Impaired wound healing presents great health risks to diabetics.Encouragingly,the current clinical successfully found out meaningful method to repair wound tissue,and stem cell therapy could be an effective method for...Impaired wound healing presents great health risks to diabetics.Encouragingly,the current clinical successfully found out meaningful method to repair wound tissue,and stem cell therapy could be an effective method for diabetic wound healing with its ability to accelerate wound closure and avoid amputation.This minireview aims at introducing stem cell therapy for facilitating tissue repair in diabetic wounds,discussing the possible therapeutic mechanism and clinical application status and problems.展开更多
AIM:To evaluate the effectiveness of Grand Seiko Ref/Keratometer WAM-5500 compared to Topcon KR800 autorefractor in detecting refractive error in large scale vision screening for Chinese school age children with the W...AIM:To evaluate the effectiveness of Grand Seiko Ref/Keratometer WAM-5500 compared to Topcon KR800 autorefractor in detecting refractive error in large scale vision screening for Chinese school age children with the WHO criteria.METHODS:A total of 886 participants were enrolled with mean age of 9.49±1.88 y from Tianjin,China.Spherical equivalent(SE)was obtained from un-cycloplegic autorefraction and cycloplegic autorefraction.Topcon KR 800(Topcon)and Grand Seiko WAM-5500(WAM)autorefractors were used.Bland-Altman Plot and regression were generated to compare their performance.The overall effectiveness of detecting early stage refractive error was analyzed with receiver operating characteristic(ROC)curves.RESULTS:The mean SE was-0.98±1.81 diopter(D)and the prevalence of myopia was 48.9%defined by WHO criteria according to the result of cycloplegic autorefraction.The mean SE of un-cycloplegic autorefraction with Topcon and WAM were-1.21±1.65 and-1.20±1.68 D respectively.There was a strong linear agreement between result obtained from WAM and cycloplegic autorefraction with an R2 of 0.8318.Bland-Altman plot indicated a moderate agreement of cylinder values between the two methods.The sensitivity and specificity for detecting hyperopia were 90.52%and 83.51%;for detecting myopia were 95.60%and 90.24%;for detecting astigmatism were 79.40%and 90.21%;for detecting high myopia were 98.16%and 98.91%respectively.CONCLUSION:These findings suggest that both Grand Seiko and Topcon autorefractor can be used in large-scale vision screening for detecting refractive error in Chinese population.Grand Seiko gives relatively better performance in detecting myopia,hyperopia,and high myopia for school age children.展开更多
The surface properties of superfine alumina trihydrate(ATH) after surface modification were studied by measuring the contact angle, active ratio, oil adsorption, total organic carbon, adsorption ratio, and Fourier tra...The surface properties of superfine alumina trihydrate(ATH) after surface modification were studied by measuring the contact angle, active ratio, oil adsorption, total organic carbon, adsorption ratio, and Fourier transform infrared(FTIR) spectrum. The contact angle increased initially and then slowly decreased with an increase of the amount of stearic acid. However, the surface free energy decreased initially and then increased. Surface modification with stearic acid or sodium stearate can benefit from elevating temperature. The base surface tension component and the free energy of Lewis acid-base both declined sharply following the surface modification. Excess stearic acid was physically adsorbed in the form of multilayer adsorption, and an interaction between oxygen on the ATH surface and hydroxyl in stearic acid was subsequently determined. Our results further indicated that the contact angle and adsorption ratio can be used as control indicators for surface modification compared with active ratio, oil adsorption and total organic carbon.展开更多
Diabetic erectile dysfunction(DED)is a common complication of diabetes mellitus,significantly impairing the quality of life of patients.The conventional clinical treatment still has limitations.Stem cells(SCs),as a ty...Diabetic erectile dysfunction(DED)is a common complication of diabetes mellitus,significantly impairing the quality of life of patients.The conventional clinical treatment still has limitations.Stem cells(SCs),as a type of cells with multidirectional or directional differentiation capability and sustainable selfrenewal potential,are widely used in regenerative medicine and tissue engineering.With the continuous update of regenerative medicine theory and the success of animal experiments,SCs as a treatment for male erectile dysfunction,especially DED,have attracted widespread attention because of curable possibility.This review focus on the current progress in the clinical application of SC treatment for DED.Moreover,we summarize the development prospects of SCs in the field of DMED therapy.展开更多
With the decline in male fertility in recent years,strategies for male fertility preservation have received increasing attention.In this study,by reviewing current treatments and recent publications,we describe resear...With the decline in male fertility in recent years,strategies for male fertility preservation have received increasing attention.In this study,by reviewing current treatments and recent publications,we describe research progress in and the future directions of stem cell-based therapies for male fertility preservation,focusing on the use of spermatogonial stem cells(SSCs),SSC niches,SSC-based testicular organoids,other stem cell types such as mesenchymal stem cells,and stem cell-derived extracellular vesicles.In conclusion,a more comprehensive understanding of the germ cell microenvironment,stem cell-derived extracellular vesicles,and testicular organoids will play an important role in achieving male fertility preservation.展开更多
AIM: To evaluate related factors with the change of spherical equivalents(ΔSE) and determine the suitable predictor of clinically significant ΔSE(≥0.50 D) with cyclopentolate hydrochloride on Chinese children. METH...AIM: To evaluate related factors with the change of spherical equivalents(ΔSE) and determine the suitable predictor of clinically significant ΔSE(≥0.50 D) with cyclopentolate hydrochloride on Chinese children. METHODS: A total of 145 right eyes of 145 children aged 4 to 15 y were enrolled. Intraocular pressure, axial length and lag of accommodation(LOA) were assessed before cycloplegia induced by 3 drops of 1% cyclopentolate at 5-minute intervals. SE was measured before and 1 h after the first drop of cyclopentolate. ΔSE was compared between different gender groups and among refractive groups. Multivariate linear regression analysis was performed to find related factors with ΔSE. ROC analysis was used to figure out the suitable predictor of clinically significant ΔSE.RESULTS: For the total 145 eyes, the mean SE reached up to-0.70±1.86 D from-1.30±1.62 D, with the mean ΔSE of 0.60±0.55 D. The mean ΔSE were 0.63±0.55 D and 0.57±0.56 D respectively in the male and female group(P=0.40). The mean ΔSE was significantly different among different refractive groups(P<0.0001), with the ΔSE of hyperopia group(1.12±0.64 D) larger than that of the emmetropia(0.56±0.43 D, P=0.001) and myopia group(0.32±0.28 D, P<0.0001). The ΔSE was correlated with LOA(B=-0.54, P<0.0001), cycloplegic SE(B=0.10, P<0.0001) and age(B=-0.04, P=0.015). ROC curve indicated that LOA predicted clinically significant ΔSE by 82% [area under the curve(AUC)=0.82] alone, while the value was slightly improved to 85%(AUC=0.85) in combination with axial length and 86%(AUC=0.86) in association with axial length as well as age.CONCLUSION: After cycloplegia with cyclopentolate, the ΔSE decreases with larger LOA, longer axial length and older age. Specifically, LOA plays a more vital role in predicting clinically significant ΔSE.展开更多
The precipitation of spherical boehmite was studied by surface energy calculations, measurements of precipitation ratios, Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and t...The precipitation of spherical boehmite was studied by surface energy calculations, measurements of precipitation ratios, Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and transmission electron microscopy. The surface energy calculation results show that the(001) and(112) planes of gibbsite surfaces are remarkably stable because of their low surface energies. In addition, the(010) plane of boehmite grows preferentially during precipitation because of its low surface energy. Thus, we propose a method to precipitate spherical boehmite from a supersaturated sodium aluminate solution by adding gibbsite as seed in a heterogeneous system. In this method, gibbsite acts as the preliminary seed and saturation modifier. The results show that the fine boehmite first nucleates on the(001) and(112) planes of gibbsite and then grows vertically on the(001) and(112) basal planes of gibbsite via self-assembly, thereby forming spherical boehmite. Simultaneously, gibbsite is dissolved into the aluminate solution to maintain the saturation for the precipitation of boehmite. The precipitation ratio fluctuates(forming an M-shaped curve) because of gibbsite dissolution and boehmite precipitation. The mechanism of boehmite precipitation was further discussed on the basis of the differences in surface energy and solubility between gibbsite and boehmite. This study provides an environmentally friendly and economical method to prepare specific boehmite in a heterogeneous system.展开更多
基金Supported by The National Natural Science Foundation of China,No.82171604。
文摘Impaired wound healing presents great health risks to diabetics.Encouragingly,the current clinical successfully found out meaningful method to repair wound tissue,and stem cell therapy could be an effective method for diabetic wound healing with its ability to accelerate wound closure and avoid amputation.This minireview aims at introducing stem cell therapy for facilitating tissue repair in diabetic wounds,discussing the possible therapeutic mechanism and clinical application status and problems.
基金Project(51604309)supported by the National Natural Science Foundation of ChinaProject(201509048)supported by the Environmental Protection’s Special Scientific Research for Chinese Public Welfare IndustryProject(2015CX001)supported by the Innovation-driven Plan in Central South University,China
基金Project(2019M652799)supported by China Postdoctoral Science FoundationProject(51604309)supported by the National Natural Science Foundation of China。
基金Project(51374239)supported by the National Natural Science Foundation of ChinaProject(201509048)supported by Environmental Protection’s Special Scientific Research for Chinese Public Welfare IndustryProject(2015CX001)supported by the Innovation-driven Plan in Central South University,China
基金Project(51274243)supported by the National Natural Science Foundation of ChinaProject(2015CX001)supported by the Innovation-driven Plan in Central South University,China
基金Supported by Tianjin Major Science and Technology Projects(No.17ZXHLSY00070)Tianjin Clinical Key Discipline Project(No.TJLCZDXKQ012)。
文摘AIM:To evaluate the effectiveness of Grand Seiko Ref/Keratometer WAM-5500 compared to Topcon KR800 autorefractor in detecting refractive error in large scale vision screening for Chinese school age children with the WHO criteria.METHODS:A total of 886 participants were enrolled with mean age of 9.49±1.88 y from Tianjin,China.Spherical equivalent(SE)was obtained from un-cycloplegic autorefraction and cycloplegic autorefraction.Topcon KR 800(Topcon)and Grand Seiko WAM-5500(WAM)autorefractors were used.Bland-Altman Plot and regression were generated to compare their performance.The overall effectiveness of detecting early stage refractive error was analyzed with receiver operating characteristic(ROC)curves.RESULTS:The mean SE was-0.98±1.81 diopter(D)and the prevalence of myopia was 48.9%defined by WHO criteria according to the result of cycloplegic autorefraction.The mean SE of un-cycloplegic autorefraction with Topcon and WAM were-1.21±1.65 and-1.20±1.68 D respectively.There was a strong linear agreement between result obtained from WAM and cycloplegic autorefraction with an R2 of 0.8318.Bland-Altman plot indicated a moderate agreement of cylinder values between the two methods.The sensitivity and specificity for detecting hyperopia were 90.52%and 83.51%;for detecting myopia were 95.60%and 90.24%;for detecting astigmatism were 79.40%and 90.21%;for detecting high myopia were 98.16%and 98.91%respectively.CONCLUSION:These findings suggest that both Grand Seiko and Topcon autorefractor can be used in large-scale vision screening for detecting refractive error in Chinese population.Grand Seiko gives relatively better performance in detecting myopia,hyperopia,and high myopia for school age children.
基金financially supported by the National Natural Science Foundation of China (No. 51274242)
文摘The surface properties of superfine alumina trihydrate(ATH) after surface modification were studied by measuring the contact angle, active ratio, oil adsorption, total organic carbon, adsorption ratio, and Fourier transform infrared(FTIR) spectrum. The contact angle increased initially and then slowly decreased with an increase of the amount of stearic acid. However, the surface free energy decreased initially and then increased. Surface modification with stearic acid or sodium stearate can benefit from elevating temperature. The base surface tension component and the free energy of Lewis acid-base both declined sharply following the surface modification. Excess stearic acid was physically adsorbed in the form of multilayer adsorption, and an interaction between oxygen on the ATH surface and hydroxyl in stearic acid was subsequently determined. Our results further indicated that the contact angle and adsorption ratio can be used as control indicators for surface modification compared with active ratio, oil adsorption and total organic carbon.
基金the National Natural Science Foundation of China,No.81971759.
文摘Diabetic erectile dysfunction(DED)is a common complication of diabetes mellitus,significantly impairing the quality of life of patients.The conventional clinical treatment still has limitations.Stem cells(SCs),as a type of cells with multidirectional or directional differentiation capability and sustainable selfrenewal potential,are widely used in regenerative medicine and tissue engineering.With the continuous update of regenerative medicine theory and the success of animal experiments,SCs as a treatment for male erectile dysfunction,especially DED,have attracted widespread attention because of curable possibility.This review focus on the current progress in the clinical application of SC treatment for DED.Moreover,we summarize the development prospects of SCs in the field of DMED therapy.
文摘With the decline in male fertility in recent years,strategies for male fertility preservation have received increasing attention.In this study,by reviewing current treatments and recent publications,we describe research progress in and the future directions of stem cell-based therapies for male fertility preservation,focusing on the use of spermatogonial stem cells(SSCs),SSC niches,SSC-based testicular organoids,other stem cell types such as mesenchymal stem cells,and stem cell-derived extracellular vesicles.In conclusion,a more comprehensive understanding of the germ cell microenvironment,stem cell-derived extracellular vesicles,and testicular organoids will play an important role in achieving male fertility preservation.
文摘AIM: To evaluate related factors with the change of spherical equivalents(ΔSE) and determine the suitable predictor of clinically significant ΔSE(≥0.50 D) with cyclopentolate hydrochloride on Chinese children. METHODS: A total of 145 right eyes of 145 children aged 4 to 15 y were enrolled. Intraocular pressure, axial length and lag of accommodation(LOA) were assessed before cycloplegia induced by 3 drops of 1% cyclopentolate at 5-minute intervals. SE was measured before and 1 h after the first drop of cyclopentolate. ΔSE was compared between different gender groups and among refractive groups. Multivariate linear regression analysis was performed to find related factors with ΔSE. ROC analysis was used to figure out the suitable predictor of clinically significant ΔSE.RESULTS: For the total 145 eyes, the mean SE reached up to-0.70±1.86 D from-1.30±1.62 D, with the mean ΔSE of 0.60±0.55 D. The mean ΔSE were 0.63±0.55 D and 0.57±0.56 D respectively in the male and female group(P=0.40). The mean ΔSE was significantly different among different refractive groups(P<0.0001), with the ΔSE of hyperopia group(1.12±0.64 D) larger than that of the emmetropia(0.56±0.43 D, P=0.001) and myopia group(0.32±0.28 D, P<0.0001). The ΔSE was correlated with LOA(B=-0.54, P<0.0001), cycloplegic SE(B=0.10, P<0.0001) and age(B=-0.04, P=0.015). ROC curve indicated that LOA predicted clinically significant ΔSE by 82% [area under the curve(AUC)=0.82] alone, while the value was slightly improved to 85%(AUC=0.85) in combination with axial length and 86%(AUC=0.86) in association with axial length as well as age.CONCLUSION: After cycloplegia with cyclopentolate, the ΔSE decreases with larger LOA, longer axial length and older age. Specifically, LOA plays a more vital role in predicting clinically significant ΔSE.
基金financially supported by the National Natural Science Foundation of China (No.51274242)the Fundamental Research Funds for the Central Universities of Central South University (No.2016zzts038)
文摘The precipitation of spherical boehmite was studied by surface energy calculations, measurements of precipitation ratios, Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and transmission electron microscopy. The surface energy calculation results show that the(001) and(112) planes of gibbsite surfaces are remarkably stable because of their low surface energies. In addition, the(010) plane of boehmite grows preferentially during precipitation because of its low surface energy. Thus, we propose a method to precipitate spherical boehmite from a supersaturated sodium aluminate solution by adding gibbsite as seed in a heterogeneous system. In this method, gibbsite acts as the preliminary seed and saturation modifier. The results show that the fine boehmite first nucleates on the(001) and(112) planes of gibbsite and then grows vertically on the(001) and(112) basal planes of gibbsite via self-assembly, thereby forming spherical boehmite. Simultaneously, gibbsite is dissolved into the aluminate solution to maintain the saturation for the precipitation of boehmite. The precipitation ratio fluctuates(forming an M-shaped curve) because of gibbsite dissolution and boehmite precipitation. The mechanism of boehmite precipitation was further discussed on the basis of the differences in surface energy and solubility between gibbsite and boehmite. This study provides an environmentally friendly and economical method to prepare specific boehmite in a heterogeneous system.
基金Project(51274242) supported by the National Natural Science Foundation of ChinaProject(2015CX001) supported by the Innovation-driven Plan of Central South University,China
基金Project(51274243)supported by the National Natural Science Foundation of ChinaProject(2015CX001)supported by the Innovation-driven Plan of Central South University,China
基金Project(2015BAB04B01)supported by the National Key Technology Research&Development Program of ChinaProject(CSUZC201811)supported by the Open-End Fund for the Valuable and Precision Instruments of Central South University,China
