Artificial Intelligence(AI)has increased as a potent tool in medicine,with promising oncology applications.The emergence of immunotherapy has transformed the treatment terrain for hepatocellular carcinoma(HCC),offerin...Artificial Intelligence(AI)has increased as a potent tool in medicine,with promising oncology applications.The emergence of immunotherapy has transformed the treatment terrain for hepatocellular carcinoma(HCC),offering new hope to patients with this challenging malignancy.This article examines the role and future of AI in forecasting the effectiveness of immunotherapy in HCC.We highlight the potential of AI to revolutionize the prediction of therapy response,thus improving patient selection and clinical outcomes.The article further outlines the challenges and future research directions in this emerging field.展开更多
BACKGROUND Cesarean scar pregnancy(CSP)is rare but may result in uterine rupture during pregnancy or massive hemorrhage during abortion procedures.Awareness of this condition is increasing,and most patients with CSP a...BACKGROUND Cesarean scar pregnancy(CSP)is rare but may result in uterine rupture during pregnancy or massive hemorrhage during abortion procedures.Awareness of this condition is increasing,and most patients with CSP are now diagnosed early and can be managed safely.However,some atypical patients are misdiagnosed,and their surgical risks are underestimated,increasing the risk of fatal hemorrhage.CASE SUMMARY A 27-year-old Asian woman visited our institution because of abnormal pregnancy,and she was diagnosed with a hydatidiform mole through transvaginal ultrasound(TVS).Under hysteroscopy,a large amount of placental tissue was found in the scar of the lower uterine segment,and a sudden massive hemorrhage occurred during the removal process.The bilateral internal iliac arteries were temporarily blocked under laparoscopy,and scar resection and repair were rapidly performed.She was discharged in good condition 5 d after the operation.CONCLUSION Although TVS is widely used in the diagnosis of CSP,delays in the diagnosis of atypical CSP remain.Surgical treatment following internal iliac artery temporary occlusion may be an appropriate management method for unanticipated massive hemorrhage during CSP surgery.展开更多
Large-scale vapor-solid synthesis of ultralong silicon nitride (Si3N4) nanowires was achieved by using simple thermal evaporation of mixture powders of active carbon and monoxide silicon. The products were characteriz...Large-scale vapor-solid synthesis of ultralong silicon nitride (Si3N4) nanowires was achieved by using simple thermal evaporation of mixture powders of active carbon and monoxide silicon. The products were characterized by X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and transmission electron microscopy. The results suggest that the silicon nitride nanowires have a smooth surface, with lengths of up to several hundreds of microns and diameters of 100-300 nm. A detailed study of both the chemical and structural composition was performed. Such ultralong silicon nitride nanowires demonstrate potential applications as materials for constructing nanoscale devices and as reinforcement in advanced composites.展开更多
Objective:To assess the relation between XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia.Methods:Related studies of XRCC3 Thr24lMet polymorphism and lung cancer susceptibility o...Objective:To assess the relation between XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia.Methods:Related studies of XRCC3 Thr24lMet polymorphism and lung cancer susceptibility of populations in East Asia were collected through searching the Pubmed,Embase Library,SPRINGER.CNKI and CSSCI.Results:According to the entry criteria,there were 8 case-control studies in the assessing system and there were 6 321study cases,including 3 215 patients with lung cancer and 3 106 cases without cancers.Meta analysis results showed the combined OR value of the ratio of genotype Thr/Met+Met/Met and Thr/Thr was 1.03(95%CI:0.89-1.20)(P>0.05).Conclusions:XRCC3 Thr241Met polymorphism may not related to lung cancer susceptibility of populations in East Asia.Allele 241Met did not increase the risk of lung cancer.展开更多
Purpose:The purpose of this study is to develop an automated frequently asked question(FAQ)answering system for farmers.This paper presents an approach for calculating the similarity between Chinese sentences based on...Purpose:The purpose of this study is to develop an automated frequently asked question(FAQ)answering system for farmers.This paper presents an approach for calculating the similarity between Chinese sentences based on hybrid strategies.Design/methodology/approach:We analyzed the factors influencing the successful matching between a user’s question and a question-answer(QA)pair in the FAQ database.Our approach is based on a combination of multiple factors.Experiments were conducted to test the performance of our method.Findings:Experiments show that this proposed method has higher accuracy.Compared with similarity calculation based on TF-IDF,the sentence surface forms and the semantic relations,the proposed method based on hybrid strategies has a superior performance in precision,recall and F-measure value.Research limitations:The FAQ answering system is only capable of meeting users’demand for text retrieval at present.In the future,the system needs to be improved to meet users’demand for retrieving images and videos.Practical implications:This FAQ answering system will help farmers utilize agricultural information resources more efficiently.Originality/value:We design the algorithms for calculating similarity of Chinese sentences based on hybrid strategies,which integrate the question surface similarity,the question semantic similarity and the question-answer similarity based on latent semantic analysis(LSA)to find answers to a user’s question.展开更多
Conversion of natural environments to human-modified landscapes is continuing at an unprecedented rate,exerting fundamental influences on global biodiversity.Understanding how wildlife communities respond to landscape...Conversion of natural environments to human-modified landscapes is continuing at an unprecedented rate,exerting fundamental influences on global biodiversity.Understanding how wildlife communities respond to landscape modifications is critical to improve biodiversity conservation in human-dominated landscapes.In this study,we surveyed bird communities in three common habitats(i.e.,farmland,village,and forest)in the southern Anhui Mountainous Area during summer(August 2019)and winter(December 2020).The diversity metrics and species compositions of the avian communities were compared among the habitats,and the effects of land use composition in these habitats were tested.During the field surveys,we recorded 7599 birds of 120 species along 45 line transects of 1km in length.The land use compositions differed among habitats,and land use diversity was the highest in villages and lowest in forests.The species richness and bird abundance in the two human-dominated habitats(i.e.,farmland and village)were higher than those in forest in both seasons.Bird species composition also differed across habitat types in both seasons.Bird species feeding on vertebrates,fish and carrion,and species feeding on plants and seeds were mainly found in habitats with less construction lands and lower land use diversity,while omnivorous species and species feeding on fruits and nectar or on invertebrates were less affected by these two variables.The indicator species analysis showed that most species associated with forest feed on invertebrates,while species feeding on plants and seeds were more correlated with farmland and village.The results indicated that the conversion of natural habitats to human-dominated landscapes has pronounced impacts on bird communities in the study area.Human-dominated habitats harboured more avian species that deserve conservation attention.Meanwhile,bird conservations should not be relaxed in forests because there were more than 20 species that had a high specificity for forests.展开更多
The abnormal expansion of G-rich hexanucleotide repeat,GGGGCC(G4C2),in chromosome 9 open reading frame 72(C9orf72)is known to be the prevailing genetic cause of two fatal degenerative neurological diseases,amyotrophi...The abnormal expansion of G-rich hexanucleotide repeat,GGGGCC(G4C2),in chromosome 9 open reading frame 72(C9orf72)is known to be the prevailing genetic cause of two fatal degenerative neurological diseases,amyotrophic lateral sclerosis(ALS)and frontotemporal dementia(FTD).It is well known that the DNA G4C2 repeat expansion with different lengths can form G-quadruplexes which affect gene transcription related to ALS/FTD,therefore it is crucial to understand DNA G4C2 G-quadruplex structures.Herein,by utilizing nuclear magnetic resonance(NMR)spectroscopy,we examined DNA G-quadruplex structure adopted by two G4C2 hexanucleotide repeats with an inosine substitution at position 4,d(G4C2)2-I4.We show that d(G4C2)2-I4 folds into an eight-layer parallel tetrameric G-quadruplex containing two parallel dimeric G-quadruplexes stacking together through p-p interaction via 50-to-50 mode in solution.Each dimeric G-quadruplex unit involves two propeller loops composed of two cytosine bases.This result is consistent with the observation in the crystal structure of d(G4C2)2.Our work not only sheds light on the structural diversity of G-quadruplexes adopted by d(G4C2)n but also provides a structural basis for drug design in treatment of ALS and FTD.展开更多
Purpose: Focusing on a comparative analysis of information visualization in library and information science(LIS) from the perspective of research subject and intellectual base, this paper aims to discover the differen...Purpose: Focusing on a comparative analysis of information visualization in library and information science(LIS) from the perspective of research subject and intellectual base, this paper aims to discover the difference and coherence between Chinese domestic studies on information visualization and those of other areas of the world so as to show their theoretical foundation and development trend in a more objective way.Design/methodology/approach: By using the social network analysis tool Ucinet, we have first constructed networks of key author collaboration for 651 articles retrieved from the Chinese Social Sciences Citation Index(CSSCI) and 910 from the Web of Science(WoS),which were published on information visualization between 1998 and 2012 in library and information science, then we compared the intellectual base by mapping analysis from perspective of half-life, centrality and burst detection with CiteSpace II.Findings: Up to date, 51 countries and regions have contributed to the research of information visualization, and in total, we found 9 research clusters of author co-occurrence matrices,among which three are in China. Within Chinese co-author networks, most Chinese scholars have come from the same research institutions, that is to say, more international cooperation and exchange are still required for the research of information visualization across different disciplines and regions.Research limitations: This co-author network and co-citation analysis is mainly based on the research field of LIS with a focus of the WoS and CSSCI databases only, further samples are required for more generalized results to increase our understanding on the development trend of information visualization.Practical implications: This study could lead to a better understanding of the applications of information visualization technologies in discovering the development trend of a research field. Originality/value: To the best of our knowledge, this is the first comparative analysis of research subject and intellectual base on information visualization, specifically, from the perspective of contributions of Chinese scholars in this regard. By dividing most frequently cited Chinese literature into two categories(original and non-original research papers), this paper shows the extent of contributions that Chinese domestic scholars have made to the research of information visualization, by revealing the contributions of different types of Chinese domestic papers on information visualization.展开更多
Plenty of gold deposits related to Late Mesozoic craton destruction are widely distributed in eastern North China Craton. However, significant differences in research degrees, ore-forming characteristics, and proven r...Plenty of gold deposits related to Late Mesozoic craton destruction are widely distributed in eastern North China Craton. However, significant differences in research degrees, ore-forming characteristics, and proven reserves exist among different regions in the North China Craton. The Liaodong Peninsula has similar regional geological characteristics to those of the Jiaodong Peninsula, with both experiencing craton destruction during Late Mesozoic, but the two areas have substantial differences in terms of gold mineralization and the proven gold resources. Based on regional geology, Mesozoic magmatictectonic evolution and ore geology, combined with integrated geophysical exploration and big data AI resource prediction, in this paper, we propose that the ore-forming materials of Late Mesozoic gold deposits in Liaodong were mainly originated from mantle-derived melts and/or fluids induced by craton destruction. The gold deposits were primarily controlled by NE-NNEtrending faults, mainly classified as fracture-controlled altered rock-type and sulfide-bearing quartz vein-type. Moreover, our study predicts that the Yalu River fault zone and its related secondary faults, as well as the periphery and deeper parts of known goldfields, are the important regions for future gold resource exploration. The Yalu River metallogenic belt has an enormous potential for gold resources, and the Liaodong Peninsula has a potential to add thousands of tons of gold resources.展开更多
The research for three-dimension(3D)printing carbon and carbide energy storage devices has attracted widespread exploration interests.Being designable in structure and materials,graphene oxide(GO)and MXene accompanied...The research for three-dimension(3D)printing carbon and carbide energy storage devices has attracted widespread exploration interests.Being designable in structure and materials,graphene oxide(GO)and MXene accompanied with a direct ink writing exhibit a promising prospect for constructing high areal and volume energy density devices.This review not only summarizes the recent advances in 3D printing energy storage devices including printing methods,ink rheological properties,and different energy storage systems,but also discusses the printing methods related to energy storage.In addition,the binder or additive free of two-dimensional carbide materials is quite important for the present electrochemical energy storage devices,which also are presented.展开更多
Nuclear proteins are major constituents and key regulators of nucleome topological organization and manipulators of nuclear events.To decipher the global connectivity of nuclear proteins and the hierarchically organiz...Nuclear proteins are major constituents and key regulators of nucleome topological organization and manipulators of nuclear events.To decipher the global connectivity of nuclear proteins and the hierarchically organized modules of their interactions,we conducted two rounds of cross-linking mass spectrometry(XL-MS)analysis,one of which followed a quantitative double chemical cross-linking mass spectrometry(in vivo qXL-MS)workflow,and identified 24,140 unique crosslinks in total from the nuclei of soybean seedlings.This in vivo quantitative interactomics enabled the identification of 5340 crosslinks that can be converted into 1297 nuclear protein–protein interactions(PPIs),1220(94%)of which were non-confirmative(or novel)nuclear PPIs compared with those in repositories.There were 250 and 26 novel interactors of histones and the nucleolar box C/D small nucleolar ribonucleoprotein complex,respectively.Modulomic analysis of orthologous Arabidopsis PPIs produced 27 and 24 master nuclear PPI modules(NPIMs)that contain the condensate-forming protein(s)and the intrinsically disordered region–containing proteins,respectively.These NPIMs successfully captured previously reported nuclear protein complexes and nuclear bodies in the nucleus.Surprisingly,these NPIMs were hierarchically assorted into four higher-order communities in a nucleomic graph,including genome and nucleolus communities.This combinatorial pipeline of 4C quantitative interactomics and PPI network modularization revealed 17 ethylene-specific module variants that participate in a broad range of nuclear events.The pipeline was able to capture both nuclear protein complexes and nuclear bodies,construct the topological architectures of PPI modules and module variants in the nucleome,and probably map the protein compositions of biomolecular condensates.展开更多
The escalating demand for micro/nano-sized devices,such as micro/nano-robots,intelligent portable/wearable microsystems,and implantable medical microdevices,necessitates the expeditious development of integrated micro...The escalating demand for micro/nano-sized devices,such as micro/nano-robots,intelligent portable/wearable microsystems,and implantable medical microdevices,necessitates the expeditious development of integrated microsystems incorporating energy conversion,storage,and consumption.Critical bottlenecks in microscale energy storage/sensors and their integrated systems are being addressed by exploring new technologies and new materials,e.g.,MXene,holding great potential for developing lightweight and deformable integrated microdevices.This review summarizes the latest progress and milestones in the realization of MXene-based micro-supercapacitors(MSCs)and sensor arrays,and thus discusses the design fundamentals and key advancements of MXene-based energy conversion-storageconsumption integrated microsystems.Finally,we outline the key challenges in fabricating MXenebased MSCs/sensors and their self-powered integrated microsystems,which is crucial for their practical applications.Particularly,we illuminate viable solutions to such unsolved issues and highlight the exciting opportunities.展开更多
The NE-to NNE-striking Tan-Lu Fault Zone(TLFZ) is the largest fault zone in East China, and a typical representative for the circum-Pacific tectonics. Its late Mesozoic evolution resulted from subduction of the Paleo-...The NE-to NNE-striking Tan-Lu Fault Zone(TLFZ) is the largest fault zone in East China, and a typical representative for the circum-Pacific tectonics. Its late Mesozoic evolution resulted from subduction of the Paleo-Pacific Plate,and can be used for indication to the subduction history. The TLFZ reactivated at the end of Middle Jurassic since its origination in Middle Triassic. This phase of sinistral motion can only be recognized along the eastern edge of the Dabie-Sulu orogenis,and indicates initiation of the Paleo-Pacific(Izanagi) Plate subduction beneath the East China continent. After the Late Jurassic standstill, the fault zone experienced intense sinistral faulting again at the beginning of Early Cretaceous under N-S compression that resulted from the NNW-ward, low-angle, high-speed subduction of the Izanagi Plate. It turned into normal faulting in the rest of Early Cretaceous, which was simultaneous with the peak destruction of the North China Craton caused by backarc extension that resulted from rollback of the subducting Izanagi Plate. The TLFZ was subjected to sinistral, transpressive displacement again at the end of Early Cretaceous. This shortening event led to termination of the North China Craton destruction. The fault zone suffered local normal faulting in Late Cretaceous due to the far-field, weak backarc extension. The late Mesozoic evolution of the TLFZ show repeated alternation between the transpressive strike-slip motion and normal faulting. Each of the sinistral faulting event took place in a relatively short period whereas every normal faulting event lasted in a longer period, which are related to the subduction way and history of the Paleo-Pacific Plates.展开更多
The Yunmengshan metamorphic core complex in the middle part of the Yanshan Fold and Thrust Belt records crust extension processes of the eastern North China Craton during its peak destruction.Development of the metamo...The Yunmengshan metamorphic core complex in the middle part of the Yanshan Fold and Thrust Belt records crust extension processes of the eastern North China Craton during its peak destruction.Development of the metamorphic core complex was controlled by the generally NNE-striking Dashuiyu Shear Zone.The shear zone dips SE and becomes shallower NE-wards,leading to exposures of a ductile shear zone in the southern and middle parts and brittle faults in the northern part.Exposure structures,microstructures,and quartz C-axis fabrics indicate that the ductile shear zone belongs to an extensional shear zone with a top-to-the-SE shear sense.Deformation temperatures of 300–520°C suggest a midcrustal origin for the ductile shear zone.A ductile deformation belt in the footwall of the shear zone is only as wide as 1–3 km,indicating no widespread mid-crustal ductile flow in the region during the deformation.Zircon U–Pb dating of dykes and plutons as well as hornblende and biotite40Ar/39Ar dating demonstrate that the metamorphic core complex originated at 135 Ma and experienced intense shearing of the Dashuiyu Shear Zone,development of the supradetachment basins,and synkinematic intrusion during 135–125 Ma.The metamorphic core complex was subjected to rapid exhumation during 125–114 Ma when the Dashuiyu Shear Zone suffered continuous activity and passive doming.The shear zone and its hanging wall were cut or replaced by a series of brittle faults when they wereuplifted to a brittle regime,showing that exhumation took place in continuous extensional activities.The metamorphic core complex turned into slow exhumation in an extensional regime in the following latest Early Cretaceous.The evolution history suggests that the Yunmengshan metamorphic core complex was developed by the rolling-hinge model,a common formation mechanism for intraplate metamorphic core complexes in the North China Craton,under the continuous NW–SE extension during the Early Cretaceous(135–100 Ma).展开更多
Corrosion protection of the hull steel by the conventional epoxy paint containing a small amount of commercial poly(3,4-ethylenedioxythiophene)/poly(styrene sulfonate)(PEDOT/PSS),which is one of the most popular and s...Corrosion protection of the hull steel by the conventional epoxy paint containing a small amount of commercial poly(3,4-ethylenedioxythiophene)/poly(styrene sulfonate)(PEDOT/PSS),which is one of the most popular and successful inherently conducting polymers as the corrosion inhibitor was studied.The corrosion behavior of the samples was investigated in seawater by electrochemical impedance spectroscopy and open circuit potential.Scanning electron microscopy was used to observe the surface morphology of the samples after corrosion.It was found that adding a small amount of PEDOT/PSS to the epoxy resin can significantly improve its corrosion protection.展开更多
基金Supported by the National Natural Science Foundation of China,No.81401988China Postdoctoral Science Foundation,No.2019M661907+4 种基金Jiangsu Postdoctoral Science Foundation,No.2019K159,and No.2019Z153General Project of Jiangsu Provincial Health Committee,No.H2023136General Project of Nantong Municipal Health Committee,No.MS2023013Jiangsu Provincial Research Hospital,No.YJXYY202204-YSB28and College Student Innovation Program,No.202210304128Y,and No.2023103041055.
文摘Artificial Intelligence(AI)has increased as a potent tool in medicine,with promising oncology applications.The emergence of immunotherapy has transformed the treatment terrain for hepatocellular carcinoma(HCC),offering new hope to patients with this challenging malignancy.This article examines the role and future of AI in forecasting the effectiveness of immunotherapy in HCC.We highlight the potential of AI to revolutionize the prediction of therapy response,thus improving patient selection and clinical outcomes.The article further outlines the challenges and future research directions in this emerging field.
基金Supported by Medical Health Science and Technology Project of Zhejiang Province,China,No.2020ZH003。
文摘BACKGROUND Cesarean scar pregnancy(CSP)is rare but may result in uterine rupture during pregnancy or massive hemorrhage during abortion procedures.Awareness of this condition is increasing,and most patients with CSP are now diagnosed early and can be managed safely.However,some atypical patients are misdiagnosed,and their surgical risks are underestimated,increasing the risk of fatal hemorrhage.CASE SUMMARY A 27-year-old Asian woman visited our institution because of abnormal pregnancy,and she was diagnosed with a hydatidiform mole through transvaginal ultrasound(TVS).Under hysteroscopy,a large amount of placental tissue was found in the scar of the lower uterine segment,and a sudden massive hemorrhage occurred during the removal process.The bilateral internal iliac arteries were temporarily blocked under laparoscopy,and scar resection and repair were rapidly performed.She was discharged in good condition 5 d after the operation.CONCLUSION Although TVS is widely used in the diagnosis of CSP,delays in the diagnosis of atypical CSP remain.Surgical treatment following internal iliac artery temporary occlusion may be an appropriate management method for unanticipated massive hemorrhage during CSP surgery.
基金supported by the Key Program of the National Natural Science Foundation of China(No.19934003)the Grand Program of Natural Science Research of Anhui Education Department(No.ZD2007003-1)+1 种基金the Natural Science Research Program of Universities and Colleges of Anhui Province(No.KJ2008A19ZC)the Opening Program of Cultivating Baseof Anhui Key Laboratory of Spintronics and Nano-materials(No.2012YKF10)
文摘Large-scale vapor-solid synthesis of ultralong silicon nitride (Si3N4) nanowires was achieved by using simple thermal evaporation of mixture powders of active carbon and monoxide silicon. The products were characterized by X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and transmission electron microscopy. The results suggest that the silicon nitride nanowires have a smooth surface, with lengths of up to several hundreds of microns and diameters of 100-300 nm. A detailed study of both the chemical and structural composition was performed. Such ultralong silicon nitride nanowires demonstrate potential applications as materials for constructing nanoscale devices and as reinforcement in advanced composites.
基金supported by Medicine Science and Technology Research Project of Hebei Province
文摘Objective:To assess the relation between XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia.Methods:Related studies of XRCC3 Thr24lMet polymorphism and lung cancer susceptibility of populations in East Asia were collected through searching the Pubmed,Embase Library,SPRINGER.CNKI and CSSCI.Results:According to the entry criteria,there were 8 case-control studies in the assessing system and there were 6 321study cases,including 3 215 patients with lung cancer and 3 106 cases without cancers.Meta analysis results showed the combined OR value of the ratio of genotype Thr/Met+Met/Met and Thr/Thr was 1.03(95%CI:0.89-1.20)(P>0.05).Conclusions:XRCC3 Thr241Met polymorphism may not related to lung cancer susceptibility of populations in East Asia.Allele 241Met did not increase the risk of lung cancer.
基金jointly supported by the National Social Science Foundation of China(Grant Nos.:08ATQ003 and 10&ZD134)
文摘Purpose:The purpose of this study is to develop an automated frequently asked question(FAQ)answering system for farmers.This paper presents an approach for calculating the similarity between Chinese sentences based on hybrid strategies.Design/methodology/approach:We analyzed the factors influencing the successful matching between a user’s question and a question-answer(QA)pair in the FAQ database.Our approach is based on a combination of multiple factors.Experiments were conducted to test the performance of our method.Findings:Experiments show that this proposed method has higher accuracy.Compared with similarity calculation based on TF-IDF,the sentence surface forms and the semantic relations,the proposed method based on hybrid strategies has a superior performance in precision,recall and F-measure value.Research limitations:The FAQ answering system is only capable of meeting users’demand for text retrieval at present.In the future,the system needs to be improved to meet users’demand for retrieving images and videos.Practical implications:This FAQ answering system will help farmers utilize agricultural information resources more efficiently.Originality/value:We design the algorithms for calculating similarity of Chinese sentences based on hybrid strategies,which integrate the question surface similarity,the question semantic similarity and the question-answer similarity based on latent semantic analysis(LSA)to find answers to a user’s question.
基金supported by the National Natural Science Foundation of China (grant numbers 31970500 and 31770571)the Excellent Youth Project of the Anhui Natural Science Foundation (2108085Y09)the Biodiversity Investigation,Observation and Assessment Program (2019-2023) of Ministry of Ecology and Environment of China
文摘Conversion of natural environments to human-modified landscapes is continuing at an unprecedented rate,exerting fundamental influences on global biodiversity.Understanding how wildlife communities respond to landscape modifications is critical to improve biodiversity conservation in human-dominated landscapes.In this study,we surveyed bird communities in three common habitats(i.e.,farmland,village,and forest)in the southern Anhui Mountainous Area during summer(August 2019)and winter(December 2020).The diversity metrics and species compositions of the avian communities were compared among the habitats,and the effects of land use composition in these habitats were tested.During the field surveys,we recorded 7599 birds of 120 species along 45 line transects of 1km in length.The land use compositions differed among habitats,and land use diversity was the highest in villages and lowest in forests.The species richness and bird abundance in the two human-dominated habitats(i.e.,farmland and village)were higher than those in forest in both seasons.Bird species composition also differed across habitat types in both seasons.Bird species feeding on vertebrates,fish and carrion,and species feeding on plants and seeds were mainly found in habitats with less construction lands and lower land use diversity,while omnivorous species and species feeding on fruits and nectar or on invertebrates were less affected by these two variables.The indicator species analysis showed that most species associated with forest feed on invertebrates,while species feeding on plants and seeds were more correlated with farmland and village.The results indicated that the conversion of natural habitats to human-dominated landscapes has pronounced impacts on bird communities in the study area.Human-dominated habitats harboured more avian species that deserve conservation attention.Meanwhile,bird conservations should not be relaxed in forests because there were more than 20 species that had a high specificity for forests.
基金the National Natural Science Foundation of China to C.L.(No.32071188)Guangdong Basic and Applied Basic Research Foundation to C.L.(No.2020A1515010034)+1 种基金the Research Grants Council of the Hong Kong Special Administrative Region,China to G.Z.(Project No.16103719,16101120,and 161011121,AoE/M-403-16,AOE/M-401/20)Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)to G.Z.(Project No.SMSEGL20SC01eH)and VPRDO19RD03-6.
文摘The abnormal expansion of G-rich hexanucleotide repeat,GGGGCC(G4C2),in chromosome 9 open reading frame 72(C9orf72)is known to be the prevailing genetic cause of two fatal degenerative neurological diseases,amyotrophic lateral sclerosis(ALS)and frontotemporal dementia(FTD).It is well known that the DNA G4C2 repeat expansion with different lengths can form G-quadruplexes which affect gene transcription related to ALS/FTD,therefore it is crucial to understand DNA G4C2 G-quadruplex structures.Herein,by utilizing nuclear magnetic resonance(NMR)spectroscopy,we examined DNA G-quadruplex structure adopted by two G4C2 hexanucleotide repeats with an inosine substitution at position 4,d(G4C2)2-I4.We show that d(G4C2)2-I4 folds into an eight-layer parallel tetrameric G-quadruplex containing two parallel dimeric G-quadruplexes stacking together through p-p interaction via 50-to-50 mode in solution.Each dimeric G-quadruplex unit involves two propeller loops composed of two cytosine bases.This result is consistent with the observation in the crystal structure of d(G4C2)2.Our work not only sheds light on the structural diversity of G-quadruplexes adopted by d(G4C2)n but also provides a structural basis for drug design in treatment of ALS and FTD.
基金jointly supported by National Social Science Foundation of China (Grant No.:10&ZD134)Jiangsu College Graduate Research and Innovation Plan (Grant No.:CXLX13_065)
文摘Purpose: Focusing on a comparative analysis of information visualization in library and information science(LIS) from the perspective of research subject and intellectual base, this paper aims to discover the difference and coherence between Chinese domestic studies on information visualization and those of other areas of the world so as to show their theoretical foundation and development trend in a more objective way.Design/methodology/approach: By using the social network analysis tool Ucinet, we have first constructed networks of key author collaboration for 651 articles retrieved from the Chinese Social Sciences Citation Index(CSSCI) and 910 from the Web of Science(WoS),which were published on information visualization between 1998 and 2012 in library and information science, then we compared the intellectual base by mapping analysis from perspective of half-life, centrality and burst detection with CiteSpace II.Findings: Up to date, 51 countries and regions have contributed to the research of information visualization, and in total, we found 9 research clusters of author co-occurrence matrices,among which three are in China. Within Chinese co-author networks, most Chinese scholars have come from the same research institutions, that is to say, more international cooperation and exchange are still required for the research of information visualization across different disciplines and regions.Research limitations: This co-author network and co-citation analysis is mainly based on the research field of LIS with a focus of the WoS and CSSCI databases only, further samples are required for more generalized results to increase our understanding on the development trend of information visualization.Practical implications: This study could lead to a better understanding of the applications of information visualization technologies in discovering the development trend of a research field. Originality/value: To the best of our knowledge, this is the first comparative analysis of research subject and intellectual base on information visualization, specifically, from the perspective of contributions of Chinese scholars in this regard. By dividing most frequently cited Chinese literature into two categories(original and non-original research papers), this paper shows the extent of contributions that Chinese domestic scholars have made to the research of information visualization, by revealing the contributions of different types of Chinese domestic papers on information visualization.
基金supported by the National Natural Science Foundation of China(Grant No.42288201)the National Key Research&Development Program of the Ministry of Science and Technology of China(Grant No.2016YFC0600109)。
文摘Plenty of gold deposits related to Late Mesozoic craton destruction are widely distributed in eastern North China Craton. However, significant differences in research degrees, ore-forming characteristics, and proven reserves exist among different regions in the North China Craton. The Liaodong Peninsula has similar regional geological characteristics to those of the Jiaodong Peninsula, with both experiencing craton destruction during Late Mesozoic, but the two areas have substantial differences in terms of gold mineralization and the proven gold resources. Based on regional geology, Mesozoic magmatictectonic evolution and ore geology, combined with integrated geophysical exploration and big data AI resource prediction, in this paper, we propose that the ore-forming materials of Late Mesozoic gold deposits in Liaodong were mainly originated from mantle-derived melts and/or fluids induced by craton destruction. The gold deposits were primarily controlled by NE-NNEtrending faults, mainly classified as fracture-controlled altered rock-type and sulfide-bearing quartz vein-type. Moreover, our study predicts that the Yalu River fault zone and its related secondary faults, as well as the periphery and deeper parts of known goldfields, are the important regions for future gold resource exploration. The Yalu River metallogenic belt has an enormous potential for gold resources, and the Liaodong Peninsula has a potential to add thousands of tons of gold resources.
基金financially supported by the Natural Science Research Project in Universities of Anhui Province in China (No.K J2020A0727)the Key Discipline of Material Science and Engineering of Suzhou University (No.2017XJZDXK3)+2 种基金the Doctor of Suzhou University Scientific Research (No.2020BS014)the Graduate Research and Innovation Fund of Suzhou University (No.2021KYCX11)the platform of Suzhou University (No.2021XJPT16)。
文摘The research for three-dimension(3D)printing carbon and carbide energy storage devices has attracted widespread exploration interests.Being designable in structure and materials,graphene oxide(GO)and MXene accompanied with a direct ink writing exhibit a promising prospect for constructing high areal and volume energy density devices.This review not only summarizes the recent advances in 3D printing energy storage devices including printing methods,ink rheological properties,and different energy storage systems,but also discusses the printing methods related to energy storage.In addition,the binder or additive free of two-dimensional carbide materials is quite important for the present electrochemical energy storage devices,which also are presented.
基金supported by grants 31370315,31570187,31870231,and 32070205 from the National Science Foundation of China16102422,16103621,16101114,16103817,16103615,16100318,16101819,16101920,16306919,AOE/M-403-16,R4012-18,and C6021-19EF from the RGC of Hong Kong+2 种基金ITS/480/18FP and MHP/033/20 from the Innovation and Technology Commission(ITC)of Hong Kongthe Hetao Shenzhen-Hong Kong Science and Technology Innovation Cooperation Zone project(HZQB-KCZYB-2020083)internal funding support from HKUST.
文摘Nuclear proteins are major constituents and key regulators of nucleome topological organization and manipulators of nuclear events.To decipher the global connectivity of nuclear proteins and the hierarchically organized modules of their interactions,we conducted two rounds of cross-linking mass spectrometry(XL-MS)analysis,one of which followed a quantitative double chemical cross-linking mass spectrometry(in vivo qXL-MS)workflow,and identified 24,140 unique crosslinks in total from the nuclei of soybean seedlings.This in vivo quantitative interactomics enabled the identification of 5340 crosslinks that can be converted into 1297 nuclear protein–protein interactions(PPIs),1220(94%)of which were non-confirmative(or novel)nuclear PPIs compared with those in repositories.There were 250 and 26 novel interactors of histones and the nucleolar box C/D small nucleolar ribonucleoprotein complex,respectively.Modulomic analysis of orthologous Arabidopsis PPIs produced 27 and 24 master nuclear PPI modules(NPIMs)that contain the condensate-forming protein(s)and the intrinsically disordered region–containing proteins,respectively.These NPIMs successfully captured previously reported nuclear protein complexes and nuclear bodies in the nucleus.Surprisingly,these NPIMs were hierarchically assorted into four higher-order communities in a nucleomic graph,including genome and nucleolus communities.This combinatorial pipeline of 4C quantitative interactomics and PPI network modularization revealed 17 ethylene-specific module variants that participate in a broad range of nuclear events.The pipeline was able to capture both nuclear protein complexes and nuclear bodies,construct the topological architectures of PPI modules and module variants in the nucleome,and probably map the protein compositions of biomolecular condensates.
文摘The escalating demand for micro/nano-sized devices,such as micro/nano-robots,intelligent portable/wearable microsystems,and implantable medical microdevices,necessitates the expeditious development of integrated microsystems incorporating energy conversion,storage,and consumption.Critical bottlenecks in microscale energy storage/sensors and their integrated systems are being addressed by exploring new technologies and new materials,e.g.,MXene,holding great potential for developing lightweight and deformable integrated microdevices.This review summarizes the latest progress and milestones in the realization of MXene-based micro-supercapacitors(MSCs)and sensor arrays,and thus discusses the design fundamentals and key advancements of MXene-based energy conversion-storageconsumption integrated microsystems.Finally,we outline the key challenges in fabricating MXenebased MSCs/sensors and their self-powered integrated microsystems,which is crucial for their practical applications.Particularly,we illuminate viable solutions to such unsolved issues and highlight the exciting opportunities.
基金supported by the National Natural Science Foundation of China(Grant Nos.41472186&91414301)the National Key Basic Research Program of China(Grant No.2016YFC0600102)
文摘The NE-to NNE-striking Tan-Lu Fault Zone(TLFZ) is the largest fault zone in East China, and a typical representative for the circum-Pacific tectonics. Its late Mesozoic evolution resulted from subduction of the Paleo-Pacific Plate,and can be used for indication to the subduction history. The TLFZ reactivated at the end of Middle Jurassic since its origination in Middle Triassic. This phase of sinistral motion can only be recognized along the eastern edge of the Dabie-Sulu orogenis,and indicates initiation of the Paleo-Pacific(Izanagi) Plate subduction beneath the East China continent. After the Late Jurassic standstill, the fault zone experienced intense sinistral faulting again at the beginning of Early Cretaceous under N-S compression that resulted from the NNW-ward, low-angle, high-speed subduction of the Izanagi Plate. It turned into normal faulting in the rest of Early Cretaceous, which was simultaneous with the peak destruction of the North China Craton caused by backarc extension that resulted from rollback of the subducting Izanagi Plate. The TLFZ was subjected to sinistral, transpressive displacement again at the end of Early Cretaceous. This shortening event led to termination of the North China Craton destruction. The fault zone suffered local normal faulting in Late Cretaceous due to the far-field, weak backarc extension. The late Mesozoic evolution of the TLFZ show repeated alternation between the transpressive strike-slip motion and normal faulting. Each of the sinistral faulting event took place in a relatively short period whereas every normal faulting event lasted in a longer period, which are related to the subduction way and history of the Paleo-Pacific Plates.
基金This research was supported by the U.S. Department of Energy, Office of Basic Energy Sciences （Award No. DE-FG02-07ER46394）, National Science Foundation （NSF） （No. 0946418）, and the Knowledge Innovation Program of the Chinese Academy of Sciences （Grant No. KJCX2-YW-M13）. Patents have been filed based on the research results presented in this manuscript.
文摘摩擦电 nanogenerators (TENG ) ，为基于摩擦电效果收获周围的机械精力的一种唯一的技术，被证明了是为自我动力的系统的一条划算、简单、柔韧的途径。这里，我们为收获颤动精力表明讲道理地设计的三倍伸臂的基于的 TENG。与制作到金皮铜合金陪衬的表面上的 nanowire 数组的帮助，最新设计的 TENG 与 252.3 mW/m2 的山峰功率密度生产开电路的电压直到 101 V 和 55.7 A 的电线走火电流。TENG 系统地为即刻地照亮 40 根商业轻射出的二极管作为直接力量来源被调查并且示威。第一次，一台 TENG 设备为收获颤动精力被设计了，特别在低频率，打开它象一种新精力技术的申请。
基金supported by the National Natural Science Foundation of China (91214301)
文摘The Yunmengshan metamorphic core complex in the middle part of the Yanshan Fold and Thrust Belt records crust extension processes of the eastern North China Craton during its peak destruction.Development of the metamorphic core complex was controlled by the generally NNE-striking Dashuiyu Shear Zone.The shear zone dips SE and becomes shallower NE-wards,leading to exposures of a ductile shear zone in the southern and middle parts and brittle faults in the northern part.Exposure structures,microstructures,and quartz C-axis fabrics indicate that the ductile shear zone belongs to an extensional shear zone with a top-to-the-SE shear sense.Deformation temperatures of 300–520°C suggest a midcrustal origin for the ductile shear zone.A ductile deformation belt in the footwall of the shear zone is only as wide as 1–3 km,indicating no widespread mid-crustal ductile flow in the region during the deformation.Zircon U–Pb dating of dykes and plutons as well as hornblende and biotite40Ar/39Ar dating demonstrate that the metamorphic core complex originated at 135 Ma and experienced intense shearing of the Dashuiyu Shear Zone,development of the supradetachment basins,and synkinematic intrusion during 135–125 Ma.The metamorphic core complex was subjected to rapid exhumation during 125–114 Ma when the Dashuiyu Shear Zone suffered continuous activity and passive doming.The shear zone and its hanging wall were cut or replaced by a series of brittle faults when they wereuplifted to a brittle regime,showing that exhumation took place in continuous extensional activities.The metamorphic core complex turned into slow exhumation in an extensional regime in the following latest Early Cretaceous.The evolution history suggests that the Yunmengshan metamorphic core complex was developed by the rolling-hinge model,a common formation mechanism for intraplate metamorphic core complexes in the North China Craton,under the continuous NW–SE extension during the Early Cretaceous(135–100 Ma).
基金the financial support from the National Natural Science Foundation of China(Nos.50963002 and 51073074)
文摘Corrosion protection of the hull steel by the conventional epoxy paint containing a small amount of commercial poly(3,4-ethylenedioxythiophene)/poly(styrene sulfonate)(PEDOT/PSS),which is one of the most popular and successful inherently conducting polymers as the corrosion inhibitor was studied.The corrosion behavior of the samples was investigated in seawater by electrochemical impedance spectroscopy and open circuit potential.Scanning electron microscopy was used to observe the surface morphology of the samples after corrosion.It was found that adding a small amount of PEDOT/PSS to the epoxy resin can significantly improve its corrosion protection.
