BACKGROUND:Cerebral venous thrombosis(CVT) is a rare disease and it has different etiologies.Inherited or acquired prothrombotic state plays a key role in the development of CVT.METHODS:A 28-year-old man who presented...BACKGROUND:Cerebral venous thrombosis(CVT) is a rare disease and it has different etiologies.Inherited or acquired prothrombotic state plays a key role in the development of CVT.METHODS:A 28-year-old man who presented to our emergency department with persistent headache and accompanied by complaints of nausea and vomiting over a week.Neurologic examination revealed bilateral papilledema.Brain computed tomography showed a hyperdense area on the posterior part of the occipital lobe.Brain magnetic resonance imaging and magnetic resonance venography revealed thrombosis of CVT.Homozygous mutations were found for methylenetetrahydrofolate reductase(MTHFR).MTHFR CG677 T gene mutation and blood tests showed elevated homocysteine levels on the etiological screening.There was no other etiology for CVT.RESULTS:Headache and other complaints were improved after treatment of heparin,warfarin,and vitamin B12.No recurrence of symptoms was observed upon outpatient follow-up.CONCLUSION:Since CVT is an important cause of headache,we recommend etiology screening for patients who present with CVT for MTHFR gene mutations and family counseling should be provided.展开更多
文摘BACKGROUND:Cerebral venous thrombosis(CVT) is a rare disease and it has different etiologies.Inherited or acquired prothrombotic state plays a key role in the development of CVT.METHODS:A 28-year-old man who presented to our emergency department with persistent headache and accompanied by complaints of nausea and vomiting over a week.Neurologic examination revealed bilateral papilledema.Brain computed tomography showed a hyperdense area on the posterior part of the occipital lobe.Brain magnetic resonance imaging and magnetic resonance venography revealed thrombosis of CVT.Homozygous mutations were found for methylenetetrahydrofolate reductase(MTHFR).MTHFR CG677 T gene mutation and blood tests showed elevated homocysteine levels on the etiological screening.There was no other etiology for CVT.RESULTS:Headache and other complaints were improved after treatment of heparin,warfarin,and vitamin B12.No recurrence of symptoms was observed upon outpatient follow-up.CONCLUSION:Since CVT is an important cause of headache,we recommend etiology screening for patients who present with CVT for MTHFR gene mutations and family counseling should be provided.
