Homologation of protected taxol side chen 8 from 4 was accomplished stereospecifically through the key intermediate diazo ketone 5 which was actually isolated. The structures of 5 and 7 were identified by spectrometri...Homologation of protected taxol side chen 8 from 4 was accomplished stereospecifically through the key intermediate diazo ketone 5 which was actually isolated. The structures of 5 and 7 were identified by spectrometric methods, mainly 1H-NMR, 1R, 13C-NMR and DEPT techniques.展开更多
Compound 2 with 14β-hydroxyl group was successfully converted into its epimerized α-counterpart via oxidation - reduction.The elimination product (6) was auto-oxidized to epoxide 8,even in the solid state
文摘Homologation of protected taxol side chen 8 from 4 was accomplished stereospecifically through the key intermediate diazo ketone 5 which was actually isolated. The structures of 5 and 7 were identified by spectrometric methods, mainly 1H-NMR, 1R, 13C-NMR and DEPT techniques.
文摘Compound 2 with 14β-hydroxyl group was successfully converted into its epimerized α-counterpart via oxidation - reduction.The elimination product (6) was auto-oxidized to epoxide 8,even in the solid state
