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Chronic hepatitis C:This and the new era of treatment 被引量:12
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作者 Gaetano Bertino Annalisa Ardiri +14 位作者 Maria Proiti giuseppe rigano Evelise Frazzetto Shirin Demma MariaIrene Ruggeri Laura Scuderi Giulia Malaguarnera Nicoletta Bertino Venerando Rapisarda Isidoro Di Carlo Adriana Toro Federico Salomone Mariano Malaguarnera Emanuele Bertino Michele Malaguarnera 《World Journal of Hepatology》 CAS 2016年第2期92-106,共15页
Over the last years it has started a real revolution in the treatment of chronic hepatitis C. This occurred for the availability of direct-acting antiviral agents that allow to reach sustained virologic response in ap... Over the last years it has started a real revolution in the treatment of chronic hepatitis C. This occurred for the availability of direct-acting antiviral agents that allow to reach sustained virologic response in approximately 90% of cases. In the near future further progress will be achieved with the use of pan-genotypic drugs with high efficacy but without side effects. 展开更多
关键词 Direct-acting ANTIVIRAL AGENTS Nucleosideinhibitors BOCEPREVIR Sofosbuvir TELAPREVIR HEPATITISC Simeprevir Daclatasvir Ledipasvir Faldaprevir Ritonavir Ombitasvir Dasabuvir
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Hepatocellular carcinoma and the risk of occupational exposure 被引量:5
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作者 Venerando Rapisarda Carla Loreto +14 位作者 Michele Malaguarnera Annalisa Ardiri Maria Proiti giuseppe rigano Evelise Frazzetto Maria Irene Ruggeri Giulia Malaguarnera Nicoletta Bertino Mariano Malaguarnera Vito Emanuele Catania Isidoro Di Carlo Adriana Toro Emanuele Bertino Dario Mangano Gaetano Bertino 《World Journal of Hepatology》 CAS 2016年第13期573-590,共18页
Hepatocellular carcinoma(HCC)is the most common type of liver cancer.The main risk factors for HCC are alcoholism,hepatitis B virus,hepatitis C virus,nonalcoholic steatohepatitis,obesity,type 2 diabetes,cirrhosis,afla... Hepatocellular carcinoma(HCC)is the most common type of liver cancer.The main risk factors for HCC are alcoholism,hepatitis B virus,hepatitis C virus,nonalcoholic steatohepatitis,obesity,type 2 diabetes,cirrhosis,aflatoxin,hemochromatosis,Wilson’s disease and hemophilia.Occupational exposure to chemicals is another risk factor for HCC.Often the relationship between occupational risk and HCC is unclear and the reports are fragmented and inconsistent.This review aims to summarize the current knowledge regarding the association of infective and non-infective occupational risk exposure and HCC in order to encourage further research and draw attention to this global occupational public health problem. 展开更多
关键词 Hepatocellular carcinoma Autophagy Epigenetic events Hepatitis B virus Hepatitis C virus Occupational exposure Chemical agents MITOPHAGY ARSENIC Cadmium
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