Objective： p53 is a tumor suppressor gene and is involved in the etiology of ovarian cancer. Studies investigating the associations between the p53 codon 72 polymorphism and ovarian cancer risk showed conflicting res...Objective： p53 is a tumor suppressor gene and is involved in the etiology of ovarian cancer. Studies investigating the associations between the p53 codon 72 polymorphism and ovarian cancer risk showed conflicting results. We performed this meta-analysis from eligible studies to evaluate this purported relationship. Methods： This meta-analysis was performed from 9 case-control studies, including 825 ovarian cases and 1073 controls. The fixed and random effect models were used to estimate the odds ratios（ORs） for various contrasts of this polymorphism. Results： The combined results based on all studies showed that a significantly decreased risk was associated with the variant Pro/Pro genotype, compared with Arg/Pro＋Arg/Arg genotypes（OR, 0.70; 95%CI, 0.51-0.95）. When stratifying the studies by ethnicity, we found that individuals with the variant genotype Pro/pro had a significantly decreased risk of ovarian cancer compared with Arg/Arg genotype（OR, 0.43; 95%CI, 0.20-0.89） and Arg/Pro＋Arg/Arg genotypes（OR, 0.61; 95%CI, 0.37-0.99） among Africans. Conclusion： This meta-analysis suggests that the p53 codon 72 polymorphism may contribute to genetic susceptibility to ovarian cancer. More studies based on larger sample size should be performed to confirm the findings.展开更多
Caspase-8 （CASPS） plays a key role in apoptosis. We examined by genotyping whether the -652 six-nucleotide insertion-deletion （6N ins/del） polymorphism in the CASP8 promoter region was associated with prostate can...Caspase-8 （CASPS） plays a key role in apoptosis. We examined by genotyping whether the -652 six-nucleotide insertion-deletion （6N ins/del） polymorphism in the CASP8 promoter region was associated with prostate cancer risk in a hospital-based case-control study of 406 Chinese prostate cancer patients and 408 age-matched cancerfree controls. Additionally, 23 prostate cancer tissues were analyzed for CASP8 mRNA expression. We found a significantly decreased prostate cancer risk for the 6N ins/del genotype [adjusted odds ratio （OR）=0.68; 95% confidence interval （C/）=0.51-0.92] and del/del genotype （OR=0.34; 95% CI=0.19-0.63） compared with the ins/ins genotype. The 6N del allele was associated dose-dependently with decreased prostate cancer risk （Ptrend = 0.001）. RT-PCR showed that individuals with the 6N del allele had lower CASP8 mRNA levels than those with the ins/ ins genotype （P = 0.024）. These findings suggested that the CASPS-652 6N ins/del polymorphism may affect the susceptibility to prostate cancer and reduce prostate cancer risk among Chinese men.展开更多
基金the National Natural Science Foun-dation of China(30571583 and 30271105)the Ph.D.Programs Foun-dation of Ministry of Education of China(20060312002)+3 种基金the NaturalScience Foundation of Jiangsu Province(BK2006231)the PostdoctoralScience Foundation of China(20060390293)the Postdoctoral ScienceFoundation of Jiangsu Province(0601049)"Qinglan Project"Fundation for the Young Academic Leader of Jiangsu Province(2006)
文摘Objective： p53 is a tumor suppressor gene and is involved in the etiology of ovarian cancer. Studies investigating the associations between the p53 codon 72 polymorphism and ovarian cancer risk showed conflicting results. We performed this meta-analysis from eligible studies to evaluate this purported relationship. Methods： This meta-analysis was performed from 9 case-control studies, including 825 ovarian cases and 1073 controls. The fixed and random effect models were used to estimate the odds ratios（ORs） for various contrasts of this polymorphism. Results： The combined results based on all studies showed that a significantly decreased risk was associated with the variant Pro/Pro genotype, compared with Arg/Pro＋Arg/Arg genotypes（OR, 0.70; 95%CI, 0.51-0.95）. When stratifying the studies by ethnicity, we found that individuals with the variant genotype Pro/pro had a significantly decreased risk of ovarian cancer compared with Arg/Arg genotype（OR, 0.43; 95%CI, 0.20-0.89） and Arg/Pro＋Arg/Arg genotypes（OR, 0.61; 95%CI, 0.37-0.99） among Africans. Conclusion： This meta-analysis suggests that the p53 codon 72 polymorphism may contribute to genetic susceptibility to ovarian cancer. More studies based on larger sample size should be performed to confirm the findings.
基金supported by National Natural Science Foundation of China (No. 30872084 and No. 30972444)the Key Programfor Basic Research of Jiangsu Provincial Department of Education (No.08KJA330001)"Qinglan Project" Foundation for the Young Academic Leader of Jiangsu Province (Zhengdong Zhang)
文摘Caspase-8 （CASPS） plays a key role in apoptosis. We examined by genotyping whether the -652 six-nucleotide insertion-deletion （6N ins/del） polymorphism in the CASP8 promoter region was associated with prostate cancer risk in a hospital-based case-control study of 406 Chinese prostate cancer patients and 408 age-matched cancerfree controls. Additionally, 23 prostate cancer tissues were analyzed for CASP8 mRNA expression. We found a significantly decreased prostate cancer risk for the 6N ins/del genotype [adjusted odds ratio （OR）=0.68; 95% confidence interval （C/）=0.51-0.92] and del/del genotype （OR=0.34; 95% CI=0.19-0.63） compared with the ins/ins genotype. The 6N del allele was associated dose-dependently with decreased prostate cancer risk （Ptrend = 0.001）. RT-PCR showed that individuals with the 6N del allele had lower CASP8 mRNA levels than those with the ins/ ins genotype （P = 0.024）. These findings suggested that the CASPS-652 6N ins/del polymorphism may affect the susceptibility to prostate cancer and reduce prostate cancer risk among Chinese men.
