversely we observed that the AUC in the EXTEM test was significantly lower in bleeders(5030±1115 Ohm*min)than non-bleeders(6568±548Ohm*min)(P<0.0001).CONCLUSION:We observed that patients with a low AUC value were at a significantly higher risk of bleeding compared to patients with higher AUC,regardless of antiplatelet treatment.This suggests that thrombin generation potential,irrespective of the degree of platelet inhibition,correlates with surgical bleeding. 展开更多
关键词 PLATELET INHIBITORS THROMBOELASTOMETRY BLEEDING AC
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Institutional re-evolution of mitral valve procedures
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作者 Matteo Ponzoni Alessandro Fiocco +9 位作者 Raphael Caraffa Matteo Nadali Lorenzo Longinotti Nicola Pradegan Olimpia Bifulco Laura Besola Luca Nai Fovino Giuseppe Tarantini Andrea Colli gino gerosa 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2022年第7期551-554,共4页
The introduction of transcatheter aortic va-lve replacement changed our approach for those patients with a high-to-prohibitive risk profile,and,more recently,for those with an in-termediate-to-low risk profile.[1]Simi... The introduction of transcatheter aortic va-lve replacement changed our approach for those patients with a high-to-prohibitive risk profile,and,more recently,for those with an in-termediate-to-low risk profile.[1]Similarly,patients with mitral valve regurgitation(MVR)can now be-nefit from various transcatheter technologies,whose indications and recommendations are the subject of intense clinical investigation. 展开更多
关键词 MITRAL patients TRANSCATHETER
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Covalent functionalization of decellularized tissues accelerates endothelialization 被引量:1
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作者 Eleonora Dal Sasso Annj Zamuner +10 位作者 Andrea Filippi Filippo Romanato Tiziana Palmosi Luca Vedovelli Dario Gregori Jose Luís Gòmez Ribelles Teresa Russo Antonio Gloria Laura Iop gino gerosa Monica Dettin 《Bioactive Materials》 SCIE 2021年第11期3851-3864,共14页
In the field of tissue regeneration,the lack of a stable endothelial lining may affect the hemocompatibility of both synthetic and biological replacements.These drawbacks might be prevented by specific biomaterial fun... In the field of tissue regeneration,the lack of a stable endothelial lining may affect the hemocompatibility of both synthetic and biological replacements.These drawbacks might be prevented by specific biomaterial functionalization to induce selective endothelial cell(EC)adhesion.Decellularized bovine pericardia and porcine aortas were selectively functionalized with a REDV tetrapeptide at 10^(-5)M and 10^(-6)M working concentrations.The scaffold-bound peptide was quantified and REDV potential EC adhesion enhancement was evaluated in vitro by static seeding of human umbilical vein ECs.The viable cells and MTS production were statistically higher in functionalized tissues than in control.Scaffold histoarchitecture,geometrical features,and mechanical properties were unaffected by peptide anchoring.The selective immobilization of REDV was effective in accelerating ECs adhesion while promoting proliferation in functionalized decellularized tissues intended for blood-contacting applications. 展开更多
关键词 Decellularized pericardium Decellularized aorta Covalent functionalization ENDOTHELIALIZATION REDV Mechanical analysis
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