What is already known about this topic?Diarrhea represents a substantial public health issue,contributing globally to a high number of pediatric medical consultations,hospital admissions,and mortality rates.What is ad...What is already known about this topic?Diarrhea represents a substantial public health issue,contributing globally to a high number of pediatric medical consultations,hospital admissions,and mortality rates.What is added by this report?An increase in diarrheal frequency serves as a critical benchmark for evaluating severity.The predominant pathogens associated with pediatric diarrhea are rotavirus and norovirus,with co-infections exerting a notable compounding effect that leads to more severe diarrhea.What are the implications for public health practice?Implementing sensitive diagnostic techniques and comprehensive monitoring is paramount in identifying co-infections.Such strategies can provide physicians with critical insights into disease progression,thus considerably reducing the burden of diarrhea.展开更多
滚环扩增(Rolling circle amplification,RCA)是一种快速、灵敏且恒温的单链DNA(Single-stranded DNA,ssDNA)扩增技术,与染色或探针联用可实现检测信号的放大,在生物检测等方面得到广泛的应用。文中对RCA的构建方法进行了简介,综述了近...滚环扩增(Rolling circle amplification,RCA)是一种快速、灵敏且恒温的单链DNA(Single-stranded DNA,ssDNA)扩增技术,与染色或探针联用可实现检测信号的放大,在生物检测等方面得到广泛的应用。文中对RCA的构建方法进行了简介,综述了近几年其在致病菌、核酸肿瘤标记物、蛋白质、生物小分子和病毒等检测中的研究进展,并对其未来的发展趋势进行了展望。展开更多
Based on the official data modeling,this paper studies the transmission process of the Corona Virus Disease 2019(COVID-19).The error between the model and the official data curve is quite small.At the same time,it rea...Based on the official data modeling,this paper studies the transmission process of the Corona Virus Disease 2019(COVID-19).The error between the model and the official data curve is quite small.At the same time,it realized forward prediction and backward inference of the epidemic situation,and the relevant analysis help relevant countries to make decisions.展开更多
The rapid miniaturization of elect, ronic devices motivates research interests in quantum transport.Recently time-dependent quantum transport has become an important research topic. Here we re- view recent progresses ...The rapid miniaturization of elect, ronic devices motivates research interests in quantum transport.Recently time-dependent quantum transport has become an important research topic. Here we re- view recent progresses in the development of time-dependent density-functional theory for quantum transport including the theoretical foundation and numerical algorithms. In particular, the reducedsingle electron density matrix based hierarchical equation of motion, which can be derived from Liouville---von Neumann equation, is reviewed in details. The numerical implementation is discussed and simulation results of realistic devices will be given.展开更多
Lithium-ion batteries(LIBs)are widely employed in electric vehicles owing to their high power density,long cycle life,and environmental friendliness.However,LIBs are hazardous in the event of a crash,leading to therma...Lithium-ion batteries(LIBs)are widely employed in electric vehicles owing to their high power density,long cycle life,and environmental friendliness.However,LIBs are hazardous in the event of a crash,leading to thermal runaway.In this study,the basic structure of a battery module is analyzed to improve the crashworthiness of LIBs.A simplified finite element model of the battery module structure,which is a battery unit composed of two pouch cells and a cooling fin,is set up and verified by conducting module-level simulations.The simulation results reveal that the cooling fin in the battery module has the potential to absorb energy.Six sandwich configurations are introduced to modify the cooling fin.With a unidirection-ally stiffened double hull USDH structure serving as an example,a parametric analysis is conducted,demonstrating that the sandwich height does not influence the areal density;a small height of 3 mm can make the material work sufficiently while avoiding early buckling of the structure.Further,the crashworthiness of different sandwich configurations with the same areal density and height is compared,leading to three deformation modes.USDH and circular core structures are found to be able to effectively reduce the peak force and improve the energy absorption ability.展开更多
基金Supported by the Three-year Action Plan for Promoting Clinical Skills and Innovation Ability of Municipal Hospitals(SHDC2022CRS039)Shanghai Natural Science Foundation(22ZR1462100,23ZR1464000,23ZR1463900)+4 种基金Medical Innovation Research Special Project of the Shanghai 2021“Science and Technology Innovation Action Plan”(21Y11922500,21Y11922400)the Talent Fund of Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine(LH001.007)Natural Science Foundation of Gansu Province(21JR11RA182)Research Ward Construction Project of Shanghai Hospital Development Center(SHDC2022CRW006)Shanghai Municipal Education Commission Collaborative Innovation Center(A1-U21-205-902).
文摘What is already known about this topic?Diarrhea represents a substantial public health issue,contributing globally to a high number of pediatric medical consultations,hospital admissions,and mortality rates.What is added by this report?An increase in diarrheal frequency serves as a critical benchmark for evaluating severity.The predominant pathogens associated with pediatric diarrhea are rotavirus and norovirus,with co-infections exerting a notable compounding effect that leads to more severe diarrhea.What are the implications for public health practice?Implementing sensitive diagnostic techniques and comprehensive monitoring is paramount in identifying co-infections.Such strategies can provide physicians with critical insights into disease progression,thus considerably reducing the burden of diarrhea.
文摘滚环扩增(Rolling circle amplification,RCA)是一种快速、灵敏且恒温的单链DNA(Single-stranded DNA,ssDNA)扩增技术,与染色或探针联用可实现检测信号的放大,在生物检测等方面得到广泛的应用。文中对RCA的构建方法进行了简介,综述了近几年其在致病菌、核酸肿瘤标记物、蛋白质、生物小分子和病毒等检测中的研究进展,并对其未来的发展趋势进行了展望。
文摘Based on the official data modeling,this paper studies the transmission process of the Corona Virus Disease 2019(COVID-19).The error between the model and the official data curve is quite small.At the same time,it realized forward prediction and backward inference of the epidemic situation,and the relevant analysis help relevant countries to make decisions.
文摘The rapid miniaturization of elect, ronic devices motivates research interests in quantum transport.Recently time-dependent quantum transport has become an important research topic. Here we re- view recent progresses in the development of time-dependent density-functional theory for quantum transport including the theoretical foundation and numerical algorithms. In particular, the reducedsingle electron density matrix based hierarchical equation of motion, which can be derived from Liouville---von Neumann equation, is reviewed in details. The numerical implementation is discussed and simulation results of realistic devices will be given.
基金This study is supported by the National Natural Science Foundation of China(Grant Nos.51675294 and U1564205)the International Science and Technology Cooperation Program of China(Grant No.2016YFE0102200)the State Key Laboratory of Vehicle NVH and Safety Technology(Contract No.NVHSKL-201907).
文摘Lithium-ion batteries(LIBs)are widely employed in electric vehicles owing to their high power density,long cycle life,and environmental friendliness.However,LIBs are hazardous in the event of a crash,leading to thermal runaway.In this study,the basic structure of a battery module is analyzed to improve the crashworthiness of LIBs.A simplified finite element model of the battery module structure,which is a battery unit composed of two pouch cells and a cooling fin,is set up and verified by conducting module-level simulations.The simulation results reveal that the cooling fin in the battery module has the potential to absorb energy.Six sandwich configurations are introduced to modify the cooling fin.With a unidirection-ally stiffened double hull USDH structure serving as an example,a parametric analysis is conducted,demonstrating that the sandwich height does not influence the areal density;a small height of 3 mm can make the material work sufficiently while avoiding early buckling of the structure.Further,the crashworthiness of different sandwich configurations with the same areal density and height is compared,leading to three deformation modes.USDH and circular core structures are found to be able to effectively reduce the peak force and improve the energy absorption ability.
